Nobel Laureates In Physiology Or Medicine

"If we don't play God, who will?"

"No one may have the guts to say this, but if we could make better human beings by knowing how to add genes, why shouldn't we?"

"Whenever you interview fat people, you feel bad, because you know you're not going to hire them."

"Never do anything that bores you. My experience in science is that someone is always telling to do something that leaves you flat. Bad idea. I'm not good enough to do something I dislike. In fact, I find it hard enough to do something that I like. … Constantly exposing your ideas to informed criticism is very important, and I would venture to say that one reason both of our chief competitors failed to reach the Double Helix before us was that each was effectively very isolated."

"Be sure you have someone up your sleeve who will save you when you find yourself in deep s—."

"To make a huge success, a scientist must be prepared to get into deep trouble. Sometime or another, someone will tell you that you are not ready to do something. … If you are going to make a big jump in science, you will very likely be unqualified to succeed by definition. The truth, however, won't save you from criticism. Your very willingness to take on a very big goal will offend some people who will think that you are too big for your britches and crazy to boot."

"To succeed in science, you have to avoid dumb people (here I was still following Luria's example). Now that might sound inexcusably flip, but the fact is that you must always turn to people who are brighter than yourself."

"To have success in science, you need some luck. But to succeed in science, you need a lot more than luck. And it's not enough to be smart — lots of people are very bright and get nowhere in life. In my view, you have to combine intelligence with a willingness not to follow conventions when they block your path forward."

"Moving forward will not be for the faint of heart. But if the next century witnesses failure, let it be because our science is not yet up to the job, not because we don't have the courage to make less random the sometimes most unfair courses of human evolution."

"When anti-DNA doomsday scenarios failed to materialize, even the modestly restrictive governmental regulations began to wither away. In retrospect, recombinant-DNA may rank as the safest revolutionary technology ever developed. To my knowledge, not one fatality, much less illness, has been caused by a genetically manipulated organism. The moral I draw from this painful episode is this: Never postpone experiments that have clearly defined future benefits for fear of dangers that can't be quantified. Though it may sound at first uncaring, we can react rationally only to real (as opposed to hypothetical) risks."

"There is only one science, physics: everything else is social work."

"The brain is the last and grandest biological frontier, the most complex thing we have yet discovered in our universe. It contains hundreds of billions of cells interlinked through trillions of connections. The brain boggles the mind."

"Watson: Our society just hasn't faced up to this problem. In a primitive society, if you saw that a baby was deformed, you would abandon it on a hillside. Today this isn't permissible, and with our medicine getting better and better in the sense of being able to keep sick people alive longer, we are going to produce more people living wretched lives. I don't know how you get a society to change on such a basic issue; infanticide isn't regarded lightly by anyone. Fortunately, now through such techniques as amniocentesis, parents can often learn in advance whether their child will be normal and healthy or hopelessly deformed. They then can choose either to have the child or opt for a therapeutic abortion. But the cruel fact remains that because of the present limits of such detection methods, most birth defects are not discovered until birth. If the child were not declared alive until three days after birth, then all parents could be allowed the choice that only a few are given under the present system. The doctor could allow the child to die if the parents so chose and save a lot of misery and suffering. I believe this view is the only rational, compassionate attitude to have."

"Prism: But how would society react to such a proposal?"

"Watson: But legalities aside, I think we must reevaluate our basic assumptions about the meaning of life. Perhaps, as my former colleague Francis Crick suggested, no one should be thought alive until about three days after birth."

"I suspect that in the beginning Maurice hoped that Rosy would calm down. Yet mere inspection suggested that she would not easily bend. By choice she did not emphasize her feminine qualities. Though her features were strong, she was not unattractive and might have been quite stunning had she taken even a mild interest in clothes. This she did not. There was never lipstick to contrast with her straight black hair, while at the age of thirty-one her dresses showed all the imagination of English blue-stocking adolescents. So it was quite easy to imagine her the product of an unsatisfied mother who unduly stressed the desirability of professional careers that could save bright girls from marriages to dull men. But this was not the case. Her dedicated austere life could not be thus explained — she was the daughter of a solidly comfortable, erudite banking family. Clearly Rosy had to go or be put in her place. The former was obviously preferable because, given her belligerent moods, it would be very difficult for Maurice to maintain a dominant position that would allow him to think unhindered about DNA. Not that at times he'd didn't see some reason for her complaints — King's had two combination rooms, one for men, the other for women, certainly a thing of the past. But he was not responsible, and it was no pleasure to bear the cross for the added barb that the women's combination room remained dingily pokey whereas money had been spent to make life agreeable for him and his friends when they had their morning coffee. Unfortunately, Maurice could not see any decent way to give Rosy the boot. To start with, she had been given to think that she had a position for several years. Also there was no denying that she had a good brain. If she could keep her emotions under control, there was a good chance she could really help him. But merely wishing for relations to improve was taking something of a gamble, for Cal Tech's fabulous chemist Linus Pauling was not subject to the confines of British fair play. Sooner or later Linus, who had just turned fifty, was bound to try for the most important of all scientific prizes. There was no doubt he was interested. … The thought could not be avoided that the best home for a feminist was in another person's lab."

"One could not be a successful scientist without realizing that, in contrast to the popular conception supported by newspapers and mothers of scientists, a goodly number of scientists are not only narrow-minded and dull, but also just stupid."

"Perfect as is the wing of a bird, it never could raise the bird up without resting on air. Facts are the air of a scientist. Without them you never can fly. Without them your "theories" are vain efforts."

"Pavlov’s findings were confirmed in the most distressing manner, and on a very large scale, during the two World Wars. As the result of a single catastrophic experience, or of a succession of terrors less appalling but frequently repeated, soldiers develop a number of disabling psycho-physical symptoms. Temporary unconsciousness, extreme agitation, lethargy, functional blindness or paralysis, completely unrealistic responses to the challenge of events, strange reversals of life-long patterns of behaviour—all the symptoms, which Pavlov observed in his dogs, re-appeared among the victims of what in the First World War was called ‘shell shock’, in the Second, ‘battle fatigue’. Every man, like every dog, has his own individual limit of endurance. Most men reach their limit after about thirty days of more or less continuous stress under the conditions of modern combat. The more than averagely susceptible succumb in only fifteen days. The more than averagely tough can resist for forty-five or even fifty days. Strong or weak, in the long run all of them break down. All, that is to say, of those who are initially sane. For, ironically enough, the only people who can hold up indefinitely under the stress of modern war are psychotics. Individual insanity is immune to the consequences of collective insanity."

"It makes not a bit of difference that Pavlov was a devout physicalist who felt that a scientific treatment of conscious experience was impossible. In time-honored scientific fashion, good data outlast the orientation of the investigators who collected them."

"I was, I am and will remain the Russian, the son of the Motherland. Her life first of all I will be interested in. I will live with her interests. With her’s dignity I will strengthen mine."

"Learn, compare, collect the facts!"

"Learn the ABC of science before you try to ascend to its summit."

"Mankind will possess incalculable advantages and extraordinary control over human behavior when the scientific investigator will be able to subject his fellow men to the same external analysis he would employ for any natural object, and when the human mind will contemplate itself not from within but from without."

"The Sun-Paul must consider only one thing: what is the relation of this or that external reaction of the animal to the phenomena of the external world?"

"Now and then philosophers invade the field of biological sciences with these beguiling generalizations, which tend to be unproductive, purely verbal solutions lacking in substance. At best, they may prove useful when viewed simply as working hypotheses."

"The severe constraints imposed by determinism may appear to limit philosophy in a rather arbitrary way. However, there is no denying that in the natural sciences — and especially in biology — it is a very effective tool for avoiding the innate tendency to explain the universe as a whole in terms of general laws."

"Knowing the conditions under which a phenomenon occurs allows us to reproduce or eliminate it at will, therefore allowing us to control and use it for the benefit of humanity. Foresight and action are the advantages we obtain from a deterministic view of phenomena."

"As Claude Bernard has pointed out, researchers cannot transcend the determinism of phenomena; instead, their mission is limited to demonstrating the how, never the why, of observed changes. This is a modest goal in the eyes of philosophy, yet an imposing challenge in actual practice."

"The intellect is presented with phenomena marching in review before the sensory organs. It can be truly useful and productive only when limiting itself to the modest tasks of observation, description, and comparison, and of classification that is based on analogies and differences. A knowledge of underlying causes and empirical laws will then come slowly through the use of inductive methods."

"This history of civilization proves beyond doubt just how sterile the repeated attempts of metaphysics to guess at nature' s laws have been. Instead, there is every reason to believe that when the human intellect ignores reality and concentrates within, it can no longer explain the simplest inner workings of life' s machinery or of the world around us ( p. 2)."

"The unique method of reflection indulged in by the Pythagoreans and followers of Plato (and pursued in modern times by Descartes, Fichte, Krause, Hegel, and more recently at least partly by Bergson) involves exploring one’s own mind or soul to discover universal laws and solutions to the great secrets of life."

"Instead of elaborating on accepted principles, let us simply point out that for the last hundred years the natural sciences have abandoned completely the Aristotelian principles of intuition, inspiration, and dogmatism."

"Any man could, if he were so inclined, be the sculptor of his own brain ( p. xv)."

"For most neuroscientists, the roots of our discipline stem from Santiago Ramón y Cajal, the Spanish scientist who, during almost half a century of patient work, showed that the nervous system is made up of independent nerve cells. His studies on the anatomical organization of the brain are still a source of inspiration for many of us. His monumental body of work fully justifies that Ramón y Cajal be singled out as the founder of modern neuroscience."

"As the decades have passed, one by one all his theories have been corroborated using modern techniques, and the main hypotheses that Cajal postulated have become universally recognized as biological laws: The neuron theory; the law of the dynamic polarization of the neuron and the principle of connectional specificity."

"Santiago Ramón y Cajal is recognized as the founder of modern neuroscience, his discoveries representing the fundamental pillars of our current understanding of the nervous system."

"Cajal is considered the father of modern neuroscience, as important in his field as Charles Darwin or Louis Pasteur are in theirs (though relatively unknown outside of it)."

"In summary, there are no small problems. Problems that appear small are large problems that are not understood (p. 17)."

"It is important to note that the most brilliant discoveries have not relied on a formal knowledge of logic. Instead, their discoverers have had an acute inner logic that generates ideas with the same unstudied unconsciousness that allowed Jourdain to create prose."

"There is no doubt that the human mind is fundamentally incapable of solving these formidable problems (the origin of life, nature of matter, origin of movement, and appearance of consciousness). Our brain is an organ of action that is directed toward practical tasks; it does not appear to have been built for discovering the ultimate causes of things, but rather for determining their immediate causes and invariant relationships."

"I don't know exactly what you guys want to do, but let me tell you why you should do it with fruit flies."

"There is no form of prose more difficult to understand and more tedious to read than the average scientific paper."

"Conversations with Crick frequently upset Sir Lawrence Bragg, and the sound of his voice was often sufficient to make Bragg move to a safer room. Only infrequently would he come to tea in the Cavendish, since it meant enduring Crick's booming over the tea room."

"It was not until May of 1986 that I met Francis Crick, at a conference in San Diego. There was a big crowd, full of neuroscientists, but when it was time to sit down for dinner, Crick singled me out, seized me by the shoulders, sat me down next to him, and said, “Tell me stories!” I have no memory of what we ate, or anything else about the dinner, only that I told him stories about many of my patients, and that each one set off bursts of hypotheses, theories, suggestions for investigation in his mind. Writing to Crick a few days later, I said that the experience was “a little like sitting next to an intellectual nuclear reactor…. I never had a feeling of such incandescence.”"

"When he discovered the structure of DNA, Francis Crick immediately understood how genetic inheritance works, announcing in the Pub that evening that he understood the secret of life."

"Before I describe in more detail exactly what is involved in seeing, let me make three general remarks."

"Our brains have evolved mainly to deal with our body and its interactions with the world it senses to be around us. Is this world real? This is a venerable philosophical issue and I do not wish to be embroiled in the finely honed squabbles to which it has led. I merely state my own working hypothesis: that there is indeed an outside world, and that it is largely independent of our observing it. We can never fully know this outside world, but we can obtain approximate information about some aspects of its properties by using our senses and our brain."

"Philosophers have been especially concerned with the problem of consciousness—for example, how to explain the redness of red or the painfulness of pain. This is a very thorny issue. The problem springs from the fact that the redness of red that I perceive so vividly cannot be precisely communicated to another human being, at least in the ordinary course of events. If you cannot describe the properties of a thing unambiguously, you are likely to have some difficulty trying to explain these properties in reductionist terms."

"My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure,” I was supposed to have said in my molecular biology days. (I believe I was sailing at the time.) I think that one should approach these problems at all levels, as was done in molecular biology. Classical genetics is, after all, a black-box subject. The important thing was to combine it with biochemistry. In nature hybrid species are usually sterile, but in science the reverse is often true. Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts."