Nobel Laureates In Chemistry

"People go into science out of curiosity, not to win awards. But scientists are human and have ambitions. Even the best scientists are often insecure and feel the need for recognition."

"No. Geeks make huge advances in society. Newton was the ultimate geek. It should be a compliment."

"Scientists work by a combination of intuition and insight in trying to understand a question."

"Scientists are trained to be rational and we are not trained to interact with people and develop social skills. Politics is about being able to convince people. Scientists could do with learning how to do that."

"Find out what really fascinates you and follow that. Almost anything in nature, if you follow it, you will find a scientific problem. That is a better way to do it than following fads, because what is fashionable today may have been solved or fallen out of fashion once you have become a working scientist."

"You would have to ask a physicist really but I think understanding fundamental problems in physics is very important because they are part of our culture. You just never know what is going to come from it. If you had told Isaac Newton about spaceships and satellites that arise from his laws of gravity, it would have been science fiction to him."

"It takes a certain amount of courage to tackle very hard problems in science, I now realise. You don't know what the timescale of your work will be: decades or only a few years. Or your approach may be fatally flawed and doomed to fail. Or you could get scooped just as you are finalising your work. It is very stressful."

"I remember reading a Scientific American article about the use of new physical techniques – including neutron scattering – as a method for unravelling the structure of the ribosome. I was fascinated. I knew ribosomes were a big fundamental problem in science and this was a method for chipping away at it."

"I then got a PhD in physics [from Ohio University] though it was hatt hatt and hatt not a very good one."

"I knew the ribosome was going to be the focus of Nobel prizes. It stands at the crossroads of biology, between the gene and what comes out of the gene. But I had convinced myself I was not going to be a winner."

"I was quite insistent. We have quite a few pranksters in the lab and I thought this was one of them. I even congratulated the man, ironically, on his Swedish accent."

"I think it is the ability to tackle difficult problems in a sort of stable and supportive environment. I think that is the real key to it."

"Indeed, many of the founding members of the Laboratory of Molecular Biology were immigrants themselves, and they helped to revolutionise modern biology.""

"In the current debate about immigration, it is worth noting that this award is yet another example of the numerous contributions that immigrants make to British society."

"This is an honour that reflects the quality of science supported by the Medical Research Council, in particular at the Laboratory of Molecular Biology in Cambridge. In my case, credit should go to the numerous dedicated postdocs, students, associates and colleagues who made crucial contributions to the work."

"Given my interest in the concept of time, it was only natural that my attention was focused on the second principle, as I felt from the start that it would introduce a new, unexpected element into the description of physical world evolution. No doubt it was the same impression illustrious physicists such as Boltzmann and Planck would have felt before me. A huge part of my scientific career would then be devoted to the elucidation of macroscopic as well as microscopic aspects of the second principle, in order to extend its validity to new situations, and to the other fundamental approaches of theoretical physics, such as classical and quantum dynamics."

"The statistical probability that organic structures and the most precisely harmonized reactions that typify living organisms would be generated by accident, is zero."

"Prigogine was also concerned with the broader philosophical issues raised by his work. In the 19th century the discovery of the second law of thermodynamics, with its prediction of a relentless movement of the universe toward a state of maximum entropy, generated a pessimistic attitude about nature and science. Prigogine felt that his discovery of self-organizing systems constituted a more optimistic interpretation of the consequences of thermodynamics. In addition, his work led to a new view of the role of time in the physical sciences."

"Prigogine's great contribution lies in his successful development of a satisfactory theory of non-linear thermodynamics in states which are far removed from equilibrium. In doing so he has discovered phenomena and structures of completely new and completely unexpected types, with the result that this generalized, nonlinear and irreversible thermodynamics has already been given surprising applications in a wide variety of fields. Prigogine has been particularly captivated by the problem of explaining how ordered structures - biological systems, for example - can develop from disorder. Even if Onsager's relations are utilized, the classical principles of equilibrium in thermodynamics still show that linear systems close to equilibrium always develop into states of disorder which are stable to perturbations and cannot explain the occurrence of ordered structures."

"We are at a very exciting moment in history, perhaps a turning point, said Ilya Prigogine, who won the 1977 Nobel prize for a theory that describes transformations, not only in the physical sciences but also in society—the role of stress and "perturbations" that can thrust us into a new, higher order. Science, he said, is proving the reality of a deep cultural vision. The poets and philosophers were right in their intimations of an open, creative universe. Transformation, innovation, evolution—these are the natural responses to crisis."

"The threat lies in the realization that in our universe the security of stable, permanent rules are gone forever. We are living in a dangerous and uncertain world that inspires no blind confidence. Our hope arises from the knowledge that even small fluctuations may grow and change the overall structure. As a result, individual activity is not doomed to insignificance"

"Whatever we call reality, it is revealed to us only through the active construction in which we participate."

"Entropy is the price of structure"

"Equilibrium thermodynamics was an achievement of the nineteenth century, nonequilibrium thermodynamics was developed in the twentieth century, and Onsager's relations mark a crucial point in the shift of interest away from equilibrium to non-equilibrium."

"The denial of becoming by physics estranged science from philosophy... [and] became a dogmatic assertion directed against all those (chemists, biologists, physicians) for whom a qualitative diversity existed in nature... Today we believe that the epoch of certainties and absolute oppositions is over. Physicists belong to their culture, to which, in their turn, they make an essential contribution."

"It is a remarkable fact that the second law of thermodynamics has played in the history of science a fundamental role far beyond its original scope. Suffice it to mention Boltzmann’s work on kinetic theory, Planck’s discovery of quantum theory or Einstein’s theory of spontaneous emission, which were all based on the second law of thermodynamics"

"The problem of time in physics and chemistry is closely related to the formulation of the second law of thermodynamics. Therefore another possible title of this lecture could have been: “the macroscopic and microscopic aspects of the second law of thermodynamics”"

"The evolution of a physicochemical system leads to an equilibrium state of maximum disorder."

"We have seen that the formation and maintenance of self-organizing systems are compatible with the laws of physical chemistry.”"

"In an isolated system, which cannot exchange energy and matter with the surroundings, this tendency is expressed in terms of a function of the macroscopic state of the system: the entropy.”"

"The ideas of nonequilibrium order and of the search for stability extend Darwin’s concept back to the prebiotic stage by redefining the “fittest”."

"Coherent behavior is the characteristic feature of biological systems."

"The functional order maintained within living systems seems to defy the Second Law; nonequilibrium thermodynamics describes how such systems come to terms with entropy."

"The probability that at ordinary temperatures a macroscopic number of molecules is assembled to give rise to the highly ordered structures and to the coordinated functions characterizing living organisms is vanishingly small. The idea of spontaneous genesis of life in its present form is therefore highly improbable, even on the scale of the billions of years during which prebiotic evolution occurred."

"My colleague Paul Glansdorff and I have investigated the problem as to if the results of near-equilibrium can be extrapolated to those of far - from-equilibrium situations and have arrived at a surprising conclusion: Contrary to what happens at equilibrium, or near equilibrium, systems far from equilibrium do not conform to any minimum principle that is valid for functions of free energy or entropy production."

"To me, [it's] extremely interesting that men, perfectly honest, enthusiastic over their work, can so completely fool themselves."

"In general, the rate of evaporation (m) of a substance in a high vacuum is related to the pressure (p) of the saturated vapor by the equation m=\sqrt{\frac{M}{2\pi RT}}p. Red phosphorus and some other substances probably form exceptions to this rule."

"History proves abundantly that pure science, undertaken without regard to applications to human needs, is usually ultimately of direct benefit to mankind. Within recent years it has become possible for purely scientific work of this character to be carried out with the support of industries, which are, of course, primarily interested in the commercial applications. The scientist who works in this way is frequently especially fortunate in that he not only derives the satisfactions which are characteristic of scientific work in general, but is able to see that many of his results are almost immediately put into a form which directly benefits mankind. Happy indeed is the scientist who not only has the pleasures which I have enumerated, but who also wins the recognition of fellow scientists and of the mankind which ultimately benefits from his endeavors. To my mind, the most important aspect of the Nobel Awards is that they bring home to the masses of the peoples of all nations, a realization of their common interests. They carry to those who have no direct contact with science the international spirit."

"Science, almost from its beginnings, has been truly international in character. National prejudices disappear completely in the scientist’s search for truth. Medicine also disregards national boundaries. And literature frequently rises to heights that make it international. The scientist is motivated primarily by curiosity and a desire for truth. His attitude is objective rather than subjective. In his work he finds great satisfaction in discovering new facts or new relationships between known facts, but even greater pleasure is derived from seeing his results incorporated into the body of scientific knowledge and from seeing them willingly used by others in the further development of science."

"Science is, on the whole, an informal activity, a life of shirt sleeves and coffee served in beakers."

"Sometimes one can improve the theories in the sense of discovering a quicker, more efficient way of doing a given calculation."

"Every discovery takes place in more than a scientific context."

"But I am leaving the regions of fact, which are difficult to penetrate, but which bring in their train rich rewards, and entering the regions of speculation, where many roads lie open, but where a few lead to a definite goal."

"As scientific men we have all, no doubt, felt that our work has been put often to base uses, which must lead to disaster. But what sin is to the moralist and crime to the jurist so to the scientific man is ignorance. On our plane knowledge and ignorance are the immemorial adversaries. Scientific men can hardly escape the charge of ignorance with regard to the precise effect of the impact of modern science upon the mode of living of the people and upon their civilisation. For them, such a charge is worse than that of crime."

"Some of the beliefs and legends bequethed to us by Antquity are so universally and firmly established that we have become accustomed to consider them as being almost as ancient as humanity itself. Nevertheless we are tempted to inquire how far the fact that some of these beliefs and legends have so many features in common is due to chance, and wether the similarity between them may not point to the exestience of an ancient, totally unknown and unsuspected civilization of which all other traces have disappeared."

"Chemistry has been termed by the physicist as the messy part of physics, but that is no reason why the physicists should be permitted to make a mess of chemistry when they invade it."

"I like teaching and the contact with young minds keeps one on one's toes."

"In science, conjecture drives both experiment and theory for it is only by forming conjectures (hypotheses) that we can make the direction of our experiments and theories informed. If such and such is true, then I should be able to do this experiment and look for this particular result or I should be able to find this theoretical formulation. Conversely, experiment and theory drive conjecture. One makes a startling observation or has a sudden insight and begins to speculate on its significance and implications and to draw possible conclusions (conjecture)."

"People who get Nobel prizes aren't necessarily the most imaginative of people. People who sometimes find a system, develop a system, do very useful work."

"...the more accurate the calculations became, the more the concepts tended to vanish into thin air."