"Available scientific knowledge provides a firm basis for believing that the groups of mankind differ in their innate capacity for intellectual and emotional development."

"… the so-called co-efficient of heritability, which I regard as one of those unfortunate short-cuts, which have often emerged in biometry for lack of a more thorough analysis of the data."

"After all, it is a common weakness of young authors to put too much into their papers."

"No, I cannot believe in the light of this speech that the reward of Lysenko's triumphant career is the advance of scientific knowledge; nor that it is the prosperity of poor peasants. The reward he is so eagerly grasping is Power, power for himself, power to threaten, power to torture, power to kill."

"He is an ambitious politician of a type likely to become prevalent in a system avowedly guided by a rigid ideology, who hopes to use the ideological dogmas to which he finds his colleagues committed as levers for his own advancement in the party and in the state."

"In organisms of all kinds the young are launched upon their careers endowed with a certain amount of biological capital derived from their parents. This varies enormously in amount in different species, but, in all, there has been, before the offspring is able to lead an independent existence, a certain expenditure of nutriment in addition, almost universally, to some expenditure of time or activity, which the parents are induced by their instincts to make for the advantage of their young. Let us consider the reproductive value of these offspring at the moment when this parental expenditure on their behalf has just ceased. If we consider the aggregate of an entire generation of such offspring it is clear that the total reproductive value of the males in this group is exactly equal to the total value of all the females, because each sex must supply half the ancestry of all future generations of the species. From this it follows that the sex ratio will so adjust itself, under the influence of Natural Selection, that the total parental expenditure incurred in respect of children of each sex, shall be equal; for if this were not so and the total expenditure incurred in producing males, for instance, were less than the total expenditure incurred in producing females, then since the total reproductive value of the males is equal to that of the females, it would follow that those parents, the innate tendencies of which caused them to produce males in excess, would, for the same expenditure, produce a greater amount of reproductive value; and in consequence would be the progenitors of a larger fraction of future generations than would parents having a congenital bias towards the production of females. Selection would thus raise the sex-ratio until the expenditure upon males became equal to that upon females."

"I could prove God statistically. Take the human body alone — the chances that all the functions of an individual would just happen is a statistical monstrosity."

"Essentially, all models are wrong, but some are useful."

"Remember that all models are wrong; the practical question is how wrong do they have to be to not be useful."

"A mechanistic model has the following advantages: 1. It contributes to our scientiﬁc understanding of the phenomenon under study. 2. It usually provides a better basis for extrapolation (at least to conditions worthy of further experimental investigation if not through the entire range of all input variables). 3. It tends to be parsimonious (i.e, frugal) in the use of parameters and to provide better estimates of the response"

"An innovative discussion of building empirical models and the fitting of surfaces to data. Introduces the general philosophy of response surface methodology, and details least squares for response surface work, factorial designs at two levels, fitting second-order models, adequacy of estimation and the use of transformation, occurrence and elucidation of ridge systems, and more. Some results are presented for the first time. Includes real-life exercises, nearly all with solutions."

"The penalty for scientific irrelevance is, of course, that the statistician's work is ignored by the scientific community."

"Statistical criteria should (1) be sensitive to change in the specific factors tested, (2) be insensitive to changes, of a magnitude likely to occur in practice, in extraneous factors."

"A man in daily muddy contact with field experiments could not be expected to have much faith in any direct assumption of independently distributed normal errors."

"For the theory-practice iteration to work, the scientist must be, as it were, mentally ambidextrous; fascinated equally on the one hand by possible meanings, theories, and tentative models to be induced from data and the practical reality of the real world, and on the other with the factual implications deducible from tentative theories, models and hypotheses."

"The researcher hoping to break new ground in the theory of experimental design should involve himself in the design of actual experiments. The investigator who hopes to revolutionize decision theory should observe and take part in the making of important decisions."

"Since all models are wrong the scientist cannot obtain a "correct" one by excessive elaboration. On the contrary following William of Occam he should seek an economical description of natural phenomena. Just as the ability to devise simple but evocative models is the signature of the great scientist so overelaboration and overparameterization is often the mark of mediocrity."

"We have a large reservoir of engineers (and scientists) with a vast background of engineering know how. They need to learn statistical methods that can tap into the knowledge. Statistics used as a catalyst to engineering creation will, I believe, always result in the fastest and most economical progress…"

"One important idea is that science is a means whereby learning is achieved, not by mere theoretical speculation on the one hand, nor by the undirected accumulation of practical facts on the other, but rather by a motivated iteration between theory and practice."

"George Box is, in the field of the quality sciences, the consummate ‘Renaissance man’ who has made significant and enduring contributions to the profession of quality control and the allied arts and sciences... [His] contributions encompass considerable scope and have already had lasting effect."

"[Box's 1960 paper Fitting empirical data is] a mature exposition of an important branch of statistics, to which the author has made great contributions. One feature of particular interest is practical discussion of genuinely nonlinear fitting problems and their solution with the help of tact and a special, publicly available, IBM-704 program. Another is insightful comments on the role of prior distributions in statistics."

"All models are wrong; some models are useful."

"I want to tell you how I got to be a statistician. I was, of course, born in England and in 1939... when war broke out in September of that year, although I was close to getting a degree in Chemistry, I abandoned that and joined the Army. They put me in the Engineers (and when I see a bridge I still catch myself calculating where I would put the charges to blow it up). Before I could actually do any of that I was moved to a highly secret experimental station in the south of England. At the time they were bombing London every night and our job was to help to find out what to do if, one night, they used poisonous gas. Some of England's best scientists were there. There were a lot of experiments with small animals, I was a lab assistant making biochemical determinations, my boss was a professor of physiology dressed up as a colonel, and I was dressed up as a staff sergeant. The results I was getting were very variable and I told my colonel that what we really needed was a statistician. He said "we can't get one, what do you know about it?" I said "Nothing, I once tried to read a book about it by someone called R. A. Fisher but I didn't understand it". He said "You've read the book so you better do it", so I said, "Yes sir""