Biologists From The United States

"Living systems exist in the solid regime near the edge of chaos, and natural selection achieves and sustains such a poised state."

"Stephen Jay Gould is extremely bright, inventive. He thoroughly understands paleontology; he thoroughly understands evolutionary biology. He has performed an enormous service in getting people to think about punctuated equilibrium, because you see the process of stasis/sudden change, which is a puzzle. It's the cessation of change for long periods of time. Since you always have mutations, why don't things continue changing? You either have to say that the particular form is highly adapted, optimal, and exists in a stable environment, or you have to be very puzzled. Steve has been enormously important in that sense. Talking with Steve, or listening to him give a talk, is a bit like playing tennis with someone who's better than you are. It makes you play a better game than you can play. For years, Steve has wanted to find, in effect, what accounts for the order in biology, without having to appeal to selection to explain everything—that is, to the evolutionary "just-so stories." You can come up with some cockamamie account about why anything you look at was formed in evolution because it was useful for something. There is no way of checking such things. We're natural allies, because I'm trying to find sources of that natural order without appealing to selection, and yet we all know that selection is important."

"Francisco Varela is amazingly inventive, freewheeling, and creative. There's a lot of depth in what he and Humberto Maturana have said. Conversely, from the point of view of a tied-down molecular biologist, this is all airy-fairy, flaky stuff. Thus there's the mixed response. That part of me that's tough-minded and critical is questioning, but the other part of me has cottoned on to the recent stuff he's doing on self- representation in immune networks. I love it."

"In such fundamental considerations it would be surprising if many new concepts appear, for countless good minds have worked long on these matters over many years. Indeed, new original ideas should at first be suspect, though if they withstand examination they should be welcomed. My intent is not to create a new school or art form but to discern the pattern of a mosaic which lies hidden in the cluttered, colored marble chips of today's empirical facts."

"My presentation of a general theory of living systems will employ two sorts of spaces in which they may exist, physical or geographical space and conceptual or abstract space... The characteristics and constraints of physical space affect the action of all concrete systems, living and nonliving... Physical space is a common space because it is the only space in which all concrete systems, living and nonliving, exist (though some may exist in other spaces simultaneously). Physical space is shared by all scientific observers, and all scientific data must be collected in it. This is equally true for natural science and behavioral science."

"My analysis of living systems uses concepts of thermodynamics, information theory, cybernetics, and systems engineering, as well as the classical concepts appropriate to each level. The purpose is to produce a description of living structure and process in terms of input and output, flows through systems, steady states, and feedbacks, which will clarify and unify the facts of life."

"The term system has a number of meanings. There are systems of numbers and of equations, systems of value and of thought, systems of law, solar systems, organic systems, management systems, command and control systems, electronic systems, even the Union Pacific Railroad system. The meanings of "system" are often confused. The most general, however, is: A system is a set of interacting units with relationships among them. The word "set" implies that the units have some common properties. These common properties are essential if the units are to interact or have relationships. The state of each unit is constrained by, conditioned by, or dependent on the state of other units. The units are coupled. Moreover, there is at least one measure of the sum of its units which is larger than the sum of that measure of its units."

"# A space representing the shortest distances for messages to travel..."

"# A space of frequency of trade relations among nations."

"The structure of a system is the arrangement of its subsystems and components in three-dimensional space at a given moment of time. This always changes over time. It may remain relatively fixed for a long period or it may change from moment to moment, depending upon the characteristics of the process in the system. This process halted at any given moment, as when motion is frozen by a high-speed photograph, reveals the three-dimensional spatial arrangement of the system's components as of that instant."

"# A space of frequency of intermarriage among ethnic groups."

"# The life space of Lewin, - the environment as seen by the subject, including the field forces or valences between him and objects in the environment, which can account for his immediately subsequent behavior."

"# Osgood's semantic space as determined by subjects' ratings of words on the semantic differential test."

"# Political distance among political parties of the right and left."

"# Sociometric space, e.g., the rating on a scale of leadership ability of each member of a group by every other member."

"# Social class space..."

"# A space of time costs of various modes of transportation, e.g., travel taking longer on foot than by air, longer upstream than down."

"The most general form of systems theory is a set of logical or mathematical statements about all conceptual systems. A subset of this concerns all concrete systems. A subsubset concerns the very special and very important living systems, i.e., general living systems theory."

"# among ethnic or racial groups."

"General systems theory is a set of related definitions, assumptions, and propositions which deal with reality as an integrated hierarchy of organizations of matter and energy. General systems behavior is concerned with a special subset of all systems, the living ones. Even more basic to this presentation than the concept of "system" are the concepts of "space," "time," "matter," "energy," and "information," because the living systems which I shall discuss exist in space and are made of matter and energy organized by information."

"In the most general mathematical sense, a space is a set of elements which conform to certain postulates."

"The universe of all things that exist may be understood as a universe of systems where a system is defined as any set of related and interacting elements. This concept is primitive and powerful and has been used increasingly over the last half-century to organize knowledge in virtually all domains of interest to investigators. As human inventions and social interactions grow more complex, general conceptual frameworks that integrate knowledge among different disciplines studying those emerging systems grow more important. Living systems theory (LST) instructs integrative research among biological and social sciences and related academic disciplines."

"More concrete, physical space is the extension surrounding a point. It may be thought of as either the compass of the entire universe or some region of such a universe."

"General systems theory is a series of related definitions, assumptions, and postulates about all levels of systems from atomic particles through atoms, molecules, crystals, viruses, cells, organs, individuals, small groups, societies, planets, solar systems, and galaxies. General behavior systems theory is a subcategory of such theory, dealing with living systems, extending roughly from viruses through societies. A significant fact about living things is that they are open systems, with important inputs and outputs. Laws which apply to them differ from those applying to relatively closed systems."

"Scientific observers often view living systems as existing in spaces which they conceptualize or abstract from the phenomena with which they deal. Examples of such spaces are:"

"In 1978 when the book Living Systems was published, it contained the prediction that the sciences that were concerned with biological and social sciences would, in the future, be stated as rigorously as the “hard sciences” that study such nonliving phenomenon as temperature, distance, and the interaction of chemical elements. Principles of Quantitative Living Systems Science, the first of a planned series of three books, begins an attempt to fulfill that prediction... It is our opinion that this book represents an important step in the development of a quantitative living systems science... As Simms shows, the concepts of available energy and the capacity to direct energy, as well as the causative relationship between information and behavior, are useful in the analysis of behavior... The systems with which this first book of the series is concerned are mainly at the level of the cell and the animal organ and organism.... It will be interesting to see how the science is applied in later volumes to the complex behaviors of human being, and higher level systems."

"# Pecking order in birds or other animals."

"James G. Miller, a psychologist and medical doctor, wrote a large book, Living Systems, which is a discussion of matter, energy, and information processes. Miller saw systems as having 19 critical subsystems at each level: cell, organ, organism, group, corporation, nation, and supranational organization. One distinguishing feature of Miller’s work is his treatment of information."

"In a life-long partnership with his wife Jessie, James Grier Miller contributed substantially to the development of and to the integration of disciplines through general systems theory, remaining actively engaged in these areas throughout his working life. From his early work on the human brain in the 1940s, Miller worked for over 60 years within influential circles to foster a wide range of new endeavours. In 1949, as Chair of the Psychology Department at the University of Chicago, he founded the new field of behavioural science, devoted to the theoretical integration of the biological and social sciences, through the establishment of the influential Committee on Behavioral Science. In 1955, he got funding from the State of Michigan to set up the Mental Health Research Institute at the University of Michigan; and in 1967, he became President of the University Louisville where he established a Systems Science Institute. His comprehensive integration of the sciences, in Living Systems (1978), remains core to the study of Living Systems and many other fields of research and practice within the systems community."

"Miller’s scientific and professional activities have centered around the single theme of integrating knowledge about biological and social systems. But there have been great changes over the years. His early approach to science, under the influence of Whitehead, was a mixture of philosophy and experimentation. His current research relates modern information processing technologies to living systems. The basic research consists of quantitative studies of cross-level identities among multiple levels of systems. The applications extend from the use of artificial intelligence ‘expert systems’ to measure matter, energy, and information flows in living systems to the development of an electronic University of the world."

"Three unique and still timely aspects of Miller's text Living Systems were his citation of 173 specific ‘cross-level’ hypotheses, his unification of a vast number of phenomena from the biomedical sciences to the social sciences using a consistent taxonomy of seven hierarchical levels and 20 subsystems, and his consistent effort to make systems hypotheses more testable."

"There are three levels of self to consider: the proto, the core, and the autobiographical. The first two are shared with many, many other species, and they are really coming out largely of the brain stem and whatever there is of cortex in those species."

"Emotions are triggered by what we like to call emotionally competent stimuli, that is, objects or situations that can be real, like in front of you, or be in your mind when you think and you recall, and they act on brain devices that were designed by evolution."

"When you have an emotion you are recruiting a variety of mechanisms that came in the long history of evolution, long before emotions arose, and those mechanisms all had to do with how an organism manages its life."

"At the hearing I not only described the EST method and the rapid rate of human gene discovery but also voiced by concerns about NIH's patent efforts, a subject I was glad to get out in the open. The room went quiet as many were startled by this discovery and then Watson suddenly shouted that it was "sheer lunacy" to file such patents, adding that "virtually any monkey" could use the EST method and that he was "horrified." As Cook-Deegan, a Duke University genome discussant, described the event, "Watson was lying in wait and took aim with heavy artillery." Cook-Deegan, who was Watson's assistant at the time, told me later that Watson had practiced the lines for a week prior to the hearing."

"Tenure actually delivers a doubly whammy to the organizations that endure this outmoded arrangement. The second-rate people who thrive in a tenured environment like nothing more than to surround themselves with more mediocrity and drive out those who might excel and reveal the shortcomings of the entrenched."

"I could trace own EST brainwave to a flight back from a trip to Japan. But, of course, great ideas are often simultaneously conceived by several people who have responded in a similar way to the climate of thinking, and it can be hard to pin down when and precisely how a flash of inspiration is born. Kaplan had taught me that good ideas are a dime of dozen for a smart person, and the only thing that distinguishes good from great is in how an idea is executed—how it becomes reality. Scientific history is littered with stories of one person having an idea but not following through on it only to see another have a similar inspiration and then prove it to be valid."

"I think from my experience in war and life and science, it all has made me believe that we have one life on this planet. We have one chance to live it and to contribute to the future of society and the future of life. The only "afterlife" is what other people remember of you."

"Moving forward in science is as much unwinding the distorted thinking of the past as it is putting a clearer idea on the table."

"Coyne is also s special kind of scientist---one who accepts some things on faith himself! Most important is "determinism," when means that all of reality as we know it evolves completely deterministically according to physical laws."

"In the end, why isn’t it better to find out how the world really works instead of making up stories about it, or accepting stories concocted centuries ago?"

"It is time to stop seeing faith as a virtue, and to stop using the term “person of faith” as a compliment."

"Indeed, secular morality, which is not twisted by adherence to the supposed commands of a god, is superior to most “religious” morality."

"What might be considered a real contribution of science to religious belief is the empirical demonstration that some of those beliefs are wrong."

"I have argued that religion is to science as superstition is to reason; indeed, that is the very reason they are incompatible."

"A world that is faithless would not be without the arts, either. Those don’t rest on faith, so imaginative art, literature, and music would still be with us. Too, we would retain justice, law, and compassion, perhaps in even greater measure than now, for our judgment wouldn’t be warped by adherence to unevidenced divine strictures."

"Above all, religion, faith healing, and alternative medicine all show the diagnostic feature of faith: an agenda not to find the truth, but to support one’s biases, emotions, and personal beliefs."

"The first argument, that religion is a social necessity and will always be with us, is dubious. It can be demolished with only two words: northern Europe."

"Medicine can cure; faith cannot."

"I’m not a Marxist, but Marx got at least one thing right: for many, religion weakens the incentive to fix both personal and societal problems."