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April 10, 2026
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"It is very expensive to obtain experimental data."
"Biotech and pharma companies try to do it and successfully in many cases."
"I am looking forward to forging new collaborations and synergies within the Department and beyond that would allow us to develop the next generation."
"I think there is some broadness to the definition of what counts as a foundation model, and more generally, artificial intelligence."
"François Chollet posits that intelligence is not about how well a specialized model performs, but how good it is in learning new things, or in other words,"
"In this sense we are probably still far away from general intelligence and this is one of the reasons why I personally donât like the term artificial intelligence."
"It will be possible to overcome the lack of experimental data with simulation and itâs an interesting question how to combine simulated data."
"How well it can generalize across tasks."
"The range and diversity of problems in biology is significantly bigger than in language."
"We donât really understand and agree on what intelligence is."
"One example is Recursion that scaled-up cell-painting technologies, allowing to image hundreds of millions of cells and see what happens to the cells. *When you perturb them either chemically or genetically."
"Any problem in computer science can be solved with another level of indirection."
"Compatibility means deliberately repeating other people's mistakes."
"(6) Lady Lovelace's ObjectionOur most detailed information of Babbage's Analytical Engine comes from a memoir by Lady Lovelace. In it she states, âThe Analytical Engine has no pretensions to originate anything. It can do whatever we know how to order it to performâ (her italics). This statement is quoted by Hartree (p. 70)... The view that machines cannot give rise to surprises is due, I believe, to a fallacy to which philosophers and mathematicians are particularly subject. This is the assumption that as soon as a fact is presented to a mind all consequences of that fact spring into the mind simultaneously with it. It is a very useful assumption under many circumstances, but one too easily forgets that it is false."
"Some of [Lovelace's] comments sound remarkably modern. One is very appropriate to a discussion there was in England which arose from a tendency, even in the more responsible press, to use the term âelectronic brainâ for equipment such as electronic calculating machines, automatic pilots for aircraft, etc. I considered it necessary to protest against this usage (51), as the term would suggest to the layman that equipment of this kind could âthink for itself,â whereas this is just what it cannot do; all the thinking has to be done beforehand by the designer and by the operator who provides the operating instructions for the particular problem; all the machine can do is to follow these instructions exactly, and this is true even though they involve the faculty of âjudgment.â I found afterwards that over a hundred years ago Lady Lovelace had put the point firmly and concisely (C, p. 44) : âThe Analytical Engine has no pretensions whatever to oriqinate anything. It can do whatever we know how to order it to performâ (her italics)."
"A large, coarse-skinned young woman but with something of my friend's features, particularly the mouth."
"I may remark that the curious transformations many formulae can undergo, the unsuspected and to a beginner apparently impossible identity of forms exceedingly dissimilar at first sight, is I think one of the chief difficulties in the early part of mathematical studies. I am often reminded of certain sprites and fairies one reads of, who are at one's elbows in one shape now, and the next minute in a form most dissimilar."
"Perhaps you have felt already, from the tone of my letter, that I am more than ever now the bride of science. Religion to me is science, and science is religion. In that deeply-felt truth lies the secret of my intense devotion to the reading of God's natural works. It is reading Him. His will â His intelligence; and this again is learning to obey and to follow (to the best of our power) that will! For he who reads, who interprets the Divinity with a true and simple heart, then obeys and submits in acts and feelings as by an impupulse and instinct. He can't help doing so. At least, it appears so to me."
"[...] engine is the material expression of any indefinite function of any degree of generality and complexity."
"[The Analytical Engine] might act upon other things besides number, were objects found whose mutual fundamental relations could be expressed by those of the abstract science of operations, and which should be also susceptible of adaptations to the action of the operating notation and mechanism of the engine. ⌠Supposing, for instance, that the fundamental relations of pitched sounds in the science of harmony and of musical composition were susceptible of such expression and adaptations, the engine might compose elaborate and scientific pieces of music of any degree of complexity or extent."
"We may say most aptly that the Analytical Engine weaves algebraical patterns just as the Jacquard-loom weaves flowers and leaves."
"The Analytical Engine has no pretensions whatever to originate any thing. It can do whatever we know how to order it to perform. It can follow analysis; but it has no power of anticipating any analytical relations or truths. Its province is to assist us in making available what we are already acquainted with. This it is calculated to effect primarily and chiefly of course, through its executive faculties; but it is likely to exert an indirect and reciprocal influence on science itself in another manner. For, in so distributing and combining the truths and the formulĂŚ of analysis, that they may become most easily and rapidly amenable to the mechanical combinations of the engine, the relations and the nature of many subjects in that science are necessarily thrown into new lights, and more profoundly investigated."
"All but one of the programs cited in her notes had been prepared by Babbage from three to seven years earlier. The exception was prepared by Babbage for her, although she did detect a 'bug' in it. Not only is there no evidence that Ada ever prepared a program for the Analytical Engine, but her correspondence with Babbage shows that she did not have the knowledge to do so."
"When I behold the scientific and so-called philosophers full of selfish feelings, and of a tenency to war against circumstances and Providence, I say to myself: They are not true priests, they are but half prophets â if not absolutely false ones. They have read the great page simply with the physical eye, and with none of the spirit within. The intellectual, the moral, the religious seem to me all naturally bound up and interlinked together in one great and harmonious whole... That God is one, and that all the works and the feelings He has called into existence are ONE; this is a truth (a biblical and scriptural truth too) not in my opinion developed to the apprehension of most people in its really deep and unfanthomable meaning. There is too much tendency to making separate and independent bundles of both the physical and the moral facts of the universe. Whereas, all and everything is naturally related and interconnected. A volume could I write you on this subject."
"With all my wiry power and strength, I am prone at times to bodily sufferings, connected chiefly with the digestive organs, of no common degree or king. I do not regret the sufferings and peculiaties of my physical constitution. They have taught me, and continue to teach me, that which I think nothing else could have developed. It is a force and control put upon me by Providence which I must obey. And the effects of this continual disciple of facts are mighty. They tame the in the best sense of that word, and they fan into existence a pure, bright, holy, unselfish flame within that sheds cheerfulness and light on many. â Ever yours truly. "A. A. Lovelace.""
"Circumstances have been such, that I have lived almost entirely secluded for some time. Those who are much in earnest and with single minds devoted to any great object in life, must find this occasionally inevitable.... You will wonder at having heard nothing from me; but you have experience and candour enough to perceive and know that God has not given to us (in this state of existence) more than very limited powers of expression of one's ideas and feelings... I shall be very desirous of again seeing you. You know what that means from me, and that it is no form, but the simple expression and result of the respect and attraction I feel for a mind that ventures to read direct in God's own book, and not merely thro' man's translation of that same vast and mighty work."
"Our family are an alternate stratification of poetry and mathematics."
"Systems engineering as an approach and methodology grew in response to the increase size and complexity of systems and projects... This engineering approach to the management of complexity by modularization was re-deployed in the software engineering discipline in the 1960s and 1970s with a proliferation of structured methodologies that enabled the the analysis, design and development of information systems by using techniques for modularized description, design and development of system components. Yourdon and DeMarco's Structured Analysis and Design, SSADM, James Martin's Information Engineering, and Jackson's Structured Design and Programming are examples from this era. They all exploited modularization to enable the parallel development of data, process, functionality and performance components of large software systems. The development of object orientation in the 1990s exploited modularization to develop reusable software. The idea was to develop modules that could be mixed and matched like Lego bricks to deliver to a variety of whole system specifications. The modularization and reusability principles have stood the test of time and are at the heart of modern software development."
"Dr James Martin, entrepreneur, visionary, "guru of the information age", "father of Case", ranked fourth in the world by Computerworld among the most influential people in the computer industry, Martin is not only a distinguished technology expert, but also a leading business authority, generally acknowledged as THE specialist on the social and business implications of computers and technology."
"Information Engineering is the application of an interlocking set of formal techniques for the planning, analysis, design, and construction of information systems on the enterprise wide basis or across a major sector of the enterprise."
"Information engineering has been defined with the reference to automated techniques as follows: An interlocking set of automated techniques in which enterprise models, data models and process models are built up in a comprehensive knowledge-base and are used to create and maintain data-processing systems."
"Enterprise Engineering is not a single methodology, but a sophisticated synthesis of the most important and successful of today's change methods. "Enterprise Engineering" first explains in detail all the critical disciplines (including continuous improvement, radical reinvention of business processes, enterprise redesign, and strategic visioning). It then illustrates how to custom-design the right combination of these change methods for your organization's specific needs."
"As technology grows in power, its ability either to disrupt or to heal increases. We can destroy the planet more easily than we can heal the harm we have done so far. To heal, we have to move to new technologies, new social patterns, new types of consumer products, new ways of generating and spending wealth. Such changes will inevitably occur, whether they are brought by healing forethought or mindless destruction. The future will not be a repetition of the past."
"A real-time computer system may be defined as one which controls an environment by receiving data, processing them, and taking action or returning results sufficiently quickly to affect the functioning of the environment at that time."
"From a very early age, we form concepts. Each concept is a particular idea or understanding we have about our world. These concepts allow us to make sense of and reason about the things in our world. These things to which our concepts apply are called objects."
"A new type of professional is emerging â the enterprise engineer"
"Enterprise engineering is an integrated set of disciplines for building an enterprise, its processes, and systems."
"A horrifying amount of "business engineering" is done with the wrong strategic vision. A horrifying amount of IT development is done with the wrong business design."
"After six years of war service, I rejoined Ilford Public Library service in 1946, and set about completing my F.L.A., begun in 1940. This service had a good tradition of assistance to readers, and when I joined the Metal Box C. in 1948, I soon realised how the skills required for a scientific and industrial research âinformation officerâ depended on the basic techniques of librarianship, notably classification and cataloguing. The enhancement of these led to the development of higher levels, in literature searching, and, more particularly, in current awareness service and selective dissemination of information.... Meeting with S. R. Ranganathan in 1948 gave me a new view of classification as facet analysis plus traditional generic analysis and I applied this in schemes for Packaging, Occupational Safety and Health, and Education. This experience has suggested to me that facet analysis applied to any subject can reveal hitherto uncoordinated concepts - materials, processes, etc â and thus offer an indication of possible areas of future research. This could be a unique Information Science to the World Wide Web."
"Scientists are more profitably occupied at the bench that in the library"
"The term âinformaticsâ was first advanced formally by the Director of VINITI, A. I. Mikhailov, and his colleagues A. I. Chernyi and R. S. Gilyarevskii, in their paper Informaticsânew name for the theory of Scientific Information published at the end of 1966. An English translation was circularized in the beginning of 1967. As the authors state in this paper, they are not the first to use this term, and they quote a review by Professor J. G. Dorfmann of their own book Fundamentals of Scientific Information in which Dorfmann criticizes the use of other terminology, such as âdocumentationâ, âdocumentalisticsâ, âinformation scienceâ, and so on. Although the authors do not object to the use of the word âDocumentationâ in the name of the International Federation for Documentation, nevertheless they claim that this term has not found application in the USSR and indeed they apologize for spending some time in discussing its suitability as a name for âthe new scientific discipline which studies the structure and properties of scientific information as well as the regularities of scientific information activity, its theory, history, methods, and organizationâ."
"After a great deal of (quite valuable) discussion, the British accepted that âfacet analysisâ must be the basis of a classification scheme able to meet the modern requirements."
"Since books are not their primary source materials, as they are for research in the humanities, most scientists prefer to spend their time on experiments and not on reading."
"consists in an analysis of a subject in its entirety into a certain number of facets or categories of things; within each category, the subject headings enumerated all possess the same relationship vis-&-vis the subject in its entirety."
"The (C.R.G.) in London has been discussing for some years the theory of documentary classification, and several papers have been published which reflect the course of the discussions (1â8). Beginning with an explicit disavowal of allegiance to any one published system, the Group has considered the well-known schemes, both general and special, and the work being published by those in other countries who have also been studying the subject theoretically. It has not, unfortunately, had the opportunity so far of seeing the system developed in the U.S.S.R. on the basis of the philosophy of dialectical materialism. While the Group has not been particularly satisfied with the development of the itself, we have nevertheless come to the conclusion that the method of facet analysis, first used systematically by , though sometimes occurring previously as it were by intuition, should form the basis of all forms of information retrieval."
"The work of the information officer [should be] regarded as the natural dynamic extension of that of the librarian."
"All information services are ultimately based on library methods and materials."
"Douglas developed a strong interest in the relations between education and classification. He explored the writings of L.S Vygotsky, L. von Bertalanffy (for systems theory), and J.K. Feibleman and wrote a number of articles on classification and integrative levels."
"The 1950s to early 1960s saw the publication of three major works on indexing, which between them span the retrieval problems of the whole spectrum of knowledge... The first was Vickeryâs Classification and indexing in science (1958), followed by Foskettâs Classification and indexing in the social sciences (1963) and finally Langridgeâs Classification and indexing in the humanities (1976). These three works, though designed principally as textbooks, expound many universal principles as well as highlighting the specific problems that the various groups of disciplines present and the solutions that have been adopted."
"Most librarians of his age were bookmen, who loved the touch, the appearance and the smell of books, and who often formed their own collections. Douglas fitted that description; we were all proud to be called âLibrariansâ. Perhaps modern information professionals are similarly inspired by the computer and the world-wide web. But the 1970s was a decade when computer technologies were assuming ever-growing importance for the future of libraries, and Douglas Foskett, as much as anyone, anticipated their value and fostered their introduction. He had already written extensively on classification, and had been a founder member of a special Classification Group. Such publications as âClassification and indexing in the social sciencesâ and âScience, humanism and librariesâ, which appeared in the 1960s are still important texts today, despite the vast deluge of literature on information management which has been published since. Of course, times and practices have changed radically in university libraries in the past twenty-five years, with the explosion of technology, and the continuous growth in all digital products and services. There have also been changes in social attitudes and in the approach to work. For example, when Douglas, in his final post, introduced the first computer system (GEAC) in the University of London Library, the junior staff went on strike! Such a response would be unthinkable today."