Screenwriters From The United States

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April 10, 2026

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April 10, 2026

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"Specific to spinal cord injured patients, immuno-suppressive drugs are not an option in a stem cell transplant procedure because of the increased risk of side effects. Spinal cord injuries cause many individuals to be more susceptible to respiratory infection due to an inability to clear secretions, limited chest movement, and a need for ventilation assistance. In addition, there is a greater risk of bladder infection and sepsis due to chronic catheterization. Some spinal cord patients who incur an infection are further compromised by the infection seeding around the heart. Urinary tract infections and skin breakdowns due to immobility are common causes of dsyreflexia, an event which often triggers heart attacks and strokes. I have been told by Dr. John McDonald of Washington University in St. Louis, that because this immune system of a spinal cord patient is already so compromised, it would be irresponsible to transplant stem cells into an individual that did not match his or her own DNA. Although there is still a risk of rejection, no reputable doctor would prescribe Cyclosporin, the leading immuno-suppressive drug therapy, to a spinal cord injured patient because the risk of death is too great. Somatic cell nuclear transfer could dramatically improve the treatment efficacy of any stem cell transplant because it uses one's own genetic makeup. In addition, there is the potential of eliminating the risks and side effects associated with highly toxic immuno-suppressive agents."

- Christopher Reeve

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"With the life expectancy of average Americans heading as high as 85 to 90 years, it is our responsibility to do everything possible to protect the quality of life of the present and future generations. A critical factor will be what we do with human embryonic stem cells. These cells have the potential to cure diseases and conditions ranging from Parkinson's and multiple sclerosis to diabetes and heart disease, Alzheimer's, Lou Gehrig's disease, even spinal-cord injuries like my own. They have been called the body's self-repair kit. Their extraordinary potential is a recent discovery. And much basic research needs to be done before they can be sent to the front lines in the battle against disease. But no obstacle should stand in the way of responsible investigation of their possibilities. To that end, the work should be funded and supervised by the Federal Government through the National Institutes of Health (NIH). That will avoid abuses by for-profit corporations, avoid secrecy and destructive competition between laboratories and ensure the widest possible dissemination of scientific breakthroughs. Human trials should be conducted either on the NIH campus or in carefully monitored clinical facilities. Fortunately, stem cells are readily available and easily harvested. In fertility clinics, women are given a choice of what to do with unused fertilized embryos: they can be discarded, donated to research or frozen for future use. Under NIH supervision, scientists should be allowed to take cells only from women who freely consent to their use for research. This process would not be open ended; within one to two years a sufficient number could be gathered and made available to investigators. For those reasons, the ban on federally funded human embryonic stem cell research should be lifted as quickly as possible. But why has the use of discarded embryos for research suddenly become such an issue? Is it more ethical for a woman to donate unused embryos that will never become human beings, or to let them be tossed away as so much garbage when they could help save thousands of lives?"

- Christopher Reeve

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"Welcome back! If you're wondering where our good friend -- Kevin Eubanks couldn't be here. Kevin is on tour. He's in France right now. He called me today and he's over there and he wouldn't be back until next week. So if you're wondering where Kevin Eubanks is, he's with us in spirit certainly. Okay. Boy, this is the hard part. I want to thank you, the audience. You folks have been just incredibly loyal. (emotionally) This is tricky. (laughs) We wouldn't be on the air without you people. Secondly, this has been the greatest 22 years of my life. (applause) I am the luckiest guy in the world. I got to meet presidents, astronauts, movie stars, it's just been incredible. I got to work with lighting people who made me look better than I really am. I got to work with audio people who made me sound better than I really do. (voice breaking) And I got to work with producers! And writers! (choked pause) And just all kinds of talented people who make me look a lot smarter than I really am. I'll tell you something. First year of this show, I lost my mom. Second year, I lost my dad; then my brother died. And after that, I was pretty much out of family. And the folks here became my family. Consequently, when they went through rough times, I tried to be there for them. The last time we left the show, you might remember we had the 64 children that were born among all our staffers that married. That was a great moment. And when people say to me, hey why don't you go to ABC? Why don't you go to FOX? Why don't you go…? I didn't know anybody over there. These are the only people I have ever known. I'm also proud to say this is a a union show. And I have never worked (applause) -- I have never worked with a more professional group of people in my life. They get paid good money and they do a good job. And when the guys and women on this show would show me the new car they bought or the house up the street here in Burbank that one of the guys got, I felt I played a bigger role in their success as they played in mine. That was just a great feeling. And I'm really excited for Jimmy Fallon. You know, it's fun to kind of be the old guy and sit back here and see where the next generation takes this great institution, and it really is. It's been a great institution for 60 years. I am so glad I got to be a part of it, but it really is time to go, hand it off to the next guy; it really is. And in closing, I want to quote Johnny Carson, who was the greatest guy to ever do this job. And he said, I bid you all a heartfelt good night. Now that I brought the room down, hey, Garth, have you got anything to liven this party up? Give it a shot! Garth Brooks!"

- Jay Leno

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