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April 10, 2026
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"The true and best way of learning any Art, is not to see a great many Examples done by another Person, but to possess ones self first of the Principles of it, and then to make them familiar, by exercising ones self in the Practice. For it is Practice alone, that makes a Man perfect in any thing."
"Hence if y be the Root of any Expression formed of y and known Quantities, and supposed equal to nothing, and z be a part of y, and x be formed of z and the known Quantities, in the same manner as the Expression made equal to nothing is formed of y; and let y be equal to z + v; the difference v will be found by Extracting the Root of this expression x + \frac {\dot{x}v}{1} + \frac {\ddot{x} v^2}{1 \cdot 2} + ... etc. = 0."
"I have endeavour'd to make every thing so plain, that a very little Skill in Geometry may be sufficient to enable one to read this Book by himself."
"This interaction of genetic and external influences makes my behaviour unpredictable, but not undetermined."
"Freedom lies in expressing your own determinism, not somebody else’s. It is not the determinism that makes a difference, but the ownership. If freedom is what we prefer, then it is preferable to be determined by forces that originate in ourselves and not in others."
"Rational optimism holds that the world will pull out of the current crisis because of the way that markets in goods, services and ideas allow human beings to exchange and specialise honestly for the betterment of all. So this is not a book of unthinking praise or condemnation of all markets, but it is an inquiry into how the market process of exchange and specialisation is older and fairer than many think and gives a vast reason for optimism about the future of the human race. Above all, it is a book about the benefits of change. I find that my disagreement is mostly with reactionaries of all political colours: blue ones who dislike cultural change, red ones who dislike economic change and green ones who dislike technological change."
"Yet the myth persists that genetic determinism is a more implacable kind of fate than social determinism."
"Full responsibility for one’s actions is a necessary fiction without which the law would flounder, but it is a fiction all the same. To the extent that you act in character you are responsible for your actions; yet acting in character is merely expressing the many determinisms that caused your character."
"I have a hard time imagining how my memory of the meaning of the word ‘volado’ consists of some strengthened synaptic connections between a few neurons. It is distinctly mind-boggling. Yet far from having removed the mystery from the problem by reducing it to the molecular level, I feel that scientists have opened before me a new and intriguing mystery, the mystery of trying to imagine how connections between nerve cells not only provide the mechanism of memory but are memory. It is every bit as thrilling a mystery as quantum physics, and a great deal more thrilling than Ouija boards and flying saucers."
"The story of p53 and the oncogenes, like much of my book, challenges the argument that genetic research is necessarily dangerous and should be curtailed. The story also strongly challenges the view that ‘reductionist’ science, which takes systems apart to understand them, is flawed and futile. Oncology, the medical study of whole cancers, diligent, brilliant and massively endowed though it was, achieved terribly little in comparison with what has already been achieved in a few years by a reductionist, genetic approach."
"The politicisation of the issue has had absurd results."
"Just as we underestimate the degree to which human brains rely upon instincts, so we have generally underestimated the degree to which other animals are capable of learning."
"The question is not whether nurture has a role to play, because nobody of any sense has ever gone on record as denying that it does, but whether nature has a role to play at all. When my one-year-old daughter discovered a plastic baby in a toy pram one day while I was writing this chapter, she let out the kinds of delighted squeals that her brother had reserved at the same age for passing tractors. Like many parents, I found it hard to believe that this was purely because of some unconscious social conditioning that we had imposed. Boys and girls have systematically different interests from the very beginning of autonomous behaviour."
"Held up as a proof of socially constructed gender roles, he proved the exact opposite: that nature does play a role in gender. The evidence from zoology has always pointed that way: male behaviour is systemically different from female behaviour in most species and the difference has an innate component. The brain is an organ with innate gender. The evidence from the genome, from imprinted genes and genes for sex-linked behaviours, now points to the same conclusion."
"The fuel on which science runs is ignorance. Science is like a hungry furnace that must be fed logs from the forests of ignorance that surround us. In the process, the clearing we call knowledge expands, but the more it expands, the longer its perimeter and the more ignorance comes into view."
"The subject of learning lies in the provinces of neuroscience and psychology. It is the opposite of instinct. Instinct is generically-determined behaviour; learning is behaviour modified by experience."
"What is true of mice is just as true of people. Flies and people are just variations on a theme of how to build a body that was laid down in some worm-like creature in the Cambrian period. They still retain the same genes doing the same job. Of course, there are differences; if there are not, we would look like flies. But the differences are surprisingly subtle."
"These two processes—linguistic philology and genetic phylogeny—are converging upon a common theme: the history of human migrations."
"This led to a neat generalization, which is so tidy it ought to be true and probably would be if physicists ran the world: every animal has roughly the same number of heartbeats per lifetime. An elephant lives longer than a mouse, but its pulse rate is so much slower that, measured in heartbeats, they both live lives of the same length."
"The evolutionary implication is that we are descended from a common ancestor with flies which used the same way of defining the pattern of the embryo more than 530 million years ago, and that the mechanism was so good that all this dead creature’s descendants have hung on to it."
"A true scientist is bored by knowledge; it is the assault on ignorance that motivates him—the mysteries that previous discoveries have revealed."
"The main purpose of most genes in the human genome is regulating the expression of other genes in the genome."
"It underscores yet again the fact that what we call personality is to a considerable degree a question of brain chemistry."
"Natural selection has designed all parts of our bodies to last just long enough to see our children into independence, no more."
"If you still thought evolution was about the good of the species, stop thinking so right now."
"Sexual relations are driven not by what is good, in evolutionary terms, for men or for women, but for their chromosomes. The ability to seduce a woman was good for Y chromosomes in the past; the ability to resist seduction by a man was good for X chromosomes in the past."
"The genome is littered, one might almost say clogged, with the equivalent of computer viruses, selfish, parasitic stretches of letters which exist for the pure and simple reason that they are good at getting themselves duplicated. We are full of digital chain letters and warnings about marmalade."
"The conclusions of both behaviour genetics and evolutionary psychology remain distinctly unpalatable to many non-scientists, whose main objection is a superficially reasonable argument from incredulity. How can a gene, a stretch of DNA ‘letters’, cause a behaviour? What conceivable mechanism could link a recipe for a protein with an ability to learn the rule for making the past tense in English? I admit that this seems at first sight a mighty leap, requiring more faith than reason. But it need not be, because the genetics of behaviour is, at root, no different from the genetics of embryonic development…The idea of genes for behaviour is no more strange than the idea of genes for development. Both are mind-boggling, but nature has never found human incomprehension a reason for changing her methods."
"In egalitarian societies, genes matter more."
"Nobody doubts that genes can shape anatomy. The idea that they also shape behaviour takes a lot more swallowing."
"Genes do indeed behave as if they have selfish goals, not consciously, but retrospectively: genes that behave in this way thrive and genes that don’t don’t."
"No matter that the social sciences set about reinventing much more alarming forms of determinism to take the place of the genetic form: the parental determinism of Freud; the socio-economic determinism of Marx; the political determinism of Lenin; the peer-pressure cultural determinism of Franz Boas and Margaret Mead; the stimulus-response determinism of John Watson and B. F. Skinner; the linguistic determinism of Edward Sapir and Benjamin Whorf. In one of the great diversions of all time, for nearly a century social scientists managed to persuade thinkers of many kinds that biological causality was determinism while environmental causality preserved free will; and that animals had instincts, but human beings did not."
"No horoscope matches this accuracy. No theory of human causality, Freudian, Marxist, Christian or animist, has ever been so precise. No prophet in the Old Testament, no entrail-gazing oracle in ancient Greece, no crystal-ball gipsy clairvoyant on the pier at Bognor Regis ever pretended to tell people exactly when their lives would fall apart, let alone got it right. We are dealing here with a prophecy of terrifying, cruel and inflexible truth."
"No study of the causes of intelligence has failed to find a substantial heritability."
"At its birth eugenics was not a politicised science; it was a science-ised political creed."
"But the astonishing result (of IQ testing) is the correlation between the scores of adopted children reared together: zero. Being in the same family has no discernible effect on IQ at all."
"A month after the Watson-Crick structure was published, Britain crowned a new queen and a British expedition conquered Mount Everest on the same day. Apart from a small piece in the News Chronicle, the double helix did not make the newspapers. Today most scientists consider it the most momentous discovery of the century, if not the millennium."
"As you grow up, you gradually express your own innate intelligence and leave behind the influences stamped on you by others. You select the environments that suit your innate tendencies, rather than adjusting your innate tendencies to the environments you find yourself in. This proves two vital things: that genetic influences are not frozen at conception and that environmental influences are not inexorably cumulative. Heritability does not mean immutability."
"Genes are recipes for both anatomy and behaviour."
"Judges were never very good at science."
"This means—and religious people might find this a useful argument—that there was only one creation, one single event when life was born. Of course, that life might have been born on a different planet and seeded here by spacecraft, or there might even have been thousands of kinds of life at first, but only Luca survived in the ruthless free-for-all of the primeval soup. But until the genetic code was cracked in the 1960s, we did not know what we now know: that all life is one; seaweed is your distant cousin and anthrax one of your advanced relatives. The unity of life is an empirical fact. Erasmus Darwin was outrageously close to the mark: ‘One and the same kind of living filaments has been the cause of all organic life.’"
"The pope notwithstanding, the human species is by no means the pinnacle of evolution. Evolution has no pinnacle and there is no such thing as evolutionary progress."
"Human beings are of course unique. They have, perched between their ears, the most complicated biological machine on the planet. But complexity is not everything, and it is not the goal of evolution. Every species on the planet is unique. Uniqueness is a commodity in oversupply."
"Life consists of the interplay of two kinds of chemicals: proteins and DNA."
"All rules have exceptions (including this one)."
"Life is a slippery thing to define, but it consists of two very different skills: the ability to replicate, and the ability to create order."
"There is no bone in the chimpanzee body that I do not share. There is no known chemical in the chimpanzee brain that cannot be found in the human brain. There is no known part of the immune system, the digestive system, the vascular system, the lymph system or the nervous system that we have and chimpanzees do not, or vice versa."
"That life is chemistry is true but boring, like saying that football is physics."
"There are genes that have not changed much since the very first single-celled creatures populated the primeval ooze. There are genes that were developed when our ancestors were worm-like. There are genes that must have first appeared when our ancestors were fish. There are genes that exist in their present form only because of recent epidemics of disease. And there are genes that can be used to write the history of human migrations in the last few thousand years. From four billion years ago to just a few hundred years ago, the genome has been a sort of autobiography for our species, recording the important events as they occurred."
"If I read the genome out to you at the rate of one word per second for eight hours a day, it would take me a century. If I wrote out the human genome, one letter per millimetre, my text would be as long as the River Danube. This is a gigantic document, an immense book, a recipe of extravagant length, and it all fits inside the microscopic nucleus of a tiny cell that fits easily upon the head of a pin."