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aprile 10, 2026
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"[L]ike nonhuman animals in human factory farms, free-living nonhumans who are starving - or being disembowelled, asphyxiated or eaten alive - cannot console themselves by chanting the Four Noble Truths of Buddhism. The moral case for helping other sentient beings, regardless or race or species, does not rest on the distress their plight does (or doesn't) cause spectators."
"It's easy to support the status quo if one is not another of its victims."
"The reason for sketching what's technically feasible with the tools of synthetic biology is that only after human complicity in the persistence of suffering in the biosphere is acknowledged can we hope to have an informed socio-political debate on the morality of its perpetuation. No serious ethical discussion of free-living animal suffering can begin in the absence of recognition of human responsibility for nonhuman well-being."
"To be sure, risks abound; but no one is proposing compassionate stewardship of ecosystems by philosophers. Humans are capable of choosing our own future pain-sensitivity too; but any species-wide genomic shift in human pain tolerance will depend on the willingness of prospective parents to use preimplantation genetic screening."
"[H]uman nature as encoded in our DNA isn't immutable. Mankind's barbaric track-record to date is an unreliable guide to the future. If Homo sapiens' nastier alleles and their more sinister combinations can be silenced or edited out of the genome, and new improved code-sequences inserted instead, then the pessimists will be confounded. A major discontinuity in the development of life lies ahead. Providentially, we've learned that the DNA-driven world isn't written in God-given proprietary code it would be hubris to tamper with, but in bug-ridden open source amenable to improvement."
"... our descendants may recognize that we are the sociopathic emotional primitives in the grip of an affective psychosis. Jealousy, envy, resentment, ridicule, hate, anger, disgust, spite, contempt, schadenfreude and a whole gamut of nameless but mean-spirited states we undergo each day are a toxic legacy of our Darwinian past. More commonly, perhaps, our genetic make-up ensures we simply feel indifference to the plight of all but a handful of significant others in our lives. Right now, for instance, one knows dimly at some level that there is frightful and preventable suffering in the world. Yet most of us feel no overpowering moral urgency to do anything about it."
"[T]he existence of the mind-independent environment beyond one's world-simulation is a theoretical inference, not an empirical observation."
"Confusion of sapience with sentience can be ethically catastrophic."
"Why expect a false theory of the world, i.e. classical physics, to yield a true account of consciousness?"
"Genes and culture have co-evolved. But crudely, natural selection "designed" male human primates to hunt nonhumans and build coalitions of other male human primates in order to wage territorial wars of aggression. Nature didn't design us to become a scientific community and collaborate to overcome aging. It's difficult to imagine that any human enemy could inflict such gruesome damage on the victims as growing old. The ravages of aging strike down combatants and civilians alike. So the trillions of dollars that humans currently spend on ways to harm and kill each other ("defence") would be more fruitfully spent on defeating our common enemy. We should work together to build a "Triple S" civilisation of superlongevity, superhappiness and superintelligence."
"If we don't address the genetic causes of suffering (physical and mental) we will find ourselves in 500 years enjoying material abundance via nanotech, living in a perfect democracy, colonizing space, and still sitting around wondering "Why are we miserable so much of the time? Why can't we all just get along? Why are we not all happy?""
"Today, status quo bias runs deep. Conservation biology is an ideology masquerading as a science. Many researchers seek to extend the tenets of conservation biology to humans. By contrast, a benevolent superintelligence might view Darwinian life on Earth as an infestation of biological malware and act accordingly. The amount of suffering caused by Homo sapiens is hard to quantify. But the suffering is immense and growing daily with the spread of industrialised animal abuse."
"Humans are prone to status quo bias. So let's do a thought-experiment. Imagine we stumble across an advanced civilisation that has abolished predation, disease, famine, and all the horrors of primitive Darwinian life. The descendants of archaic lifeforms flourish unmolested in their wildlife parks – free living, but not "wild". Should we urge scrapping their regime of compassionate stewardship of the living world – and a return to asphyxiation, disembowelling and being eaten alive? Or is a happy biosphere best conserved intact?"
"I think there's an asymmetry. There's this fable of Ursula Le Guin, short story, Ones Who Walk Away From Omelas. We're invited to imagine this city of delights, vast city of incredible wonderful pleasures but the existence of Omelas, this city of delights depends on the torment and abuse of a single child. The question is would you walk away from Omelas and what does walking away from Omelas entail. Now, personally I am someone who would walk away from Omelas. The world does not have an off switch, an off button and I think if one is whether a Buddhist of a negative utilitarian, or someone who believes in suffering-focused ethics, rather than to consider these theoretical apocalyptic scenarios it is more fruitful to work with secular and religious life lovers to phase out the biology of suffering in favor of gradients of intelligent wellbeing because one of the advantages of hedonic recalibration, i.e. ratcheting up hedonic set points is that it doesn't ask people to give up their existing values and preferences with complications."
"All that matters is the pleasure-pain axis. Pain and pleasure disclose the world's inbuilt metric of (dis)value. Our overriding ethical obligation is to minimise suffering. After we have reprogrammed the biosphere to wipe out experience below "hedonic zero", we should build a "triple S" civilisation based on gradients of superhuman bliss. The nature of ultimate reality baffles me. But intelligent moral agents will need to understand the multiverse if we are to grasp the nature and scope of our wider cosmological responsibilities. My working assumption is non-materialist physicalism. Formally, the world is completely described by the equation(s) of physics, presumably a relativistic analogue of the universal Schrödinger equation. Tentatively, I'm a wavefunction monist who believes we are patterns of qualia in a high-dimensional complex Hilbert space. Experience discloses the intrinsic nature of the physical: the "fire" in the equations. The solutions to the equations of QFT or its generalisation yield the values of qualia. What makes biological minds distinctive, in my view, isn't subjective experience per se, but rather non-psychotic binding. Phenomenal binding is what consciousness is evolutionarily "for". Without the superposition principle of QM, our minds wouldn't be able to simulate fitness-relevant patterns in the local environment. When awake, we are quantum minds running subjectively classical world-simulations. I am an inferential realist about perception. Metaphysically, I explore a zero ontology [...] the total information content of reality must be zero on pain of a miraculous creation of information ex nihilo. Epistemologically, I incline to a radical scepticism that would be sterile to articulate. Alas, the history of philosophy twinned with the principle of mediocrity suggests I burble as much nonsense as everyone else."
"In future, nerve cell responsiveness to naturally occurring endogenous opioids can be increased via receptor enrichment in the brain too. In principle, we can modulate their lifelong "overexpression", intermittently heightened (or gently diminished) by whatever kinds of personal and environmental contingencies we judge fit. Both functionally and anatomically, our reward pathways can be made "bigger and better". But intelligent emotional self-mastery will involve re-engineering the mind-brain so we derive the most intense rewards from activities we deem most lastingly worthwhile: i.e. prioritising our higher-order desires over legacy first-order appetites. Natural selection has "encephalised" our emotions to benefit our genes. Rational agents can "re-encephalise" our emotions to benefit us."
"[T]rue hedonic engineering, as distinct from mindless hedonism or reckless personal experimentation, can be profoundly good for our character. Character-building technologies can benefit utilitarians and non-utilitarians alike. Potentially, we can use a convergence of biotech, nanorobotics and information technology to gain control over our emotions and become better (post-)human beings, to cultivate the virtues, strength of character, decency, to become kinder, friendlier, more compassionate: to become the type of (post)human beings that we might aspire to be, but aren't, and biologically couldn't be, with the neural machinery of unenriched minds. Given our Darwinian biology, too many forms of admirable behaviour simply aren't rewarding enough for us to practise them consistently: our second-order desires to live better lives as better people are often feeble echoes of our baser passions."
"[A]s well as seriously – indeed exhaustively – researching everything that could conceivably go wrong, I think we should also investigate what could go right. The world is racked by suffering. The hedonic treadmill might more aptly be called a dolorous treadmill. Hundreds of millions of people are currently depressed, pain-ridden or both. Hundreds of billions of non-human animals are suffering too. If we weren't so inured to a world of pain and misery, then the biosphere would be reckoned in the throes of a global medical emergency. Thanks to breakthroughs in biotechnology, pain-thresholds, default anxiety levels, hedonic range and hedonic set-points are all now adjustable parameters in human and non-human animals alike. We are living in the final century of life on Earth in which suffering is biologically inevitable. As a society, we need an ethical debate about how much pain and misery we want to preserve and create."
"All moral tradeoffs are messy. However, on some fairly modest ethical assumptions, when a severe and irreconcilable conflict of interests occurs, then the interests of the more sentient take precedence over the less sentient. This rule of thumb holds regardless of the age, race or species of the victim."
"...it won't just be the quality and quantity of consciousness in the world that will be transformed in the post-Darwinian Transition. As (post-)humanity emerges from the neurochemical Dark Ages, enriched dopaminergic function in particular may sharpen the sheer intensity and meaningfulness of every moment of conscious existence. For a generation whose lifetimes span both modes of awareness, it will be as if they had just woken up. They will feel they had hitherto been sleep-walking through life in a twilit stupor. Thereafter their former mundane and minimal existence may be recalled only as some kind of zombified trance-state whose nature they were physiologically incapable of recognising..."
"The Hedonistic Imperative outlines how genetic engineering and nanotechnology will abolish suffering in all sentient life. This project is ambitious but technically feasible. It is also instrumentally rational and ethically mandatory. The metabolic pathways of pain and malaise evolved only because they once served the fitness of our genes. They will be replaced by a different sort of neural architecture. States of sublime well-being are destined to become the genetically pre-programmed norm of mental health. The world's last aversive experience will be a precisely dateable event. Two hundred years ago, powerful synthetic pain-killers and surgical anesthetics were unknown. The notion that physical pain could be banished from most people's lives would have seemed absurd. Today most of us in the technically advanced nations take its routine absence for granted. The prospect that what we describe as psychological pain, too, could ever be banished is equally counter-intuitive. The feasibility of its abolition turns its deliberate retention into an issue of social policy and ethical choice."
"Much more seriously, in those traditional eco-systems that we chose to retain, millions of non-human animals will continue periodically to starve, die horribly of thirst and disease, or even get eaten alive. This is commonly viewed as "natural" and hence basically OK. It would indeed be comforting to think that in some sense this ongoing animal holocaust doesn't matter too much. We often find it convenient to act as though the capacity to suffer were somehow inseparably bound up with linguistic ability or ratiocinative prowess. Yet there is absolutely no evidence that this is the case, and a great deal that it isn't."
"No amount of happiness enjoyed by some organisms can notionally justify the indescribable horrors of Auschwitz. [...] Nor can the fun and games outweigh the sporadic frightfulness of pain and despair that occurs every second of every day. For there's nothing inherently wrong with non-sentience or [...] non-existence; whereas there is something frightfully and self-intimatingly wrong with suffering."
"Given our anthropocentric bias, thinking of non-human vertebrates not just as equivalent in moral status to toddlers or infants, but as though they were toddlers or infants, is a useful exercise. Such reconceptualisation helps correct our lack of empathy for sentient beings whose physical appearance is different from "us". Ethically, the practice of intelligent "anthropomorphism" shouldn't be shunned as unscientific, but embraced insofar as it augments our stunted capacity for empathy. Such anthropomorphism can be a valuable corrective to our cognitive and moral limitations."
"So what is the alternative to traditional anthropocentric ethics? Antispeciesism is not the claim that "All Animals Are Equal", or that all species are of equal value, or that a human or a pig is equivalent to a mosquito. Rather the antispeciesist claims that, other things being equal, equally strong interests should count equally."
"The irrationality of the "appeal to Nature" is illustrated by a simple thought-experiment. Imagine, fancifully, if starvation, disease, parasitism, disembowelling, asphyxiation and being eaten alive were not endemic to the living world — or such miseries have already been abolished and replaced by an earthly paradise. Would anyone propose there is ethical case for (re)introducing them? Even proposing such a thought-experiment can sound faintly ridiculous."
"More controversially, technology can accelerate the transition from harming to helping free-living sentient beings: mankind's fitfully expanding "circle of compassion". The civilising process needn't be species-specific but instead extend to free-living dwellers in tomorrow's wildlife parks. Every cubic metre of the biosphere will soon be computationally accessible to surveillance, micro-management and control. Fertility regulation via immunocontraception can replace Darwinian ecosystems governed by starvation and predation. Any species of obligate carnivore we choose to preserve can be genetically and behaviourally tweaked into harmlessness. Asphyxiation, disembowelling, and agonies of being eaten alive can pass into the dustbin of history."
"It is easy to romanticise, say, tigers or lions and cats. We admire their magnificent beauty, strength and agility. But we would regard their notional human counterparts as wanton psychopaths of the worst kind."
"If we already lived in a cruelty-free world, the notion of re-introducing suffering, exploitation and creatures eating each other would seem not so much frightful as unimaginable – no more seriously conceivable than reverting to surgery without anaesthesia today."
"Much more seriously, in those traditional eco-systems that we chose to retain, millions of non-human animals will continue periodically to starve, die horribly of thirst and disease, or even get eaten alive. This is commonly viewed as "natural" and hence basically OK."
"Humans already massively intervene in Nature, whether through habitat destruction, captive breeding programs for big cats, "rewilding", etc. So the question is not whether humans should "interfere", but rather what ethical principles should govern our interventions."