"On October 30th, 1920, I was attracted by an article by , in which he pointed out the similarity between the degenerative changes in the cells of the pancreas following experimental ligation of the duct, and the changes following blockage of the duct with s. Having read this article, the idea presented itself that by ligating the duct and allowing time for the degeneration of the acinus cells, a means might be provided for obtaining an extract of the islet cells free from the destroying influence of trypsin and other pancreatic enzymes."
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Frederick G. Banting, ""Diabetes and Insulin", Nobel Lecture, September 15, 1925.
https://en.wikiquote.org/wiki/Diabetes
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Diabetes
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