"Influenza was a major public health problem for centuries before 1918, and remains so today, in terms of both sporadic pandemics and annual seasonal epidemic recurrences of variable severity. There will undoubtedly be influenza pandemics in the future, but despite an enormous amount of study, it is not possible to predict when and where they will appear, what viral subtypes they will be caused by, or what pathogenic properties they will display. Enhanced influenza virus surveillance, especially at the animal-human interface, is clearly important, but we lack any real ability to identify pre-pandemic viruses before they become pandemic."
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Influenza
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