Nobel Laureates In Physiology Or Medicine

"The job of theorists, especially in biology, is to suggest new experiments. A good theory makes not only predictions, but surprising predictions that then turn out to be true. (If its predictions appear obvious to experimentalists, why would they need a theory?)"

"What is found in biology is mechanisms, mechanisms built with chemical components and that are often modified by other, later, mechanisms added to the earlier ones. While Occam's razor is a useful tool in the physical sciences, it can be a very dangerous implement in biology. It is thus very rash to use simplicity and elegance as a guide in biological research. While DNA could be claimed to be both simple and elegant, it must be remembered that DNA almost certainly originated fairly close to the origin of life when things were necessarily simple or they would not have got going. Biologists must constantly keep in mind that what they see was not designed, but rather evolved. It might be thought, therefore, that evolutionary arguments would play a large part in guiding biological research, but this is far from the case. It is difficult enough to study what is happening now. To figure out exactly what happened in evolution is even more difficult. Thus evolutionary achievements can be used as hints to suggest possible lines of research, but it is highly dangerous to trust them too much. It is all too easy to make mistaken inferences unless the process involved is already very well understood."

"Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene."

"Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick."

"I argued that it was important not to place too much reliance on any single piece of experimental evidence. It might turn out to be misleading, as the 5.1 Å reflection undoubtedly was. Jim was a little more brash, stating that no good model ever accounted for all the facts, since some data was bound to be misleading if not plain wrong. A theory that did fit all the data would have been "carpentered" to do so and would thus be open to suspicion. (pp. 59-60)"

"Big questions get big answers."

"An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going. But this should not be taken to imply that there are good reasons to believe that it could not have started on the earth by a perfectly reasonable sequence of fairly ordinary chemical reactions. The plain fact is that the time available was too long, the many microenvironments on the earth's surface too diverse, the various chemical possibilities too numerous and our own knowledge and imagination too feeble to allow us to be able to unravel exactly how it might or might not have happened such a long time ago, especially as we have no experimental evidence from that era to check our ideas against."

"I wasn't aware of Chargaff's rules when he said them, but the effect on me was quite electric because I realized immediately that if you had this sort of scheme that John Griffith was proposing, of adenine being paired with thymine, and guanine being paired with cytosine, then you should get Chargaff's rules. I was very excited, but I didn't actually tell Chargaff because it was something I was doing with John Griffith. ... This was very exciting, and we thought "ah ha!" and we realized - I mean what anyone who is familiar with the history of science ought to realize - that when you have one-to-one ratios, it means things go to together. And how on Earth no one pointed out this simple fact in those years, I don't know."

"Unlike you and your colleagues I have formed the opinion that there is much substance to Jensen's arguments. In brief I think it likely that more than half the difference between the average I.Q. of American whites and Negroes is due to genetic reasons, and will not be eliminated by any foreseeable change in the environment. Moreover I think the social consequences of this are likely to be rather serious unless steps are taken to recognize the situation."

"And so to those of you who may be vitalists I would make this prophecy: what everyone believed yesterday, and you believe today, only cranks will believe tomorrow."

"The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry."

"If for example I had some idea, which as it turned out would be quite wrong, was going off of the tangent, Watson would tell me in no uncertain terms this was nonsense, and vice-versa. If he would have some idea I didn't like, and I would say so, this would shake his thinking about, and draw him back again. And in fact it is one of the requirements for collaborations of this sort, is you must be perfectly candid, one might almost say rude, to the person you're working with. It's useless working with somebody who is either much too junior than yourself or much too senior because then politeness creeps in. And this is the end of all real collaboration in science (giggles)."

"It would have been a great disappointment to me if Vibration did not somewhere make itself felt, for all scientistic mystics either vibrate in person or find themselves resonant with cosmic vibrations; but I am happy to say that on page 266 Teilhard will be found to do so."

"French is not a language that lends itself naturally to the opaque and ponderous idiom of nature-philosophy, and Teilhard has according resorted to the use of that tipsy, euphoristic prose-poetry which is one of the more tiresome manifestations of the French spirit."

"Karl Popper’s conception of the scientific process is that is realistic – it gives a pretty fair picture of what goes on in real life laboratories."

"When asked to make the formal declaration that I did not intend to overthrow the Constitution of the United States, I was fool enough to reply that I had no such purpose, but that were I to do it by mistake I should be inexpressibly contrite."

"I do not believe—indeed, I deem it a comic blunder to believe—that the exercise of reason is sufficient to explain our condition and where necessary to remedy it, but I do believe that the exercise of reason is at all times necessary..."

"No virus is known to do good: it has been well said that a virus is "a piece of bad news wrapped up in protein.""

"The attempt to discover and promulgate the truth is nevertheless an obligation upon all scientists, one that must be persevered in no matter what the rebuffs—for otherwise what is the point in being a scientist?"

"A scientist is no more a collector and classifier of facts than a historian is a man who complies and classifies a chronology of the dates of great battles and major discoveries."

"Observation is the generative act in scientific discovery. For all its aberrations, the evidence of the senses is essentially to be relied upon—provided we observe nature as a child does, without prejudices and preconceptions, but with that clear and candid vision which adults lose and scientists must strive to regain."

"I once spoke to a human geneticist who declared that the notion of intelligence was quite meaningless, so I tried calling him unintelligent. He was annoyed, and it did not appease him when I went on to ask how he came to attach such a clear meaning to the notion of lack of intelligence. We never spoke again."

"I believe in "intelligence," and I believe also that there are inherited differences in intellectual ability, but I do not believe that intelligence is a simple scalar endowment that can be quanitified by attaching a single figure to it—an I.Q. or the like."

"To be creative, scientists need libraries and laboratories and the company of other scientists; certainly a quiet and untroubled life is a help. A scientist's work is in no way deepened or made more cogent by privation, anxiety, distress, or emotional harassment. To be sure, the private lives of scientists may be strangely and even comically mixed up, but not in ways that have any special bearing on the nature and quality of their work. If a scientist were to cut off an ear, no one would interpret such an action as evidence of an unhappy torment of creativity; nor will a scientist be excused any bizarrerie, however extravagant, on the grounds that he is a scientist, however brilliant."

"It can be said with complete confidence that any scientist of any age who wants to make important discoveries must study important problems. Dull or piffling problems yield dull or piffling answers. It is not enough that a problem should be "interesting" - almost any problem is interesting if it is studied in sufficient depth."

"Only human beings guide their behaviour by a knowledge of what happened before they were born and a preconception of what may happen after they are dead; thus only humans find their way by a light that illuminates more than the patch of ground they stand on."

"It is the great glory as well as the great threat of science that everything which is in principle possible can be done if the intention to do it is sufficiently resolute."

"We wring our hands over the miscarriages of technology and take its benefactions for granted. We are dismayed by air pollution but not proportionately cheered up by, say, the virtual abolition of poliomyelitis."

"We shall not read it for its sociological insights, which are non-existent, nor as science fiction, because it has a general air of implausibility; but there is one high poetic fancy in the New Atlantis that stays in the mind after all its fancies and inventions have been forgotten. In the New Atlantis, an island kingdom lying in very distant seas, the only commodity of external trade is — light: Bacon's own special light, the light of understanding."

"Creosote has a pretty technological smell."

"Today the world changes so quickly that in growing up we take leave not just of youth but of the world we were young in. I suppose we all realize the degree to which fear and resentment of what is new is really a lament for the memories of our childhood."

"We cannot point to a single definitive solution of any one of the problems that confront us — political, economic, social or moral, that is, having to do with the conduct of life. We are still beginners, and for that reason may hope to improve. To deride the hope of progress is the ultimate fatuity, the last word in poverty of spirit and meanness of mind. There is no need to be dismayed by the fact that we cannot yet envisage a definitive solution of our problems, a resting-place beyond which we need not try to go."

"There is no such thing as a Scientific Mind. Scientists are people of very dissimilar temperaments doing different things in very different ways. Among scientists are collectors, classifiers and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics. What sort of mind or temperament can all these people be supposed to have in common? Obligative scientists must be very rare, and most people who are in fact scientists could easily have been something else instead."

"The similarity between them is not the taxonomic key to some other, deeper, affinity, and our recognizing its existence marks the end, not the inauguration, of a train of thought."

"Simultaneous discovery is utterly commonplace, and it was only the rarity of scientists, not the inherent improbability of the phenomenon, that made it remarkable in the past. Scientists on the same road may be expected to arrive at the same destination, often not far apart."

"How have people come to be taken in by The Phenomenon of Man? We must not underestimate the size of the market for works of this kind, for philosophy-fiction. Just as compulsory primary education created a market catered for by cheap dailies and weeklies, so the spread of secondary and latterly tertiary education has created a large population of people, often with well-developed literary and scholarly tastes, who have been educated far beyond their capacity to undertake analytical thought."

"If politics is the art of the possible, research is surely the art of the soluble. Both are immensely practical-minded affairs."

"The human mind treats a new idea the same way the body treats a strange protein; it rejects it."

"Scientific discovery is a private event, and the delight that accompanies it, or the despair of finding it illusory, does not travel. One scientist may get great satisfaction from another’s work and admire it deeply; it may give him great intellectual pleasure; but it gives him no sense of participation in the discovery, it does not carry him away, and his appreciation of it does not depend on his being carried away. If it were otherwise the inspirational origin of scientific discovery would never have been in doubt."

"I could quote evidence of the beginnings of a whispering campaign against the virtues of clarity. A writer on structuralism in the Times Literary Supplement has suggested that thoughts which are confused and tortuous by reason of their profundity are most appropriately expressed in prose that is deliberately unclear. What a preposterously silly idea! I am reminded of an air-raid warden in wartime Oxford who, when bright moonlight seemed to be defeating the spirit of the blackout, exhorted us to wear dark glasses. He, however, was being funny on purpose."

"The purpose of scientific enquiry is not to compile an inventory of factual information, nor to build up a totalitarian world picture of natural Laws in which every event that is not compulsory is forbidden. We should think of it rather as a logically articulated structure of justifiable beliefs about nature."

"Yet the greater part of it, I shall show, is nonsense, tricked out with a variety of metaphysical conceits, and its author can be excused of dishonesty only on the grounds that before deceiving others he has taken great pains to deceive himself."

"It is written in an all but totally unintelligible style, and this is construed as prima-facie evidence of profundity."

"In no sense other than an utterly trivial one is reproduction the inverse of chemical disintegration. It is a misunderstanding of genetics to suppose that reproduction is only 'intended' to make facsimiles, for parasexual processes of genetical exchange are to be found in the simplest living things."

"There is much else in the literary idiom of nature-philosophy: nothing-buttery, for example, always part of the minor symptomatology of the bogus."

"The Phenomenon of Man stands square in the tradition of Naturphilosophie, a philosophical indoor pastime of German origin which does not seem even by accident (though there is a great deal of it) to have contributed anything of permanent value to the storehouse of human thought."

"I do not propose to criticize the fatuous argument I have just outlined; here, to expound is to expose."

"Watson's childlike vision makes them seem like the creatures of a Wonderland, all at a strange contentious noisy tea-party which made room for him because for people like him, at this particular kind of party, there is always room."

"It just so happens that during the 1950s, the first great age of molecular biology, the English Schools of Oxford and particularly of Cambridge produced more than a score of graduates of quite outstanding ability —much more brilliant, inventive, articulate and dialectically skilful than most young scientists; right up in the Watson class. But Watson had one towering advantage over all of them: in addition to being extremely clever he had something important to be clever about. This is an advantage which scientists enjoy over most other people engaged in intellectual pursuits, and they enjoy it at all levels of capability. To be a first-rate scientist it is not necessary (and certainly not sufficient) to be extremely clever, anyhow in a pyrotechnic sense. One of the great social revolutions brought about by scientific research has been the democratization of learning. Anyone who combines strong common sense with an ordinary degree of imaginativeness can become a creative scientist, and a happy one besides, in so far as happiness depends upon being able to develop to the limit of one's abilities."

"Scientists are entitled to be proud of their accomplishments, and what accomplishments can they call 'theirs' except the things they have done or thought of first? People who criticize scientists for wanting to enjoy the satisfaction of intellectual ownership are confusing possessiveness with pride of possession. Meanness, secretiveness and, sharp practice are as much despised by scientists as by other decent people in the world of ordinary everyday affairs; nor, in my experience, is generosity less common among them, or less highly esteemed."