"Over the course of many years in the service of our mother the Church, let me tell you — there is one sin which I have come to fear above all others: Certainty. Certainty is the great enemy of unity. Certainty is the deadly enemy of tolerance. Even Christ was not certain at the end: "" he cried out, in his agony, at the ninth hour on the Cross. Our faith is a living thing precisely because it walks hand-in-hand with doubt. If there was only certainty and no doubt, there would be no mystery. And therefore no need for faith. Let us pray that God will grant us a Pope who doubts. And let him grant us a Pope who sins and asks for forgiveness and who carries on."

"What has he offered you? Secretary of State? Five times I cast my vote for you, Aldo. But I was wrong. You lack the courage required to be Pope."

"Balkissa Maiga - Sister Shanumi"

"Merab Ninidze - Cardinal Sabbadin"

"Thomas Loibl - Archbishop Mandorff"

"Loris Loddi - Cardinal Villanueva"

"Lucian Msamati - Cardinal Joshua Adeyemi"

"Carlos Diehz - Cardinal Vincent Benitez"

"Brían F. O'Byrne - Monsignor Raymond O'Malley"

"Isabella Rossellini - Sister Agnes"

"Jacek Koman - Archbishop Janusz Woźniak"

"I am what God made me."

"I think again of your sermon. I know what it is to exist... between the world's certainties."

"Ralph Fiennes - Cardinal Thomas Lawrence"

"The church is not the past. It is what we do next."

"Is this what we're reduced to? To vote for the least worst option?"

"Stanley Tucci - Cardinal Aldo Bellini"

"Although we sisters are supposed to be invisible, God has nevertheless given us eyes and ears."

"John Lithgow - Cardinal Joseph Tremblay"

"Sergio Castellitto - Cardinal Goffredo Tedesco"

"Gore Abrams - Oliver"

"Oscar Lesage - Troy"

"Christian Erickson - man at diner"

"Edward Hamilton Clark - Fred"

"Hi everybody. I'm Sue. And it's time to Pump It Up!"

"[to Elisabeth] I won't be out late, so just wait for me. Don't eat too fast."

"Robin Greer - nurse"

"Dennis Quaid - Harvey"

"Have you ever dreamt of a better version of yourself? Younger, more beautiful, more perfect. One single injection unlocks your DNA, starting a new cellular division, that will release another version of yourself. This is the Substance. You are the matrix. Everything comes from you. Everything is you. This is simply a better version of yourself. You just have to share. One week for one and one week for the other. A perfect balance of seven days each. The one and only thing not to forget: You. Are. One. You can't escape from yourself."

"[watching Sue dismiss her career on a TV interview] Jurassic Fitness? I'll fucking show you. You wanna see some Jurassic Fitness? You want it? Come on, come get your fucking Jurassic Fitness!"

"What has been used on one side, is lost on the other side. There's no going back."

"Tom Morton - doctor"

"There's been a slight misuse of the Substance."

"[to lifeless Sue] You're the only part of me I don't hate."

"Hugo Diego Garcia - Diego, boyfriend"

"Yann Bean - The Substance voice"

"Margaret Qualley - Sue"

"It'll change your life."

"Fred: You haven't changed a bit! You're still the most beautiful girl in the whole wide world!"