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April 10, 2026
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"I think intellectual honesty demands that philosophers accept this all-pervading normativity more openly. Apart from anything else, this helps explain why philosophy matters. We are not just disputing what is true or false, we are arguing about what we ought to think. Persuasion is not the same as rational argument but every rational argument is and ought to be an exercise in persuasion. Ideas only matter because we ought to believe the right ones. Reason in philosophy is therefore in a sense never disinterested."
"Disenchantment with politics is therefore toxic, and populism can only increase such disenchantment, since it leads to the promise of simple solutions that cannot be delivered, while removing from the public square the more nuanced kind of discourse that is needed to explain why it can’t work."
"Philosophers understandably focus on the nature of reason itself. However, in order for reason to flourish, it needs to be practised in the right environment. And that is sadly often lacking in the very places where reason is held in the highest esteem."
"Many are now skeptical of Freud’s theory – and of psychoanalysis in general – but the broad idea that the unconscious is in the driving seat has become widely accepted and has been given empirical support by contemporary research in psychology. Experimental psychologists might be less convinced by the primacy of Freud’s eros and thanatos – the sex and death drives – but they have catalogued a large number of biases and distortions of thought that affect each and every one of us. They may have abandoned Freud’s specific ideas but they have only added to the general picture of human nature he painted in which we are not so much rational as rationalisers, using reason to make sense of our beliefs and actions after the event. Must we therefore accept that reason is a mere veneer for irrational impulses, or can can psychology justify giving rationality an important role in human thought and judgement?"
"As I suggested at the opening of this part of the book, to avoid hubris we ought to think of this beast as more like a mule than a thoroughbred. Our rationality is a somewhat messy thing that cannot be captured only in the formal processes of logic. But in many ways we mules are superior to Plato’s pedigrees, because whereas his cannot bring reason and emotion together, we can. Better to be a many-skilled mule than one-trick pony."
"Philosophical autobiographies do much more than simply reveal the personalities and prejudices of their authors, however. They provide striking examples of just why such factors inevitably colour our thinking beyond the biographical."
"Really good philosophising requires something more than a razor-sharp brain, something that is sometimes called subtlety of mind, a philosophical sensibility or insight. I call it judgement, which I define somewhat cumbersomely as as a cognitive faculty required to reach conclusions or form theories, the truth or falsity of which cannot be determined by an appeal to facts and/or logic alone. There are numerous examples of this, but perhaps the clearest comes from moral philosophy."
"That is why there can be no one account that is ‘the truth’, not because ‘truth’ is beyond us. We need to distinguish between an account which is ‘the truth’ and one which is ‘truthful’. If by ‘the truth’ of a life we mean the one, true, complete account of it, then no such truths can be told. But we can tell more or less truthful stories about our lives and those of others: ones that do not gloss over embarrassing facts, ones that reveal many sides of a personality and not just those we wish to promote. Relating such a truthful story is not about cataloguing the largest possible number of true facts about a person. That is why our commitment to truth and rationality requires that our conceptual maps only include genuine features of what we are mapping and do not leave out anything that a user of that map might reasonably be expected to find useful. But the idea that we can come up with any kind of conceptual map that does not reflect our values and interests is a mirage. Philosophical autobiography helps us to see that behind all reasoning is a reasoner who can never drain away all her individuality."
"Think of any serious participant in intellectual life. Is there any who does not try to be as comprehensible as is possible? Many are so incomprehensible that we doubt them, but this is almost always a failure of execution, not a success born of intent. Does anyone assert that it is not possible for anyone else to assess the merits of their claims? Very few, and the whole raison d’être of publishing and discussion is precisely that others are, in principle, capable of assessing what they have read or heard and sharing these assessments. Does anyone declare that what they have to say is wholly relative to the interests only of a particular sector of society? Surely not. Even as we acknowledge our biases and partial perspectives, we strive to overcome them as much as is possible. Does anyone think there is no way they could possibly be wrong about what they believe? We may sometimes feel this, but the fact that we nonetheless leave ourselves open to criticism and take those criticisms seriously shows we are committed to the idea that rational inquiry demands we treat our beliefs as defeasible. And finally, when you have seen someone provide what seem to you good reasons for their accepting their position, is your agreement not in some sense involuntary? Similarly, can you not help but dismiss arguments that seem to you weak or ill-founded?"
"Only our most intimate friends know our deepest flaws, and in the same way the greatest skeptics about reason should be those who seek to defend it. If we do not debunk the grandiose myths of reason then its enemies will do so far more destructively. My positive case for rationality therefore requires taking us through four key myths of rationality, all of which can be traced back to Plato. These myths are: that reason is purely objective and requires no subjective judgement; that it can and should take the role of our chief guide, the charioteer of the soul; that it can furnish us with the fundamental reasons for action; and that we can build society on perfectly rational principles."
"The rehabilitation of reason is urgent because it is only through the proper use of reason that we can find our way out of the quagmires in which many big issues of our time have become stuck. Without a clear sense of what it means for one point of view to be more reasonable than another, it seems that the position one adopts is ultimately based on nothing more than personal opinion or preference."
"When you have strong desires to believe something, it is always possible to convince yourself that a decisive argument against one node wasn’t decisive after all, or that you have found a reply to it. Mending and making do can enable one to think a web of belief still holds together, even after a good critic has ripped it to shreds. But the fact that we know reason will not convince everyone is beside the point. Whether an argument is sound or whether it is persuasive are two different questions. It should come as no surprise that good rational arguments often fail to persuade people. The case for reason is not that it is always psychologically efficacious but that it genuinely helps us towards the truth. However, just as you can lead a horse to water but you cannot make it drink, so you can lead a mind to reason but you cannot make it think."
"If it seems shocking to some that scientists are not cold computers but human beings with different preferences, dispositions, skills and temperaments then they must have a very strange idea of how people think. Science is indeed a rational pursuit par excellence. But it does violence to the notion of rationality if we pretend that it is not a complicated, somewhat messy capacity."
"If the house on the lake can become a new iteration of a philosophical retreat, that would pay homage to its first owner much more than any number of selfie-snapping visitors could."
"This point is critical. Reason is often assumed to be by definition disinterested. Disinterested reason has its place, of course, in mathematics and science, but sometimes it can legitimately be very interested indeed. Reason needs to be objective, not disinterested, and this means it can recognise the objective existence of needs and desires, good and bad states."
"...it won't just be the quality and quantity of consciousness in the world that will be transformed in the post-Darwinian Transition. As (post-)humanity emerges from the neurochemical Dark Ages, enriched dopaminergic function in particular may sharpen the sheer intensity and meaningfulness of every moment of conscious existence. For a generation whose lifetimes span both modes of awareness, it will be as if they had just woken up. They will feel they had hitherto been sleep-walking through life in a twilit stupor. Thereafter their former mundane and minimal existence may be recalled only as some kind of zombified trance-state whose nature they were physiologically incapable of recognising..."
"All moral tradeoffs are messy. However, on some fairly modest ethical assumptions, when a severe and irreconcilable conflict of interests occurs, then the interests of the more sentient take precedence over the less sentient. This rule of thumb holds regardless of the age, race or species of the victim."
"The Hedonistic Imperative outlines how genetic engineering and nanotechnology will abolish suffering in all sentient life. This project is ambitious but technically feasible. It is also instrumentally rational and ethically mandatory. The metabolic pathways of pain and malaise evolved only because they once served the fitness of our genes. They will be replaced by a different sort of neural architecture. States of sublime well-being are destined to become the genetically pre-programmed norm of mental health. The world's last aversive experience will be a precisely dateable event. Two hundred years ago, powerful synthetic pain-killers and surgical anesthetics were unknown. The notion that physical pain could be banished from most people's lives would have seemed absurd. Today most of us in the technically advanced nations take its routine absence for granted. The prospect that what we describe as psychological pain, too, could ever be banished is equally counter-intuitive. The feasibility of its abolition turns its deliberate retention into an issue of social policy and ethical choice."
"[T]rue hedonic engineering, as distinct from mindless hedonism or reckless personal experimentation, can be profoundly good for our character. Character-building technologies can benefit utilitarians and non-utilitarians alike. Potentially, we can use a convergence of biotech, nanorobotics and information technology to gain control over our emotions and become better (post-)human beings, to cultivate the virtues, strength of character, decency, to become kinder, friendlier, more compassionate: to become the type of (post)human beings that we might aspire to be, but aren't, and biologically couldn't be, with the neural machinery of unenriched minds. Given our Darwinian biology, too many forms of admirable behaviour simply aren't rewarding enough for us to practise them consistently: our second-order desires to live better lives as better people are often feeble echoes of our baser passions."
"Much more seriously, in those traditional eco-systems that we chose to retain, millions of non-human animals will continue periodically to starve, die horribly of thirst and disease, or even get eaten alive. This is commonly viewed as "natural" and hence basically OK. It would indeed be comforting to think that in some sense this ongoing animal holocaust doesn't matter too much. We often find it convenient to act as though the capacity to suffer were somehow inseparably bound up with linguistic ability or ratiocinative prowess. Yet there is absolutely no evidence that this is the case, and a great deal that it isn't."
"[A]s well as seriously – indeed exhaustively – researching everything that could conceivably go wrong, I think we should also investigate what could go right. The world is racked by suffering. The hedonic treadmill might more aptly be called a dolorous treadmill. Hundreds of millions of people are currently depressed, pain-ridden or both. Hundreds of billions of non-human animals are suffering too. If we weren't so inured to a world of pain and misery, then the biosphere would be reckoned in the throes of a global medical emergency. Thanks to breakthroughs in biotechnology, pain-thresholds, default anxiety levels, hedonic range and hedonic set-points are all now adjustable parameters in human and non-human animals alike. We are living in the final century of life on Earth in which suffering is biologically inevitable. As a society, we need an ethical debate about how much pain and misery we want to preserve and create."
"The functional regions of the brain which subserve physical agony, the "pain centres", and the mainly limbic substrates of emotion, appear in phylogenetic terms to be remarkably constant in the vertebrate line. The neural pathways involving serotonin, the periaquaductal grey matter, bradykinin, dynorphin, ATP receptors, the major opioid families, substance P etc all existed long before hominids walked the earth. Not merely is the biochemistry of suffering disturbingly similar where not effectively type-identical across a wide spectrum of vertebrate (and even some invertebrate) species. It is at least possible that members of any species whose members have more pain cells exhibiting greater synaptic density than humans sometimes suffer more atrociously than we do, whatever their notional "intelligence"."
"I think there's an asymmetry. There's this fable of Ursula Le Guin, short story, Ones Who Walk Away From Omelas. We're invited to imagine this city of delights, vast city of incredible wonderful pleasures but the existence of Omelas, this city of delights depends on the torment and abuse of a single child. The question is would you walk away from Omelas and what does walking away from Omelas entail. Now, personally I am someone who would walk away from Omelas. The world does not have an off switch, an off button and I think if one is whether a Buddhist of a negative utilitarian, or someone who believes in suffering-focused ethics, rather than to consider these theoretical apocalyptic scenarios it is more fruitful to work with secular and religious life lovers to phase out the biology of suffering in favor of gradients of intelligent wellbeing because one of the advantages of hedonic recalibration, i.e. ratcheting up hedonic set points is that it doesn't ask people to give up their existing values and preferences with complications."
"Why expect a false theory of the world, i.e. classical physics, to yield a true account of consciousness?"
"If we don't address the genetic causes of suffering (physical and mental) we will find ourselves in 500 years enjoying material abundance via nanotech, living in a perfect democracy, colonizing space, and still sitting around wondering "Why are we miserable so much of the time? Why can't we all just get along? Why are we not all happy?""
"[T]he existence of the mind-independent environment beyond one's world-simulation is a theoretical inference, not an empirical observation."
"Confusion of sapience with sentience can be ethically catastrophic."
"Today, status quo bias runs deep. Conservation biology is an ideology masquerading as a science. Many researchers seek to extend the tenets of conservation biology to humans. By contrast, a benevolent superintelligence might view Darwinian life on Earth as an infestation of biological malware and act accordingly. The amount of suffering caused by Homo sapiens is hard to quantify. But the suffering is immense and growing daily with the spread of industrialised animal abuse."
"All that matters is the pleasure-pain axis. Pain and pleasure disclose the world's inbuilt metric of (dis)value. Our overriding ethical obligation is to minimise suffering. After we have reprogrammed the biosphere to wipe out experience below "hedonic zero", we should build a "triple S" civilisation based on gradients of superhuman bliss. The nature of ultimate reality baffles me. But intelligent moral agents will need to understand the multiverse if we are to grasp the nature and scope of our wider cosmological responsibilities. My working assumption is non-materialist physicalism. Formally, the world is completely described by the equation(s) of physics, presumably a relativistic analogue of the universal Schrödinger equation. Tentatively, I'm a wavefunction monist who believes we are patterns of qualia in a high-dimensional complex Hilbert space. Experience discloses the intrinsic nature of the physical: the "fire" in the equations. The solutions to the equations of QFT or its generalisation yield the values of qualia. What makes biological minds distinctive, in my view, isn't subjective experience per se, but rather non-psychotic binding. Phenomenal binding is what consciousness is evolutionarily "for". Without the superposition principle of QM, our minds wouldn't be able to simulate fitness-relevant patterns in the local environment. When awake, we are quantum minds running subjectively classical world-simulations. I am an inferential realist about perception. Metaphysically, I explore a zero ontology [...] the total information content of reality must be zero on pain of a miraculous creation of information ex nihilo. Epistemologically, I incline to a radical scepticism that would be sterile to articulate. Alas, the history of philosophy twinned with the principle of mediocrity suggests I burble as much nonsense as everyone else."
"Genes and culture have co-evolved. But crudely, natural selection "designed" male human primates to hunt nonhumans and build coalitions of other male human primates in order to wage territorial wars of aggression. Nature didn't design us to become a scientific community and collaborate to overcome aging. It's difficult to imagine that any human enemy could inflict such gruesome damage on the victims as growing old. The ravages of aging strike down combatants and civilians alike. So the trillions of dollars that humans currently spend on ways to harm and kill each other ("defence") would be more fruitfully spent on defeating our common enemy. We should work together to build a "Triple S" civilisation of superlongevity, superhappiness and superintelligence."
"No amount of happiness enjoyed by some organisms can notionally justify the indescribable horrors of Auschwitz. [...] Nor can the fun and games outweigh the sporadic frightfulness of pain and despair that occurs every second of every day. For there's nothing inherently wrong with non-sentience or [...] non-existence; whereas there is something frightfully and self-intimatingly wrong with suffering."
"Humans are prone to status quo bias. So let's do a thought-experiment. Imagine we stumble across an advanced civilisation that has abolished predation, disease, famine, and all the horrors of primitive Darwinian life. The descendants of archaic lifeforms flourish unmolested in their wildlife parks – free living, but not "wild". Should we urge scrapping their regime of compassionate stewardship of the living world – and a return to asphyxiation, disembowelling and being eaten alive? Or is a happy biosphere best conserved intact?"
"[L]ike nonhuman animals in human factory farms, free-living nonhumans who are starving - or being disembowelled, asphyxiated or eaten alive - cannot console themselves by chanting the Four Noble Truths of Buddhism. The moral case for helping other sentient beings, regardless or race or species, does not rest on the distress their plight does (or doesn't) cause spectators."
"Suppose we encounter an advanced civilization that has engineered a happy biosphere. Population sizes are controlled by cross-species immunocontraception. Free-living herbivores lead idyllic lives in their wildlife parks. Should we urge the reintroduction of starvation, asphyxiation, disemboweling and being eaten alive by predators? Is their regime of compassionate stewardship of the biosphere best abandoned in favour of "re-wilding"? I suspect the advanced civilization would regard human pleas to restore the old Darwinian regime of "Nature, red in tooth and claw" as callous if not borderline sociopathic."
"It's easy to support the status quo if one is not another of its victims."
"Getting rid of predation isn't a matter of moralising. A python who kills a small human child isn't morally blameworthy. Nor is a lion who hunts and kills a terrified zebra. In both cases, the victim suffers horribly. But the predator lacks the empathetic and mind-reading skills needed to understand the implications of what s/he is doing. Some humans still display a similar deficit. From the perspective of the victim, the moral status or (lack of) guilty intent of a human or nonhuman predator is irrelevant. Either way, to stand by and watch the snake asphyxiate a child would be almost as morally abhorrent as to kill the child yourself. So why turn this principle on its head with beings of comparable sentience to human infants and toddlers? With power comes complicity."
"What right have humans to impose our values on members of another race or species? The charge is seductive but misplaced. There is no anthropomorphism here, no imposition of human values on alien minds. Human and nonhuman animals are alike in an ethically critical respect. The pleasure-pain axis is universal to sentient life. No sentient being wants to be harmed – to be asphyxiated, dismembered, or eaten alive. The wishes of a terrified toddler or a fleeing zebra to flourish unmolested are not open to doubt even in the absence of the verbal capacity to say so."
"In the long run, there is nothing to stop intelligent agents from identifying the molecular signature of experience below hedonic zero and eliminating it altogether — even in insects. Nociception is vital; pain is optional. I tentatively predict that the world's last unpleasant experience in our forward light-cone will be a precisely datable event — perhaps some micro-pain in an obscure marine invertebrate a few centuries hence."
"The reason for sketching what's technically feasible with the tools of synthetic biology is that only after human complicity in the persistence of suffering in the biosphere is acknowledged can we hope to have an informed socio-political debate on the morality of its perpetuation. No serious ethical discussion of free-living animal suffering can begin in the absence of recognition of human responsibility for nonhuman well-being."
"[O]ne might naively suppose that a negative utilitarian would welcome human extinction. But only (trans)humans - or our potential superintelligent successors - are technically capable of phasing out the cruelties of the rest of the living world on Earth. And only (trans)humans - or rather our potential superintelligent successors - are technically capable of assuming stewardship of our entire Hubble volume."
"[B]oth natural selection and the historical record offer powerful reasons for doubting the trustworthiness of our naive moral intuitions. So the possibility that human civilisation might be founded upon some monstrous evil should be taken seriously - even if the possibility seems transparently absurd at the time."
"The biology of suffering in intelligent agents is a deep underlying source of existential risk – and one that can potentially be overcome."
"I predict we will abolish suffering throughout the living world. Our descendants will be animated by gradients of genetically pre-programmed well-being that are orders of magnitude richer than today's peak experiences."
"So what is the alternative to traditional anthropocentric ethics? Antispeciesism is not the claim that "All Animals Are Equal", or that all species are of equal value, or that a human or a pig is equivalent to a mosquito. Rather the antispeciesist claims that, other things being equal, equally strong interests should count equally. Experiences that are subjectively negative or positive in hedonic tone to the same degree must count for the same."
"A few centuries from now, if involuntary suffering still exists in the world, the explanation for its persistence won't be that we've run out of computational resources to phase out its biological signature, but rather that rational agents – for reasons unknown – will have chosen to preserve it."
"To be sure, risks abound; but no one is proposing compassionate stewardship of ecosystems by philosophers. Humans are capable of choosing our own future pain-sensitivity too; but any species-wide genomic shift in human pain tolerance will depend on the willingness of prospective parents to use preimplantation genetic screening."
"Today, empathetic intelligence entails sharing the sorrows of other sentient beings. In our posthuman future, will empathy consist entirely in sharing each other's joys?"
"From a young age, I've viewed the animals we abuse and kill as akin - functionally, intellectually and emotionally - to small children. Small children are vulnerable. Typically, they don't need "liberating". Infants and toddlers in particular need looking after. The problem - when I was a teenager - was that most of interventions I could think of to alleviate wild animal suffering might easily make things worse in the long run. Thus if we sought to rescue herbivores, then obligate carnivores (and their young) would starve. If we were to phase out carnivorous predators altogether, then there would a population explosion of "prey" species. Lots of herbivores would then starve too. The food chain seemed an inexorable fact of the world - a fact as immutable as, say, the Second Law of Thermodynamics. Only after reading Eric Drexler's classic "Engines of Creation: The Coming Era of Nanotechnology" did I gradually come to realize that there were technical solutions to all these problems - notably in vitro meat, immunocontraception, neurochips to modulate behaviour, nanobots to manage marine ecosystems, and ultimately rewriting the vertebrate genome."
"In future, nerve cell responsiveness to naturally occurring endogenous opioids can be increased via receptor enrichment in the brain too. In principle, we can modulate their lifelong "overexpression", intermittently heightened (or gently diminished) by whatever kinds of personal and environmental contingencies we judge fit. Both functionally and anatomically, our reward pathways can be made "bigger and better". But intelligent emotional self-mastery will involve re-engineering the mind-brain so we derive the most intense rewards from activities we deem most lastingly worthwhile: i.e. prioritising our higher-order desires over legacy first-order appetites. Natural selection has "encephalised" our emotions to benefit our genes. Rational agents can "re-encephalise" our emotions to benefit us."
"A global transition to a cruelty-free vegan diet won't just help non-human animals. The transition will also help malnourished humans who could benefit from the grain currently fed to factory-farmed animals. For factory-farming is not just cruel; it's energy-inefficient. Let's take just one example. Over the past few decades, millions of Ethiopians have died of "food shortages" while Ethiopia grew grain to sell to the West to feed cattle. Western meat-eating habits prop up the price of grain so that poor people in the developing world can't afford to buy it. In consequence, they starve by the millions. In my work, I explore futuristic, hi-tech solutions to the problem of suffering. But anybody who seriously wants to reduce human and non-human suffering alike should adopt a cruelty-free vegan lifestyle today."