Biochemists

"Science fiction may be defined as that branch of literature which deals with the response of human beings to advances in science and technology. Actual change in science and technology, occurring quickly enough and striking deeply enough to affect a human being in the course of his normal lifetime, is a phenomenon peculiar to the world only since the Industrial Revolution ... The first well-known writer who responded to this new factor in human affairs by dealing regularly with science fiction, by studying the effect of additional scientific advance upon mankind ... was Jules Verne. In the English language, the early master was H. G. Wells. Between them, they laid the foundation for every theme upon which science fiction writers have been ringing variations ever since."

"It is only afterward that a new idea seems reasonable. To begin with, it usually seems unreasonable."

"It is the nature of science that answers automatically pose new and more subtle questions."

"People who want to do so can lose weight most safely and permanently if they realize that above all they must be patient. ... It is better to eat a little less at each meal than impulse would suggest and to do that constantly. Add to this a little more exercise or activity than impulse suggests and keep that up constantly too. A few less calories taken in each day and a few more used up will decrease weight, slowly, to be sure, but without undue misery. And with better long-range results too."

"The dullness of fact is the mother of fiction."

"An observer studying the Solar system dispassionately, and finding himself capable of bringing the four giant planets to his notice, could reasonably say that the Solar system consisted of one star, four planets, and some traces of debris."

"Outside intelligences, exploring the Solar System with true impartiality, would be quite likely to enter the Sun in their records thus: Star X, spectral class G0, 4 planets plus debris."

"Predicting the future is a hopeless, thankless task, with ridicule to begin with and, all too often, scorn to end with."

"Ten years on the moon could tell us more about the universe than a thousand years on the earth might be able to."

"The fact that the general incidence of leukemia has doubled in the last two decades may be due, partly, to the increasing use of x-rays for numerous purposes. The incidence of leukemia in doctors, who are likely to be so exposed, is twice that of the general public. In radiologists … the incidence is ten times greater."

"[B]y 1204, the only place where the entire body of Greek learning existed, still intact, was Constantinople. As a result of the crusaders' conquest, however, Constantinople was ruthlessly pillaged and destroyed and almost all the great treasures of ancient Greek learning were lost forever. It is because of that sack, for instance, that we have only seven plays left out of the better than one hundred written by Sophocles. The tragedy of 1204 can never be undone and for all of time, only bits and pieces of the marvelous Greek world can be known to us."

"History is a story without an end."

"Private profit is often hidden under a careful coating of great patriotism."

"I don't believe in flying saucers... The energy requirements of interstellar travel are so great that it is inconceivable to me that any creatures piloting their ships across the vast depths of space would do so only in order to play games with us over a period of decades."

"Start with a planet like the earth, with a complement of simple compounds bound to exist upon it, add the energy of a nearby sun, and you are bound to end with nucleic acids. You can't avoid it."

"It is important to remember that the viciousness and wrongs of life stick out very plainly but that even at the worst times there is a great deal of goodness, kindness, and day-to-day decency that goes unnoticed and makes no headlines."

"Indeed, it may well be argued that one reason for the decline in science, art, and literature was the increasing absorption of the better minds into a new sort of intellectual pursuit – theology."

"[W]hen one plays for top prizes one must be prepared to pay top stakes."

"It seems to be almost an invariable rule that as real power declines, the symbols of power multiply and intensify in compensation."

"There is a kind of selective memory that afflicts men when they view the past. They see the good and overlook the evil."

"476 ... is usually taken as the date of the "fall of the Roman Empire." The date, however, is a false one. No one at this period of time considered that the Roman Empire had "fallen." Indeed, it still existed and was the most powerful realm in Europe. Its capital was at Constantinople and the Emperor was Zeno. It is only because we ourselves are culturally descended from the Roman west, that we tend to ignore the continued existence of the Roman Empire in the east."

"Often, writers on historical events tend to consider ... a loss of willingness to fight as a sign of "decadence," as though there were something despicable about not being a bully and not being willing to engage in mass murder. Perhaps we ought to feel instead that to cease to be warlike means to begin to be civilized and decent."

"Generals are usually a conservative force who can be relied on to oppose social change."

"In the world of today can there be peace anywhere until there is peace everywhere?"

"The article was essentially about the coming disappearance of women. I pointed out that the only differences between men and women are the women are smaller and weaker than men, and women have to bear the children, and that all other differences are really social. They are born of the environment. They're not real. [...] You say, "Women are so pure and sweet and nice, if only they have the vote, they would clean up politics." So you give them the vote, and politics is just as dirty as ever. [...] If we get into the 21st century when all the work that's required to be done (and there won't be much of it) doesn't require muscles anyway (it's all a matter of closing contacts, pushing papers, whatever the heck you do), women can do it as well as men. And when it comes to children, there's going to have to be a low birth rate (we'll have to or everything goes 'blooey!'). And in addition, children will be considered, I think, the responsibility of society and not the responsibility of their mothers. Children will be far too valuable to trust to their mothers (most of them are complete incompetents as mothers)."

"Religion is more conservative than any other aspect of human life."

"[N]o matter how outrageous a lie may be, it will be accepted if stated loudly enough and often enough."

"It is by the Imperial Capital that contemporaries (and posterity, too) judge an Empire, and its magnificence impresses them mightily and leads them to judge the Emperor a great man and hero, even though it may all be based on robbery, and though the provinces of the Empire may be sunk in misery."

"We can hope that the ways of peace will attract the Arabic nations, for their territory and opportunities are broad enough for immeasurable advance, if the energies vented in spleen, are turned instead to a modernisation of the technology, a restoration of the soil, and a renovation of the economic, social, and political structure of those great and venerable lands."

"It is an odd fact that anyone who wishes to start a war must always make it appear that he is fighting in a just cause even if the real motive is naked aggression. Fortunately for the would-be aggressor, a "just cause" is very easy to find."

"Probably, the most-often-repeated lesson in history is that foreigners who are called in to help one side in a civil war take over for themselves. It is a lesson that seems never to be learned despite endless repetition."

"There has never been any custom, however useless it may become with changing conditions, that isn't clung to desperately simply because it is something old and familiar."

"It is all too easy to forget that there are emotional motivations in history, as well as economic ones."

"It seemed to him https://en.wikipedia.org/wiki/Euphemius_(Sicily) Euphemius it would be a brilliant notion to call in an outside force to fight on his behalf. This same brilliant notion has occurred to participants in civil wars uncounted times in history and it has ended in catastrophe just about every time, since those called in invariably take over for themselves. Of all history's lessons, this seems to be the plainest, and the most frequently ignored."

"Had Hannibal had a government behind him that knew how to exploit victories – had he been born a Roman, for instance – he might have conquered the world."

"Throughout history there have been peasant rebellions which have followed always the same course. Blindly, the peasants sacked and destroyed, and when members of the "upper classes" fell into their hands, they killed ruthlessly and cruelly, for never in their lives had they been taught gentleness and mercy by those now in their power."

"I consider one of the most important duties of any scientist the teaching of science to students and to the general public."

"I recognize the necessity of animal experiments with my mind but not with my heart."

"Inspect every piece of pseudoscience and you will find a security blanket, a thumb to suck, a skirt to hold. What does the scientist have to offer in exchange? Uncertainty! Insecurity!"

"For man to become successful, for man to establish himself as the ruler of the planet, it was necessary for him to use his brain as something more than a device to make the daily routine of getting food and evading enemies a little more efficient. Man had to learn to control his environment.""

"Can the word ‘best’ mean anything at all, except to some particular person in some particular mood? Perhaps not — so if we allow the word to stand as an absolute, you, or you, or perhaps you, may be appalled at omissions or inclusions or, never having read me before, may even be impelled to cry out, ‘Good heavens, are those his best?’"

"Hypocrisy is a universal phenomenon. It ends with death, but not before."

"Science is a systematic method for studying and working out those generalizations that seem to describe the behavior of the universe. It could exist as a purely intellectual game that would never affect the practical life of human beings either for good or evil, and that was very nearly the case in ancient Greece, for instance. Technology is the application of scientific findings to the tools of everyday life, and that application can be wise or unwise, useful or harmful. Very often, those who govern technological decisions are not scientists and know little about science."

"What I will be remembered for are the Foundation Trilogy and the Three Laws of Robotics. What I want to be remembered for is no one book, or no dozen books. Any single thing I have written can be paralleled or even surpassed by something someone else has done. However, my total corpus for quantity, quality and variety can be duplicated by no one else. That is what I want to be remembered for."

"The true discovery of America by mankind came when those first hunting bands crossed over from Siberia 25,000 years ago. This, however, never seems to count. When people speak of the "discovery of America" they invariably mean its discovery by Europeans."

"There is no belief, however foolish, that will not gather its faithful adherents who will defend it to the death."

"If, as I maintain and firmly believe, there is no objective definition of intelligence, and what we call intelligence is only a creation of cultural fashion and subjective prejudice, what the devil is it we test when we make use of an intelligence test?"

"My parents, both of whom spoke Russian fluently, made no effort to teach me Russian, but insisted on my learning English as rapidly and as well as possible. They even set about learning English themselves, with reasonable, but limited, success. In a way, I am sorry. It would have been good to know the language of Pushkin, Tolstoy, and Dostoevski. On the other hand, I would not have been willing to let anything get in the way of the complete mastery of English. Allow me my prejudice: surely there is no language more majestic than that of Shakespeare, Milton, and the King James Bible, and if I am to have one language that I know as only a native can know it, I consider myself unbelievably fortunate that it is English."

"Science fiction writers foresee the inevitable, and although problems and catastrophes may be inevitable, solutions are not."

"Self-education is, I firmly believe, the only kind of education there is."

"Straightforward preaching spoils the effectiveness of a story. If you can't resist the impulse to improve your fellow human beings, do it subtly."

"There is no way of being almost funny or mildly funny or fairly funny or tolerably funny. You are either funny or not funny and there is nothing in between. And usually it is the writer who thinks he is funny and the reader who thinks he isn't."

"[S]cientific writing is abhorrently stylized and places a premium on poor quality."

"If you're going to write a story, avoid contemporary references. They date a story and they have no staying power."

"Generals are, as a matter of course, allowed to be far more idiotic than ordinary human beings are permitted to be."

"People are entirely too disbelieving of coincidence. They are far too ready to dismiss it and to build arcane structures of extremely rickety substance in order to avoid it. I, on the other hand, see coincidence everywhere as an inevitable consequence of the laws of probability, according to which having no unusual coincidence is far more unusual than any coincidence could possibly be."

"The history of science is full of revolutionary advances that required small insights that anyone might have had, but that, in fact, only one person did."

"We cannot afford enemies any more... Within a generation or two human society will be in total destructive disarray. Heaven knows how bad it will be. The most optimistic view I can take is this: Things will get so bad within a dozen years that it will become obvious ... that we must, whether were like each other or not, work together. We have no choice in the matter. ... Technologically, we can stop overpopulation, but we have to persuade people to accept the technology. ... Babies are the enemies of the human race ... Let's consider it this way: by the time the world doubles its population, the amount of energy we will be using will be increased sevenfold which means probably the amount of pollution that we are producing will also be increased sevenfold. If we are now threatened by pollution at the present rate, how will we be threatened with sevenfold pollution by, say, 2010 A.D., distributed among twice the population? We'll be having to grow twice the food out of soil that is being poisoned at seven times the rate."

"What, then, of human activities? Is humankind itself hastening its own end? Man has, for instance, been burning carbon-containing fuel — wood, coal, oil, gas — at a steadily accelerating rate. All these fuels form carbon dioxide. Some is absorbed by plants and the oceans but not as fast as it is produced. This means the carbon dioxide content of the air is going up — slightly but nevertheless up. Carbon dioxide retains heat, and even a small rise means a warming of the Earth's atmosphere. This may result in the melting of the polar ice caps with unusual speed, flooding the world before we have learned climate control. In reverse, our industrial civilization is making our atmosphere dustier so that it reflects more sunlight away and cools the Earth slightly — thus making possible a glacial advance in a few centuries, also before we have learned climate control."

"I believe that only scientists can understand the universe. It is not so much that I have confidence in scientists being right, but that I have so much in nonscientists being wrong."

"Individual science fiction stories may seem as trivial as ever to the blinder critics and philosophers of today — but the core of science fiction, its essence, the concept around which it revolves, has become crucial to our salvation if we are to be saved at all."

"It is change, continuing change, inevitable change, that is the dominant factor in society today. No sensible decision can be made any longer without taking into account not only the world as it is, but the world as it will be ... This, in turn, means that our statesmen, our businessmen, our everyman must take on a science fictional way of thinking."

"Science Digest asked me to see the movie Close Encounters of the Third Kind and write an article for them on the science it contained. I saw the picture and was appalled. I remained appalled even after a doctor's examination had assured me that no internal organs had been shaken loose by its ridiculous soundwaves. (If you can't be good, be loud, some say, and Close Encounters was very loud.) ... Hollywood must deal with large audiences, most of whom are utterly unfamiliar with good science fiction. It has to bend to them, meet them at least half-way. Fully appreciating that, I could enjoy Planet of the Apes and Star Wars. Star Wars was entertainment for the masses and did not try to be anything more. Leave your sophistication at the door, get into the spirit, and you can have a fun ride. ... Seeing a rotten picture for the special effects is like eating a tough steak for the smothered onions, or reading a bad book for the dirty parts. Optical wizardry is something a movie can do that a book can't but it is no substitute for a story, for logic, for meaning. It is ornamentation, not substance. In fact, whenever a science fiction picture is praised overeffusively for its special effects, I know it's a bad picture. Is that all they can find to talk about?"

"Where any answer is possible, all answers are meaningless."

"I simply don't think it is reasonable to use IQ tests to produce results of questionable value, which may then serve to justify racists in their own minds and to help bring about the kinds of tragedies we have already witnessed earlier in this century."

"In memory yet green, in joy still felt, The scenes of life rise sharply into view. We triumph; Life’s disasters are undealt, And while all else is old, the world is new."

"I wouldn't give an astrologer the time of day."

"It is surely better to be wronged than to do wrong."

"The purpose of aphorisms is to keep fools who have memorised them from having nothing to say."

"There is less trouble and trauma involved in writing a new piece than in trying to salvage an unsatisfactory old one."

"The undramatic fact is that I just think and think and think until I have something [for a story], and there is nothing marvelous or artistic about the phenomenon."

"Certain success evicts one from the paradise of winning against the odds."

"The military mind remains unparalleled as a vehicle of creative stupidity."

"It is very likely that there are many, many planets carrying life, even intelligent life, throughout the universe, because there are so many stars. By sheer chance, even if those chances are small, a great many life forms and a great many intelligences may exist."

"There is a cult of ignorance in the United States, and there always has been. The strain of anti-intellectualism has been a constant thread winding its way through our political and cultural life, nurtured by the false notion that democracy means that "my ignorance is just as good as your knowledge.""

"I believe that every human being with a physically normal brain can learn a great deal and can be surprisingly intellectual. I believe that what we badly need is social approval of learning and social rewards for learning. We can all be members of the intellectual elite and then, and only then, will a phrase like "America's right to know" and, indeed, any true concept of democracy, have any meaning."

"[Creationists] make it sound as though a "theory" is something you dreamt up after being drunk all night."

"It is my own experience ... that commentators are far more ingenious at finding meaning than authors are at inserting it."

"Weisinger, a couple of years ago, made up the following story: "Isaac Asimov was asked how Superman could fly faster than the speed of light, which was supposed to be an absolute limit. To this Asimov replied, 'That the speed of light is a limit is a theory; that Superman can travel faster than light is a fact.'""

"When you write a short story ... you had better know the ending first. The end of a story is only the end to the reader. To the writer, it's the beginning. If you don't know exactly where you're going every minute you're writing, you'll never get there — or anywhere."

"Necessity makes a joke of civilization."

"I make no secret about being Jewish ... I just think it's more important to be human and to have a human heritage; and I think it is wrong for anyone to feel that there is anything special about any one heritage of whatever kind. It is delightful to have the human heritage exist in a thousand varieties, for it makes for greater interest, but as soon as one variety is thought to be more important than another, the groundwork is laid for destroying them all."

"I am not a visual person. I have spent so many bounded years in my childhood that I have grown used to having books as my window on reality."

"Writing is hard work. The fact that I love doing it doesn't make it less hard work. People who love tennis will sweat themselves to exhaustion playing it, and the love of the game doesn't stop the sweating. The casual assumption that writers are unemployed bums because they don't go to the office and don't have a boss is something every writer has to live with. I have never known a writer who hasn't suffered as a result of this, hasn't resented it, and hasn't dreamed of murdering the next person who says "Boy, you've sure got it made. You just sit there and toss off a story or something whenever you feel like it.""

"The fact is that I've never called myself a genius, and I think the term has been cheapened by overuse into meaninglessness. If other people want to call me that, that's their problem."

"I joke sometimes to the effect that when I approach a part of a book where I must explain something I don't understand, I just type faster and faster and faster. Then, when I get to the part I don't understand, sheer inertia pushes me through. That's not literally true, of course, but there's something to it psychologically."

"No matter how various the subject matter I write on, I was a science-fiction writer first and it is as a science-fiction writer that I want to be identified."

"Of all the books I have ever worked on, I think Asimov's Guide to Shakespeare gave me the most pleasure, day in, day out. For months and months I lived and thought Shakespeare, and I don't see how there can be any greater pleasure in the world—any pleasure, that is, that one can indulge in for as much as ten hours without pause, day after day indefinitely."

"The best way to describe anyone is to give an example of the kind of thing he would do."

"People don't stop things they enjoy doing just because they reach a certain age. They don't stop playing tennis just because they turn 40, they don't stop with sex just because they turn 40; they keep it up as long as they can if they enjoy it, and learning will be the same thing."

"There are many aspects of the universe that still cannot be explained satisfactorily by science; but ignorance only implies ignorance that may someday be conquered. To surrender to ignorance and call it God has always been premature, and it remains premature today."

"There is no version of primeval history, preceding the discoveries of modern science, that is as rational and as inspiring as that of the first eleven chapters of the Book of Genesis."

"The Bible and science agree in being unable to say anything certainly about what happened before the beginning. There is this difference. The Bible will never be able to tell us. It has reached its final form, and it simply doesn't say. Science, on the other hand, is still developing, and the time may come when it can answer questions that, at present, it cannot."

"If one thing goes without saying, almost anything can."

"To be sure, the Bible contains the direct words of God. How do we know? The Moral Majority says so. How do they know? They say they know and to doubt it makes you an agent of the Devil or, worse, a Lbr-l Dm-cr-t. And what does the Bible textbook say? Well, among other things it says the earth was created in 4004 BC. (Not actually, but a Moral Majority type figured that out three and a half centuries ago, and his word is also accepted as inspired.) The sun was created three days later. The first male was molded out of dirt, and the first female was molded, some time later, out of his rib. As far as the end of the universe is concerned, the Book of Revelation (6:13-14) says: "And the stars of heaven fell unto the earth, even as a fig tree casteth her untimely figs, when she is shaken of a mighty wind." ... Imagine the people who believe such things and who are not ashamed to ignore, totally, all the patient findings of thinking minds through all the centuries since the Bible was written. And it is these ignorant people, the most uneducated, the most unimaginative, the most unthinking among us, who would make themselves the guides and leaders of us all; who would force their feeble and childish beliefs on us; who would invade our schools and libraries and homes in order to tell us what books to read and what not, what thoughts to think and what not, what conclusions to accept and what not. And what does the Bible say? "If the blind lead the blind, both shall fall into the ditch" (Matthew 15:14)."

"But suppose we were to teach creationism. What would be the content of the teaching? Merely that a creator formed the universe and all species of life ready-made? Nothing more? No details?"

"I am an atheist, out and out. It took me a long time to say it. I've been an atheist for years and years, but somehow I felt it was intellectually unrespectable to say one was an atheist, because it assumed knowledge that one didn't have. Somehow, it was better to say one was a humanist or an agnostic. I finally decided that I'm a creature of emotion as well as of reason. Emotionally, I am an atheist. I don't have the evidence to prove that God doesn't exist, but I so strongly suspect he doesn't that I don't want to waste my time."

"Earth is a ball that is over 12,000 kilometres in diameter, and if it were modelled into an object the size of a billiard ball, with all its surface unevenness reproduced exactly to scale, the model would be smoother than an ordinary billiard ball—and the ocean would be an all but unnoticeable mist of dampness over 70 percent of its surface."

"An optimistic view of the future would indicate that before long, the clear necessity of expanding humanity's horizons would cause ... space settlements to be built. The construction would also serve as a great project that not only would be clearly of great benefit, but might induce human cooperation in something large enough to fire the heart and mind, and make people forget the petty quarrels that have engaged them for thousands of years in wars over insignificant scraps of earthly territory."

"[S]cientists have pushed back the horizon of time from the biblical 6,000 years to 4,600,000,000 years for the age of Earth—a 760,000-fold increase."

"There were many more stories in the course of the year that were printed and that dealt with the nuclear nightmare, and who knows how many stories that were written and were never published. It was an overriding terror in the years that immediately followed Hiroshima; and it is only the callousness of habituation that hasn’t caused the terror to increase steadily—for the danger has."

"It is a rather sad commentary on humanity that it is always so attractive to think that some small group “controls the Earth”—the Jews, the international bankers, the Communists, the Masons, the Trilateral Commission. Those who believe such things are so sincere, so harried, so paranoid and, if the times are bad enough, and if the hunger for a scapegoat is great enough—so convincing. The Nazis are the most dreadful example in recent history of how far madmen can go when riding the skeletal horse of paranoia, but their example has by no means cured the world."

"Are there things about the universe that we cannot know in the usual way of observing and measuring, but that we can know in some other way—intuition, revelation, mad insight? If so, how can you know that what you know in these non-knowing ways is really so. Anything you know without knowing, others can know only on your flat statement without any proof other than “I know!”"

"I get a certain pleasure in knowing that I live not merely in a city but in Manhattan, the center of New York City, a region so unique in many ways that I honestly believe that Earth is divided into halves: Manhattan and non-Manhattan."

"Consider the most famous pure dystopian tale of modern times, 1984, by George Orwell (1903-1950), published in 1948 (the same year in which Walden Two was published). I consider it an abominably poor book. It made a big hit (in my opinion) only because it rode the tidal wave of cold war sentiment in the United States."

"Miniaturization doesn't actually make sense unless you miniaturize the very atoms of which matter is composed. Otherwise a tiny brain in a man the size of an insect, composed of normal atoms, is composed of too few atoms for the miniaturized man to be any more intelligent than the ant. Also, miniaturizing atoms is impossible according to the rules of quantum mechanics."

"Titles are an important part of a story and I take considerable care in choosing one. In fact, I cannot start a story until I have chosen a title."

"Once you've dissected a joke, you're about where you are when you've dissected a frog. It's dead."

"In my fiction I am careful to make everything probable and to tie up all loose ends. Real life is not hampered by such considerations."

"Science fiction offers its writers chances of embarrassment that no other form of fiction does."

"There is more to a science fiction story than the science it contains. There is also the story."

"There are limits beyond which your folly will not carry you. I am glad of that. In fact, I am relieved."

"The most exciting phrase to hear in science, the one that heralds new discoveries, is not 'Eureka!', but 'That's funny ...'"

"All life is nucleic acid; the rest is commentary"

"I suppose he's entitled to his opinion, but I don't suppose it very hard."

"Good literature, all if it, is supposed to illuminate the human condition."

"Of all the cultural aspects of humanity, the only one which is not broken up into national or regional splinters is science. Different nations have different languages, they may have different religions, may have different dietaries, may have different holidays, different ways of thinking, but here’s only one science."

"[In response to this question by Bill Moyers: What do you see happening to the idea of dignity to human species if this population growth continues at its present rate?] "It's going to destroy it all. I use what I call my bathroom metaphor. If two people live in an apartment, and there are two bathrooms, then both have what I call freedom of the bathroom, go to the bathroom any time you want, and stay as long as you want to for whatever you need. And this to my way is ideal. And everyone believes in the freedom of the bathroom. It should be right there in the Constitution. But if you have 20 people in the apartment and two bathrooms, no matter how much every person believes in freedom of the bathroom, there is no such thing. You have to set up, you have to set up times for each person, you have to bang at the door, aren't you through yet, and so on. And in the same way, democracy cannot survive overpopulation. Human dignity cannot survive it. Convenience and decency cannot survive it. As you put more and more people onto the world, the value of life not only declines, but it disappears. It doesn't matter if someone dies."

"Science doesn't purvey absolute truth. Science is a mechanism. It's a way of trying to improve your knowledge of nature. It's a system for testing your thoughts against the universe and seeing whether they match. And this works, not just for the ordinary aspects of science, but for all of life. I should think people would want to know that what they know is truly what the universe is like, or at least as close as they can get to it."

"The Law of conservation of energy tells us we can't get something for nothing, but we refuse to believe it."

"The saddest aspect of life right now is that science gathers knowledge faster than society gathers wisdom."

"As indicated by our very name, we humanists celebrate humanity, want humanity to survive, and recognize that if humanity does survive, it will be by its own efforts. Never can we sit back and wait for miracles to save us. Miracles don't happen. Sweat happens. Effort happens. Thought happens. And it is up to us humanists to help — to expend our sweat, our effort and our thought. Then there will be hope for the world."

"All mankind, right down to those you most despise, are your neighbors."

"We are meant to know, or we are amoebae. Suppose that we are wise enough to learn and know — and yet not wise enough to control our learning and knowledge, so that we use it to destroy ourselves? Even if that is so, knowledge remains better than ignorance. It is better to know — even if the knowledge endured only for the moment that comes before destruction — than to gain eternal life at the price of a dull and swinish lack of comprehension of a universe that swirls unseen before us in all its wonder. That was the choice of Achilles, and it is mine, too."

"I made up my mind long ago to follow one cardinal rule in all my writing — to be clear. I have given up all thought of writing poetically or symbolically or experimentally, or in any of the other modes that might (if I were good enough) get me a Pulitzer prize. I would write merely clearly and in this way establish a warm relationship between myself and my readers, and the professional critics — Well, they can do whatever they wish."

"[Writing] is an addiction more powerful than alcohol, than nicotine, than crack. I could not conceive of not writing."

"Radiation, unlike smoking, drinking, and overeating, gives no pleasure, so the possible victims object."

"Books ... hold within them the gathered wisdom of humanity, the collected knowledge of the world's thinkers, the amusement and excitement built up by the imaginations of brilliant people. Books contain humor, beauty, wit, emotion, thought, and, indeed, all of life. Life without books is empty."

"The foundation of all technology is fire."

"If anyone can be considered the greatest writer who ever lived, it is Shakespeare."

"Scientific theories can always be improved and are improved. That is one of the glories of science. It is the authoritarian view of the Universe that is frozen in stone and cannot be changed, so that once it is wrong, it is wrong forever."

"It's my belief that the Universe possesses, in its essence, fractal properties of a very complex sort and that the pursuit of science shares those properties. It follows that any part of the Universe that remains un-understood, and any part of scientific investigation that remains unresolved, however small that might be in comparison to what is understood and resolved, contains within it all the complexity of the original. Therefore, we'll never finish. No matter how far we go, the road ahead will be as long as it was at the start, and that's the secret of the Universe."

"The job of science will never be done, it will just sink deeper and deeper into never-ending complexity."

"Ideas are cheap. It's only what you do with them that counts."

"Someone once asked me, "If you had your choice, Dr. Asimov, would it be women or writing?" My answer was, "Well, I can write for twelve hours at a time without getting tired.""

"In the course of my fight with the school, I couldn't help but notice that I became a pariah. [...] Once, however, a fellow faculty member, making sure we were unobserved, said to me, "Isaac, the faculty is proud of you for your courage in fighting the administration for academic freedom." I said, "There's no courage involved in it. Don't you know my definition of academic freedom?" "No. What's your definition of academic freedom?" I said, "Independent income.""

"I was once being interviewed by Barbara Walters [...] In between two of the segments she asked me [...] "But what would you do if the doctor gave you only six months to live?" I said, "Type faster." This was widely quoted, but the "six months" was changed to "six minutes," which bothered me. It's "six months.""

"If you suspect that my interest in the Bible is going to inspire me with sudden enthusiasm for Judaism and make me a convert of mountain‐moving fervor and that I shall suddenly grow long earlocks and learn Hebrew and go about denouncing the heathen — you little know the effect of the Bible on me. Properly read, it is the most potent force for atheism ever conceived."

"I don't believe in an afterlife, so I don't have to spend my whole life fearing hell, or fearing heaven even more. For whatever the tortures of hell, I think the boredom of heaven would be even worse."

"A robot may not injure a human being, or, through inaction, allow a human being to come to harm."

"A robot must obey the orders given it by human beings except where such orders would conflict with the First Law."

"A robot must protect its own existence as long as such protection does not conflict with the First or Second Laws."

"A robot may not injure humanity, or, through inaction, allow humanity to come to harm."

"If the love of money is the root of all evil, the need of money is most certainly the root of all despair."

"Earth governments in moments of stress are not famous for being reasonable."

"“But you really are, you know.” This was said with intense earnestness. “I mean good, really good. I think it is wonderful to be an author like you. It must be almost like being God.” Graham stared blankly. “Not to editors, sister.” Sister didn’t get the whisper. She continued, “To be able to create living characters out of nothing; to unfold souls to all the world; to put thoughts into words; to build pictures and create worlds. I have often thought that an author was the most gloriously gifted person in all creation. Better an inspired author starving in a garret than a king upon his throne. Don’t you think so?” “Definitely,” lied Graham."

"“Things in the past always seem greater.” Brand condescended with a smile. “There is a theorem to that effect which you’ll find in any elementary text. Freshmen invariably call it the ‘GOD Theorem.’ Stands for ‘Good-Old-Days,’ you know. But go on.” Theor frowned at the digression. He hid the beginning of a sneer. “You can always dismiss an uncomfortable fact by pinning a dowdy label to it.”"

"Modesty is an unnatural attitude, and one which is only with difficulty taught to children."

"Self-preservation has frequently knuckled under to that tremendous yearning to ‘get even.’"

"What a human being believes, however, no matter with what ardor, is not necessarily objective truth."

"“The evil drink does,” said George, with a heavily alcoholic sigh, “would be hard to assess.” “Not if you were sober,” I said."

"“An accent?” “Substandard English. Foreigners who have not learned the language as infants but who pick it up in later life invariably mispronounce the vowels, miss out on word order, break up the grammar, and so on.” A look of sheer horror crossed Azazel’s tiny face. “But that’s a capital offense,” he said. “Not on this world,” I said. “It should be, but it isn’t.”"

"“You clearly know nothing at all about economics, old fellow.” “Neither do economists, George,” I said."

"“He seemed so pleasant, so friendly, so grateful for little favors. How could I know that underneath it all he was a vicious, libelous hellhound.” George said, “But he was a critic. How could he be anything else? You train for the post by maligning your mother.”"

"“Arrange for the statue to come to life while we are watching, and make sure that it is terribly in love with Elderberry.” “Love is easy. That’s just a matter of adjusting hormones.”"

"He could almost wish he were superstitious. He could then console himself with the thought that the casual meaningless meeting had really been directed by a knowing and purposeful Fate."

"“Surely you believe in God?” “Well, said R.E., “I believed a lot of things about Him that would probably startle you.”"

"We face eternity now. We have no universe left, no outside phenomena, no emotions, no passions. Nothing but ourselves and thought. We face an eternity of introspection, when all through history we have never known what to do with ourselves on a rainy Sunday."

"The Dantean conceptions of Inferno were childish and unworthy of the Divine imagination: fire and torture. Boredom is much more subtle. The inner torture of a mind unable to escape itself in any way, condemned to fester in its own exuding mental pus for all time, is much more fitting. Oh, yes, my friend, we have been judged, and condemned, too, and this is not Heaven, but hell."

"“Why didn’t people just use a computer?” “That was before they had computers,” cried Paul. “Before?” “Sure. Do you think people always had computers? Didn’t you ever hear of cavemen?”"

"Printing will tell you such useful things and such interesting things that not being able to read would be as bad as not being able to see."

"I don’t say it was deliberate fraud. He was probably madly sincere, and sincerely mad."

"“If you can see the future –” “Why am I not the richest man on earth? Is that it? But I am rich—in all I want. You want recognition and I want to be left alone. I do my work. No one bothers me. That makes me a billionaire.”"

"The newsmen were writing down sentences busily as Hoskins spoke to them. They did not understand and they were sure their readers would not, but it sounded scientific and that was what counted."

"“You are an important man–” Ralston snorted. “You do not consider that to be so?” asked Blaustein. “No, I don’t. There are no important men, any more than there are important individual bacteria.” “I don’t understand.” “I don’t expect you to.”"

"Psychiatry is becoming too popular. Everybody talks of complexes and neuroses and psychoses and compulsions and whatnot. One man’s guilt complex is another man’s good night’s sleep."

"Look around you. Look at the planet, Earth. What kind of a ridiculous animal are we to be lords of the world after the dinosaurs had failed? Sure, we’re intelligent, but what’s intelligence? We think it is important because we have it. If the Tyrannosaurus could have picked out the one quality that he thought would ensure species domination, it would be size and strength. And he would make a better case for it. He lasted longer than we are likely to."

"It is no one’s privilege to despise another. It is only a hard-won right after long experience."

"It’s funny the respectable names you can give to superstition."

"“That’s The Goose,” he said. The way he said it, I could hear the capitals. I stared at it. It looked like any other goose, fat, self-satisfied and short-tempered."

"“Curing diabetes is just a detail and it will merely mean that the death rate will go down slightly and produce just a bit more pressure in the direction of population increase. I’m not interested in achieving that.” “You don’t value human life?” “Not infinitely. There are too many people on earth.” “I know that some think so.” “You’re one of them, Mr. Secretary. You have written articles saying so. And it’s obvious to any thinking man—to you more than anyone—what it’s doing. Overpopulation means discomfort, and to reduce the discomfort private choice must disappear. Crowd enough people into a field and the only way they can all sit down is for all to sit down at the same time. Make a mob dense enough and they can move from one point to another quickly only by marching in formation. That is what men are becoming; a blindly marching mob knowing nothing about where it is going or why.”"

"It built itself up endlessly, like a chess game, and the telemetrists began to use a computer to program the computer that designed the program for the computer that programmed the robot-controlling computer."

"“Nobody in the government,” said Edwards stubbornly, “seems to care whether we reach the bottom of the matter or not.” “I’ve already explained that there have been no consequences but good ones. Why stir the mud at the bottom, when the water above is clear?”"

"“Fifty years,” I hackneyed, “is a long time.” “Not when you’re looking back at them,” she said. “You wonder how they vanished so quickly.”"

"“Nonsense,” Weston denied, with an involuntary nervous shiver. “That’s completely ridiculous. We had a long discussion at the time we bought Robbie about the First Law of Robotics. You know that it is impossible for a robot to harm a human being; that long before enough can go wrong to alter that First Law, a robot would be completely inoperable. It’s a mathematical impossibility. Besides I have an engineer from U.S. Robots here twice a year to give the poor gadget a complete overhaul. Why, there’s no more chance of anything at all going wrong with Robbie than there is of you or I suddenly going looney—considerably less, in fact.”"

"There's nothing like deduction. We've determined everything about our problem but the solution."

"I accept nothing on authority. A hypothesis must be backed by reason, or else it is worthless."

"“You can prove anything you want by coldly logical reason—if you pick the proper postulates. We have ours and Cutie [robot QT-1] has his.” “Then let’s get at those postulates in a hurry. The storm’s due tomorrow.” Powell sighed wearily. “That’s where everything falls down. Postulates are based on assumptions and adhered to by faith. Nothing in the Universe can shake them. ...”"

"The unwritten motto of United States Robot and Mechanical Men Corp. was well-known: “No employee makes the same mistake twice. He is fired the first time.”"

"Just you think first, and don't bother to speak afterward, either."

"Milton Ashe is not the type to marry a head of hair and a pair of eyes."

"Francis Quinn was a politician of the new school. That, of course, is a meaningless expression, as are all expressions of the sort. Most of the “new schools” we have were duplicated in the social life of ancient Greece, and perhaps, if we knew more about it, in the social life of ancient Sumeria and in the lake dwellings of prehistoric Switzerland as well."

"“You’re the U. S. Robot’s psychologist, aren’t you?” “Robopsychologist, please.” “Oh, are robots so different from men, mentally?” “Worlds different.” She allowed herself a frosty smile, “Robots are essentially decent.”"

"“There’s danger of violence?” “The Fundamentalists threaten it, so I suppose there is, in a theoretical sense. But I don’t really expect it. The Fundies have no real power. They’re just the continuous irritant factor that might stir up a riot after a while.”"

"The machine is only a tool after all, which can help humanity progress faster by taking some of the burdens of calculations and interpretations off its back. The task of the human brain remains what it has always been; that of discovering new data to be analyzed, and of devising new concepts to be tested."

"There is nothing so eternally adhesive as the memory of power."

"Why, Stephen, if I am right, it means that the Machine is conducting our future for us not only simply in direct answer to our direct questions, but in general answer to the world situation and to human psychology as a whole. And to know that may make us unhappy and may hurt our pride. The Machine cannot, must not, make us unhappy. "Stephen, how do we know what the ultimate good of Humanity will entail? We haven't at our disposal the infinite factors that the Machine has at its! Perhaps, to give you a not unfamiliar example, our entire technical civilization has created more unhappiness and misery than it has removed. Perhaps an agrarian or pastoral civilization, with less culture and less people would be better. If so, the Machines must move in that direction, preferably without telling us, since in our ignorant prejudices we only know that what we are used to, is good—and we would then fight change. Or perhaps a complete urbanization, or a completely caste-ridden society, or complete anarchy, is the answer. We don't know. Only the Machines know, and they are going there and taking us with them." "But you are telling me, Susan, that the 'Society for Humanity' is right; and that Mankind has lost its own say in its future." "It never had any, really. It was always at the mercy of economic and sociological forces it did not understand—at the whims of climate, and the fortunes of war. Now the Machines understand them; and no one can stop them, since the Machines will deal with them as they are dealing with the Society,—having, as they do, the greatest of weapons at their disposal, the absolute control of our economy." "How horrible!" "Perhaps how wonderful! Think, that for all time, all conflicts are finally evitable. Only the Machines, from now on, are inevitable!"

"Men grew desperate and the border between bitter frustration and wild destruction is sometimes easily crossed."

"The division between human and robot is perhaps not as significant as that between intelligence and nonintelligence."

"It was the addition of status that brought the little things: a more comfortable seat here, a better cut of meat there, a shorter wait in line at the other place. To the philosophical mind, these items might seem scarcely worth any great trouble to acquire. Yet no one, however philosophical, could give up those privileges, once acquired, without a pang. That was the point."

"“How does it concern you people? It’s our problem. We’ll solve it. If not, it’s our own particular road to hell.” “Better your own road to hell than another’s road to heaven, eh?”"

"“Logically, developing children are carefully screened for physical and mental defects before being allowed to mature.” Baley interrupted. “You mean you kill them if they don’t—” “If they don’t measure up. Quite painlessly, I assure you. The notion shocks you, just as the Earthman’s uncontrolled breeding shocks us.”"

"I tell you I know the type of people that become Medievalists. They’re soft, dreamy people who find life too hard for them here and get lost in an ideal world of the past that never really existed."

"Remember, you once said, Lije, that people sometimes mistake their own shortcomings for those of society and want to fix the Cities because they don’t know how to fix themselves."

"There are degrees of justice, Elijah. When the lesser is incompatible with the greater, the lesser must give way."

"I have been trying, friend Julius, to understand some remarks Elijah made to me earlier. Perhaps I am beginning to, for it suddenly seems to me that the destruction of what should not be, that is, the destruction of what you people call evil, is less just and desirable than the conversion of this evil into what you call good. He hesitated, then, almost as though he were surprised at his own words, he said, “Go, and sin no more!”"

"A robot, the man had said, is logical but not reasonable."

"Civilizations have always been pyramidal in structure. As one climbs toward the apex of the social edifice, there is increased leisure and increasing opportunity to pursue happiness. As one climbs, one finds also fewer and fewer people to enjoy this more and more. Invariably, there is a preponderance of the dispossessed. And remember this, no matter how well off the bottom layers of the pyramid might be on an absolute scale, they are always dispossessed in comparison with the apex. So there is always social friction in ordinary human societies. The action of social revolution and the reaction of guarding against such revolution or combating it once it has begun are the causes of a great deal of the human misery with which history is permeated."

"There isn’t an instinct around that can’t give way to a good, persistent education. Not in human beings, where instincts are weak anyway. In fact, if you go about it right, education gets easier with each generation."

"“Ah, the future good!” Leebig’s eyes glowed with passion and he seemed to grow less conscious of his listener and correspondingly more talkative. “A simple concept, you think. How many human beings are willing to accept a trifling inconvenience for the sake of a large future good? How long does it take to train a child that what tastes good now means a stomach-ache later, and what tastes bad now will correct the stomach-ache later? Yet you want a robot to be able to understand?”"

"“Is that important?” “Everything is important till proven otherwise.”"

"Genes aren’t everything. Environment counts too, and environment can bend into actual psychosis where genes indicate only a potentiality for a particular psychosis."

"Without the interplay of human against human, the chief interest in life is gone; most of the intellectual values are gone; most of the reason for living is gone."

"Anything could be found in figures if the search were long enough and hard enough and if the proper pieces of information were ignored or overlooked."

"Victories over ingrained patterns of thought are not won in a day or a year."

"Goodbye, friend Elijiah, and remember that, although people apply the phrase to Aurora, it is, from this point on, Earth itself that is the true World of the Dawn."

"The work of each individual contributes to a totality and so becomes an undying part of the totality. That totality of human lives - past and present and to come - forms a tapestry that has been in existence now for many thousands of years and has been growing more elaborate and, on the whole, more beautiful in all that time. Even the Spacers are an offshoot of the tapestry and they, too, add to the elaborateness and beauty of the pattern. An individual life is one thread in the tapestry and what is one thread compared to the whole?"

"Daneel rose. He was alone - and with a Galaxy to care for."

"The same man who could not find it in his conscience to curb his curiosity into the nuclear studies that might someday kill half of Earth would risk his life to save that of an unimportant fellow man."

"To the rest of the Galaxy, if they are aware of us at all, Earth is but a pebble in the sky. To us it is home, and all the home we know."

"It is because you yourself fear the propaganda created, after all, only by the stupidity of your own bigots."

"There can never be a man so lost as one who is lost in the vast and intricate corrdiors of his own lonely mind, where none may reach and none may save. There never was a man so helpless as one who cannot remember."

"There was no denying that he would always be conscious of the fact that an Earthman was an Earthman. He couldn’t help that. That was the result of a childhood immersed in an atmosphere of bigotry so complete that it was almost invisible, so entire that you accepted its axioms as second nature. Then you left it and saw it for what it was when you looked back."

"That is the most stupid thing yet. I tell you that I could despair of human intelligence when I see what can exist in men’s minds."

"The stars, like dust, encircle me In living mists of light; And all of space I seem to see In one vast burst of sight."

"Nonsense. You are a military man and should know better. If there is one science into which man has probed continuously and successfully, it is that of military technology. No potential weapon would remain unrealized for ten thousand years."

"“That’s an amusing thought, if you’ll consider it.” “Do you find everything amusing?” “Why not? As an attitude toward life, it’s an amusing one. It’s the only adjective that will fit. Observe the universe, young man. If you can’t force amusement out of it, you might as well cut your throat, since there’s damn little good in it.”"

"The Autarch maintained his indifferent calm, but a certain lack of certainty was gathering, and he did not like to experience a lack of certainty. He liked nothing which made him aware of limitations. An Autarch should have no limitations, and on Lingane he had none that natural law did not impose."

"Gillbret said, “Statistics show that one out of three stars has a planetary system.” Biron nodded. It was a well-worn statistic. Every child was taught that in elementary Galactography."

"I see your vile implication. My only explanation for it is that you are criminally insane."

"“At least try to see my motives. Granted that I was foolish—criminally foolish—can’t you understand? Can’t you try not to hate me?” She said softly, “I have tried not to love you and, as you see, I have failed.”"

"Well, it was healthy to miss once in a while. It kept self-confidence balanced at a point safely short of arrogance."

"How then to enforce peace? Not by reason, certainly, nor by education. If a man could not look at the fact of peace and the fact of war and choose the former in preference to the latter, what additional argument could persuade him? What could be more eloquent as a condemnation of war than war itself? What tremendous feat of dialectic could carry with it a tenth the power of a single gutted ship with its ghastly cargo?"

"An unpleasant nest of nasty, materialistic and aggressive people, careless of the rights of others, imperfectly democratic at home though quick to see the minor slaveries of others, and greedy without end."

"Trantor could win even such a war, but perhaps not without paying a price that would make victory only a pleasanter name for defeat."

"First, there must be an end to war and national rivalry and only then could one turn to the internal miseries that, after all, had external conflict as their chief cause."

"Truth is a discredited commodity among diplomats."

"No one is so modest as not to believe himself a competent amateur sleuth."

"“You make interstellar politics sound a very dirty game.” “It is, but disapproving of dirt doesn’t remove it.”"

"“Then why did you run? A man who runs needs no other accusation.” “Is that so? Really?” cried Steen. “Well, I would run out of a burning building even if I had not set the fire myself.”"

"Junz found revulsion growing strong within him. A planet full of people meant nothing against the dictates of economic necessity!"

"Economics is on the side of humanity now."

"Q. You do not consider your statement a disloyal one? A. No, sir. Scientific truth is beyond loyalty and disloyalty. Q. You are sure that your statement represents scientific truth? A. I am."

"The fall of Empire, gentlemen, is a massive thing, however, and not easily fought. It is dictated by a rising bureaucracy, a receding initiative, a freezing of caste, a damming of curiosity — a hundred other factors. It has been going on, as I have said, for centuries, and it is too majestic and massive a movement to stop."

"“That insufferable, dull-witted donkey! That—” Hardin broke in: “Not at all. He’s merely the product of his environment. He doesn’t understand much except that ‘I got a gun and you ain’t.’ ”"

"It seems an uncommonly woundabout and hopelessly wigmawolish method of getting anywheahs."

"“Such unsubtle escapism! Really, Dr. Fara, such folly smacks of genius. A lesser mind would be incapable of it.""

"“Violence,” came the retort, “is the last refuge of the incompetent.”"

"First, you refused to admit that there was a menace at all! Then you reposed an absolutely blind faith in the Emperor! Now you've shifted it to Hari Seldon. Throughout you have invariably relied on authority or on the past – never on yourselves. It amounts to a diseased attitude – a conditioned reflex that shunts aside the independence of your minds whenever it is a question of opposing authority. There seems no doubt ever in your minds that the Emperor is more powerful than you are, or Hari Seldon wiser. And that's wrong, don't you see? It isn't just you. It's the whole Galaxy. Pirenne heard Lord Dorwin's idea of scientific research. Lord Dorwin thought the way to be a good archaeologist was to read all the books on the subject – written by men who were dead for centuries. He thought that the way to solve archaeological puzzles was to weigh the opposing authorities. And Pirenne listened and made no objections. Don't you see that there's something wrong with that? And you men and half of Terminus as well are just as bad. We sit here,considering the Encyclopedia the all-in-all. We consider the greatest end of science is the classification of past data. It is important, but is there no further work to be done? We're receding and forgetting, don't you see? Here in the Periphery they've lost nuclear power. In Gamma Andromeda, a power plant has undergone meltdown because of poor repairs, and the Chancellor of the Empire complains that nuclear technicians are scarce. And the solution? To train new ones? Never! Instead they're to restrict nuclear power. Don't you see? It's Galaxy wide. It's a worship of the past. It's a deterioration – a stagnation!"

"Well, then, arrest him. You can accuse him of something or other afterward."

"“That was the time to begin all-out preparations for war.” “On the contrary. That was the time to begin all-out prevention of war.”"

"It pays to be obvious, especially if you have a reputation for subtlety."

"Courtiers don't take wagers against the king's skill. There is the deadly danger of winning."

"He believes in that mummery a good deal less than I do, and I don't believe in it at all."

"For it is the chief characteristic of the religion of science, that it works, and that such curses as that of Aporat's are really deadly."

"A fire eater must eat fire even if he has to kindle it himself."

"Never let your sense of morals prevent you from doing what is right."

"“Ponyets! They sent you?” “Pure chance,” said Ponyets, bitterly, “or the work of my own personal malevolent demon.”"

"There's something about a pious man such as he. He will cheerfully cut your throat if it suits him, but he will hesitate to endanger the welfare of your immaterial and problematical soul."

"The whole business is the crudest sort of stratagem, since we have no way of foreseeing it to the end. It is a mere paying out of rope on the chance that somewhere along the length of it will be a noose."

"He is energetic only in evading responsibility."

"To succeed, planning alone is insufficient. One must improvise as well."

"Korell is that frequent phenomenon in history: the republic whose ruler has every attribute of the absolute monarch but the name. It therefore enjoyed the usual despotism unrestrained even by those two moderating influences in the legitimate monarchies: regal “honor” and court etiquette."

"Now any dogma, based primarily on faith and emotionalism, is a dangerous weapon to use on others, since it is almost impossible to guarantee that the weapon will never be turned on the user."

"An atom blaster is a good weapon, but it can point both ways."

"It's a poor atom blaster that won't point both ways."

"He is a dreamer of ancient times, or rather, of the myths of what ancient times used to be. Such men are harmless in themselves, but their queer lack of realism makes them fools for others."

"You are a valuable subject, Brodrig. You always suspect far more than is necessary, and I have but to take half your suggested precautions to be utterly safe."

"Inertia! Our ruling class knows one law; no change. Despotism! They know one rule; force. Maldistribution! They know one desire; to hold what is theirs."

"To him, a stilted geometric love of arrangement was “system,” an indefatigable and feverish interest in the pettiest facets of day-to-day bureaucracy was “industry,” indecision when right was “caution,” and blind stubbornness when wrong, “determination.”"

"It is the invariable lesson to humanity that distance in time, and in space as well, lends focus. It is not recorded, incidentally, that the lesson has ever been permanently learned."

"“Were I to use the wits the good Spirits gave me,” he said, “then I would say this lady can not exist — for what sane man would hold a dream to be reality. Yet rather would I not be sane and lend belief to charmed, enchanted eyes.”"

"“When the twenty-seven independent Trading Worlds, united only by their distrust of mother planet of the Foundation, concert an assembly among themselves, and each is big with a pride grown of its smallness, hardened by its own insularity and embittered by eternal danger — there are preliminary negotiations to be overcome of a pettiness sufficiently staggering to heart-sicken the most persevering.”"

"It is well-known that the friend of a conqueror is but the last victim."

"Secrecy as deep as this is past possibility without nonexistence as well."

"He never created a finished product. Finished products are for decadent minds."

"Your emotions are, of course, only the children of your background and are not to be condemned - merely changed."

"Every human being lived behind an impenetrable wall of choking mist within which no other but he existed. Occasionally there were the dim signals from deep within the cavern in which another man was located — so that each might grope toward the other. Yet because they did not know one another, and could not understand one another, and dared not trust one another, and felt from infancy the terrors and insecurity of that ultimate isolation — there was the hunted fear of man for man, the savage rapacity of man toward man."

"The most hopelessly stupid man is he who is not aware that he is wise."

"One should cultivate an innocence, an awareness of self, and an unselfconsciousness of self which leaves one nothing to hide."

"The house was somehow very lonely at night and Dr. Darell found that the fate of the Galaxy made remarkably little difference while his daughter's mad little life was in danger."

"Remarkable what a fragile flower romance is. A gun with a nervous operator behind it can spoil the whole thing."

"No matter how the conomy and sociology of the neighbouring sectors of the Galaxy changes, there was always an elite; and it is always the characteristic of an elite that it possesses leisure as the great reward of its elite-hood."

"The spell of power never quite releases its hold."

"To us, all life is a series of accidents to be met with improvisations. To them, all life is purposive and should be met with precalculation."

"At odd and unpredictable times, we cling in fright to the past."

"It seems to me, Golan, that the advance of civilization is nothing but an exercise in the limiting of privacy."

"If there is a misuse of power, it is on her part. My crime is that I have never labored to make myself popular — I admit that much — and I have paid too little attention to fools who are old enough to be senile but young enough to have power."

"Pelorat sighed. “I will never understand people.” “There’s nothing to it. All you have to do is take a close look at yourself and you will understand everyone else. We’re in no way different ourselves... You show me someone who can’t understand people and I’ll show you someone who has built up a false image of himself.”"

"Once you get it into your head that somebody is controlling events, you can interpret everything in that light and find no reasonable certainty anywhere."

"“Is not all this an extraordinary concatenation of coincidence?” Pelorat said, “If you list it like that—” “List it any way you please,” said Trevize. “I don’t believe in extraordinary concatenations of coincidence.”"

"It's one thing to have guts; it's another to be crazy."

"“Stories grow by accretion. Tales accumulate — like dust. The longer the time lapse, the dustier the history — until it degenerates into fables.” Pelorat said, “We historians are familiar with the process, Dom. There is a certain preference for the fable. The falsely dramatic drives out the truly dull.”"

"Societies create their own history and tend to wipe out lowly beginnings, either by forgetting them or inventing totally fictitious heroic rescues."

"It was easy to cover up ignorance by the mystical word “intuition.”"

"It is better to go to defeat with free will than to live in a meaningless security as a cog in a machine."

"We abandoned the appearance of power to preserve the essence of it."

"If you were to insist I was a robot, you might not consider me capable of love in some mystic human sense, but you would not be able to distinguish my reactions from that which you would call love — so what difference would it make?"

"Old memories - really old - are almost all in the mountain roots where it takes time to dig them out."

"Now the plan was threatend by something more serious than the Mule had ever been. It was to be diverted from a renewal of Empire to something utterly different from anything in history - Galaxia. And he himself had agreed to that. But why? Was there a flaw in the plan? a basic flaw? For one flashing moment, it seemed to Trevize that this flaw did indeed exist and that he knew what it was, that he had known what it was when he made his decision - but the knowledge...if that were what it was...vanished as fast as it came, and left him with nothing."

"The robot has wanted Fallom all along, Janov."

"Yet even mathematicians must be young to begin with."

"All history shows that we do not learn from the lessons of the past."

"Mathematicians deal with large numbers sometimes, but never in their income."

"Walking is still the best form of short-distance transportation. It’s the most convenient, the cheapest, and the most healthful, Countless years of technological advance have not changed that."

"We might not be able to give out the news for security reasons—that’s the excuse they always advance for hiding bad news—but I would know."

"“But it’s been quiet under Cleon. And we’ve had fifty years of peace.” “Yes, but soldiers who are well-paid would resent having that pay reduced just because there is peace. Admirals resist mothballing ships and having themselves reduced in rank simply because there is less for them to do. So the credits still go—unproductively—to the armed forces and vital areas of the social good are allowed to deteriorate. That’s what I call decay. Don’t you?”"

"“It is absolutely forbidden for the Imperial government to exercise any security control over the University or its members. There is complete freedom. Anything can be discussed here, anything can be said here.” “What about violent crime?” “Then the University authorities themselves handle it, with reason and care—and there are virtually no crimes of violence. The students and faculty appreciate their freedom and understand its terms. Too much rowdiness, the beginning of riot and bloodshed, and the government may feel it has the right to break the unwritten agreement and send in the troops. No one wants that, not even the government, so a delicate balance is maintained.”"

"“My field of specialization is the mathematical analysis of social structure.” “Sounds horrible.”"

"“As for status, that’s the sort of push and pull I’d just as soon avoid. I’ve seen many people with status, but I’m still looking for a happy one. Status won’t sit still under you; you have to continually fight to keep from sinking."

"It’s a dull world, full of farms and with lots of cattle, both four-legged and two-legged."

"Apparently, mathematics and the martial arts are not necessarily mutually exclusive."

"There is too much history and there is too little of it that is told."

"I have always dealt with economic forces, rather than philosophic forces, but you can’t split history into neat little nonoverlapping divisions. For instance, religions tend to accumulate wealth when successful and that eventually tends to distort the economic development of a society."

"But it seemed so likely to him that on every world the earliest histories were medleys of self-serving heroisms and minidramas that were meant as morality plays and were not to be taken literally. It was surely true of Helicon, yet you would find scarcely a Heliconian who would not swear by all the tales told and insist it was all true history."

"I don’t want to believe it just because I want to believe it."

"The cure for advanced gullibility is to go to sleep and consider matters again the next day."

"Does said, “You’re not a…a believer?” “I’m a scholar,” said Mycelium with obvious pride."

"Why, he wondered, did so many people spend their lives not trying to find answers to questions—not even thinking of questions to begin with? Was there anything more exciting in life than seeking answers?"

"Asceticism among a ruling class—except for public show—is very rare."

"At the slightest stress, human beings seemed to divide themselves into antagonistic groups."

"You can always put something noble in a sneering fashion if you try."

"“It strikes me that no one could possibly want to be Emperor.” “No sane person would, I agree, but the ‘Imperial wish,’ as it is frequently called, is like a disease that, when caught, drives out sanity. And the closer you get to high office, the more likely you are to catch the disease.”"

"It is not important what can or cannot be done. What is important is what people will or will not believe can be done."

"You’re naïve Hari. Or not a historian, which is the same thing."

"If all human beings understood history, they might cease making the same stupid mistakes over and over."

"There is social and psychological inertia, as well as physical inertia."

"Seldon found himself raging at the passage of time."

"For ten years the Galactic Empire had been without an Emperor, but there was no indication of that fact in the way the Imperial Palace grounds were operated. Millennia of custom made the absence of an Emperor meaningless."

"Riots! What do I care about riots now? - What do I care about anything now?"

"This - this - was my life's work. My past - humanity's future. Foundation. So beatiful. So alive. And nothing can...Dors!"

"Confidence is rewarded, apparently. There was a homewhen proverb that went, "Grip the nettle firmly and it will become a stick with which to beat your enemy.""

"How can the net amount of entropy of the universe be massively decreased?"

""The Last Question" is my personal favorite, the one story I made sure would not be omitted from this collection. Why is it my favorite? For one thing I got the idea all at once and didn't have to fiddle with it; and I wrote it in white-heat and scarcely had to change a word. This sort of thing endears any story to any writer. Then, too, it has had the strangest effect on my readers. Frequently someone writes to ask me if I can give them the name of a story, which they think I may have written, and tell them where to find it. They don't remember the title but when they describe the story it is invariably "The Last Question". This has reached the point where I recently received a long-distance phone call from a desperate man who began, "Dr. Asimov, there's a story I think you wrote, whose title I can't remember—" at which point I interrupted to tell him it was "The Last Question" and when I described the plot it proved to be indeed the story he was after. I left him convinced I could read minds at a distance of a thousand miles. No other story I have written has anything like this effect on my readers — producing at once an unshakeable memory of the plot and an unshakeable forgettery of the title and even author. I think it may be that the story fills them so frighteningly full, that they can retain none of the side-issues."

"To Mankind And the hope that the war against folly may someday be won, after all."

"Don't finish, Pete. I've heard it all before. All I have to do is decipher the thinking of a non-human intelligence." "A better-than-human intelligence. Those creatures from the para-Universe are trying to make themselves understood." "That may be," sighed Bronowski, "but they're trying to do it through my intelligence, which is better than human I sometimes think, but not much. Sometimes, in the dark of the night, I lie awake and wonder if different intelligences can communicate at all; or, if I've had a particularly bad day, whether the phrase 'different intelligences' has meaning at all." "It does," said Lamont savagely, his hands clearly bailing into fists within his lab coat pockets. "It means Hallam and me. It means that fool-hero, Dr. Frederick Hallam and me. We're different intelligences because when I talk to him he doesn't understand. His idiot face gets redder and his eyes bulge and his ears block. I'd say his mind stops functioning, but lack the proof of any other state from which it might stop."

"“It is a mistake,” he said, “to suppose that the public wants the environment protected or their lives saved and that they will be grateful to any idealist who will fight for such ends. What the public wants is their own individual comfort. We know that well enough from our experience in the environmental crisis of the twentieth century.”"

"He sat in his chair, fingers aimlessly drumming, drumming. Somewhere in the Sun, protons were clinging together with just a trifling additional avidity and with each moment that avidity grew and at some moment the delicate balance would break down . . . "And no one on Earth will live to know I was right," cried out Lamont, and blinked and blinked to keep back the tears."

"Tritt listened placidly, clearly understanding nothing, but content to be listening; while Odeen, transmitting nothing, was as clearly content to be lecturing."

"I don't like anything that's got to be. I want to know why."

"I know nothing of that directly; I only know what I have been told by other young ones who couldn't have known directly either. I want to find out the truth about them and the wanting has grown until there is more of curiosity in me than fear."

"I fear my ignorance."

"The easiest way to solve a problem is to deny it exists."

"You know that prudery is only the other side of prurience. The words are even on the same page in the dictionary."

"I've lived most of my life already and I suppose I can argue myself into believing that I have no great cause to love humanity. However, only a few people have hurt me, and if I hurt everyone in return that is unconscionable usury."

"If an interaction is too weak to be detectable or to exert influence in any way, then by any operational definition, it doesn't exist."

"There are no happy endings in history, only crisis points that pass."

"Asimov: Well, I liked Star Wars. I thought Battlestar Galactica was such a close imitation of Star Wars, emphasizing the less attractive portions, that I was a little impatient with it."

"Asimov: Battlestar Galactica for instance, started off with twenty to thirty minutes of space battles which looked exactly like air battles in World War I. You could swear that the space ships were surrounded by air the way the maneuvered. One felt it was unworthy."

"SWA Magazine: Talking about spacecraft, what do you think about the shuttle program?"

"Asimov: I don't know of any science fiction writer who really attempts to be a prophet. Such authors accomplish their tasks not by being correct in their predictions, necessarily, but merely by hammering home—in story after story—the notion that life is going to be different."

"Asimov: Science fiction always bases its future visions on changes in the levels of science and technology. And the reason for that consistency is simply that—in reality—all other changes throughout history have been irrelevant and trivial. For example, what difference did it make to the people of the ancient world that Alexander the Great conquered the Persian Empire? Obviously, that event made some difference to a lot of individuals. But if you look at humanity in general, you'll see that life went on pretty much as it had before the conquest. On the other hand, consider the changes that were made in people's daily lives by the development of agriculture or the mariner's compass ... and by the invention of gunpowder or printing. Better yet, look at recent history and ask yourself, "What difference would it have made if Hitler had won World War II?" Of course, such a victory would have made a great difference to many people. It would have resulted in much horror, anguish, and pain. I myself would probably not have survived. But Hitler would have died eventually, and the effects of his victory would gradually have washed out and become insignificant—in terms of real change—when compared to such advances as the actual working out of nuclear power, the advent of television, or the invention of the jet plane."

"Plowboy: You truly feel that all the major changes in history have been caused by science and technology?"

"Plowboy: In your opinion, what are mankind's prospects for the near future?"

"Don't you believe in flying saucers, they ask me? Don't you believe in telepathy? — in ancient astronauts? — in the Bermuda triangle? — in life after death? No, I reply. No, no, no, no, and again no. One person recently, goaded into desperation by the litany of unrelieved negation, burst out "Don't you believe in anything?" "Yes", I said. "I believe in evidence. I believe in observation, measurement, and reasoning, confirmed by independent observers. I'll believe anything, no matter how wild and ridiculous, if there is evidence for it. The wilder and more ridiculous something is, however, the firmer and more solid the evidence will have to be.""

"Knowledge is indivisible. When people grow wise in one direction, they are sure to make it easier for themselves to grow wise in other directions as well. On the other hand, when they split up knowledge, concentrate on their own field, and scorn and ignore other fields, they grow less wise — even in their own field."

"How often people speak of art and science as though they were two entirely different things, with no interconnection. An artist is emotional, they think, and uses only his intuition; he sees all at once and has no need of reason. A scientist is cold, they think, and uses only his reason; he argues carefully step by step, and needs no imagination. That is all wrong. The true artist is quite rational as well as imaginative and knows what he is doing; if he does not, his art suffers. The true scientist is quite imaginative as well as rational, and sometimes leaps to solutions where reason can follow only slowly; if he does not, his science suffers."

"I received the fundamentals of my education in school, but that was not enough. My real education, the superstructure, the details, the true architecture, I got out of the public library. For an impoverished child whose family could not afford to buy books, the library was the open door to wonder and achievement, and I can never be sufficiently grateful that I had the wit to charge through that door and make the most of it. Now, when I read constantly about the way in which library funds are being cut and cut, I can only think that the door is closing and that American society has found one more way to destroy itself."

"Happiness is doing it rotten your own way."

"He [Robert A. Heinlein] always pictured himself a libertarian, which to my way of thinking means "I want the liberty to grow rich and you can have the liberty to starve". It's easy to believe that no one should depend on society for help when you yourself happen not to need such help."

"If I were not an atheist, I would believe in a God who would choose to save people on the basis of the totality of their lives and not the pattern of their words. I think he would prefer an honest and righteous atheist to a TV preacher whose every word is God, God, God, and whose every deed is foul, foul, foul. I would also want a God who would not allow a Hell. Infinite torture can only be a punishment for infinite evil, and I don't believe that infinite evil can be said to exist even in the case of Hitler. Besides, if most human governments are civilized enough to try to eliminate torture and outlaw cruel and unusual punishments, can we expect anything less of an all-merciful God? I feel that if there were an afterlife, punishment for evil would be reasonable and of a fixed term. And I feel that the longest and worst punishment should be reserved for those who slandered God by inventing Hell."

"The trouble is that I am one of that common breed of human being who finds it very easy to strew noble little homilies far and wide but considerably less easy to follow those homilies himself."

"When Israel was first founded in 1948 and all my Jewish friends were jubilant, I was the skeleton at the feast. I said, ‘“We are building ourselves a ghetto. We will be surrounded by tens of millions of Muslims who will never forgive, never forget, and never go away.” I was right [...]"

"When an old person dies who has been a part of your life, it is part of your youth that dies."

"We could have told you that our character paused to strap on his quonglishes before setting out on a walk of seven vorks along the main gleebish of his native znoob, and everything would have seemed ever so much more thoroughly alien. But it also would have been ever so much more difficult to make sense out of what we were saying, and that did not seem useful."

"I read Harlan Ellison's stories and also John Wyndham, Arthur C. Clarke, A. E. Van Vogt, Isaac Asimov-all the SF classics, whatever I got my hands on."

"My history is really pretty scroungy. I'm certainly not like Asimov, who I've heard has an office full of charts."

"A national wonder and a natural resource."

"When I first met Asimov, I asked him if he was a professor at Boston University. He said no and ... asked me where I got my Ph.D. I said I didn't have one and he looked startled. "You mean you're in the same racket I am," he said, "you just read books by the professors and rewrite them?" That's really what I do."

"The great explainer of our [technological] age."

"Although he spends many pages writing about his friends in the science-fiction community, the true value of Asimov's insight is his reflections on his life — and, in his mind, Asimov was first a genius, second a prolific writer, and only thirdly a sci-fi writer. Asimov tells the reader repeatedly that his life would have been easier if he had learned to submerge his ego and get along with others. "It really puzzles me as I look back on it that I didn't make a greater effort to placate the powers that be," he writes. Indeed, it was this inability to get along with others that forced Asimov out of academia and into the solitary life of a freelance writer."

"In the science fiction genre, I am a fan of Ray Bradbury and Isaac Asimov."

"I am honorary president of the American Humanist Association, having succeeded the late, great, spectacularly prolific writer and scientist, Dr. Isaac Asimov in that essentially functionless capacity. At an A.H.A. memorial service for my predecessor I said, "Isaac is up in Heaven now." That was the funniest thing I could have said to an audience of humanists. It rolled them in the aisles. Mirth! Several minutes had to pass before something resembling solemnity could be restored."

"I met Asimov once, when he visited my undergraduate university. They thought it would be fun to show him around the astronomy department, much to his bemusement (he was trained as a chemist). He used his advanced age as an excuse for shamelessly flirting with every attractive woman within leering distance. I wonder what he was like before his age was so advanced?"

"the most fruitful ways to approach the future for me are speculative fiction or utopian fiction. Isaac Asimov once said that all science fiction falls into three categories: What if, If only, and If this continues."

"He had writer's block once. It was the worst ten minutes of his life."

"Asimov was the sort of urbanophile who, if you dragged him out of New York to some backwater like Greensboro, NC, would probably crumble to dust to reform somewhere near Times Square."

"A substance showing resonance between two or more valence-bond structures does not contain molecules with the configurations and properties usually associated with these structures."

"Science cannot be stopped. Man will gather knowledge no matter what the consequences – and we cannot predict what they will be. Science will go on — whether we are pessimistic, or are optimistic, as I am. I know that great, interesting, and valuable discoveries can be made and will be made… But I know also that still more interesting discoveries will be made that I have not the imagination to describe — and I am awaiting them, full of curiosity and enthusiasm."

"We may, I believe, anticipate that the chemist of the future who is interested in the structure of proteins, nucleic acids, polysaccharides, and other complex substances with high molecular weight will come to rely upon a new structural chemistry, involving precise geometrical relationships among the atoms in the molecules and the rigorous application of the new structural principles, and that great progress will be made, through this technique, in the attack, by chemical methods, on the problems of biology and medicine."

"We must not have a Nuclear war. We must begin to solve international disputes by the application of man's power of reason in a way that is worthy of the dignity of man. We must solve them by arbitration, negotiation, and the development of international law, the making of international agreements that will do justice to all nations and to all peoples and will benefit all nations and to all people. Now is the time to start."

"Planck’s constant and the quantum theory that is built around it are of extreme importance for chemistry—we may well be justified in saying that quantum theory is of greater importance to chemistry than to physics ... there is no part of chemistry that does not depend, in its fundamental theory, upon quantum principles."

"The power to destroy the world by the use of nuclear weapons is a power that cannot be used - we cannot accept the idea of such monstrous immorality.The time has now come for morality to take its proper place in the conduct of world affairs; the time has now come for the nations of the world to submit to the just regulation of their conduct by international law."

"The only sane policy for the world is that of abolishing war."

"Everyone should know that the "war on cancer" is largely a fraud, and that the National Cancer Institute and American Cancer Society are derelict in their duties to the people who support them."

"I realized that more and more I was saying, "It seems to me that we have come to the time war ought to be given up. It no longer makes sense to kill 20 million or 40 million people because of a dispute between two nations who are running things, or decisions made by the people who really are running things. It no longer makes sense. Nobody wins. Nobody benefits from destructive war of this sort and there is all of this human suffering." And Einstein was saying the same thing of course. So that is when we decided — my wife and I — that first, I was pretty effective as a speaker. Second, I better start boning up, studying these other fields so that nobody could stand up and say, "Well, the authorities say such and such ""

"I've been asked from time to time, "How does it happen that you have made so many discoveries? Are you smarter than other scientists?" And my answer has been that I am sure that I am not smarter than other scientists. I don't have any precise evaluation of my IQ, but to the extent that psychologists have said that my IQ is about 160, I recognize that there are one hundred thousand or more people in the United States that have IQs higher than that. So I have said that I think I think harder, think more than other people do, than other scientists. That is, for years, almost all of my thinking was about science and scientific problems that I was interested in."

"As far as women are concerned, I am old-fashioned enough to like the idea of a woman's managing the household. This is an important activity. A woman does not have to be a bank vice-president to find happiness. I should think routine work like sitting at a desk writing letters, making reports, or punching data into computers would be much less interesting and satisfying than running a home."

"If you want to have good ideas you must have many ideas. Most of them will be wrong, and what you have to learn is which ones to throw away."

"I have always wanted to know as much as possible about the world."

"Only when I began studying chemical engineering at Oregon Agricultural College did I realize that I myself might discover something new about the nature of the world."

"When an old and distinguished person speaks to you, listen to him carefully and with respect — but do not believe him. Never put your trust into anything but your own intellect. Your elder, no matter whether he has gray hair or has lost his hair, no matter whether he is a Nobel laureate — may be wrong. The world progresses, year by year, century by century, as the members of the younger generation find out what was wrong among the things that their elders said. So you must always be skeptical — always think for yourself."

"What astonished me was the very low toxicity of a substance that has such very great physiological power. A little pinch, 5 mg, every day, is enough to keep a person from dying of pellagra, but it is so lacking in toxicity that ten thousand times as much can be taken without harm."

"I have something that I call my Golden Rule. It goes something like this: "Do unto others twenty-five percent better than you expect them to do unto you." … The twenty-five percent is for error."

"Just think of the differences today. A young person gets interested in chemistry and is given a chemical set. But it doesn't contain potassium cyanide. It doesn't even contain copper sulfate or anything else interesting because all the interesting chemicals are considered dangerous substances. Therefore, these budding young chemists don't get a chance to do anything engrossing with their chemistry sets. As I look back, I think it is pretty remarkable that Mr. Ziegler, this friend of the family, would have so easily turned over one-third of an ounce of potassium cyanide to me, an eleven-year-old boy."

"He combined scientific brilliance, political courage, and a stubborn, quirky single-mindedness in ways that... will probably always resist simple explanation."

"Linus Pauling was not always right in his ideas. But my belief is that, in most cases, if somebody is always right in his ideas you find that he does not have much to say. It is an expression of somebody's fertility that he does produce quite a number of ideas, and I think Linus Pauling's score is pretty high... I do not think, as I said earlier, that it is right to discuss the impact of Linus Pauling on molecular biology. Rather, he was one of the founders of molecular biology. It was not that it existed in some way, and he simply made a contribution. He was one of the founders who got the whole discipline going."

"Whatever the context and whatever the audience, he was clear, he was committed, he was compassionate, and, far more often than most, he was right — or if not, at least on the side of the angels."

"If there is a need for a universal hero, it is easy to see why Linus Pauling would be nominated for the role. In many ways he seemed larger than life."

"While still in his twenties, he became a world famous scientist... His work in chemical biology, done during the middle years of his life, was almost equally outstanding... Pauling was also acclaimed for his activism as a citizen, although his activities were controversial."

"He used his scientific credentials to challenge the government's claims that fallout from nuclear testing was not harmful."

"The right wing of the 1950s denounced Pauling as a Communist, or at the least a fellow traveler. Pauling and his wife were, in fact, openly active in several organizations dominated by Soviet sympathizers, as well as dozens of others. But they were never apologists for the Soviet party line, or any other organizational dogma, nor did Pauling refrain from challenging the Soviets when he thought them wrong."

"Then, at the peak of his prestige and renown, instead of settling into a comfortable elder statesman role, Pauling shocked his friends and admirers by launching a crusade to prove that vitamin C would cure the common cold... While Pauling quickly recognized his error on DNA, accept­ing it as the kind of mistake any scientist can make and more or less dis­carding his previous ideas about vitamin treatment of schizophrenia, he never abandoned his claims about vitamin C and the treatment of cancer, and in the last years of his life he felt vindicated when a national medical conference gave him a standing ovation, claiming that "Pauling was right all along.""

"Pauling was not superhuman, but he was a very great man, with an extraordinarily sharp and creative mind, a firm inner determination, and a strong moral sense. His life holds many lessons and poses many intriguing questions for all of us."

"Pauling scooped out a hollow on the narrow ledge and covered himself with a big map he carried in his pocket. He dared not sleep because of the cold. He counted in French and German and Italian to keep himself awake; he exercised as he lay in his narrow quarters. He told the unheeding ocean about the nature of the chemical bond. When the stars came out, he sighted the end of his walking stick and tried to tell time by the constellations. He recited the periodic table of the elements. He grew more and more anxious, not for himself, since he knew he would eventually be found, but for Ava Helen, whom he could not tell that he was uncomfortable, but unharmed. He was chagrined by his predicament…."

"Linus Pauling undoubtedly stands as one of the most influential scientists of the twentieth century."

"Although Pauling was often controversial and was sometimes criticized in both scientific and political arenas, it is incontrovertible that he had a major impact on science, education, and international peace."

"As my father's son I am certainly among his fondest admirers. Now I have ample evidence that all over the nation, and elsewhere in the world, innumerable people share my affection and admiration in their own ways. They not only admire but love him. They have read his books and articles, have seen him on television, have attended meetings where he spoke, or by chance sat next to him at a banquet or on the airplane. A number have received personal messages from him or talked with him over the phone. They feel a personal connection, a strong bond, with his values-his valiant anti-nuclear-testing stance, his dedication to world peace, his emphasis on vitamin C as a valuable nutrient for both preven­tion and treatment of disease, his compassion for the human condition of suffering. For a number of our supporters, Linus Pauling may be the closest embodiment, in this age of uncertainty, amorality, and constant conflict, of a living universal hero."

"From time to time throughout his long life, scientists and commentators dismissed him as a showman. Would that we had a whole troupe of such scientific showmen."

"The esteem with which he was regarded was vividly illustrated to me in 1951 when, as a postdoctoral fellow of Pauling's, I visited Albert Einstein in Princeton. Einstein's comment to me was "Ah, that man is a real genius!""

"An extraordinary person — a scientist, educator, humanist, and statesman with worldwide impact in each of these roles."

"In spite of our advances... there is no scientific evidence that can convince... more potently than a sincere and emotional testimonial. Such... does not always come from the regular guy... Linus Pauling... was said to believe in vitamin C's medicinal properties, himself ingesting massive doses. With his bully pulpit, he contributed to the common belief in vitamin C's curative properties. Many medical studies, unable to replicate Pauling's claims, fell on dear ears as it was difficult to undo the testimonial by a "Nobel Prize winner," even if he was not qualified to discuss matters related to medicine."

"If we stay strong, then I believe we can stabilize the world and have peace based on force. Now, peace based on force is not as good as peace based on agreement, but in the terrible world in which we live, in the world where the Russians have enslaved many millions of human beings, in the world where they have killed men, I think that for the time being the only peace we can have is the peace based on force. Furthermore, I do not think that this peace based on force is, can be, or should be, an ultimate end. Our ultimate end must be precisely what Dr. Pauling says, peace based on agreement, on understanding, on universally agreed and enforced law. I think this is a wonderful idea, but peace based on force buys the necessary time, and in this time we can work for better understanding, for closer collaboration, first with the countries which are closest to us, which we understand better, our allies, the western countries, the NATO countries, which believe in human liberties as we do. Then, as soon as possible, with the rest of the free world, and eventually, I hope, with the whole world, including Russia, even though it may take many years to come."

"I don't want to kill anybody. I am passionately opposed to killing, but I'm even more passionately fond of freedom. The freedom of Dr. Pauling and of myself expressing our opinions freely on any subject, however broad, however far removed of our proper competence, but particularly, to be able to express our opinions in the fields we really know; this would not be possible in Russia."

"... Particularly important were the exact arguments needed to understand how Linus Pauling had discovered the . I soon was taught that Pauling's accomplishment was a product of common sense, not the result of complicated mathematical reasoning. Equations occasionally crept into his argument, but in most cases words would have sufficed. The key to Linus' success was his reliance on the simple laws of . The α-helix had not been found by only staring at X-ray pictures; the essential trick, instead, was to ask which atoms like to sit next to each other. In place of pencil and paper, the main working tools were a set of molecular models superficially resembling the toys of preschool children."

"It’s not even probable, let alone scientifically proven, that HIV causes AIDS. If there is evidence that HIV causes AIDS, there should be scientific documents which either singly or collectively demonstrate that fact, at least with a high probability. There are no such documents."

"People keep asking me, "You mean you don’t believe that HIV causes AIDS?" And I say, "Whether I believe it or not is irrelevant! I have no scientific evidence for it." I might believe in God, and He could have told me in a dream that HIV causes AIDS. But I wouldn’t stand up in front of scientists and say, "I believe HIV causes AIDS because God told me." I’d say, "I have papers here in hand and experiments that have been done that can be demonstrated to others." It’s not what somebody believes, it’s experimental proof that counts. And those guys don’t have that."

"I once heard, and I think it is true, that only one man in the world—some Indian mathematician—understood the mathematics of string theory in eleven-dimensional space, and he dreamed it."

"Years from now, people will find our acceptance of the HIV theory of AIDS as silly as we find those who excommunicated Galileo."

"It was a bank holiday, and Mr Tompkins, the little clerk of a big city bank, slept late and had a leisurely breakfast. Trying to plan his day, he first thought about going to some afternoon movie and, opening the morning paper, turned to the entertainment page. But none of the films looked attractive to him. He detested all this Hollywood stuff, with infinite romances between popular stars. If only there were at least one film with some real adventure, something unusual and maybe even fantastic about it. But there was none. Unexpectedly, his eye fell on a little notice in the corner of the page. The local university was announcing a series of lectures on the problems of modern physics, and this afternoon's lecture was to be about Einstein's Theory of Relativity. Well, that might be something!"

"There was a young fellow from Trinity, Who took the square root of infinity. But the number of digits, Gave him the fidgets; He dropped Math and took up Divinity."

"It is well known that theoretical physicists cannot handle experimental equipment; it breaks whenever they touch it. Pauli was such a good theoretical physicist that something usually broke in the lab whenever he merely stepped across the threshold. A mysterious event that did not seem at first to be connected with Pauli's presence once occurred in Professor J. Franck's laboratory in Göttingen. Early one afternoon, without apparent cause, a complicated apparatus for the study of atomic phenomena collapsed. Franck wrote humorously about this to Pauli at his Zürich address and, after some delay, received an answer in an envelope with a Danish stamp. Pauli wrote that he had gone to visit Bohr and at the time of the mishap in Franck's laboratory his train was stopped for a few minutes at the Göttingen railroad station. You may believe this anecdote or not, but there are many other observations concerning the reality of the Pauli Effect!"

"With very few exceptions, philosophers do not know much science and do not understand it, which is quite natural because science lies beyond the boundaries of typical philosophical subjects such as ethics, aestetics, and gnosiology. But while in the free countries philosophers are quite harmless, in the dictatorial countries they constitute a great danger for the development of science. In Russia, state philosophers are bred in the Communist Academy in Moscow and are placed in all the educational and research institutions to prevent the professors and researchers from falling into idealistic, capitalistic heresies. The state philosophers are usually familiar with the subject of the research institution they are going to supervise, being either former schoolteachers or having taken in the academy a one-semester course on the subject in question. But they rank in the their power above the scientific directors of the institution and can veto any research project on publication which deviates from the correct ideology. One notable example of philosophical dictatorship in Russian science was the prohibition of Einstein's theory of relativity on the ground that it denied world ether, "the existence of which follows directly from the philosophy of dialectical materialism". It is interesting to note that the existence of the "world ether" was doubted long before Einstein by Engels, who in one of his letter to friend wrote "...the world ether, if it exists"."

"I decided to get Ph.D. in experimental physics because experimental physicists have their own room in the Institute where they can hang their coat, whereas theoretical physicists have to hang their coat at the entrance."

"I feel that matter has properties which physics tells you."

"So I am just sitting and waiting, listening, and if something exciting comes, I just jump in."

"If the expansion of the space of the universe is uniform in all directions, an observer located in anyone of the galaxies will see all other galaxies running away from him at velocities proportional to their distances from the observer."

"It took less than an hour to make the atoms, a few hundred million years to make the stars and planets, but five billion years to make man!"

"The physicist George Gamow was also an entertaining popularizer. He once told the story of how with his wife and their baby daughter he visited the Leaning Tower of Pisa. As they climbed the steps, they noticed an increasingly musty smell, which they first attributed to the ancient walls of the building. Then, however, they began to suspect their little girl, and by the time they reached the top it was clear that she needed immediate attention. “And from the very place,” explained Gamow, raising his arm and his voice dramatically, “where Galileo launched his experimental objects, we also propelled…”"

"Rutherford did not pretend to understand quantum mechanics, but he understood that the Gamow formula would give his accelerator a crucial advantage. Even particles accelerated at much lower energies... would be able to penetrate into nuclei. Rutherford invited Gamow to Cambridge in January 1929... [They] became firm friends and Gamow's insight gave Rutherford the impetus to go full steam ahead with the building of his accelerator."

"Take a look at George Gamow, who is now recognized as one of the great cosmologists of the last hundred years. I speculate that he probably didn't win the Nobel Prize because people could not take him seriously. He wrote children's books. His colleagues have publicly stated his writing children's books on science had an adverse effect on his scientific reputation, and people could not take him seriously when he and his colleagues proposed that there should be a cosmic background radiation, which we now know to be one of the greatest discoveries of 20th-century physics."

"Gamow was rather childlike, always wanting to play, and introducing a sort of light humor into all occasions. He was very fond of drawing pictures of Mickey Mouse. He added a lot to the entertainment that we had. He had some good ideas, applications which led to important developments in quantum theory, but I do not think he did any work which was very deep."

"If contribution in life is measured by the influence of a person's best ideas, then George Gamow's contribution has been immense. He explained radioactive decay, described reaction mechanisms and rates in the interior of stars, proposed how the elements were made, and suggested how DNA might provide the code for protein synthesis. Those topics have evolved into major fields of science..."

"Es Gamow't wieder"

"Gamow was fantastic in his ideas. He was right, he was wrong. More often wrong than right. Always interesting; … and when his idea was not wrong it was not only right, it was new."

"By an incredible coincidence, Gamow and Edward Condon, who had discovered simultaneously and independently the explanation of radioactivity (one in Russia, the other in this country), came to spend the last ten years of their lives within a hundred yards of each other in Boulder."

"[Duesberg] is absolutely correct in saying that no one has proven that AIDS is caused by the AIDS virus. And he is absolutely correct that the virus cultured in the laboratory may not be the cause of AIDS."

"The community as a whole doesn't listen patiently to critics who adopt alternative viewpoints. Although the great lesson of history is that knowledge develops through the conflict of viewpoints. If you simply have a consensus, it generally stultifies. It fails to see the problems of that consensus and it depends on the existence of critics to break up that iceberg and permit knowledge to develop. This is in fact one of the underpinnings of democratic theory. It is one of the reasons why we believe in notions of free speech and it's one of the great forces in terms of intellectual development."

"I would not be surprised if there were another cause of AIDS and even that HIV is not involved."

"I am afraid that those comments go back to the late 80's. At that time I was a skeptic — the argument based on Koch's postulates to try to distinguish between cause and association. … Today I would regard the success of the many antiviral agents which lower the virus titers (to be expected) and also resolve the failure of the immune system (only expected if the virus is the cause of the failure) as a reasonable proof of the causation argument"

"Outside his own ever-narrowing field of specialization, a scientist is a layman. What members of an academy of science have in common is a certain form of semiparasitic living."

"In 1945, therefore, I proved a sentimental fool; and Mr. Truman could safely have classified me among the whimpering idiots he did not wish admitted to the presidential office. For I felt that no man has the right to decree so much suffering, and that science, in providing and sharpening the knife and in upholding the ram, had incurred a guilt of which it will never get rid. It was at that time that the nexus between science and murder became clear to me. For several years after the somber event, between 1947 and 1952, I tried desperately to find a position in what then appeared to me as a bucolic Switzerland,—but I had no success."

"What I see coming is a gigantic slaughterhouse, a molecular Auschwitz, in which valuable enzymes, hormones, and so on will be extracted instead of gold teeth."

"Now one could say, at the risk of some superficiality, that there exist principally two types of scientists. The ones, and they are rare, wish to understand the world, to know nature; the others, far more frequent, wish to explain it. The first are searching for truth, often with knowledge that they will not attain it; the second strive for plausibility, for the achievement of an intellectually consistent, and hence successful, view of the world."

"We do not know what life is, and yet we manipulate it as if it were an inorganic salt solution..."

"Unangenehme Seher werden meistens als Narren abgeschrieben [Visionaries of uncomfortable truths are mostly dismissed as fools]"

"I find it hard to swallow that I have only ten times more genes than those lowly bacteria in my gut. I had always liked the fact that they have ten thousand times less DNA than I did — that felt about right — but a factor of ten was carrying democracy a bit too far."

"I am tired of hearing that the DNA in my cells nucleus is the complete blueprint of what is, or could be, me. There is more to me than that. The sequence of my nuclear DNA is not "My Genome.""

"Hold somebody's hand and feel its warmth. Gram per gram, it converts 10 000 times more energy per second that the sun. You find this hard to believe? Here are the numbers: an average human weighs 70 kilograms and consumes about 12 600 kilojoules / day; that makes about 2 millijoules / gram.second, or 2 milliwatts / gram. For the sun it's a miserable 0.2 microjoules / gram.second. Some bacteria, such as the soil bacterium "Azotobacter" convert as much as 10 joules / gram.second, outperforming the sun by a factor 50 million. I am warm because inside each of my body cells there are dozens, hundreds or even thousands of mitochondria that burn the food I eat."

"Ionizing radiation has always been with us and will be for all foreseeable time. Our genetic system is probably well adjusted by natural selection to normal background radiation. Added radiation will increase the frequency of mutations; most of these will be harmful. Exposure to radiation in large amounts will increase malignant disease; small amounts may possibly do the same. In view of these potentially harmful effects every reasonable effort should be made to reduce the levels of ionizing radiation to which man is exposed to to the lowest levels that can reasonably be attained."

"How scientists go about their job: and it's a process, it's a question of asking questions, respecting observation, respecting experiment, having tentative explanations and then testing them.... There is a problem sometimes with how we teach science at schools. Because we sometimes teach it as if it has been chiseled in stone."

"Even at the level of the cell, phenomena such as general cellular homeostasis and the maintenance of cell integrity, the generation of spatial and temporal order, inter- and intracellular signalling, cell 'memory' and reproduction are not fully understood. ...This is also true for the levels of organization seen in tissues, organs and organisms, which feature more complex phenomena such as and operation of the immune and s."

"We need to focus more on how information is managed in living systems and how this brings about higher level biological phenomena... more investigation into how living systems gather, process, store and use information, as was emphasized at the birth of ."

"DNA can act as a digital information storage device that can be precisely copied. Similarly, the mechanism of the lac operon... can be described in terms of molecular interactions between DNA, protein and s. But these interactions make sense only when they are translated into a negative loop..."

"We need to describe the molecular interactions and biochemical transformations that take place in living organisms, and then translate these descriptions into the logic circuits that reveal how information is managed. This analysis should not be confined to the flow of information from to , but should also be applied to all functions operating in cells and organisms, including chemical interactions and transformations as well as physical phenomena, such as electrical signalling and mechanical processes."

"Ever since Sir Isaac Newton's times, scientists have worked in the same sort of way:"

"This notion of information being at the heart of life... is not restricted to me. I'm in good company. Sir Paul Nurse, former president of the Royal Society, in his visionary essay in Nature, "Life, Logic and Information", extols the virtues of thinking in an information, web-based way about life, and how, instead of worrying too much about what is going on at the molecular level, we should think of life as being a collection of logic modules... with information flowing between them, and control systems... a sort of engineering approach."

"It is as though a puzzle could be put together simply by shaking its pieces."

"Mi è impossibile cingere i fianchi di una ragazza con il mio braccio destro e serrare il suo sorriso nella mia mano sinistra, per poi tentare di studiare i due oggetti separatamente. Allo stesso modo, non ci è possibile separare la vita dalla materia vivente, allo scopo di studiare la sola materia vivente e le sue reazioni. Inevitabilmente, studiando la materia vivente e le sue reazioni, studiamo la vita stessa."

"[When I joined the Institute for Advanced Study in Princeton] I did this in the hope that by rubbing elbows with those great atomic physicists and mathematicians I would learn something about living matters. But as soon as I revealed that in any living system there are more than two electrons, the physicists would not speak to me. With all their computers they could not say what the third electron might do. The remarkable thing is that it knows exactly what to do. So that little electron knows something that all the wise men of Princeton don't, and this can only he something very simple."

"When I received the Nobel Prize, the only big lump sum of money I have ever seen, I had to do something with it. The easiest way to drop this hot potato was to invest it, to buy shares. I knew that World War II was coming and I was afraid that if I had shares which rise in case of war, I would wish for war. So I asked my agent to buy shares which go down in the event of war. This he did. I lost my money and saved my soul."

"If any student comes to me and says he wants to be useful to mankind and go into research to alleviate human suffering, I advise him to go into charity instead. Research wants real egotists who seek their own pleasure and satisfaction, but find it in solving the puzzles of nature."

"Research is to see what everybody has seen and think what nobody has thought."

"Discovery consists of looking at the same thing as everyone else and thinking something different."

"Life is water, dancing to the tune of macro molecules."

"I am not religious, but I am a pious man... A religious man has a definite religion. He says "God is there" or "God is there," "God is there." "Your god is not my god, and that's all." But the pious man, he just looks out with awe, and says, "where is God?" And "well, I don't understand it and I would like to know what this creation really means." That is a pious man, who is really touched by the greatness of nature and of the creation."

"It is probably this dual code of morals which underlies the break in... many leading politicians who begin their political efforts with the desire to improve the lot of their fellow men. Once they reach the top they tend to exchange their individual code of morals for the collective one... to serve abstract ideas, which have little to do with their people's well being, and they make war."

"Collective human suffering easily becomes an abstraction... being unable to multiply death or suffering by 100,000. This... is a number, an abstraction. One death is a tragedy. 100,000 deaths are statistics. So it must also seem to men in high offices."

"From on high a human life must look very small, a notion that moved Walt Whitman to sing about the arrogance and audacity of elected government officials. ...Unfortunately, this collective code of morals... [w]e all share... as soon as... we participate in government... when we go to the polls to elect hawks and vote the endless billions for war and... formidable machines for killing and destruction, and then go to church and ask for God's blessing."

"Between the two world wars, at the heydey of Colonialism, force reigned supreme. ...[I]t was natural for the weaker to lie down before the stronger. ...Gandhi, chasing out of his country... the greatest military power on earth... taught the world that there are higher things than force, higher even than life... [H]e proved that force had lost its suggestive power... information which did not reach the Pentagon or the government: we cannot win in win in Viet Nam because the people are willing to die faster than we can kill them."

"DNA... is the most wonderful thing in the world... Mankind went through epidemics, famine, and...trials, yet nature kept this... intact, because all life depends on it. ...[M]an has found a means to damage it. High energy radiation does so. ...There may ...be survivors after after an atomic war, but those... will be unable to produce a healthy progeny. Their progeny will be beset by abnormalities, monstrosities and diseases... and there will be no way back."

"The primary aim of science is to find... new truth. The search is the more successful the more it is directed towards... truth for its own sake, regardless of... possible use or application. ...If everything given to us by research were to be taken away, civilization would collapse and we would stand naked, searching for caves again."

"Even pure truth, which has no application... elevates life."

"Science is life-oriented. ...[A]rmies and armaments are death-oriented. Armies are instruments of organized manslaughter... All its tools are the tools of death... instruments of killing. ...[A] society dominated by the military is death-centered, as pointed out by in his famous Moratorium Speech."

"Out children came into this world with "clean and empty minds." What they learn... is markedly different from... children of the pre-War world. Today's adults look... through glasses of pre-War and pre-scientific values. They think... all the world needs a little bit of patching... The result... we get deeper... into trouble. The modern scientific revolution had made all human s age faster... as a consequence we have a hypocritical world... Our youth rejects this anachronism wholesale. ...They find everything a lie. The great political parties... out for profit and power, the military for domination, fattening itself with their young bodies... churches preaching love but raising no voice against the slaughter of undeveloped people... driving the world toward overpopulation... resisting family planning... always on the side of power. And they see while half of the children of the world go to sleep hungry... we spend hundreds of billions to raise our stack of nuclear bombs and missiles... They see... most political leaders... mindful only of... re-election... keeping power... with arguments which should be rejected by the simplest logic, refuting the great ideals on which our country was built."

"[T]here is only one medicine that will be effective against drug use: a livible, a restoration of faith in life—its dignity, value and longevity. Police raids and jail terms are not the answer."

"I am not dreaming of a Utopia, only of a world in which problems are not resolved by force but by intelligence, good will and equity; a world in which killing, no matter the reason, and the destruction of a fellow man's life or home, is a crime; a world in which our youth in which our youth will not have to spend their years studying organized manslaughter, in which neither force nor megatons nor poison gases will decide a nation's standing but the sum of its knowledge, its ethics, the gifts it makes to mankind, the happiness it gives to men, the measure in which it lifts human life."

"The battle... is for the minds of men; the outcome... does not depend on numbers of missiles, but on the question of which system can raise life higher, give more happiness... and raise the great undeveloped masses out of their misery. ...Now there are two parties: democracy and communism. Why not embark on a noble competition by showing which... can create a better, freer, happier life?"

"The great hope of mankind is still the United Nations."

"[B]rutalizing wars and military life... are capable of turning decent fellows into ers who can shoot women and children down in cold blood."

"Psalmus Humanus My Lord, Who are You? ... Are you the Universe itself? Or the Law which Ruled it? ... Are you the maker, or did I shape You, That I may share my loneliness and shun my responsibility? God! ...I am calling to You, for I am in trouble, Frightened of myself and my fellow men! ..."

"Szent-Györgyi's offbeat ideas came to Mr. Moss's attention in 1980 when he was promoting his book The Cancer Syndrome. "I was dubious about his work," Mr. Moss said. Then The Saturday Evening Post asked him to interview Szent-Györgyi and "I was just bowled over by him. Linus Pauling said he was the most charming man in science. He had this easy gift of winning people over.""

"The strong appearance of design [in nature] allows a disarmingly simple argument: if it looks, walks and quacks like a duck, then, absent compelling evidence to the contrary, we have warrant to conclude it's a duck. Design should not be overlooked simply because it's so obvious."

"Under my definition, a scientific theory is a proposed explanation which focuses or points to physical, observable data and logical inferences. There are many things throughout the history of science which we now think to be incorrect which nonetheless would fit that — which would fit that definition. Yes, astrology is in fact one."

"... I have no reason to doubt that the universe is the billions of years old that physicists say it is. Further, I find the idea of common descent (that all organisms share a common ancestor) fairly convincing, and have no reason to doubt it. ... I think that evolutionary biologists have contributed enormously to our understanding of the world. Although Darwin's mechanism - natural selection working on variation - might explain many things, however, I do not believe it explains molecular life."

"As the number of unexplained, irreducibly complex biological systems increases, our confidence that Darwin’s criterion of failure has been met skyrockets toward the maximum that science allows."

"If a theory claims to be able to explain some phenomenon, but does not generate even an attempt at an explanation, then it should be banished."

"The result of [the] cumulative efforts to investigate the cell—to investigate life at the molecular level—is a loud, clear, piercing cry of ‘design!’ The result is so unambiguous and so significant that it must be ranked as one of the greatest achievements in the history of science. The discovery rivals those of Newton and Einstein, Lavoisier and Schrödinger, Pasteur, and Darwin. The observation of the intelligent design of life is as momentous as the observation that the earth goes around the sun."

"If you search the scientific literature on evolution, and if you focus your search on the question of how molecular machines—the basis of life—developed, you find an eerie and complete silence. The complexity of life’s foundation has paralyzed science’s attempt to account for it; molecular machines raise an as-yet-impenetrable barrier to Darwinism’s universal reach."

"Many people, including many important and well-respected scientists, just don’t want there to be anything beyond nature. They don’t want a supernatural being to affect nature."

"In private many scientists admit that science has no explanation for the beginning of life. . . . Darwin never imagined the exquisitely profound complexity that exists even at the most basic levels of life."

"Molecular evolution is not based on scientific authority. . . . There are assertions that such evolution occurred, but absolutely none are supported by pertinent experiments or calculations. Since no one knows molecular evolution by direct experience, and since there is no authority on which to base claims of knowledge, it can truly be said that . . . the assertion of Darwinian molecular evolution is merely bluster."

"Professor Behe admitted that his broadened definition of science, which encompasses ID [Intelligent Design], would also embrace astrology."

"Scientists in peer-reviewed publications have refuted Professor Behe's predication about the alleged irreducible complexity of the blood-clotting cascade."

"In Darwin's Black Box [1996], Professor Behe wrote that not only were there no natural explanations for the immune system at the time, but that natural explanations were impossible regarding its origin. However, Dr. Miller presented peer-reviewed studies refuting Professor Behe's claim that the immune system was irreducibly complex. … In fact, on cross-examination, Professor Behe was questioned concerning his 1996 claim that science would never find an evolutionary explanation for the immune system. He was presented with fifty-eight peer-reviewed publications, nine books, and several immunology textbook chapters about the evolution of the immune system; however, he simply insisted that this was still not sufficient evidence of evolution, and that it was not "good enough.""

"Professor Behe's claim for irreducible complexity has been refuted in peer-reviewed research papers and has been rejected by the scientific community at large."

"Professor Behe remarkably and unmistakably claims that the plausibility of the argument for ID [Intelligent Design] depends upon the extent to which one believes in the existence of God. As no evidence in the record indicates that any other scientific proposition's validity rests on belief in God, nor is the Court aware of any such scientific propositions, Professor Behe's assertion constitutes substantial evidence that in his view, as is commensurate with other prominent ID leaders, ID is a religious and not a scientific proposition."

"If Behe's formulation of intelligent design as science is illogical, his mechanism for how the work of the designer was inserted into living systems is almost laughable."

"There can be no question that Darwin had nothing like sufficient evidence to establish his theory of evolution. . . . His general theory, that all life on earth had originated and evolved by a gradual successive accumulation of fortuitous mutations, is still, as it was in Darwin’s time, a highly speculative hypothesis entirely without direct factual support and very far from that self-evident axiom some of its more aggressive advocates would have us believe. . . . One might have expected that a theory of such cardinal importance, a theory that literally changed the world, would have been something more than metaphysics, something more than a myth."

"Darwin’s model of evolution . . . , being basically a theory of historical reconstruction, . . . is impossible to verify by experiment or direct observation as is normal in science . . . Moreover, the theory of evolution deals with a series of unique events, the origin of life, the origin of intelligence and so on. Unique events are unrepeatable and cannot be subjected to any sort of experimental investigation."

"The raising of the status of Darwinian theory to a self-evident axiom has had the consequence that the very real problems and objections with which Darwin so painfully laboured in the Origin have become entirely invisible. Crucial problems such as the absence of connecting links or the difficulty of envisaging intermediate forms are virtually never discussed and the creation of even the most complex of adaptations is put down to natural selection without a ripple of doubt."

"The overriding supremacy of the myth has created a widespread illusion that the theory of evolution was all but proved one hundred years ago . . . Nothing could be further from the truth."

"Molecular biology has shown that even the simplest of all living systems on earth today, bacterial cells, are exceedingly complex objects. Although the tiniest bacterial cells are incredibly small, weighing less than 10−12gms, each is in effect a veritable micro-miniaturized factory containing thousands of exquisitely designed pieces of intricate molecular machinery, made up altogether of one hundred thousand million atoms, far more complicated than any machine built by man and absolutely without parallel in the nonliving world."

"Molecular biology has also shown that the basic design of the cell system is essentially the same in all living systems on earth from bacteria to mammals. In all organisms the roles of DNA, mRNA and protein are identical. The meaning of the genetic code is also virtually identical in all cells. The size, structure and component design of the protein synthetic machinery is practically the same in all cells. In terms of their basic biochemical design, therefore no living system can be thought of as being primitive or ancestral with respect to any other system, nor is there the slightest empirical hint of an evolutionary sequence among all the incredibly diverse cells on earth."

"[W]ithout an agreement imposed from the outside, our situation will deteriorate to that of a second Vietnam, to a war in constant escalation without the prospect of ultimate resolution."

""Security" is a reality only where there is true peace between neighbors, as in the case of Holland/Belgium, Sweden/Norway, the United States/Canada. In the absence of peace there is no security, and no geographic-strategic settlement on the land can change this. There is no direct link between security and the territories."

"Our security has been diminished rather than enhanced as a result of the conquests in this war."

"Our real problem is not the territory but rather the population of about a million and a half Arabs who live in it and over whom we will need to impose our rule. Inclusion of these Arabs (in addition to the half a million who are citizens of the state) in the area under our rule will effect the liquidation of the state of Israel as the state of the Jewish people and bring about catastrophe for the Jewish people as a whole; it will undermine the social structure that we have created in the state and cause the corruption of individuals, both Jew and Arab."

"Rule over the occupied territories would have social repercussions. After a few years there would be no Jewish workers or Jewish farmers. The Arabs would be the working people and the Jews the administrators, inspectors, officials, and police—mainly secret police. A state ruling a hostile population of 1.5 to 2 million foreigners would necessarily become a secret-police state, with all that this implies for education, free speech, and democratic institutions. The corruption characteristic of every colonial regime would also prevail in the state of Israel. The administration would have to suppress Arab insurgency on the one hand and acquire Arab Quislings on the other. There is also good reason to fear that the Israel Defense Force, which has been until now a people's army, would, as a result of being transformed into an army of occupation, degenerate, and its commanders, who will have become military governors, resemble their colleagues in other nations.Out of concern for the Jewish people and its state we have no choice but to withdraw from the territories and their population of one and a half million Arabs."

"As for the "religious" arguments for the annexation of the territories—these are only an expression, subconsciously or perhaps even overtly hypocritical, of the transformation of the Jewish religion into a camouflage for Israeli nationalism. Counterfeit religion identifies national interests with the service of God and imputes to the state—which is only an instrument serving human needs—supreme value from a religious standpoint."

"Not every "return to Zion" is a religiously significant achievement: one sort of return which may be described in the words of the prophet: "When you returned you defiled my land and made my heritage an abomination" (Jeremiah 2:7)."

"Most characteristic of the Halakhah is its lack of pathos."

"Only a religion addressed to life's prose, a religion of the dull routine of daily activity, is worthy of the name."

"The religion of halakhic practice is the religion of life itself."

"The formulation "ways to faith" could be interpreted as implying that faith is a conclusion a person may come to after pondering certain facts about the world-facts about history, nature, or consciousness. If that were the case, one could lead a person to this conclusion by presenting these facts to him and pointing out their implications. I, however, do not regard religious faith as a conclusion. It is rather an evaluative decision that one makes, and, like all evaluations, it does not result from any information one has acquired, but is a commitment to which one binds himself. In other words, faith is not a form of cognition; it is a conative element of consciousness."

"From a religious point of view the triadic classification of being as nature, spirit, and God has no validity. There is only the dyad: nature, which includes the human spirit, and God. The only way man can break the bonds of nature is by cleaving to God; by acting in compliance with the divine will rather than in accordance with the human will."

"The essence of Jewish faith is consistent with no embodiment other than the system of halakhic praxis."

"Only the prayer which one prays as the observance of a Mitzvah is religiously significant. The spontaneous prayer ("when he is overwhelmed and pours out his complaint before God") a man prays of his own accord is, of course, halakhically permissible, but, like the performance of any act which has not been prescribed, its religious value is limited. As a religious act it is even faulty, since he who prays to satisfy his needs sets himself up as an end, as though God were a means for promotion of his welfare."

"Emancipation from the bondage of nature can only be brought about by the religion of Mitzvoth"

"Leibowitz regarded Judaism as a religious and historical phenomenon, which is characterized by a recognition of the duty to serve God in performing mitzvot. The service of God according to binding halakhic norms must be "for its own sake" (li-shemah), and its purpose is not designed to achieve personal perfection or to improve society. Religion is thus not a means toward any specific end. Judaism is for Leibowitz not humanism, or a sentiment or a bundle of memories. Jews have the obligation to take upon themselves the yoke of Torah and mitzvot. Leibowitz's standpoint is thus neither anthropocentric or ethnocentric, but theocentric."

"Leibowitz had a very negative view of Christianity as well as of modern Jewish thinkers like Rosenzweig and Buber, who showed intellectual and religious interest in Christianity. In contrast to scholars and thinkers like David Flusser, who investigated the Jewish roots of Christianity, Leibowitz wrote that the very concept of a "Judeo-Christian heritage" is a square circle. A synthesis or symbiosis is impossible; Christianity is for Leibowitz the adversary of Judaism. In his view, Christianity is the heir who does not want to admit that the testator is still alive. Judaism and Christianity cannot coexist, because Christianity claims that it is true Judaism, and is interested in the liquidation of Judaism as the religion of Torah and mitzvot."

"In his essays, Leibowitz produced sharp and thought-provoking insights on many subjects such as the nature of holiness, chosenness, Messianism, prayer, redemption, and general and personal providence. His consistent and provocative thought gave him a prominent position in contemporary Jewish thought, especially in Israel. His thinking, even when contested, is stimulating and powerful and invites or even forces people to respond by formulating their own views."

"On the one hand he was a libertarian, an extreme form of classical liberalism, and believed that human beings should be free to determine their way of life without any state interference. On the other hand, he was an ultra-Orthodox Jew who insisted that the state and religion must be separated completely to avoid corrupting each other."

"Leibowitz argued vehemently for two positions: that holding any state as a value in itself was inherently fascist and that sanctifying any piece of land, including Israel, was a form of idolatry. Very soon after the Six-Day War, Leibowitz predicted that if Israel didn't withdraw immediately from the occupied territories, all of the state's energy would be tied up in ruling another people against its will."

"The theme of this book is encapsulated in its portrayal of one of my heroes—or, I should say, my newest hero, since I had no knowledge of him before reading Blumenthal's work: his name is Yeshayahu Leibowitz. The Israeli polymath, who fled Germany in 1933 and emigrated to Palestine where he taught brain physiology at Tel Aviv University, starting teaching philosophy at the age of 72 (!), was an Orthodox Jewish scholar who edited the Encyclopedia Hebraica—and a hardcore libertarian only a little less radical than Murray Rothbard, whom he resembles in style and mannerisms to an amazing degree."

"It was strange to Leibowitz, who fled anti-Jewish persecution in Europe and emigrated to Israel to become one of the giants of the founding generation, because it inverted the whole history of the Jewish people, turning them into the spitting image of the pogromists whose terrorism he had fled."

"As the trends he abhorred gained ground in Israeli society Leibowitz's dark vision of Israel's future went pitch black."

"The concept of the « struggle for existence » has been applied to microbial interrelationships in nature in a manner comparable to the effects assigned by Darwin to higher forms of life. It has also been suggested that the ability of a microbe to produce an antibiotic substance enables it to survive Giom. in competition for space and for nutrients with other microbes. Such assumptions appear to be totally unjustified on the basis of existing knowledge. Before we proceed with a discussion of the formation and activities of antibiotics under natural conditions, we must consider certain fundamental aspects of the problem of antibiotic production under controlled laboratory or factory conditions... All the discussion of a "struggle for existence" in which antibiotics are supposed to play a part, is merely a figment of the imagination, and an appeal to the melodramatic rather than the factual."

"Biochemistry asks how the remarkable properties of living organisms arise from the thousands of different biomolecules."

"Organisms possess extraordinary attributes, properties that distinguish them from other collections of matter. What are these distinguishing features of living organisms?"

"Despite these common properties, and the fundamental unity of life they reveal, it is difficult to make generalizations about living organisms."

"The unity and diversity of organisms become apparent even at the cellular level."

"Cells of all kinds share certain structural features."

"The upper limit of cell size is probably set by the rate of diffusion of solute molecules in aqueous systems."

"All living organisms fall into one of three large groups (domains) [Bacteria, Archeara, Eukarya] that define three branches of evolution from a common progenitor."

"The distinguishing characteristics of eukary­otes are the nucleus and a variety of membrane-enclosed organelles with specific functions."

"The current understanding that all organisms share a common evolutionary origin is based in part on this observed universality of chemical intermediates and transformations, often termed "biochemical unity.""

"The chemistry of living organisms is organized around carbon, which accounts for more than half the dry weight of cells."

"We can consider cellular energy conversions—like all other energy conversions—in the context of the laws of thermodynamics."

"Virtually every chemical reaction in a cell occurs at a significant rate only because of the presence of enzymes."

"Perhaps the most remarkable property of living cells and organisms is their ability to reproduce themselves for countless generations with nearly perfect fidelity. This continuity of inherited traits implies constancy, over millions of years, in the structure of the molecules that contain the genetic information."

"Among the seminal discoveries in biology in the twentieth century were the chemical nature and the three-dimensional structure of the genetic material, deoxyribonucleic acid, DNA."

"The remarkable similarity of metabolic pathways and gene sequences across the phyla argues strongly that all modern organisms are derived from a common evolutionary progenitor by a series of small changes (mutations), each of which conferred a selective advantage to some organism in some ecological niche."

"The first living organisms on Earth doubtless arose in an aqueous environment, and the course of evolution has been shaped by the proper­ ties of the aqueous medium in which life began."

"As a result, there is an electrostatic attraction between the oxygen atom of one water molecule and the hydrogen of another (Fig. 2-lb), called a hydrogen bond."

"Water is a polar solvent. It readily dissolves most bio­ molecules, which are generally charged or polar com­ pounds (Table 2-2); compounds that dissolve easily in water are hydrophilic (Greek, "water-loving"). In contrast, nonpolar solvents such as chloroform and benzene are poor solvents for polar biomolecules but easily dis­ solve those that are hydrophobic-nonpolar molecules such as lipids and waxes."

"In thermodynamic terms, formation of the solution occurs with a fa vorable free-energy change: ΔG = ΔH - TΔS, where ΔH has a small positive value and TΔS a large positive value; thus ΔG is negative."

"We're basically a vegetarian species and should be eating a wide variety of plant foods and minimizing our intake of animal foods. … Usually, the first thing a country does in the course of economic development is to introduce a lot of livestock. Our data are showing that this is not a very smart move, and the Chinese are listening. They're realizing that animal-based agriculture is not the way to go. … Ironically, osteoporosis tends to occur in countries where calcium intake is highest and most of it comes from protein-rich dairy products. The Chinese data indicate that people need less calcium than we think and can get adequate amounts from vegetables."

"Our study [China Diet and Health Study] suggests that the closer one approaches a total plant food diet, the greater the health benefit. … It turns out that animal protein, when consumed, exhibits a variety of undesirable health effects. Whether it is the immune system, various enzyme systems, the uptake of carcinogens into the cells, or hormonal activities, animal protein generally only causes mischief. High fat intake still can be a problem, and we ought not to be consuming such high-fat diets. But I suggest that animal protein is more problematic in this whole diet/disease relationship than is total fat."

"No chemical carcinogen is nearly so important in causing human cancer as animal protein."

"Don’t be afraid of hard work. Nothing worthwhile comes easily. Don’t let others discourage you or tell you that you can’t do it. In my day I was told women didn’t go into chemistry. I saw no reason why we couldn’t."

"People ask me often (was) the Nobel Prize the thing you were aiming for all your life? And I say that would be crazy. Nobody would aim for a Nobel Prize because, if you didn’t get it, your whole life would be wasted. What we were aiming at was getting people well, and the satisfaction of that is much greater than any prize you can get."

"I had no specific bent toward science until my grandfather died of stomach cancer. I decided that nobody should suffer that much."

"Many cissexual people seem to have a hard time accepting the idea that they too have a subconscious sex — a deep-rooted understanding of what sex their bodies should be. I suppose that when a person feels right in the sex they were born into, they are never forced to locate or question their subconscious sex, to differentiate it from their physical sex. In other words, their subconscious sex exists, but it is hidden from their view. They have a blind spot. (5 - Blind Spots: On Subconscious Sex and Gender Entitlement)"

"There are numerous forms of marginalization that exist in our society: , classism, sexism, , heterosexism, and so on. If you happen to be on the wrong side of any of these hierarchies, you will face many inequities and injustices. ... Some people are single-issue activists that are only concerned about a single form of marginalization, usually one that impacts them personally. Single-issue perspectives create a distorted view of the world, and lead activists to propose solutions that will help some people while hurting others and leaving countless more behind. ... In contrast, others of us take a more intersectional approach, recognizing that all forms of marginalization intersect with and exacerbate one another, and that we must challenge all of them simultaneously."

"People usually gravitate toward single-issue activism because they are unconcerned about forms of marginalization that do not personally impact them."

"The “principal contradiction” refers to the idea that there is some original or primary form of oppression that gives rise to all the others. ... Of course, there is really only one purpose for making such a claim: to persuade others to join you in your single-issue activist campaign, under the pretense that once your pet oppression is eliminated, all other forms of marginalization will subsequently fall by the wayside too. But the thing is, there is simply no evidence for a principal contradiction. ... There is no primary contradiction, just lots of different hierarchies that people may or may not endorse."

"Here is how I describe the concept of privilege to skeptics: Do you believe that marginalized/minority groups face discrimination and are as a result? If the answer is yes, then another equally valid way of describing the same situation is to say that dominant/majority groups are relatively advantaged in comparison. “Privilege” simply refers to those advantages. One of the reasons why activists frame such matters in terms of privilege is to illustrate how *all of us* are impacted by unjust hierarchies and systems, even if it is not always apparent to us."

"Once a person acknowledges that they possess some form of privilege, they are more likely to accept the reality that they are not in any way objective about the form of marginalization in question"

"I mentioned at the outset that I dislike the term "identity politics." This is because the phrase seems to suggest that our identities (rather than the marginalization we face) is the most salient feature of our activism. Indeed, this is probably why those who oppose IP-umbrella activism seem so fond of calling it “identity politics” in the first place. [...] In contrast, within IP circles, the term is often reserved for a specific brand of single-issue activism that completely precludes perspectives from those who do not share the identity in question."

"Accusations that IP is inherently “narcissistic” and “divisive” have become quite prevalent among EC-centric leftists lately. [...] In addition to disregarding all forms of non-EC marginalization, accusations that IP activism is inherently “narcissistic” or "divisive" severely confuse cause and effect. After all, I’m not the one who is “obsessed” with my identity. [...] It’s the people who harbor anti-trans attitudes who are obsessed with my identity, not the other way around! While I would absolutely love to live in a world where my trans identity was not especially notable or worth calling attention to, these people insist on making an issue out of it. Furthermore, by making a distinction between transgender people (who they single out for discrimination) and non-transgender people (whose identities and experiences they respect), it is they (not us) who are the ones being divisive. Once we acknowledge this causality, it becomes clear that IP is not an expression of navel-gazing or narcissism, but rather a form of organized resistance against those who are actively trying to delegitimize and disenfranchise us."

"I would love to live in a world where the word “transgender” serves the same simple purpose — a mere sharing of information about my life experiences — but unfortunately, it doesn’t. On top of being a descriptor, the word "transgender" is also politically loaded. But that is not my, nor other trans people’s, fault. As discussed in the last section, there’s a long history of people hating, ostracizing, and criminalizing us, and much of this history took place before words like "transgender," "transphobia," and analogous terms even existed. In fact, those terms were created in response to that marginalization, not the other way around. And even if I were to relinquish my trans identity, those people would still exist and continue to discriminate against me for supposedly being a sinner, or freak, or deviant, or for being delusional, or whatever other rationales they might concoct in order to justify their bigotry."

"Women who insist that trans women are not women often object to being called “cis women” under the false assumption that it somehow undermines their femaleness — this is not at all the purpose of this language. The sole purpose of cis terminology is to name the unmarked majority (similar to how one might refer to white women, or heterosexual women, or able-bodied women, etc.). In other words, referring to someone as “cisgender” simply means that they have not had a transgender experience."

"Trans women differ greatly from one another. Perhaps the only thing that we share in common is a self-understanding that there was something wrong with our being assigned a male sex at birth and/or that we should be female instead. While some cisgender people refuse to take our experiences seriously, the fact of the matter is that transgender people can be found in virtually every culture and throughout history; current estimates suggest that we make up 0.2 – 0.3% of the population [or possibly more]. [...] In other words, we simply exist."

"Like women more generally, many trans women are feminists. Feminism and transgender activism are not in any way incompatible or mutually exclusive. As feminists who acknowledge intersectionality, we believe that we should be fighting to end all forms of sexism and marginalization — this includes both traditional sexism and transphobia. Forcing trans women into a separate group that is distinct from cis women does not in any way help achieve feminism’s central goal of ending sexism."

"Claims that trans women are not women often rely on essentialist (and therefore incorrect) assumptions about biology. For instance, people might argue that trans women are not “genetically female,” despite the fact that we cannot readily ascertain anybody’s sex chromosomes. Indeed, most people have never even had their sex chromosomes examined, and those that do are sometimes surprised by the results. Other common appeals to biology center on reproduction — e.g., stating that trans women have not experienced menstruation, or cannot become pregnant. This ignores the fact that some cisgender women never menstruate and/or are unable to become pregnant. Claims about genitals are similarly problematic: Women’s genitals vary greatly, and as with chromosomes and reproductive capabilities, we cannot readily see other people’s genitals in everyday encounters. If you and I were to meet, should I refuse to recognize or refer to you as a woman unless you show me your genitals? And frankly, what could possibly be more sexist than reducing a woman to what’s between her legs? Isn’t that precisely what sexist men have been doing to women for centuries on end?"

"While gender socialization is quite real, all of us are capable of overcoming or transcending the socialization that we experienced as children. And gender socialization doesn’t simply stop when one reaches adulthood: All of us are constantly facing gender-related social pressures, expectations, and obstacles throughout our lives. If you believe that these statements are true for cis women, then they also must be true for trans women."

"Trans women do not transition out of a desire to be feminine; we transition out of a self-understanding that we are or should be female (commonly referred to as gender identity)."

"Trans women who are conventionally feminine are not in any way asserting or insinuating that all women should be conventionally feminine, or that femininity is all there is to being a woman. Like cis women, trans women dress the way we do in order to express ourselves, not to critique or caricature other women."

"As a trans woman, I will be the first to admit that I cannot possibly know what any other woman experiences or feels on the inside. But the thing is, the trans-women-aren’t-women crowd cannot possibly know what any other woman experiences or feels either! Every woman is different. We share some overlapping experiences, but we also differ in every possible way. Every trans woman I know acknowledges this diversity. In contrast, it’s the cis women who attempt to exclude us who seem to have a singular superficial stereotypical notion of what constitutes a woman, or of what women experience."

"Trans women are women. We may not be “exactly like” cis women, but then again, cis women are not all “exactly like” one another either. But what we do share is that we all identify and move through the world as women. And because of this, we all regularly face sexism. That is what we should be focusing on and working together to challenge. And as I said at the outset, forcing trans women into a separate group that is distinct from cis women does not in any way help achieve feminism’s central goal of ending sexism. In fact, it only serves to undermine our collective cause."

"People tend to harbor essentialist beliefs about sex — that is, they presume that each sex category has an underlying "essence" that makes them what they are. This is what leads people to assume that trans women remain "biologically male" despite the fact that many of our sex characteristics are now female. However, there is no “essence” underlying sex; it is simply a collection of sexually dimorphic traits. Some people will presume that sex chromosomes must be this "essence," even though we cannot readily see them, plus there are non-XX or XY variants. Others presume that genitals are this "essence" (probably because they are used to determine our birth-assigned and legal sex), although they can vary too, and may eventually change (e.g., if one undergoes sex reassignment surgery). In day-to-day life, we primarily rely on secondary sex characteristics to determine (or more precisely, presume) what sex a person is — and of course, these traits may change via a simple hormone prescription. Like I said, there is no mystical “essence” underlying sex."

"Sex is a collection of traits that, while generally dimorphic, can vary greatly in the population, and some can change over time. While the terms "male" and "female" have some utility, we should not view them as strictly dichotomous or mutually exclusive. Rather, “female” and “male” are best thought of as umbrella terms that describe groupings of people (or animals) who generally share many of the same traits, albeit with considerable variability and some exceptions."

"The most infuriating assertion regularly made by the "trans women are biologically male" camp is that trans people are somehow "denying" or "erasing" biological sex differences, and that this hurts cisgender women/"[w:Female|biological females]].” This is patently untrue. I can assure you that trans people are highly aware of biological sex differences — the fact that many of us physically transition demonstrates that we acknowledge that sexually dimorphic traits exist and may be important to some people! I would reframe things this way: Transgender people often have a more complicated relationship with our sex-related traits (as they may be discordant with our identified and lived genders), and thus the language that we use to describe or discuss these traits may seem arcane, or nonsensical, or unnecessary to the average cisgender person. And because they are unfamiliar with this language (and/or flat-out antagonistic toward us), some cisgender people will subsequently misinterpret this language and differing perspective as some sort of "denial.""

"We cannot forejudge what the future developments of the history of science will bring forth, but if India was probably less original than China in the engineering and physico-chemical sciences, Indian culture in all probability excelled in systematic thought about Nature (as for example in the Samkhya atomic theories of Kshana, bhutadi, paramanu, etc.), including also biological speculations .... When the balance comes to be made up, it will be found I believe, that Indian scientific history holds as many brilliant surprises as those which have emerged from the recent study of China -whether in mathematics, chemistry, or biology, and especially the theories which were framed about them."

"For three thousand years a dialogue has been going on between the two ends of the Old World. Greatly have they influenced each other, and very different are the cultures they have produced. We have now good reason to think that the problems of the world will never be solved so long as they are considered only from a European point of view. It is necessary to see Europe from the outside, to see European history, and European failure no less than European achievement, through the eyes of that larger part of humanity, the peoples of Asia (and indeed also of Africa)."

"We know that the trigonometric sine is not mentioned by Greek mathematicians and astronomers, that it was used in India from the Gupta period onwards (third century).... The only conclusion possible is that the use of sines is an Indian development and not a Greek one. But Tannery, persuaded that the Indians could not have made any mathematical inventions, preferred to assume that the sine was a Greek idea not adopted by Hipparchus, who gave only a cable of chords. For Tannery, the fact that the Indians knew of sines was sufficient proof that they must have heard about them from the Greeks."

"To seek the ultimate origin or predisposition of the Indian conviction in the profoundly Hindu world view of endless cyclical change, kalpa and mahakalpas succeeding one another in self-sufficient and unwearying round. For Hindus as well as Taoists, the universe itself was a perpetual motion machine."

"It is good to remember, therefore, that our own pious founders were not the only men, and that Christendom was not the only culture, to set on foot great and noble institutions of learning where successive generations of students assembled to get the benefits of education and research. When the men of Alexander the Great came to Taxila in India in the fourth century BC they found a university the like of which had not then been seen in Greece ... and was still existing when the Chinese pilgrim Fa-Hsien went there about AD 400."

"Indian culture in all probability excelled in systematic thought about Nature (as for example in the Sarokhya atomic theories of Kshana, bhutadim paramanu, etc.), including also biological speculations ... When the balance comes to be made up, it will be found I believe, that Indian scientific history holds as many brilliant surprises ..."

"Joseph Needham, has stated, "Future research on the history of science and technology in Asia will in fact reveal that the achievements of these peoples contribute far more in all pre-Renaissance periods to the development of world science than has yet been realized.""

"European and America must stand ready not only to share with all Asians and Africans those treasures of understanding and use of Nature which modern science and technology brought forth, but also to learn from them many things concerning individual life and society which they are more than competent to teach. If this is not done, the achievements of Europe (and America) will in any case become the common property of mankind, but our civilization will go down in history as distorted and evil, unwilling to practice what it preached, and worthy of the condemnation of ten thousand generations."

"He had a tendency — not entirely justified in the light of more recent research — to think well of Taoism, because he saw it as playing a part that could not be found elsewhere in Chinese civilization. The mainstream school of thinking of the bureaucratic Chinese elite, or 'Confucianism' (another problematic term) in his vocabulary, seemed to him to be less interested in science and technology, and to have 'turned its face away from Nature.' Ironically, the dynasty that apparently turned away from printing from 706 till its demise in 907 was as Taoist as any in Chinese history, though perhaps its 'state Taoism' would have seemed a corrupt and inauthentic business to Needham.[31]"

"Cambridge scientist historian Joseph Needham’s loyalty was to Mao’s version of Stalinism as a system, but he got enamoured with China itself and wrote a very Sinocentric history of Science and Civilization in China, highlighting the unexpectedly large contribution which China has made to human progress."

"Alas, it was also originally Needham's Marxist and Weberian point of departure. As Needham found more and more evidence about science and technology in China, he struggled to liberate himself from his Eurocentric original sin, which he had inherited directly from Marx, as Cohen also observes. But Needham never quite succeeded, perhaps because his concentration on China prevented him from sufficiently revising his still ethnocentric view of Europe itself.[29]"

"J Needham's (1971) monumental work on Chinese nautics offers by far the most scholarly synthesis on the subjects of Chinese shipbuilding and navigation. His propensity to view the Chinese as the initiators of all things and his constant references to the superiority of Chinese over the rest of the world's techniques does at times detract from his argument.[28]"

"However critical I gradually turned of most of Needham’s views, it was his work above all that convinced me of the indispensable aid cross-culturally comparative history of science..."

"Every night I was working: grant, grant, grant. And it came back always no, no, no."

"The idea was to give our cells, thanks to messenger Rna (mRna), the instructions to produce proteins capable of curing diseases. ... with RNA he can make his cells produce that protein continuously for 2-3 days and everything is resolved."

"With mRna I can get my muscle cells to start producing Epo. And even if Epo degrades after two hours and mRna degrades after five days, once you have produced red blood cells they last up to three hundred days. I'm working on an anticancer idea: injecting an mRna into the tumor that prompts the cancer cells to do something that gets the attention of the immune system: release cytokines. It's like saying to the immune cells, "Come here! Come here!"."

"In the American university system you are not salaried: you have to bring the funding for your research, winning scholarships. I kept trying, but my questions were turned down. My research colleagues understood that I was working on interesting things and they subsidized me until the beautiful age of 58. I left the University of Pennsylvania after 24 years of work, without ever having had a proposal for a professorship or a permanent contract."

"Quorum sensing, or the control of gene expression in response to cell density, is used by both Gram-negative and Gram-positive bacteria to regulate a variety of physiological functions. In all cases, quorum sensing involves the production and detection of extracellular signalling molecules called autoinducers. While universal signalling themes exist, variations in the design of the extracellular signals, the signal detection apparatuses, and the biochemical mechanisms of signal relay have allowed quorum sensing systems to be exquisitely adapted for their varied uses."

"Quorum sensing-controlled behaviors are those that only occur when bacteria are at high cell population densities. These behaviors are ones that are unproductive when undertaken by an individual bacterium but become effective by the simultaneous action of a group of cells. For example, quorum sensing regulates bioluminescence, virulence factor expression, biofilm formation, sporulation, and mating. Quorum sensing is achieved through the production, release, and subsequent detection of and response to threshold concentrations of signal molecules called autoinducers. The accumulation of a stimulatory concentration of an extracellular autoinducer can only occur when a sufficient number of cells, a “quorum,” is present."

"... if we could either keep harmful bacteria from communicating, or help beneficial bacteria to communicate, those could be new kinds of therapeutics that could be developed in the future."

"With the right investment, Africa could get real benefits from growing the latest GM crops."

"Feeding the Planet by Leveling the Plowing Field for Women."

"We are not in the business of farming for pests but for food and nutrition.Insects and viruses can be eliminated by low tech biotechnology. This country must invest in that GM technology."

"It's important for us as scientific researchers to engage in some dialogue with the people and Government to help create understanding of biotechnology issues and allay fears."

"There is so much value in having well-meaning mentors and you being receptive and responsive to such interventions."

"All career women struggle with responding to their reproductive needs, and societal pressure to settle down"

"Your achievements have inspired passion among the scientific community for life changing research onto problems that are facing the African continent, especially the smallholder farmer."

"When people push for a quota for a woman among invited speakers for example, I feel terrible as it is a conscious bias. In joint grant application preparation, many investigators think women should not be the Principal Investigators, citing society-assigned roles to women to manage welfare issues and not be a chief planner."

"Follow your dream. Your passion will sustain you through the thick and thin of science and do not forget to deliberately have mentors and champions. These individuals will always fan your flame into fire."

"I was a curious child of educated parents who thought I was a scientist in the making. They sent me to a specialised Science High School and my interest grew stronger and here I am today."

"Evidence has shown that women have the capacity to excel in any field of research provided they have adequate training, enabling environment, and interest."

"I have a peaceful home and I am known in my field of phytoremediation and in community engagement."

"Increase the intensity of advocacy for gender equality in our society. Develop the confidence of mid-career and advanced women scientists to be mentors, as younger female scientists are more motivated when accomplished women scientists serve as mentors, speakers, and leaders in their field."

"Some professional colleagues have shoved aside some of my position papers because they come from a ‘women’. We, as women scientists, often get a ‘second-citizen role’ in science events, activities, and jobs. When people push for a quota for a woman among invited speakers for example, I feel terrible as it is a conscious bias."

"In joint grant application preparation, many investigators think women should not be the Principal Investigators, citing society-assigned roles to women to manage welfare issues and not be a chief planner. Non-flexible work schedules and non-gender-friendly management policies have also not helped the female scientist."

"It feels good. I was always first position in the class for maths and physics. It made me stand out. My father encouraged me, always made me feel like a superstar. I went to as high school specialised in science. I got to love the profession of scientist. I did industrial training (in Nigeria, students have a period of hands on industrial training) with a subsidiary of Nigerian National Petroleum Corporation and experienced hands on environmental monitoring."

"The environment needs to be protected. The degradation has gone beyond what you can sweep under the carpet. I discovered the indigenes are part of the pollution. They tap into the pipeline and do illegal, artisanal refining, but without the technical know-how."

"How did you become involved in scientific research?"

"Crude oil has many components. In the soil, it leaves high concentration of heavy metals, which are inorganic and cannot be degraded by micro-organisms. The current practice by polluters is to use excavations, but that is only shifting the goal post. The goal is to reduce the contaminants to the barest minimum. Polluted land can become viable for agriculture again. I will study a similar process in Poland."

"From pilot studies, we have reached 75% to 80% of heavy metals removal and this biological process can be repeated several times over until desired results are achieved."

"Science is the bedrock of development. The way we live is a biological process. Young girls should be interested in science. Man can crack it; woman can crack it! We have to work hard for what we believe in."

"If you don't engage with people properly, you run the risk of being kidnapped. First I meet the community chief, the women's leader, the youth leaders."

"People get excited and feel like scientists, because they're working with us researchers to fix the problem."

"We also learn from them. They have planting techniques that we don't know - they teach us how to make the solution work in their area."

"I stayed to work in Niger Delta, because my mission is to make my country great."

"We are not here for battle. We just want people to be responsible."

"Being responsible is more important than fighting. It's more enduring."

"Mother nature called on me to be a steward."

"The power of science is that people can prove that this wasn't done based on bias or someone's personal interests."

"We want solutions that are green and based on nature. We aim to do no harm in everything we do."

"Encourage women scientists to act as agents of change."

"Even as a student I was already interested in helping girls enter science. At one time my plan was to provide scholarships to secondary school girls, but when I won the L'OREAL-UNESCO For Women in Science Award I began to aim much higher."

"I have been working with the Nigerian branch of TWOWS (Third World Organization for Women in Science) to encourage women in their research projects and to encourage them to become leaders in our profession. At a meeting of this organization in Cape Town, South Africa I am proud to say that several other L'OREAL-UNESCO For Women in Science Laureates were in attendance. In fact, I took a tape of the 1998 ceremony to show everyone there that L'OREAL and UNESCO really are doing something for women in science."

"Implicit in the devotion to purifying enzymes, is the faith of a dedicated biochemist of being able to reconstitute in a test tube anything a cell can do."

"These scientists, once young and eager, had become gnomes grappling hopelessly with problems far beyond their reach."

"We have left undone those things which we ought to have done, and we have done those things which we ought not to have done."

"Education is a war against ignorance. Quality science education is not cheap. If we are serious about science education, we should declare war on ignorance and provide the necessary resources to fight it."

"When in 1993/94, during the planning of a televised quiz programme on science, I was asked to be the Quiz Mistress, I could not say No."

"Prof Addy was a strong advocate of women in science and a champion of the development of plant medicine who helped place the University of Ghana on the map of world scholarship."

"(Students) take courses in science subjects……The practical component of the program may be dismissed in one phrase: subject to availability of funds…..The fact that finance is the main problem with respect to capacity building in the sciences is acknowledged…Yet, there has been no special initiative to find solutions to the problem. When it comes to science, we in Ghana want to go to heaven but we do not want to die."

"Mitochondria are a badly kept secret. ...There are usually hudreds or thousands of them in a single cell, where they use oxygen to burn up food. ...[O]ne billion ...would fit comfortably on a grain of sand."

"According to mitochondrial gene analysis, man didn't interbreed with Homo Sapiens..."

"[T]he contends that ageing and many of... [its associated] diseases... are caused by... free radicals leaking from mitochondria during normal . ...As they burn up food using oxygen, the free-radical sparks escape to damage adjacent structures ...Many cruel inherited conditions... are linked with mutations caused by free radicals attacking mitochondrial genes."

"From around the mid 1990s, researchers discovered that is... governed... by the mitochondria. ...[T]he failure to commit apoptosis is the root cause of cancer. ...In cancer, individual cells bid for freedom ...Without , the bonds that bind cells in complex s might never have ebvolved."

"[A]ll multicellular plants and animals... contain mitochondria."

"[A]fter a decade of careful , it looks as if all known eukaryotic cells either have or once had... mitochondria."

"[T]he mechanism by which mitochondria generate energy, by pumping protons across a membrane (), is found in all forms of life... It's a bazarre way... This idea, however... won Peter Mitchell a Nobel Prize..."

"Different species have transferred different genes to the nucleus, but all species with mitochondria have... retained... the same core contingent of mitochondrial genes."

"[L]ife will probably get stuck in a bacterial rut elsewhere in the universe... we might not be alone, but will almost certainly be lonely."

"This membrane, so vanishingly thin, looms large... for bacteria use it for generating their energy."

"[[Bacteria|[B]acteria]], the simplest of cells, are... so complex that we still have almost everything to learn about their invisible organization."

"The possessors of... nuclei, the s, are the most important cells in the world. ...[A]ll plants and animals, all and fungi... essentially everything we can see with the naked eye, is composed of [them]..."

"In bacteria, the DNA forms into a long and twisted loop. The contorted tracks... close... to form a singular circular . In eukaryotic cells, there are usually a number of different chromosomes... each has two separate ends."

"[N]o bacteria coat their DNA with s: their DNA is naked. The histones not only protect eukaryotic DNA from chemical attack, but also guard access to the genes."

"The information encoded in DNA spells out the molecular structure of s. This, said Crick, is the 'central dogma' of all biology: genes code for proteins."

"The sequence of letters in a specifies the sequence of s in a protein. If the sequence of letters is changed—a —this may change the structure of the protein (...not always, there is some redundancy... technically degeneracy..—several combinations... can code for the same amino acid.)"

"s are the crowning glory of life. ...[T]he rich variety of life is almost entirely attributable to the... variety of proteins. ...Perhaps the most important group are the s ...biological catalysts that speed up the rate of biochemical reactions ...with an astonishing degree of selectivity for ...raw materials."

"The DNA code is inert... stored safely... For daily use the cell relies on disposable photocopies... made of RNA... composed of similar building blocks... spun out on a single strand rather than the... double helix."

"Does it make sense that life is cellular? Would you expect to find life being cellular elsewhere? I suspect that for organic life... it would be cellular."

"Whether or not it would be possible to drive the kind of protein machinery that you see in modern cells, like an ... that makes the energy currency of life... If it were just sitting there in a in a vent, can work out whether the natural... ion gradients in these vents would be... powerful enough to drive this machine to work. ...[Y]ou need to know what are the substrates, what are... the materials that it needs to operate? Where are they coming from? What's the concentration of them? You realize that you have no answer to any of those, and then what's the product? Well, it disappears off somewhere else, as well. So how can selection act if you've got stuff coming in from some unknown place and the product leaving to some unknown place? It made me realize that cellularization is important as a way of keeping the inside in and in keeping the outside out, and so I now have problems with the idea of seeing the entire vent as a kind of a living system."

"[T]here's a limit to just how far vents can take you... but... once you've gotten as far as , then you've freed yourself from a fairly small energy flow, a fairly tight and focused energy flow."

"It does seem to me, from our experience of life on earth that allows you to... step up, by probably orders of magnitude in just how much life can take over a planet."

"It would be a little disappointing if we didn't even find bacteria in our own solar system. I would be rather surprised to find what I would describe as large, morphologically complex life. ...It only arose once on earth. That doesn't necessarily mean that it's improbable... but it does raise some interesting questions about why, and... I think we can apply principles to it, and those principles effectively are why do bacteria and , as assistive groups to the bacteria... They're biochemically very complex. They're genetically very complex. They're kind of structured in a different way where they have large, complex metagenomes, but... I doubt very much that we'll ever find anything of the [morphological] level of complexity of a flea, composed of bacterial cells."

"One is pretty much the same as another stromatolite, to my eye. That probably gets the stromatolite biologists in a fury, I suspect..."

"I'm not particularly... eucaryocentric, but I do think there is a problem to solve there. ...There is a difference in morphology ..."

"To me it [we] means life as a whole, so I would include bacteria in we. ...Life on earth is a whole, yes I think so. We share the . We share the same cell structures. I feel quite a strong fellow feeling with bacteria."

"If we, meaning humans now... find life somewhere else, most people would be disappointed if it turned out only to be bacteria."

"What is [life] it? Would we even recognize it. What I imagine we would find would be cell-like things. Not a million miles away from bacteria, using , probably in water, not because it's the only way of organizing. It's just that carbon is very good at that kind of chemistry. It's very common in the universe. Water is ubiquitous. We know, from the principles of life on earth, that all this stuff works and we know that it's thermodynamically favored. ...[J]ust statistically, I would expect, maybe 900 times out of a thousand that life would be organized in a similar way to life here. That's not to say it can't be different. It's just probably... going to be similar."

"Now, if we get to complex life and we get beyond organic life forms into artificial intelligence, post-biological, then anything goes and maybe that's what we should be looking for."

"I would define complexity, not really as genetic complexity because if you take it purely as genetic complexity, E. coli... a single cell may have 4,000 genes but the metagenome, the pool of genes in E. coli around the place may be on the order to 30,000 or more... [T]hat's the level of complexity equivalent to the human genome, or even more complex than the human genome, but it's organized and structured in a different way. ...You might say that it's structured in a similar way to an ... but I think an ant colony has taken that level of Eusocial behavior a long way beyond anything you would see in E. coli. So I would define it as morphologically complex, meaning cells are larger and have a lot of stuff in them."

"[W]e are biochemically quite simple in comparison bacteria. Simpler than bacteria. In terms of our metabolic biochemistry we are really limited. ...[W]e have ...across the entire domain of s, about the same degree of metabolic sophistication as a single bacterial cell."

"They [bacteria] haven't used it [their more complex metabolism]... to give rise to more complex morphologies beyond the kind of stromatolite type structures, beyond s. That seems to be a limit. Some multicellularity, some degree of differentiation and complexity, but nothing... to compare with the flea."

"I think we share consciousness right across... not just even the animal world. I would see it going down even to the level of cells, some kind of flickering of consciousness. So I don't feel alone on earth, but I do think that there is something different about humans."

"We also have a power to destroy the earth, and... it's probably unique. ...Destroy ourselves, destroy a large part of life in earth, not the bacteria... If we take ourselves out, we'll give it five million years and it will be indistinguishable, apart from ourselves."

"I'm... interested in the principles of what governs the emergence of life on the planet, with a certain set of resources. Can we understand it? We'll never know what happened, so we'll never know how life started on earth. ...[I]f those principles are enormously difficult, if it turns out that it's a freak statistical accident, then there's little point in studying it and we will gain... very little. If, on the other hand, those principles are reasonable, intelligible, that we can study them in the lab and demonstrate that the steps that we propose are plausible and... we can demonstrate it, then I think that's as close to understanding the origin of life [as] we can get. ...[I]f those principles are generalizable, then as a scientist, that's... a pleasing thing. I'm not sure there's any more that's more pleasing to me, personally as a scientist."

"[W]e can't agree among ourselves, as an origins of life community, what were the conditions... under which life arose on earth. ...Within the field itself, probably the leading candidate... would be terrestrial geothermal systems, starting with and powered by UV radiation. There's been a lot of rather beautiful chemistry... in a terrestrial environment in some kind of geothermal pool... and cyanide chemistry, it works well as chemistry. The problem I have with that is that it doesn't link up very well to biochemistry of cells. I'm a biochemist and I would like to see some continuity between and , and there's not much there, to me. That doesn't mean that it's wrong. It's just that... [I] would like to see some continuity."

"What does life do then? ...it seems reasonable that the earliest forms of life were ic... [i.e.,] they grew from gases... found in normal geological environments through an energy flux which is equivalent to cells which we see today, which is to say, what all life does today. There's a very simple phrase from Mike Russell... "hydrogenate CO2"... [i.e.,] add onto to make organic molecules. That is the structure of in cells, and different cells can get hydrogen from all kinds places. They can strip it out of water. They can get it from , but it also comes bubbling out of the ground as hydrogen gas, and that seems to be the simplest form of life imaginable as... life on earth. It's reacting hydrogen and CO2, and they don't react easily. The way that cells make them react... is to effectively use an electrical charge on a ... [T]here are environments like deep sea s that provide... for free with an equivalent electrical charge across a barrier, and I think... that's the way to see the question."

"[Life is] a continuum. I think there are some phase transitions, probably, and the origin of... genetic information is probably one of them. ...[W]e are doing some modeling work to try and work out how evolvable... a geological system [can] be along the path to getting to cell-like things that... most people would understand as life. How far can you go down that line before you have genetic inheritance? ...[A] long way, but you get to a point where... it's no longer evolvable. ...[I]n our modeling, you can get to a point where you're capable of producing s capable of making copies of themselves with a degree of sophistication, but getting beyond that, to specializing to different niches and so on, I don't see the way, without genetic inheritance."

"I deliberately avoid having... [a working definition of life]. What I quote... is... from Peter Mitchell... a pioneer... of... , that essentially all cells, with very very few exceptions, are powered by... proton gradients across the membrane. So on one side of the membrane surrounding the cell you've got the high concentration on the inside, a low proton concentration [on the outside]. Protons are... the positively charged nuclei of atoms, so... [y]ou're pumping them out and... putting a charge on the membrane... That's as universally conserved across life on earth as the itself, which implies, as a mechanism, it's very early... [I]t's not something anyone ever predicted. It's not something that... emerges from a chemical understanding of the biochemistry of cells."

"It could be any of those [sodium, or other ion gradients]. The fact of life on earth is that it tends to use proton gradients, and we know particular environments that do use proton gradients, and the reason I think protons is because , which is to say the proton concentration, can modulate the reactivity of both and . Now sodium concentrations wouldn't do that, but protons, if you've got gas in alkaline fluids, hydrothermal fluids... what you've got coming out of these s, hydrogen is more reactive in alkaline conditions. It really doesn't want to push its electrons onto something else, but if it's in alkaline conditions it pushes its electrons onto something else, and the protons are left behind and they will react immediately with the hydroxide ions to form water, which is thermodynamically very favored, and so it's far more likely to push its electrons onto CO2 if it's in alkaline solution."

"Now CO2 itself... doesn't really want to pick up any electrons and become reduced to an organic molecule, but if it's in a relatively ic environment where there's s available, it picks up a negative charge. It doesn't want another negative charge. It's going to try and repel that, but if there's a proton around, it picks up the proton. Now it's neutralized the charges... pick up another electron, another proton. So it's much easier to accept electrons in an acidic environment. And this is the structure of these vents and it's the structure of cells, and it's how these earliest, most ancient cells we know about actually do fix CO2. They use the proton channel in the , which effectively locally acidifies an environment and allows this reaction to proceed. So I think that's fundamental, simple... works well, and it's testable in the lab."

"We've had some success and quite a lot of failure too. ...[T]he problem we're having... is reproducing the successes we have had. The big problem... for anyone working on this is that hydrogen gas is not soluble in water at atmospheric pressure. What we really need to do to make this work is to ramp up the pressure in the system to 300 bars and then we need a continuous flow. For this to work you need a across a barrier. Then it should work. We don't know, and we haven't got the funding to build a high pressure reactor. We're collaborating with a group in Utrecht to do that. ...If we can do that experiment and then it fails, then my confidence that this would be a suitable possible origin of life would take a serious knock."

"That's a question about the meaning of life... Why are we here? What are we doing? What's important to us? Why should we struggle to do anything, and I think most of the answers to those questions lie within society itself. ...I don't see a greater meaning, that we've been put here as a species, that we're exceptional in any way. We're just another species. We're very much similar to pretty much everything else, and I think what we've done that's good has been the achievement of society as a whole... [A] lot of people within society... humans have a need for an origins myth, and that origins myth, if it happens to bear some semblance to reality, I think a lot of people are genuinely interested to know what can we say about the origins of the Universe, about the origins of the solar system, about the origins of life. ...[C]an we as ...puny-brained humans come to, through logic, through experiments, through thinking about it, through observations, come to an explanation for how life came to be. It's a grand question. It would be wonderful to know the answer. I think a lot of people would love to know that answer, and I personally would love to know that answer, even if my own views on the subject turn out to be completely wrong."

"Yes I do think that... [viruses] are alive, not for the obvious reasons. ...I was invited to do some filming with the BBC... it was about cells, but they'd been asked to tell a story... about the viral infection of a cell, and I said, "Well I don't know anything about viruses," and they said "No, we just want to know a little bit about early evolution," and I said, "Great, I can talk about early evolution in cells, but I can't really talk about viruses." ...[T]hey said "OK, no problem," and they flew me out to Iceland to some black sand beach that I think had been used in some science fiction movie, and they said "Right, so Nick, what can you tell us about how viruses... drove the early evolution of life?" and I said, "Oh God, guys, come on!" and they said, "No, this is a film about viruses." So I had to think quickly... What I found myself saying was that viruses were parasitic on their environment and can afford to be very simple because their environment is very rich. They live inside cells. Everything that they need is provided for them, but plants are parasitic on their environment. They still need CO2. They still need water. They still need light. ...I wouldn't hesitate to call it [parasitism] a definition of life... [L]ife as a rule is parasitic on its environment, and the level of parasitism depends on the sophistication of the environment. So in that sense viruses use the richness of their local environment to make copies of themselves and they behave with the kind of low cunning that's characteristic of life. So I think of them as alive, yes."

"Viruses are quite sophisticated in the sense that they're forming virion particles and they're infecting other cells... s and things... selfish genes, I suppose in the broadest sense."

"s of some sort [lie between a hydrothermal vent system and a virus] in my mind. The trouble with viruses is that they do need a sophisticated environment to make copies of themselves. Same with selfish jumping genes, transposable elements and so on. They need to be in an environment where they can take advantage of something which is converting the environment into copies of themselves, and there's a rule... This is changing with the discovery of all these es, but as a rule you need some form of to convert the environment into copies of yourself."

"Now it's possible to have some kind of protocell with some form of metabolism without any genetic heredity. It's possible in principle. Is it alive?"

"I read some of those ideas years ago, , and thought it was thrilling. Over recent years I don't really see the need for a kind of genetic intermediary between an RNA level of genetic replication and some other form of replicator. ...[T]here's no suggestion that it's there in biology. There's no suggestion that I know from geology that is capable of giving rise to more complex systems, or to having an organic takeover. It seems to add in a layer of unnecessary complexity. So I much prefer to get straight into organic chemistry, and straight into as we know it."

"[W]hy is metabolism structured this way? There has to be thermodynamic underpinnings for it, otherwise it wouldn't happen. It had to have arisen in the absence of genes... in my mind and therefore there must be environments which are favoring protocells with this kind of metabolism, making copies of themselves... In my mind they have to get better at it, otherwise RNA is just never going to appear."

"Life as we know it has both, and the people who say s first are in effect saying, "Well, there's plenty of s, there's plenty of RNA. The environment's providing it for free," without worrying themselves too much about what kind of an environment is going to provide all of that for free, and by definition, an environment which is effectively metabolically sophisticated enough to provide s is non-living and therefore not part of the question, so they're just pushing it aside. I would say that the whole metabolic side is needed to give rise to genetic information and nucleotides in an RNA world in the first place, that it would be a dirty RNA world contaminated with s and s, and s and things..."

"Whether you define life as living or not is really a matter of opinion... It's a continuum. You can draw a line wherever you want or healthier not to draw a line at all... I think there has to be some form of an environment capable of giving rise to some form of , which is capable of giving rise to nucleotides. ...They would put me in the metabolism first camp, but I dislike the tag... because I think it's simply about... the line across a continuum..."

"It's interesting... that life as a rule does not use UV radiation as an energy source, and the kind of chemistry that's being done using it doesn't resemble biochemistry as I know it... [T]he kind of environment that I'm talking about is deep sea s, and the question is, "Well, does it have to be deep sea? Could it... be same systems on land?" and they exist on land. They perfectly could. So it's perfectly feasible."

"[Yellowstone] are not alkaline thermal vents... There are vents... of this serpentinized hosted systems with alkaline fluids rich in gas. ...A place called The Cedars in northern California ...Ken Nealson is the guy. ...He's done a lot of work up in The Cedars."

"[On the :] It's a bit of a sterile conversation. I suppose I think of it as the cell. That's not to say that it can't act at the level of s. Of course it can. It does all the time. Any selfish gene is acting in it's own interest. I think the trouble with looking at selection only at the level of genes is it tends to downplay the importance of genetic conflict in a strange way... [I]f you have levels of selection you can have, for example... mitochondria... They were bacteria once. They're the power packs inside eukaryotic cells... [O]nce they get inside another cell, inside another originally, then they have an agenda of their own. They're making copies of themselves, and it's the speed at which the bacterium as a whole is making a copy of itself that means whether it tends to dominate in the population or not. It's not the individual genes. They will tend to throw away genes that they don't really need. And the host cell itself has got its agenda. It needs to make sure that it's getting benefits from this symbiont. It's not being taken over. It's not being eaten, and so it's... more intuitive to think of the interests of the cells themselves. And if you simply think of all of them as genes then you don't have that discrimination between the layers. Again, if you're thinking about s at the origin of life, the unit of selection in my mind is, "Can a cell make a copy of itself?" If you have a pure RNA world..."

"[Why a cell vs a gene or partial gene?] There's been plenty of work done on RNA replicators and they have a tendency to become smaller and simpler and effectively better able to make copies of themselves with whatever you provide them in the environment, and they end up with a thing called , which is basically the binding sequence of the which allows it to furiously replicate away. ...If you're providing in the environmwent an RNA polymerase and an infinite supply of s then... they become simpler and simpler, and faster and faster at copying. ...The trouble is there isn't ever going to be an environment that's providing that for you except in a cellular context... If you're selecting at the level of genetic replication, the replicators that are better able to make copies of themselves fast are those which are, in effect, the most selfish and the least likely to cooperate to try and convert the environment into ."

"The only way that you can really get a selfish replicator to be unselfish is to put it in a bag with a bunch of other selfish replicators, and then they're more or less obliged to cooperate."

"So if you think of it from a protocell point of view, the selfish replicators which are the best at making copies of themselves are necessarily those that are best able to make the entire protocell replicate itself."

"What I would say with some degree of certainty from the example of life on earth, is that if you simply have a population of bacteria... the chances of it giving rise to the kind of morphological complexity... we see in eukariotic cells, and we do not see in bacteria, is remote... because bacteria and archaea, if you look at the amount of , they dwarf the genetic variation that we see in Eukaryotes. They have explored genetic sequence space to orders of magnitude greater that Eukaryotes did, and despite exploring all of that space, they haven't come up with morphological complexity. ...[T]hey did through an endosymbiosis. ...It's rare between prokaryotes, rare to the point that we know of one example of free-living bacteria with bacterial cells living inside it. We know of two other examples where, there's a for example, which has inside its own cells... some gamma protein bacteria, with beta protein bacteria living inside them. It's a little bit of a strange system and it's hard to know, again, can you generalize from this, because it's all inside a Russian doll?"

"So there's one example of free living ... with bacteria living inside it. It wasn't . It's got a cell wall and it's not a . So they can get inside, but we can say for sure it's rare. What does it do? In a nutshell it changes the topology of the cell. It allows you to internalize respiration and it's not just internalizing the membranes. It's internalizing a genetic control system with in our own case, which by standard selection is whittled down to a kind of minimal unit required to do the job, and that in effect allows the nuclear genome to expand up to anything it wants to be. So... it's a structural change. It's not something which you can find by genetic exploration of the evolutionary space. It's something [in] which you change the topology of a cell. And once you've got that, you've got bacteria living inside another bacterial cell. You've got a fight on your hands! They've got to get along with each another somehow. So the chances of it going wrong is quite high. So I would imagine if we know of one or two examples now, there must have been thousands, millions, billions of cases of this over earth history. The fact that... all this searching across the earth that we've done for life, we find bacteria, we find , we find these candidate phyla. We're not sure what they are, exactly, but they seem to be very simple and probably s, and we see Eukaryotic cells, all the cases that appear to be potentially evolutionary intermediates, something slightly different, have turned out to be highly derived... from more complex ancestors."

"I would say that if there's a probability of life being cellular, which I think there is. Life being based, which I think there is. Life starting out with CO2 because it's so common in planetary atmospheres, and , which is very common, from the kind of s which I'm talking about... and liquid water. They need liquid water for , but we know of it on ... on Europa... [Serpentinization] is giving rise to alkaline fluids with hydrogen gas. Most hydrogen gas you find in planetary atmosphere are coming from serpentinization. , which is the mineral required for that... is ubiquitous in interstellar dust... So all of this pushes you down a certain avenue, and if that's correct it gives you bacteria... and if that's correct then bacteria have a structural problem, and they're not going to get beyond bacteria except with an endosymbiosis, and that in itself is improbable, unlikely... because it only happened once, to our knowledge, on earth."

"The s were acquired by a eukaryotic cell that was already a fully fledged eukaryotic cell."

"[A]cquiring mitochondria gives you a headache that can go wrong very easily, but here's an interesting problem in a nutshell. You look at a plant cell under a microscope, or an animal cell, or a fungal cell, or an or something, and you'll recognize the same structure in all of them. They've all got a nucleus. They've all got the s as straight chromosomes. They've all got s. They've all got s. They've all got complexes. They all do as a division mechanism. They all do as two steps where you first double everything and then half it twice. They all go through the same rigmarole. They've all got mitochondria. They've all got the same system, endoplasmic reticulum, things like that. ...[Y]ou could list page after page after page in a text book and it would be exactly the same for a plant, or a fungal cell, or an animal cell. Now they have really different ways of life. If you were to simply think, "Well, there's some inevitability that bacteria will give rise to complex life." ...You would imagine that a photosynthetic bacteria, a would give rise directly to photosynthetic , eukaryotic algae, but they didn't. It was by the intermediary of acquisition of a . There was a common ancestor of eukaryotes that was nothing like a cyanobacterium and nothing... quite like an algae except without the chloroplasts. So... why is it that we all have the same machinery inside, but we have such different lifestyles? Why don't we see multiple origins of complex life where cyanobacteria give rise to photosynthetic trees? Why don't we see predatory bacteria?"

"These are all lifestyles that exist in bacteria anyway. ...Photosynthesis obviously. The only eukaryotic lifestyle that does not exist at all in bacteria is ... the ability to engulf other cells, to grow around them. That's never been found yet in bacteria. It seems to require... a lot of energy, a large complicated system capable of changing shape and moving around. ...For whatever reasons it never evolved. I would say the reason was that you need mitochondria to get that large and complex in the first place."

"A single discovery tomorrow could disprove everything I'm saying now. That's quite thrilling. ...We have been looking for several hundred years since Leeuwenhoek and we've not found anything really shocking that falls out of the system."

"We all share this basic machinery in cells, and it's not related to whether you're photosynthetic or whether you're phagocytes or whether you are a fungus or whether you're an animal cell. We all share the same machinery. Why? The possibility is that it's not about adaptation to the external world, it's about adaptation to these s. These pesky bacteria that went on to become a mitochondria. Maybe this conflict of interest... [that] had to be resolved somehow was what was driving a lot the elaboration of cellular machinery. It's a kind of local... intimate conflict."

"I wouldn't expect populations of bacteria to give rise, without endosymbiosis, to complex morphology and the kind of intelligence that we have, elsewhere. I think that it would require (I'm going out on a limb here)... an endosymbiosis for the reasons I've been saying, and... that endosymbiosis is a) rare and b) likely to go wrong. So I can't put a number on how improbable it is. It's just that I would say that it's a factor that a lot of people would rather not think about. If you have an agenda where you'd like to find complex life out there, the SETI people for example... probably don't want to hear this kind of stuff. It says that it's less likely... it's not an inevitable outcome of physics."

"I think there's plenty of solutions to Fermi's paradox, that we don't need to add this as an extra one, but yes, this would be my favorite explanation for it, that there is no inevitability about complex life, that there's nothing in the laws of cosmology that say, "[Complex] Life will start." I think that there probably is something in the laws of cosmology lending itself towards bacteria, but the idea of more complex life... I certainly wouldn't see a Simon Conway Morris view, for example, that the origin of life is so complex that you require God to put everything in motion and then will take you all the way to humans."

"I said you [bacteria] are not morphologically complex, you are biochemically awesome."

"[I]t's interesting to me that the bacteriophages, the viruses that you find in bacteria, are not remotely similar to the ones that you find infecting archaea, which again are not remotely similar to eukaryotic viruses. ...They're different in their appearance. They're different in their mechanisms in which they force their... I mean the bacteriophages are these classic lunar module landing things... They are stunning things to look at. ...Some es look like bottle balls or postage stamps, strange shapes... They don't have any genes in common. They don't have mechanisms of entry into cells in common. They appear to be independently derived."

"That's why they [viruses] are not in the tree of life. They don't relate in a very direct way. ...[T]he tree of life now is not only about ribosomes. You can build trees from whole genomes, but viral genomes? They don't really fit in, in a way which makes sense to people."

"I've been asked on various occasions, "Why don't we, as an origins of life community, get together, think what a killer experiment is, and then go and build a or something, where we go and do the experiment?" And the answer to that is... [W]e can't agree with each other about what experiment would you do? ...[I]t is intrinsically a lot more complex, precisely because it's a continuum. We don't know. We don't agree about what environment, we don't agree about what kind of chemistry or biochemistry. We can't join these things up, and so it seems to me a much healthier environment is to be deliberately multiple about it. Not to say, "Ok, this particular world view is going to dominate." I think we have to have multiple views until we know more."

"I like philosophers. I think they can teach scientists how to think very often, and... there's a lot of sloppy thinking among scientists, and I think philosophers can be quite rigorous about it. It gets a lot of scientists cross with philosophers who don't engage with science, but I think there are more philosophers these days who are engaging in a serious way with science. I think they have important things to say."

"[Martin Rees] may be right. If we were to go back 5 million years, as intelligent apes, and ask ourselves "What is postbiological life?" I think the answer is it's not a concept that would possibly mean anything. So we've had... 4 billion years of life on earth, and it's come up with an enormous wealth and variation, but it's all organic and... the chances of it coming up with humans? I can't put a number on that. ...I don't think there's an inevitability that life, once it's started will give rise to a human-like intelligence or beyond that. I think there's nothing inevitable about it, and if we just go back a few million years on earth, there was nothing inevitable about it. So I, personally would still look for organic life, but... I'm not sure that would be the easiest thing to find. It may be that it's easier to find, yes, nano aliens or something."

"It requires that life elsewhere should be modeled along similar lines to life here, which is that it should be cellular, it should be carbon-based. It should be in water. If those things are not true, then there's no reason why that numbers game would apply anywhere else. But if those things are true, then yes, I think the fact that photosynthesis only arose once, that Eucaryotes only arose once, that what Nick [Nicholas J.] Butterfield calls organ grade multicellularity, which is to say quite serious differentiation with scores of different cell types and specializations. We don't see that in fungi. We don't see that in algae. ...[Y]ou see two or three different types of cell. So that's rare. It's in plants and it's in animals. It begins to look less likely. I think it's reasonable to say it's less likely, but I wouldn't like to rely too much or put too much weight on it."

"[On the controversy between and .] [T]he classic case of convergence would be the eye and the human eye, or ian eyes. ...The common ancestor they had had a light sensitive spot, they did have some regulatory genes in common... for example, but that had to effectively independently recruit all the rest of the genes required to make a camera type eye, and that direction of evolutionary travel was in parallel. It was convergent. We even see in some s... a camera-type eye in single-celled critters where there's a retina made from s. There's a made from mitochondria. There's a there. They don't have a brain. I don't know how they use this thing but... plainly it's a camera-type eye. ...It's a of some sort. ...I would see that as a completely independent origin of a camera-type eye, albeit without a brain. I would see the octopus' and mammalian eye as being convergence in the Simon Conway Morris sense... There are certain ways that you can make an eye, that work, and all the steps along the way have to be favored, and... perhaps there are seven or eight... fundamentally different types of eye that we see on earth, and most of them have arisen more than once, always from a common ancestor, generally, that had as a light sensitive pigment. So you're then into an interesting terrain or... How common are the right types of light sensitive pigment? They're chemically not so straight forward."

"I do like this quote from Simon Conway Morris that if the aliens call then don't pick up the phone. I'm not sure I'd really like to meet any of them very much. Perhaps... meeting bacteria would be the least scary... [T]he chances of meeting aliens is so remote that I haven't really troubled myself very much about it. It would be nice to think that if we did, somehow they would be a superior intelligence... they would have solved a lot of the problems of aggression and whatever else that humans have, but I fear not. I fear that it would be the opposite, that... natural selection has a knack of producing nastiness in intelligence."

"Does anyone care if there's an awful waste of space? It's a form of wishful thinking... We would love for the Universe to be full. ...Personally, I grew up on the Hichiker's Guide to the Universe, those kind of crazy science fiction yarns, or Star Wars or whatever it may be. The idea that the Universe is full of other intelligent beings, all kind of finding a way of getting along or having a war, but having some heroism thrown in, but... it's all human vision of ourselves thrown onto a cosmic scale. Do I believe any of it? No... Is there anything that I think, from my understanding as a biologist, that would tend to lead to that? No... Does it matter if it's a tremendous waste of space? Well, that's to say "What's the point of the Big Bang?" I don't know. The idea that the Universe may be completely empty apart from matter and energy? It would seem to be, perhaps, the default hypothesis. The fact that we find life is surprising. It would be nice if there were laws of the Universe that tended to give rise to life. Maybe there are at the level of bacteria. I don't see it at the level of large, morphologically complex beings... I think it's emotive. It's pleasing, but I doubt it's true."

"[M]ost of what I teach and interact with the students is more about life on earth and the principles governing evolution, and from my own point of view, the biochemical side, which is not normally part of the evolutionary biology... [I]t's relatively rare for me to discuss life elsewhere in the Universe with them."

"Thew problem here for me is that I'm in a biology department and is still somewhat frowned upon by a lot of biologists who would see it as a form of speculation. So the courses that I teach are about life on earth and they're not so much about life in the Universe... [I]t is something that I should develop, I think."

"There are people at UCL, Ian Crawford, who's doing a great deal for , but it's not something which is happening through my department. It's happening through s. It's not happening in biological sciences..."

"I've had long and sometimes difficult discussions, especially about the singularity of the origin of Eukaryotes... A lot of people don't like that. ...[I]t's not really about what does it say about the probability of life elsewhere, although it has things to say to that. It's really about life on earth, and a lot of people are very uncomfortable with the idea of improbability... I've had quite difficult discussions with some students about that, but rarely... about life elsewhere in the Universe."

"I see myself as a biologist or a biochemist, but... in the context of as a broader subject, it forces me to wrestle with physics, with cosmology, with chemistry, with geology, with earth sciences or planetary sciences, and that's a thrill. ...I think it's what most people are drawn into science in the first place for, because science, in its biggest sense, is what inspires people, and by the time that you've got to the level of doing a PhD, it's narrowed down so much that a lot of people are almost forced to lose their imagination, and their creativity as a scientist... I think astrobiology is a subject that puts all that back in, in heaps."

"No, we're not alone [in the universe]. We share it with lots of friendly bacteria [and this includes bacteria on other planets]."

"For decades, biology has been dominated by information—the power of genes. ...[Y]et there is no difference in the information content of a living protozoon and one that died ...The difference between alive and dead lies in energy flow ...the ability of cells to continually regenerate themselves from simpler building blocks."

"Even the laws of thermodynamics... can be recast in terms of information — Shannon entropy, the laws of bits of information. But this view generates its own paradox at the origin of life. ...Place information at the heart of life, and there is a problem with the emergence of function ...the origin of biological information. There are problems... in understanding why we age and die... diseases... and how experiences can give rise to conscious mind. ...A far better question ...what processes animate cells and set them apart from inanimate matter?"

"This book will explore how the flow of energy and matter structures the evolution of life and even genetic information."

"It is the movement that creates the form."

"Flux is a form of flow, but with one crucial difference. ...In biochemistry flux is the flow of things that are transformed along the way."

"[[w:Flux (metabolism)|[M]etabolic flux]]... Even a simple bacterial cell can undergo... a billion trnasformations per second... is... what being alive is."

"became the study of how... simple molecules were interconnected one into another. ...The [simple] molecules ...containing ...up to about twenty carbons, but most ...have fewer than ten."

"[B]iochemical pathways that produce the basic building blocks of life are... conserved across practically all cells."

"The double helix of DNA... is composed of two long chains [of 'letters'] that snake around each other... each strand providing an exact template for the other. ...[E]ach strand ...contains just four types of letter, with ...billions ...arranged down... the chain. ...3,000 million letters ...make up the human genome ...[T]he same — the same lines of code — can have different effects depending on the context."

"The is riddled with redundancy."

"The driving force of is thermodynamics. ...[I]n this context ...the chemical need to react (to dissipate energy) in the same way that water needs to flow downhill."

"If the Krebs cycle is ordained by thermodynamics, then it should take place spontaneously in some suitably propitious envirnonment, even in the absence of s."

"The inner logic of ... Much of it is imposed by thermodynamics; some is facilitated by catalysts. Some is refined by genes. And part stems from the vicissitudes of life itself, which forced evolution down improbable paths, while transforming our geologically restless globe from a sterile, anoxic planet into the living, high-octane world of today."

"In Transformer, Lane indulges in a great many of the banes of popular science writing... These kinds of over-earnest attempts to defang a complicated subject are an enduring mystery; the people who need them won't read the book, and the people who'll read the book don't need them. ...Fortunately, Lane’s discussion ...is itself very winningly animated, and that saves it ...Lane’s personal excitement ...goes a long way toward making ...biochemistry comprehensible ...[T]his is done through personalities; Transformer is as much about the people investigating the Krebs cycle as it is about the cycle ...That kind of personality pervades the book and makes it ...consistently fascinating reading."

"I read a book called The Vital Question. ...A few months later... I had also ordered Nick’s three other books, read two of them, and arranged to meet him in New York City. ...He is one of those original thinkers who makes you say: More people should know about this guy’s work. ...Nick is talking about how getting energy right at the cellular level explains how life began, and how it got so complex. ...I'm intrigued by the practical applications of Nick’s work. Mitochondria could play a role in diseases like cancer. ...[O]ur foundation’s global health team is talking to Nick about the potential implications for the fight against malnutrition. ...[T]here’s no telling whether his specific arguments will turn out to be right. But even if they don’t, I suspect his focus on energy will be seen as an important contribution to our understanding of where we come from, and where are we going."

"Nick Lane thinks life first evolved in hydrothermal vents where precursors of metabolism appeared before genetic information. His ideas could lead us to think differently about aging and cancer."

"Knowledge not only has to be compiled and presented, it also has to actually reach people. We worked on how we expressed ourselves, and always remained as objective as possible. Knowledge from other disciplines helped us communicate."

"I mean a lot of African countries cannot meet the AU requirement of 15% of your GDP"

"I think that, my expectations from this conference, is that, we must be able to have a good leverage when it comes to health issues"

"Climate change is a phenomenon that has come to stay with the world, so the public needs to be educated on the nature and how to cope with the situation"

"Climate change" affects more than just a change in the weather; it refers to seasonal changes over a long period of time"

"We must work together as a team – both developing countries and the developed countries. And I think that the issue of knowledge sharing is very, very important because these days, viruses, bacteria, they don’t know whether you’re a developing country, or you’re a developed country. Looking at the various epidemics, that, we’re experiencing all over the world. So, this is the time that we need to forge together, work together, share our knowledge and then also help regional institutions with common focus to enable us fight the disease burden."

"Well, I think, yes, he will still achieve his zero level tolerance towards corruption. I think it’s something that happened about two to three years ago. And the Ministry of Health, we have instituted an enquiry into the importation into the country of these fake condoms, the culprits are going to be dealt with and we’ll make sure that the policies regarding inspection and importation of, not only condoms but medicines, and any medical logistics would be strengthened."

"In Ghana, we have some priority; we’re looking at access to quality health care and then we’re also looking at maternal and child health care; we’re looking at providing skilled medical personnel, doctors, nurses, midwives, to support maternal and child care. Then we’re also looking at strengthening community health centres across the country which we call the chip compounds."

"Basically, it means that we can reach out to the vulnerable community to provide them with basic health care; and on our high agenda is also dealing with malaria, tuberculosis, HIV. So, these are some of the critical areas that the ministry is dealing with; and of course, public health. And when we talk about public health, we are talking about prevention, we’re talking about information and also we’re talking about immunization and then also dealing with epidemics our readiness to combat epidemics as it surfaces."

"... More explicitly than ever before the modern principles of physical science seem to compel us to recognized absolute mechanical necessity in all things. We may not understand organic regulations, or organic evolution, or the origin of life; in fact we are still unable with the necessary clearness to represent to ourselves the structure of a cell; yet theses are at least phenomena. As phenomena they are subject to the two laws of thermodynamics. For the laws of conservation and degradation of energy have long since supplanted Leibniz's rudimentary idea of the conservation of ', as the ground of our conception of necessary causation."

"It is in proportion to our success or failure in conceiving facts simply that sciences are abstract or concrete, rational or descriptive. In these respects the contrast is great between the physical and the biological sciences. The figure of the earth, its path about the sun, and its relations to the other planets are readily conceivable in a first approximation as simple; but the forms of life seem complex, their activities manifold, and the concatenations interminable. Therefore, unlike celestial mechanics, the science of biology, which is the record of efforts accurately to describe and clearly to understand living things, is chiefly a science descriptive of concrete fact. It bears little resemblance to the more perfect science and as yet is in no danger of a relativist revolution. It has never attained, perhaps, as some have argued, it can never in any respect achieve and should not strive for the abstractness, the elegance, and the simplicity which are the mark of the classical epoch of many the physical sciences and the ideal of those who follow Newton and Willard Gibbs."

"Four centuries ago, Machiavelli was thinking of certain great problems of human society and writing two famous books. In so doing he reached scientific generalizations about the influence of the sentiments upon the actions of men and, through these actions, upon the fate of human societies. As a whole, these conclusions stand; but from this great and ingenious work of Machiavelli's almost no developments have followed. The science of statecraft and of the influence of the sentiments upon human behavior is little different to-day from what it was in in the 16th century."

"Matooke is a very starchy food, more so even than maize or potatoes. We realised we could do more with matooke flour than with maize, if you add matooke flour to wheat or maize flour, you get a better product. With its nutrients it can be used as an alternative to wheat."

"By adding value, farmers can sustainably produce bananas as a food and to increase income."

"I grew up in a family that so much cherished matooke as a food crop and as a child, I started developing a special attachment to the same. However, I later realized that there was not much literature or research done on matooke."

"Uganda is among the top five leading banana producers in the world, with a 30% estimated contribution to the world banana production."

"The establishment of BIRDC has presented to Uganda an opportunity to showcase a variety of tooke products with a unique taste and full nutritional value on the world market. The products exported are branded in such a way that promotes our country and culture on the international scene."

"I believe the benefits of two civilizations – a European education followed by the freedom and opportunities of this country – have been essential to whatever contributions I have been able to make to science."

"My own belief is that science remains the most powerful tool we have yet generated to apply leverage for our future. It is the instrument which is most useful for guiding our own destinies, for assuring the condition of man in the years to come. I have much to hope that we will not abandon that tool, leaving us to our own brute devices."

"I am very happy, now more motivated. I feel there is now more to do because people are asking questions. I feel that there is a long road to travel and we have only just started."

"Jamaica can really run with yam. In fact, Jamaica should be in a position where, at the next Olympics, we have bombarded the market with yam products. The world is looking out for that."

"The best thing that has ever happened to me is becoming a mother and entering into a personal relationship with the Almighty Father through Jesus Christ."

"My research into yams, which originated in Nigeria and was fostered in Germany, became buttressed in Jamaica and has since radiated out to many parts of the world, resulting in many UWI-trained PhD scholars."

"A previous publication reported the occurrence of in the eyes of all rats fed on rations containing as the chief source of . Negative results with other carbohydrates tested led to an investigation of as the next logical step. This sugar was fed to young rats at 35% and 25% levels corresponding to the galactose available from the 70% and 50% lactose rations fed in previous experiments. Four rats on the 35% galactose ration developed mature bilateral cataract in 12, 14, 14, and 37 days respectively (average 19 days), whereas those on the 25% galactose ration were somewhat more delayed. The average time for the development of mature bilateral cataract in 49 rats fed the 70% lactose ration was 10 weeks, approximately 4 times as long. Controls fed on the 70% starch ration showed no eye changes."

"... Even minor during the growing period may prevent full potential growth from being attained. ... Growth potential is not a thing that can be speeded up and lowed down and still obtain the same end results. According to ..., if one does not use the full potential alI the way along, one does not achieve full development. The same ultimate weight may be reached but not the ideal shape and composition. If the rate of growth is sufficiently slowed down, the adult is not only smalI but under-developed with normal or nearly normal head size, moderately retarded trunk and relatively short legs."

"(quote from p. 521)"

"Remember that there were no in the 1920's, and every had to depend on a few recognized authorities for estimates of needs of children. In 1923, called attention ... to the protein needs for optimal growth in rats which he estimated to be about 15 per cent of the calories. He contrasted that with which provides only 7 per cent of the calories in the form of protein, to provide for the growth of the infant. He also emphasized what and had demonstrated earlier that animal proteins were more efficient for growth than plant proteins."