"You are the missing link. Goodbye. [Reference to the game show The Weakest Link - or to the "missing link" species between ape and human in misunderstood evolution theory - when Duke spots any mutant]"

"Your kung-fu is through! [after killing a mutant crocodile]"

"Space, the final frontier. These are the voyages of Duke Nukem. My continuing mission: to explore strange new babes, to seek out new aliens and kick their asses."

"Jeez… You’d think Morphix could afford a few light bulbs? [in the early parts of E5L1]"

"I oughta break a broomhandle off in your ass! [when spots any mutant]"

"Quit wasting my time! [after killing any mutant]"

"Oh well; looks like I've broken another woman's heart. [when killing the female bot at E7L3]"

"I'll bet this teleporter is an express delivery to Morphix. Well; I've got a special package and I'm gonna make him sign for it. [when Duke teleports at Morphix's space station]"

"This is it! Let's you and me finish off this bastard once and for all! [before final fight with Morphix at E8L3]"

"Clean up on Aisle Four! [when he blows enemies up]"

"I don't remember buying tickets to Mutants on Ice. [in the middle of tanker freezer at E6L1]"

"Hmm... Babealicious! [after rescuing a babe]"

"Ahh, just in time! [before final fight with roachoid queen at E4L3]"

"Buzz off! [after killing a mutant fly]"

"No more left! [when Duke doesn't have pipebombs]"

"Now you see me, now you're dead! [after killing a robot]"

"Incoming! [when spots a mutant fly]"

"You talking to me [when Duke staying inactive with a pistol all the time]"

"Time to fumigate! [when spots a mutant roach]"

"Okay, cycloid shithead, happy now? (First battle with Cycloid Emperor) (Reference on Moonwing Warrior)"

"Take your tentacles back to Japan, you freak! (after killing an Octobrain)(This is a reference to tentacle hentai.)"

"Take those tentacles and shove `em up your ass! (after killing an Octabrain)"

"My balls, your face."

"Have a taste of my ball! (after crushing a condemned building full of enemies with the wrecking ball)"

"All right, time for my reward! (while meeting with the Holsom Twins)"

"Looks like those alien bastards drank all my beer."

"[slapping alien breasts] Got milk?"

"Hmm... convenient."

"I'm from Las Vegas, and I say: kill 'em all. (reference to Rico's quote in Starship Troopers)"

"I guess pigs DO fly! (after causing an explosion that makes a pig-cop fly)"

"It's down to you and me!"

"It's good!"

"No! Come on! No! (after grabbing the piece of crap)"

"I'm the Duke, I'm A-number 1. (Reference to The Duke of New York City in Escape From New York)"

"Now what am I doing? (after taking a piece of crap)"

"Oh yeah! I'm bringing sexy back. (A possible reference to Justin Timberlake's song 'SexyBack')"

"A turd in the hand is worth two in the bush. (while holding a piece of crap)"

"Power armor is for pussies! (while looking at a suit of armor resembling that of a Master Chief's from HALO)"

"Size only matters when you're full grown, baby!"

"This is taking forever. Time to stop pissing around and get this big guy back into action. Woah, that water's cold. (while pissing at the beginning of the game, a reference to the protracted and extensive development time of Duke Nukem Forever) A reference to a famous old joke involving John Holmes, the late porn star. I say this as he then adds "And deep too""

"Tonight, You dine in hell! (reference from the movie 300)"

"A crowbar would come in handy right about now. (While looking at boarded mine. Reference to Gordon Freeman and the use of crowbars in Half-Life series)"

"[after solving a gear puzzle] Duke one, gears none."

"Bonjour, le hot stuff."

"Squeal piggy! Squeal [reference to Deliverance. Could be also a reference from the first Unreal Tournament "Squeal boy, squeal!" as DNF is based on Unreal Engine]"