"The singleton hypothesis is that Earth-originating intelligent life will (eventually) form a singleton. It is an open question whether the singleton hypothesis is true. My own opinion is that it is more likely true than not. Historically, we have seen an overarching trend towards the emergence of higher levels of social organization, from hunter-gatherer bands, to chiefdoms, city-states, nation states, and now multinational organizations, regional alliances, various international governance structures, and other aspects of globalization. Extrapolation of this trend points to the creation of a singleton."

"Searching for a cure for aging is not just a nice thing that we should perhaps one day get around to. It is an urgent, screaming moral imperative. The sooner we start a focused research program, the sooner we will get results. It matters if we get the cure in 25 years rather than in 24 years: a population greater than that of Canada would die as a result. In this matter, time equals life, at a rate of approximately 70 lives per minute. With the meter ticking at such a furious rate, we should stop faffing about."

"The Internet is a big boon to academic research. Gone are the days spent in dusty library stacks digging for journal articles. Many articles are available free to the public in open-access journal or as preprints on the authors’ website."

"By anybody’s standards, there is a huge amount of unnecessary and undeserved suffering that is just bad and that we should get rid of."

"[If] our actions have even the slightest effect on the probability of eventual colonization, this will outweigh their effect on when colonization takes place. For standard utilitarians, priority number one, two, three and four should consequently be to reduce existential risk. The utilitarian imperative “Maximize expected aggregate utility!” can be simplified to the maxim “Minimize existential risk!”"

"What could be more fascinating than discovering life that had evolved entirely independently of life here on Earth? Many people would also find it heartening to learn that we are not entirely alone in this vast cold cosmos. But I hope that our Mars probes will discover nothing. It would be good news if we find Mars to be completely sterile. Dead rocks and lifeless sands would lift my spirit."