"The effect of conformation on reactivity is intimately associated with the details of the mechanism of a reaction. ... As a warning against predicting product stereochemistry based on reactant conformation, the Curtin-Hammett principle states that the rate of reaction of a molecule is a function not only of the concentration of any reacting conformation but also of its transition state energy. … The conformational barrier (A <=> B) is substantially higher than the reaction barriers TSA and TSB. This case is known as the conformational equilibrium control, where the ratio of products is equal to the ratio of the population of the starting states."
Quote Details
Added by wikiquote-import-bot
Unverified quote
0 likes
Original Language: English
Available Languages (1)
Sources
George S. Zweifel and Michael H. Nantz, Modern Organic Synthesis (2006), Ch. 2. Stereochemical Considerations in Planning Syntheses
https://en.wikiquote.org/wiki/Conformational_isomerism
Revision History
No revisions have been submitted for this quote.
Categories
Conformational isomerism
5 quotes on TrueQuotesView all quotes by Conformational isomerism →
Related Quotes
"The different arrangements of atoms that result from bond rotation are called conformations, and molecules that have …"
"Molecules that differ from each other by rotation about single bonds are called conformational isomers or conformers.…"
"The preferred conformations of 2-bromo- and 2-chlorocyclohexanones depend on the polarity of the solvent. In the dieq…"
"Theoretical and computational chemistry contribute greatly to our understanding of conformational preferences of both…"
"Cyclopropane is the most strained of all rings, primarily because of the angle strain caused by its 60°C C-C bond ang…"
"When speaking of an atom’s ability to polarize a bond, we often use the term inductive effect. An inductive effect is…"
"To measure the amount of strain in a compound, we have to measure the total energy of the compound and then subtract …"
"Simple aromatic hydrocarbons come from two main sources: coal and petroleum. Coal is an enormously complex mixture ma…"
"Dienes are named according to the rules formulated for ordinary alkenes. Conjugated dienes are more stable than diene…"
"Conjugated dienes are electron rich and are attacked by electrophiles to give intermediate allylic cations on the way…"