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April 10, 2026
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"[R]ecent experience has shown that even the most formidable lobbyists cannot derail legislation that has bipartisan and public support. The NRA was not successful in repealing the ban on assault weapons. The American public watched in disbelief as a dozen tobacco company executives testified at a Senate hearing that nicotine is not addictive and denied allegations that nicotine levels were being raised in cigarettes in order to increase addiction. Now we are witnessing the demise of the "Marlboro Man" and "Joe Camel". There are lawsuits in virtually every state by individuals demanding punitive damages against the tobacco companies. Just this week, thousands of government workers petitioned the President to ban smoking in government buildings. I sincerely doubt that the tobacco lobby will be able to stop this initiative. The religious right led by Pat Robertson, Pat Buchanan and the Christian Coalition tried twice unsuccessfully (in 1992 and 1996) to hijack the Republican Party and failed in both attempts. Here again, was a case when a supposedly powerful lobby did not succeed in promoting their agenda."
"We must not stop this progress because we are unwilling to commit enough money to get the job done. It is imperative that the public--and more importantly our elected representatives understand that research today is not speculative. It is not a waste of money. It is the only way to relieve suffering while helping to save the American economy at the same time. Making this a reality demands an investment of real dollars--funds that just don't fit within the constraints of the Budget Agreement passed by Congress this week, which proposes to reduce overall health spending by $100 million next year and by more than $2 billion over the next 5 years."
"When I met with the President in May of 1996, he stated that the ratio of research to clinical results is greater in this country than anywhere else in the world. Money spent on research brings practical results that absolutely justify the investment. Let's look at a few examples. NIH-sponsored research has resulted in the identification of genetic mutations that cause osteoporosis, Lou Gehrig's Disease, cystic fibrosis and Huntington's disease. Effective treatment for Acute Lymphoblastic Leukemia (ALL) has been developed and today nearly 80 percent of children diagnosed with ALL are alive and disease-free after 5 years. Because of research, the nature of medicine is changing. We are approaching disease at the cellular level. We are targeting problems earlier, more specifically, less intrusively, with greater success and fewer side effects. Advances in genetics will soon let us intervene in disease before symptoms appear."
"What I do is based on powers we all have inside us; the ability to endure; the ability to love, to carry on, to make the best of what we have — and you don’t have to be a ‘Superman’ to do it."
"Perhaps it is my job to offend some scientists. I'm not asking them to be reckless or unprofessional, but I do want to reinforce a sense of urgency."
"It gives me a moral compass. I often refer to Abe Lincoln, who said, "When I do good, I feel good. When I do bad, I feel bad. And that is my religion." I think we all have a little voice inside us that will guide us. It may be God, I don't know. But I think that if we shut out all the noise and clutter from our lives and listen to that voice, it will tell us the right thing to do. The Unitarian believes that God is good, and believes that God believes that man is good. Inherently. The Unitarian God is not a God of vengeance. And that is something I can appreciate."
"In the early '80s, the public discourse about AIDS was divisive and ugly. Some elected officials said the disease was God's revenge on people who lived a certain lifestyle. The federal government wouldn't fund research for a cure. But, today, the NIH spends $1.8 billion on AIDS research annually, and the virus is no longer an epidemic in this country. So, how did we get from that climate of fear and animosity in the early '80s to where we are today? Well, it's by the extraordinary efforts of ordinary individuals, then change occurred, as it has time and time again throughout our history."
"The budget of the National Institute of Health in 1998 was 12 billion dollars. However, due to Congress and also got pressure applied by a number of disease groups, the budget for fiscal 2003 will be 27.2 billion dollars. And human ... HHS Secretary Thompson has said there is plenty of money available for the kind of research. Doubling the budget of the NIH and more within five years has been an extraordinary accomplishment. So to say that there isn't ... I mean, more money would be nice, but to say there's not enough money to do research into therapeutic cloning is a false statement."
"Specific to spinal cord injured patients, immuno-suppressive drugs are not an option in a stem cell transplant procedure because of the increased risk of side effects. Spinal cord injuries cause many individuals to be more susceptible to respiratory infection due to an inability to clear secretions, limited chest movement, and a need for ventilation assistance. In addition, there is a greater risk of bladder infection and sepsis due to chronic catheterization. Some spinal cord patients who incur an infection are further compromised by the infection seeding around the heart. Urinary tract infections and skin breakdowns due to immobility are common causes of dsyreflexia, an event which often triggers heart attacks and strokes. I have been told by Dr. John McDonald of Washington University in St. Louis, that because this immune system of a spinal cord patient is already so compromised, it would be irresponsible to transplant stem cells into an individual that did not match his or her own DNA. Although there is still a risk of rejection, no reputable doctor would prescribe Cyclosporin, the leading immuno-suppressive drug therapy, to a spinal cord injured patient because the risk of death is too great. Somatic cell nuclear transfer could dramatically improve the treatment efficacy of any stem cell transplant because it uses one's own genetic makeup. In addition, there is the potential of eliminating the risks and side effects associated with highly toxic immuno-suppressive agents."
"With the life expectancy of average Americans heading as high as 85 to 90 years, it is our responsibility to do everything possible to protect the quality of life of the present and future generations. A critical factor will be what we do with human embryonic stem cells. These cells have the potential to cure diseases and conditions ranging from Parkinson's and multiple sclerosis to diabetes and heart disease, Alzheimer's, Lou Gehrig's disease, even spinal-cord injuries like my own. They have been called the body's self-repair kit. Their extraordinary potential is a recent discovery. And much basic research needs to be done before they can be sent to the front lines in the battle against disease. But no obstacle should stand in the way of responsible investigation of their possibilities. To that end, the work should be funded and supervised by the Federal Government through the National Institutes of Health (NIH). That will avoid abuses by for-profit corporations, avoid secrecy and destructive competition between laboratories and ensure the widest possible dissemination of scientific breakthroughs. Human trials should be conducted either on the NIH campus or in carefully monitored clinical facilities. Fortunately, stem cells are readily available and easily harvested. In fertility clinics, women are given a choice of what to do with unused fertilized embryos: they can be discarded, donated to research or frozen for future use. Under NIH supervision, scientists should be allowed to take cells only from women who freely consent to their use for research. This process would not be open ended; within one to two years a sufficient number could be gathered and made available to investigators. For those reasons, the ban on federally funded human embryonic stem cell research should be lifted as quickly as possible. But why has the use of discarded embryos for research suddenly become such an issue? Is it more ethical for a woman to donate unused embryos that will never become human beings, or to let them be tossed away as so much garbage when they could help save thousands of lives?"
""Neglect - even misstatement - of recent scientific data was also evident in last year's testimony before this subcommittee by the Christopher Reeve Paralysis Foundation. Mr. Reeve, on behalf of the Foundation, testified that adult stem cells are no substitute for embryonic cells because they cannot be "pluripotent" but are confined to a narrow range of specialization. Yet a few weeks after that hearing, researchers funded by the NIH and the Christopher Reeve Paralysis Foundation published a study indicating that adult bone marrow stem cells "may constitute an abundant and accessible cellular reservoir for the treatment of a variety of neurologic diseases." The first sentence of the published study states: "Pluripotent stem cells have been detected in multiple tissues in the adult, participating in normal replacement and repair, while undergoing self-renewal. The authors cite eleven other studies in support of this observation. Their article, prepared under the aegis of Mr. Reeve's foundation, was received for publication in March 2000, before Mr. Reeve testified in April that adult stem cells cannot be pluripotent."
"In 1984, the government spent zero dollars on AIDS research, because AIDS was thought to be a death sentence, and the virus was far too complicated to deal with. Today, the government spends annually $1.8 billion a year on research, and people who would have been dead four or five years ago now have the virus virtually undetectable in their bloodstream, and they're living normal lives. That was something thought impossible until we put money and talent together and aimed it toward a problem."
"What makes Superman a hero is not that he has power, but that he has the wisdom and the maturity to use the power wisely."
"When the first Superman movie came out, I gave dozens of interviews to promote it. The most frequent question was: What is a hero? My answer was that a hero is someone who commits a courageous action without considering the consequences. Now my definition is completely different. I think a hero is an ordinary individual who finds the strength to persevere and endure in spite of overwhelming obstacles. They are the real heroes, and so are the families and friends who have stood by them."
"We live in a time when the words impossible and unsolvable are no longer part of the scientific community's vocabulary. Each day we move closer to trials that will not just minimize the symptoms of disease and injury but eliminate them."
"I'm starting a new chapter in my life, and you have no idea how much that means."
"So many of our dreams at first seem impossible, then they seem improbable, and then, when we summon the will, they soon become inevitable."
"Superman is nothing more than a popular retelling of the Christ story, or Greek mythology. It's an archetype, watered down and made in vivid colors for twelve-year-old's mentality. It's pop mythology, which extends to the actor, then seeps over to a demand that that actor reflect the needs of the worshipers. The worship doesn't only go on in the temples — it goes on in the streets, and restaurants, in magazines. But, you know, I'm from New Jersey, I'm not from Olympus or Krypton, so back off 'cause I can't take the responsibility."
"Somewhere in Time, while it errs on the side of pretentiousness, is an absolutely honest attempt to create an old-fashioned romance. It's based on love rather than on sex or X-rated bedroom scenes. I don't know how to talk about a love story without getting all gooey about it, but the script excited me because of the situation of the leading character... His problem struck me as that of many people. They've got everything going for them, or so they say, except for a real commitment, a real love."
"The key word for me on him is "inspiration." He is a leader by inspiration. He sets an example. It's quite important that people realize that I don't see him as a glad-handing show-off, a one-man vigilante force who rights every wrong. Basically, he's a pacifist, a man who comes along and says, 'What can I do to help?' He stands on the sidelines until there is real trouble. He does not want to get involved unless it's absolutely necessary because he thinks people should learn to make their own decisions."
"There were just things in Disney movies that probably were too scary for kids."
"Please accept my apology for not going public with what I've been facing the last six years. I have always felt a huge amount of love and respect from my friends, fans and supporters. I have loved you all so much and enjoyed making art for you."
"Does anyone come back from this? I don't know the answer to that, but I'll be damned if I'm going to let this destroy me."
"There were nude pictures... a lot of it is erotic or sexual. But I don't view my collection as dirty in any way. I view it as art."
"[about the Chicago Cubs being swept by the L.A. Dodgers in the 2008 NLDS]: How about next year, we only let the Cubs play using steroids?"
"How many of you watched the vice presidential debate expecting Sarah Palin to screw up? Be honest. [cheers and applause] : And how many of you watched the debate expecting Joe Biden to screw up? [more cheers and applause] : And how many of you watched the baseball game knowing the Cubs would screw up? [more applause]"
"I didn't realize it was October until I saw the Chicago Cubs choking."
"Fred, what happened to your ass?" "Oh, the fat guy at the office sneezed on me."
"No, they said they do not believe in evolution, then they said the biggest threat to America: religious radicals living in the Dark Ages."
"Women will soon be able to make their own sperm using their own bone marrow. Is that unbelievable? How unfair is that for us guys, huh? I mean, all these years, we've been in charge of manufacturing and distribution, you know what I'm saying? We provide free delivery and installation…"
"Now, today is the day we honor, of course, the Presidents, ranging from George Washington, who couldn't tell a lie, to George Bush, who couldn't tell the truth, to Bill Clinton, who couldn't tell the difference."
"Afterwards, President Bush said, "Maliki is the right man for the job." Just to remind you, Bush also said FEMA's Michael Brown was the right man for the job, Donald Rumsfeld was the right man for the job, Tom DeLay was the right man for the job… which would be okay if Bush was the right man for the job."
"Stephen Hawking is getting a divorce. That's scary. If the smartest guy in the world can't figure out women, we're screwed."
"And some sad news… the first lesbian couple to legally get married in the state of Massachusetts has split up. They cited irreconcilable similarities."
"A new poll shows that Americans now believe that Bill Clinton is more honest than President Bush. […] At least when Clinton screwed the nation, he did it one person at a time."
"So China's president [Hu Jintao] meets, uh— meets America's president. It's like President "Who?" meeting President "Huh?"."
"How many watched the President's speech last night? [half-hearted audience applause] How many watched American Idol? [thundering applause] Okay, there you go! You get the government you deserve."
"I was in the ROTC. Of course, ROTC stood for "Running off to Canada"."
"106 [degrees] in the valley… I was sweating like Dan Rather checking for forged documents."
"Welcome back! If you're wondering where our good friend -- Kevin Eubanks couldn't be here. Kevin is on tour. He's in France right now. He called me today and he's over there and he wouldn't be back until next week. So if you're wondering where Kevin Eubanks is, he's with us in spirit certainly. Okay. Boy, this is the hard part. I want to thank you, the audience. You folks have been just incredibly loyal. (emotionally) This is tricky. (laughs) We wouldn't be on the air without you people. Secondly, this has been the greatest 22 years of my life. (applause) I am the luckiest guy in the world. I got to meet presidents, astronauts, movie stars, it's just been incredible. I got to work with lighting people who made me look better than I really am. I got to work with audio people who made me sound better than I really do. (voice breaking) And I got to work with producers! And writers! (choked pause) And just all kinds of talented people who make me look a lot smarter than I really am. I'll tell you something. First year of this show, I lost my mom. Second year, I lost my dad; then my brother died. And after that, I was pretty much out of family. And the folks here became my family. Consequently, when they went through rough times, I tried to be there for them. The last time we left the show, you might remember we had the 64 children that were born among all our staffers that married. That was a great moment. And when people say to me, hey why don't you go to ABC? Why don't you go to FOX? Why don't you go…? I didn't know anybody over there. These are the only people I have ever known. I'm also proud to say this is a a union show. And I have never worked (applause) -- I have never worked with a more professional group of people in my life. They get paid good money and they do a good job. And when the guys and women on this show would show me the new car they bought or the house up the street here in Burbank that one of the guys got, I felt I played a bigger role in their success as they played in mine. That was just a great feeling. And I'm really excited for Jimmy Fallon. You know, it's fun to kind of be the old guy and sit back here and see where the next generation takes this great institution, and it really is. It's been a great institution for 60 years. I am so glad I got to be a part of it, but it really is time to go, hand it off to the next guy; it really is. And in closing, I want to quote Johnny Carson, who was the greatest guy to ever do this job. And he said, I bid you all a heartfelt good night. Now that I brought the room down, hey, Garth, have you got anything to liven this party up? Give it a shot! Garth Brooks!"
"Racecar driving is a lot like sex; all men think they're good at it."
"In America, we like everyone to know about the good work we're doing anonymously."
"Congratulations to the Italian people for winning the World Cup. … They won after France’s best player got ejected for head butting. That’s the closest anyone in a French uniform has come to combat in 60 years"
""This is now the twelfth day of rioting in France. They have been rioting for almost two weeks. And France has still not surrendered. That's like a record."
"French troops arrived in Afghanistan last week, and not a minute too soon. The French are acting as advisers to the Taliban, to teach them how to surrender properly."
"Well, there's nothing funnier to me than the French. The French Resistance is probably the biggest mythical joke that ever existed. There were four guys in the French Resistance. They couldn't hand over the Jewish people fast enough. Oh, please, don't tell me about the French. The French have all sorts of secret deals with Saddam and everybody else for two cents a liter. It's an easy target."
"The economy is so bad, two Milwaukee men were arrested this week for trying to join ISIS. Did you hear their excuse, they said, "Hey! Nobody else is hiring!" THAT'S how bad it is!"
"The economy is so bad, I saw Matthew McConaughey talking to himself in a Kia! THAT'S how bad it is!"
"And as you know, this whole Hillary e-mail scandal brought Anthony Wiener back into the news. Now here's a question nobody has asked. Anthony Wiener is Jewish, right? Right? So does this scandal make him a Hebrew National Wiener?"
"Hillary says she has been tested. Well, I hope so. You never know what Bill might bring home."