"Believing that the want of success to prepare extracts of uniform potency as due to the destruction of the antidiabetic hormone by the digestive enzymes also present in the gland, F. G. Banting suggested preparing them from duct-ligated pancreas, and with the aid of C. H. Best, and under my direction, he succeeded in 1922 in showing that such extracts reduced the hyperglycaemia and glycosuria in depancreatized dogs. The general symptoms of diabetes were also found to be alleviated and the duration of life of the depancreatized animal prolonged, by the repeated injection of alcoholic extracts of foetal, as well as of adultox pancreas. Later it was shown, in collaboration with Collip, that other symptoms of diabetes, namely the ketonuria and the absence of glycogen from the liver, were favourably influenced by the extracts and, with Hepburn, that the respiratory quotient became raised. These results on depancreatized dogs showed beyond doubt that the antidiabetic hormone was present in potent form in the extracts, and the time seemed ripe to investigate their action on the clinical forms of diabetes. This was done by Banting in a severe case under the care of W. R. Campbell, with the result that the hyperglycaemia and glycosuria were diminished. At the same time, however, it was found that it would be necessary to rid the extracts of irritating substances before the value of their repeated injection in the treatment of diabetes in man could be adequately put to the test. This was accomplished by Collip, and the name insulin was decided upon for the purified extract."