"[Miffed at Brazilian street racer challenging him for pink slips] That little coupe may run the streets around here, but [Indicating his Charger] that monster has never seen a set of tail lights, ever."

"[Sees DSS readouts of the entire team] We just went from the middle of the "most wanted" list to the very top."

"[Briefing his team] All right, listen up. The men we're after are professional runners. They like speed and are guaranteed to go down in the hardest possible way, so make sure you got your funderwear on. We find them; we take them as a team and we bring them back. And above all else, we don't ever– EVER– let them get into cars."

"Tego Calderon — Tego Leo"

"John Mahoney - Sam Campagna"

"Gregory Alan Williams - Matt Wilder"

"Fred Dalton Thompson - White House Chief of Staff Harry Sargent"

"Clyde Kusatsu - FBI agent Jack Okura"

"Rene Russo - Lilly Raines"

"Dylan McDermott - Al D'Andrea"

"Steve Hytner - FBI agent Tony Carducci"

"Gary Cole - Bill Watts"

"[at the Lincoln Memorial] Well, Abe? ...Damn. Wish I could have been there for you, pal."

"For years, I've been listening to all these idiots on barstools with all their pet theories on Dallas. How it was the Cubans, or the C.I.A., or the white supremacists, or the Mob. Whether there was one weapon, or whether there was five. None of that's meant too much to me. But Leary, he questioned whether I had the guts to take that fatal bullet. God, that was a beautiful day. The sun was out, been raining all morning, the air was... First shot, sounded like a firecracker. I looked over, I saw him, I could tell he was hit. I don't know why I didn't react. I should have reacted. I should have been running flat out. I just couldn't believe it. If only I'd reacted, I could have taken that shot. And that would have been alright with me."

"[last words, left on Frank's answering machine] Hello, Frank. By the time you hear this, it'll be over. The President is most likely dead, and so am I. I wonder, Frank, did you kill me? Who won our game? Not that it really matters, for among friends like you and me, it's not whether you win or lose but how you play the game, and now the game is done and it's time to get on with your life. But I worry, that you have no life to get on with, Frank. You're a good man, and good men like you and me are destined to travel a lonely road. Goodbye, and good luck."

"Clint Eastwood - Frank Horrigan"

"John Malkovich - Mitch Leary"

"Patrika Darbo - Pam Magnus"

"What did happen to you that day? Only one agent reacted to the gunfire, and you were closer to Kennedy than he was. You must have looked up at the window of the Texas Book Depository, but you didn't react. Late at night, when the demons come, do you see the rifle coming out of that window, or do you see Kennedy's head being blown apart? If you'd reacted to that first shot, could you have gotten there in time to stop the big bullet? And if you had - that could've been your head being blown apart. Do you wish you'd succeeded, Frank? Or is life too precious?"

"John Heard - Prof. Riger"

"Joshua Malina - Secret Service Agent Chavez"

"Steve Railsback - CIA Agent David Coppinger"

"Jeff Wincott as Jesse Colson"

"David Warshofsky as Judd Stewart"

"Victor Gojcaj as Groundman"

"Jessy Schram as Darcy Colson"

"Meagan Tandy and Elizabeth Mathis as Maya and Nicole Barnes"

"Kevin Corrigan as Scott Werner"

"Kevin Chapman as Bunny"

"Ryan Ahern as Ryan Scott"

"T. J. Miller as Gilleece"

"Rosario Dawson as Connie Hooper"

"Lew Temple as Ned Oldham"

"Chris Pine as Will Colson"

"Ethan Suplee as Dewey"

"Kevin Dunn as Oscar Galvin"

"Aisha Hinds as Railroad Safety Campaign Coordinator"

"Denzel Washington as Frank Barnes"

"This ain't training. In training, they just give you an F. Out here, you get killed."

"This is Will Colson, [the] conductor. I'm letting you know we're going to run this bitch down."

"[to Will] You are a funny guy. Well-trained, but funny."

"[to Will] I only got one rule. One rule only: you're gonna do something, you do it right. You don't know how to do it, you ask me, all right? Likewise, if you need anything from me, you'd better speak up. 'Cause, uh, you're the conductor. Once we get our freight, it's your train; I'm just the guy driving it."