"Sue! These are the Shareholders, they are dying to meet you! Is everything okay? So SMILE! That's what we want tonight! Pretty girls should always SMILE!"

"[in a panic] I need a better version of myself. Please give me a better version of myself, please! Please! Come on!"

"Fred: You haven't changed a bit! You're still the most beautiful girl in the whole wide world!"

"[on the phone in the bathroom] I don't care if I see every fucking young girl in this fucking town in the next few weeks. Look, I made it simple. We need her young. We need her hot. We need her now. How the old bitch has been able to stick around for this long, that's the fucking mystery to me. Oh, Oscar winner, my ass. When was that back in the 30s? What, for King Kong? [laughs] No, I don't give a fuck what we promised her. This is network TV, not a fucking charity. Find me someone new. NOW! Hey, did you know that a woman's fertility starts to decrease by the age of 25? How old is Jennifer? Ha ha. You better get busy. [laughs as he walks out]"

"Dennis Quaid - Harvey"

"Have you ever dreamt of a better version of yourself? Younger, more beautiful, more perfect. One single injection unlocks your DNA, starting a new cellular division, that will release another version of yourself. This is the Substance. You are the matrix. Everything comes from you. Everything is you. This is simply a better version of yourself. You just have to share. One week for one and one week for the other. A perfect balance of seven days each. The one and only thing not to forget: You. Are. One. You can't escape from yourself."

"What has been used on one side, is lost on the other side. There's no going back."

"[to lifeless Sue] You're the only part of me I don't hate."

"There's been a slight misuse of the Substance."

"Margaret Qualley - Sue"

"Yann Bean - The Substance voice"

"[to Sue] Gorgeous. With a pure heart. People are gonna love that!"

"[to the shareholders, about Sue] You will not be disappointed. She's my most beautiful creation. I have shaped her for success."

"Casting Director: Too bad her boobs aren't in the middle of her face instead of that nose!"

"Arden Roger Meyer as Man With Towel"

"Edith Fellows as Mrs. Wilson"

"Michael Berryman as Pluto"

"Brenda Marinoff as Katy (archive footage)"

"Lance Gordon as Mars (archive footage)"

"Martin Speer as Doug (archive footage)"

"John Bloom as The Reaper"

"Peter Frechette as Harry"

"Willard E. Pugh as Foster (as Willard Pugh)"

"Colleen Riley as Jane"

"Kevin Blair as Roy"

"Tamara Stafford as Cass"

"John Laughlin as Hulk"

"Penny Johnson Jerald as Sue"

"Virginia Vincent as Ethel Carter (archive footage)"

"David Nichols as The Psychiatrist"

"James Whitworth as Jupiter (archive footage)"

"[Only line] Reaper don't get fooled like Papa Jupe! Oh no!"

"Camping out with the family can be murder."

"We guarantee you will jump out of your seat and scream in fear!"

"[After just dodging and catching a cylinder with spikes sticking out of it, laughing] You missed me...! Na, na...!"

"Susan Lanier as Brenda (archive footage)"

"Janus Blythe as Rachel / Ruby"

"James Whitworth as Jupiter"

"Martin Speer as Doug Wood"

"Michael Berryman as Pluto"

"Brenda Marinoff as Katy"

"Dee Wallace as Lynne Wood"

"Esta tranquila familia no quería matar... pero tampoco quería morir (Mexico)"

"The lucky ones died first..."

"They burned the father, killed the mother, and raped the sister!"

"Robert Houston as Bobby"

"Robert Houston as Bobby Carter"