Biologists From The United States

"For a long time, people have been trying to characterize or define the notion of system. After all, “systems” are supposed to be what System Theory is about. The results so far have been contradictory and unsatisfactory. This confusion at the foundations has led many to conclude that there is no such thing as a "system" and hence to deny that System Theory is about anything. Even those most sympathetic to the notion have difficulties at this level. The very founders of System Theory did not try to say what a system was; and as for System Theory, they characterized it only obliquely, by saying it comprised all studies of interest to more than one discipline. They thereby begged the entire question."

"The point of departure is the measurement problem, as it appears in physics; the manner in which measurements allow us to characterize subsystems; the role of such subsystems as tools in system analysis; and the relationships existing between different ways of perceiving or interacting with the same system. Our conclusions are: (1) there exists no universal family of analytic units appropriate for the treatment of all interactions; (2) there are on the contrary many such families of analytic units, all of which are equally “real” and entitled to be treated on the same footing; (3) the appropriate use of natural interactions can enormously extend the class of physical observables accessible to us; (4) the concept of a model must be formulated, in its most general terms, as the sharing of a subsystem by two otherwise distinct systems, capable of imposing the same dynamic on an appropriate system with which they can both interact. We establish these results through a variety of terminologies which turn out to be equivalent: stability, invariance, symmetry, homeostasis."

"Let us begin by observing that the word "system" is almost never used by itself; it is generally accompanied by an adjective or other modifier: physical system; biological system; social system; economic system; axiom system; religious system; and even "general" system. This usage suggests that, when confronted by a system of any kind, certain of its properties are to be subsumed under the adjective, and other properties are subsumed under the "system," while still others may depend essentially on both. The adjective describes what is special or particular; i.e., it refers to the specific "thinghood" of the system; the "system" describes those properties which are independent of this specific "thinghood.""

"I do not consider myself a philosopher. I am a biologist, attempting to grapple with the Schrodinger question, “What is Life?” It turns out that this is not an empirical question, to be resolved through observation in a laboratory."

"On balance, the cartesian metaphor of organism as machine has proved to be a good idea. Ideas do not have to be correct in order to be good; its only necessary that, if they do fail, they do so in an interesting way."

"Perhaps the first lesson to be learned from biology is that there are lessons to be learned from biology."

"The physical structures of organisms play only a minor and secondary role... The only requirement which physical structure must fulfill is that it allow the characteristic behaviors themselves to be manifested. Indeed, if this were not so, it would be impossible to understand how a class of systems as utterly diverse in physical structure as that which comprises biological organisms could be recognised as a unity at all."

"The study of twigs seems esoteric. But this impression is dangerously wrong. Counting back through bud scars, tallying yearly growth, I not only see the struggle among native and foreign trees, I read the ledger of the world's atmosphere."

"The old "red in tooth and claw" view of the natural economy has to be updated. We need a new metaphor for the forest, one that helps us visualize plants both sharing and competing. … Evolution's engine is fired by genetic self-interest, but this manifests itself in cooperative action as well as solo selfishness. The natural economy has as many trade unions as robber barons, as much solidarity as individualistic entrepreneurship."

"Our sensitivity to the tone, hue, and intensity of light is bound up with our evolutionary heritage. Even the diversity of our visual abilities may echo our ancestors' ecology."

"Storms in the forest have a more primal character than storms playing over tamed urban land. A vigorous cloudburst is exhilarating, a burst of sensory delight with its leafy smells, gray light, and chill. But a full tree-ripping storm pushes the senses beyond exhilaration or thrill, into fear."

"Human artifacts are not stains imposed on nature. Such a view drives a wedge between humanity and the rest of the community of life. A golf ball is the manifestation of the mind of a clever, playful African primate. This primate loves to invent games to test its physical and mental skill. Generally, these games are played on carefully reconstructed replicas of the savanna from which the ape came and for which its subconscious still hankers. The clever primate belongs in this world. … To love nature and to hate humanity is illogical."

"The skin is impossibly wet, a cloud condensed into animate matter."

"We can find our way back to thoughtful management for the long-term well-being of both humans and forests. But finding this way will require some quiet and humility."

"When laughing children chase after fireflies, they are not pursuing beetles but catching wonder.When wonder matures, it peels back experience to seek deeper layers of marvel below. This is science's highest purpose."

"You are as responsible for what you let happen as for the actions you share."

"She watched the indigo sky, and the stars coming out tranquil as ever, as if this were any ordinary evening. Only humans knew what an evil time this was."

"Death hastens those who hasten death."

"If every planet in the Patriarchy refused to be ruled, we all would be free."

"Death can be hastened but never shared."

"“I can’t change what I am ovenight.” “Nor can I. And yet, one can’t stop changing, either.”"

"There was no time for bitterness now: eat bitterness, and bitterness eats you."

"Few fears are rational."

"A life postponed too long might never be lived."

"“People fear stone,” Usha said, “because it contains never-life.” “Non-life? You mean, death?” “Nonsense,” she repeated vehemently. “What’s to fear about death? Death is natural. Stone is never-life.” Spinel took another tack. “If they fear it, then how come enough Sharers want it so the traders stock shelves full?” “How should I know? Why do Valans drink the toxic waste product of sugar-eating yeast?”"

"Of all the well-meant emotions pity is the cruelest to share."

"A thousand fools believe a lie, and it’s good as truth."

"“Magic is nonsense.” “Magic is anything you don’t understand.”"

"She tended to keep her eyes half closed, as if full sight of the world’s absurdity might be too much to bear."

"Usha had said that males were not all that different, just bigger outside to make up for what they lacked within."

"This new consensus seemed so compelling that Ernst Mayr, the dean of modern Darwinians, opened the ashcan of history for a deposit of Geoffrey's ideas about anatomical unity."

"Having reached the rare age of 100 years, I find myself in a unique position: I'm the last survivor of the golden age of the Evolutionary Synthesis. That status encourages me to present a personal account of what I experienced in the years (1920s to the 1950s) that were so crucial in the history of evolutionary biology."

"Life is simply the reification of the process of living."

"I published that theory [of speciational evolution] in a 1954 paper…and I clearly related it to paleontology. Darwin argued that the fossil record is very incomplete because some species fossilize better than others... I noted that you are never going to find evidence of a small local populatlon that changed very rapidly in the fossil record... Gould was my course assistant at Harvard where I presented this theory again and again for three years. So he knew it thoroughly. So did Eldredge. In fact, in his 1971 paper Eldredge credited me with it. But that was lost over time."

"The funny thing is if in England, you ask a man in the street who the greatest living Darwinian is, he will say Richard Dawkins. And indeed, Dawkins has done a marvelous job of popularizing Darwinism. But Dawkins' basic theory of the gene being the object of evolution is totally non-Darwinian. I would not call him the greatest Darwinian"

"The idea that a few people have about the gene being the target of selection is completely impractical; a gene is never visible to natural selection, and in the genotype, it is always in the context with other genes, and the interaction with those other genes make a particular gene either more favorable or less favorable. In fact, Dobzhanksy, for instance, worked quite a bit on so-called lethal chromosomes which are highly successful in one combination, and lethal in another. Therefore people like Dawkins in England who still think the gene is the target of selection are evidently wrong. In the 30s and 40s, it was widely accepted that genes were the target of selection, because that was the only way they could be made accessible to mathematics, but now we know that it is really the whole genotype of the individual, not the gene. Except for that slight revision, the basic Darwinian theory hasn't changed in the last 50 years"

"According to the concept of transformational evolution, first clearly articulated by Lamarck, evolution consists of the gradual transformation of organisms from one condition of existence to another"

"Biological classifications have two major objectives: to serve as a basis of biological generalizations in all sort of comparative studies and to serve as a key to an information storage system... Is the classification that is soundest as a basis of generalizations also most convenient for information retrieval? This, indeed, seems to have been true in most cases I have encountered."

"Evolution, thus, is merely contingent on certain processes articulated by Darwin: variation and selection. No longer is a fixed object transformed, as in transformational evolution, but an entirely new start is, so to speak, made in every generation."

"If biologists have ignored self-organization, it is not because self-ordering is not pervasive and profound. It is because we biologists have yet to understand how to think about systems governed simultaneously by two sources of order. Yet who seeing the snowflake, who seeing simple lipid molecules cast adrift in water forming themselves into cell-like hollow lipid vesicles, who seeing the potential for the crystallization of life in swarms of reacting molecules, who seeing the stunning order for free in networks linking tens upon tens of thousands of variables, can fail to entertain a central thought: if ever we are to attain a final theory in biology, we will surely, surely have to understand the commingling of self-organization and selection. We will have to see that we are the natural expressions of a deeper order. Ultimately, we will discover in our creation myth that we are expected after all."

"One of the most important presuppositions of Darwin's entire thesis is gradualism, the idea that mutations to the genome can cause minor variations in the organism's properties, which can be accumulated piecemeal, bit by bit, over the eons to create the complex order found in the organisms we observe."

"Life does not depend on the magic of Watson-Crick base pairing or any other specific template-replicating machinery. Life lies ... in the property of catalytic closure among a collection of molecular species"

"In his famous book, What is Life?, Erwin Schrödinger asks, "What is the source of the order in biology?" He arrives at the idea that it depends upon quantum mechanics and a microcode carried in some sort of aperiodic crystal—which turned out to be DNA and RNA—so he is brilliantly right. But if you ask if he got to the essence of what makes something alive, it's clear that he didn't. Although today we know bits and pieces about the machinery of cells, we don't know what makes them living things. However, it is possible that I've stumbled upon a definition of what it means for something to be alive. For the better part of a year and a half, I've been keeping a notebook about what I call autonomous agents. An autonomous agent is something that can act on its own behalf in an environment. Indeed, all free-living organisms are autonomous agents. Normally, when we think about a bacterium swimming upstream in a glucose gradient we say that the bacterium is going to get food. That is to say, we talk about the bacterium teleologically, as if it were acting on its own behalf in an environment. It is stunning that the universe has brought about things that can act in this way. How in the world has that happened?"

"Living systems exist in the solid regime near the edge of chaos, and natural selection achieves and sustains such a poised state."

"Evolution is not just "chance caught on the wing". It is not just a tinkering of the ad hoc, of bricolage, of contraption. It is emergent order honored and honed by selection."

"As I thought about this, I noted that the bacterium is just a physical system; it's just a bunch of molecules that hang together and do things to one another. So, I wondered, what characteristics are necessary for a physical system to be an autonomous agent? After thinking about this for a number of months I came up with a tentative definition. My definition is that an autonomous agent is something that can both reproduce itself and do at least one thermodynamic work cycle. It turns out that this is true of all free-living cells, excepting weird special cases. They all do work cycles, just like the bacterium spinning its flagellum as it swims up the glucose gradient. The cells in your body are busy doing work cycles all the time."

"It is not necessary that a specific set of 2000 enzymes be assembled... Whenever a collection of chemicals contains enough different kinds of molecules, a metabolism will crystallize from the broth."

"The strange thing about the theory of evolution is that everyone thinks he understands it. But we do not. A biosphere, or an econosphere, self-consistently coconstructs itself according to principles we do not yet fathom."

"It would be a triumph to find universal laws of organization for life, ecosystems, and biospheres. The candidate criticality law is emergent and not reducible to physics alone."

"Francisco Varela is amazingly inventive, freewheeling, and creative. There's a lot of depth in what he and Humberto Maturana have said. Conversely, from the point of view of a tied-down molecular biologist, this is all airy-fairy, flaky stuff. Thus there's the mixed response. That part of me that's tough-minded and critical is questioning, but the other part of me has cottoned on to the recent stuff he's doing on self- representation in immune networks. I love it."