Biochemists

"From on high a human life must look very small, a notion that moved Walt Whitman to sing about the arrogance and audacity of elected government officials. ...Unfortunately, this collective code of morals... [w]e all share... as soon as... we participate in government... when we go to the polls to elect hawks and vote the endless billions for war and... formidable machines for killing and destruction, and then go to church and ask for God's blessing."

"When I received the Nobel Prize, the only big lump sum of money I have ever seen, I had to do something with it. The easiest way to drop this hot potato was to invest it, to buy shares. I knew that World War II was coming and I was afraid that if I had shares which rise in case of war, I would wish for war. So I asked my agent to buy shares which go down in the event of war. This he did. I lost my money and saved my soul."

"It is as though a puzzle could be put together simply by shaking its pieces."

"Ever since Sir Isaac Newton's times, scientists have worked in the same sort of way:"

"We need to describe the molecular interactions and biochemical transformations that take place in living organisms, and then translate these descriptions into the logic circuits that reveal how information is managed. This analysis should not be confined to the flow of information from to , but should also be applied to all functions operating in cells and organisms, including chemical interactions and transformations as well as physical phenomena, such as electrical signalling and mechanical processes."

"This notion of information being at the heart of life... is not restricted to me. I'm in good company. Sir Paul Nurse, former president of the Royal Society, in his visionary essay in Nature, "Life, Logic and Information", extols the virtues of thinking in an information, web-based way about life, and how, instead of worrying too much about what is going on at the molecular level, we should think of life as being a collection of logic modules... with information flowing between them, and control systems... a sort of engineering approach."

"How scientists go about their job: and it's a process, it's a question of asking questions, respecting observation, respecting experiment, having tentative explanations and then testing them.... There is a problem sometimes with how we teach science at schools. Because we sometimes teach it as if it has been chiseled in stone."

"Even at the level of the cell, phenomena such as general cellular homeostasis and the maintenance of cell integrity, the generation of spatial and temporal order, inter- and intracellular signalling, cell 'memory' and reproduction are not fully understood. ...This is also true for the levels of organization seen in tissues, organs and organisms, which feature more complex phenomena such as and operation of the immune and s."

"We need to focus more on how information is managed in living systems and how this brings about higher level biological phenomena... more investigation into how living systems gather, process, store and use information, as was emphasized at the birth of ."

"DNA can act as a digital information storage device that can be precisely copied. Similarly, the mechanism of the lac operon... can be described in terms of molecular interactions between DNA, protein and s. But these interactions make sense only when they are translated into a negative loop..."

"Ionizing radiation has always been with us and will be for all foreseeable time. Our genetic system is probably well adjusted by natural selection to normal background radiation. Added radiation will increase the frequency of mutations; most of these will be harmful. Exposure to radiation in large amounts will increase malignant disease; small amounts may possibly do the same. In view of these potentially harmful effects every reasonable effort should be made to reduce the levels of ionizing radiation to which man is exposed to to the lowest levels that can reasonably be attained."

"Hold somebody's hand and feel its warmth. Gram per gram, it converts 10 000 times more energy per second that the sun. You find this hard to believe? Here are the numbers: an average human weighs 70 kilograms and consumes about 12 600 kilojoules / day; that makes about 2 millijoules / gram.second, or 2 milliwatts / gram. For the sun it's a miserable 0.2 microjoules / gram.second. Some bacteria, such as the soil bacterium "Azotobacter" convert as much as 10 joules / gram.second, outperforming the sun by a factor 50 million. I am warm because inside each of my body cells there are dozens, hundreds or even thousands of mitochondria that burn the food I eat."

"I find it hard to swallow that I have only ten times more genes than those lowly bacteria in my gut. I had always liked the fact that they have ten thousand times less DNA than I did — that felt about right — but a factor of ten was carrying democracy a bit too far."

"I am tired of hearing that the DNA in my cells nucleus is the complete blueprint of what is, or could be, me. There is more to me than that. The sequence of my nuclear DNA is not "My Genome.""

"Unangenehme Seher werden meistens als Narren abgeschrieben [Visionaries of uncomfortable truths are mostly dismissed as fools]"

"What I see coming is a gigantic slaughterhouse, a molecular Auschwitz, in which valuable enzymes, hormones, and so on will be extracted instead of gold teeth."

"Now one could say, at the risk of some superficiality, that there exist principally two types of scientists. The ones, and they are rare, wish to understand the world, to know nature; the others, far more frequent, wish to explain it. The first are searching for truth, often with knowledge that they will not attain it; the second strive for plausibility, for the achievement of an intellectually consistent, and hence successful, view of the world."

"In 1945, therefore, I proved a sentimental fool; and Mr. Truman could safely have classified me among the whimpering idiots he did not wish admitted to the presidential office. For I felt that no man has the right to decree so much suffering, and that science, in providing and sharpening the knife and in upholding the ram, had incurred a guilt of which it will never get rid. It was at that time that the nexus between science and murder became clear to me. For several years after the somber event, between 1947 and 1952, I tried desperately to find a position in what then appeared to me as a bucolic Switzerland,—but I had no success."

"Outside his own ever-narrowing field of specialization, a scientist is a layman. What members of an academy of science have in common is a certain form of semiparasitic living."

"We do not know what life is, and yet we manipulate it as if it were an inorganic salt solution..."

"I am afraid that those comments go back to the late 80's. At that time I was a skeptic — the argument based on Koch's postulates to try to distinguish between cause and association. … Today I would regard the success of the many antiviral agents which lower the virus titers (to be expected) and also resolve the failure of the immune system (only expected if the virus is the cause of the failure) as a reasonable proof of the causation argument"

"I would not be surprised if there were another cause of AIDS and even that HIV is not involved."

"[Duesberg] is absolutely correct in saying that no one has proven that AIDS is caused by the AIDS virus. And he is absolutely correct that the virus cultured in the laboratory may not be the cause of AIDS."

"The community as a whole doesn't listen patiently to critics who adopt alternative viewpoints. Although the great lesson of history is that knowledge develops through the conflict of viewpoints. If you simply have a consensus, it generally stultifies. It fails to see the problems of that consensus and it depends on the existence of critics to break up that iceberg and permit knowledge to develop. This is in fact one of the underpinnings of democratic theory. It is one of the reasons why we believe in notions of free speech and it's one of the great forces in terms of intellectual development."

"Gamow was fantastic in his ideas. He was right, he was wrong. More often wrong than right. Always interesting; … and when his idea was not wrong it was not only right, it was new."

"By an incredible coincidence, Gamow and Edward Condon, who had discovered simultaneously and independently the explanation of radioactivity (one in Russia, the other in this country), came to spend the last ten years of their lives within a hundred yards of each other in Boulder."

"Es Gamow't wieder"

"Gamow was rather childlike, always wanting to play, and introducing a sort of light humor into all occasions. He was very fond of drawing pictures of Mickey Mouse. He added a lot to the entertainment that we had. He had some good ideas, applications which led to important developments in quantum theory, but I do not think he did any work which was very deep."

"If contribution in life is measured by the influence of a person's best ideas, then George Gamow's contribution has been immense. He explained radioactive decay, described reaction mechanisms and rates in the interior of stars, proposed how the elements were made, and suggested how DNA might provide the code for protein synthesis. Those topics have evolved into major fields of science..."

"Take a look at George Gamow, who is now recognized as one of the great cosmologists of the last hundred years. I speculate that he probably didn't win the Nobel Prize because people could not take him seriously. He wrote children's books. His colleagues have publicly stated his writing children's books on science had an adverse effect on his scientific reputation, and people could not take him seriously when he and his colleagues proposed that there should be a cosmic background radiation, which we now know to be one of the greatest discoveries of 20th-century physics."

"It took less than an hour to make the atoms, a few hundred million years to make the stars and planets, but five billion years to make man!"

"The physicist George Gamow was also an entertaining popularizer. He once told the story of how with his wife and their baby daughter he visited the Leaning Tower of Pisa. As they climbed the steps, they noticed an increasingly musty smell, which they first attributed to the ancient walls of the building. Then, however, they began to suspect their little girl, and by the time they reached the top it was clear that she needed immediate attention. “And from the very place,” explained Gamow, raising his arm and his voice dramatically, “where Galileo launched his experimental objects, we also propelled…”"

"If the expansion of the space of the universe is uniform in all directions, an observer located in anyone of the galaxies will see all other galaxies running away from him at velocities proportional to their distances from the observer."

"I feel that matter has properties which physics tells you."

"So I am just sitting and waiting, listening, and if something exciting comes, I just jump in."

"I decided to get Ph.D. in experimental physics because experimental physicists have their own room in the Institute where they can hang their coat, whereas theoretical physicists have to hang their coat at the entrance."

"Rutherford did not pretend to understand quantum mechanics, but he understood that the Gamow formula would give his accelerator a crucial advantage. Even particles accelerated at much lower energies... would be able to penetrate into nuclei. Rutherford invited Gamow to Cambridge in January 1929... [They] became firm friends and Gamow's insight gave Rutherford the impetus to go full steam ahead with the building of his accelerator."

"It was a bank holiday, and Mr Tompkins, the little clerk of a big city bank, slept late and had a leisurely breakfast. Trying to plan his day, he first thought about going to some afternoon movie and, opening the morning paper, turned to the entertainment page. But none of the films looked attractive to him. He detested all this Hollywood stuff, with infinite romances between popular stars. If only there were at least one film with some real adventure, something unusual and maybe even fantastic about it. But there was none. Unexpectedly, his eye fell on a little notice in the corner of the page. The local university was announcing a series of lectures on the problems of modern physics, and this afternoon's lecture was to be about Einstein's Theory of Relativity. Well, that might be something!"

"There was a young fellow from Trinity, Who took the square root of infinity. But the number of digits, Gave him the fidgets; He dropped Math and took up Divinity."

"It is well known that theoretical physicists cannot handle experimental equipment; it breaks whenever they touch it. Pauli was such a good theoretical physicist that something usually broke in the lab whenever he merely stepped across the threshold. A mysterious event that did not seem at first to be connected with Pauli's presence once occurred in Professor J. Franck's laboratory in Göttingen. Early one afternoon, without apparent cause, a complicated apparatus for the study of atomic phenomena collapsed. Franck wrote humorously about this to Pauli at his Zürich address and, after some delay, received an answer in an envelope with a Danish stamp. Pauli wrote that he had gone to visit Bohr and at the time of the mishap in Franck's laboratory his train was stopped for a few minutes at the Göttingen railroad station. You may believe this anecdote or not, but there are many other observations concerning the reality of the Pauli Effect!"

"With very few exceptions, philosophers do not know much science and do not understand it, which is quite natural because science lies beyond the boundaries of typical philosophical subjects such as ethics, aestetics, and gnosiology. But while in the free countries philosophers are quite harmless, in the dictatorial countries they constitute a great danger for the development of science. In Russia, state philosophers are bred in the Communist Academy in Moscow and are placed in all the educational and research institutions to prevent the professors and researchers from falling into idealistic, capitalistic heresies. The state philosophers are usually familiar with the subject of the research institution they are going to supervise, being either former schoolteachers or having taken in the academy a one-semester course on the subject in question. But they rank in the their power above the scientific directors of the institution and can veto any research project on publication which deviates from the correct ideology. One notable example of philosophical dictatorship in Russian science was the prohibition of Einstein's theory of relativity on the ground that it denied world ether, "the existence of which follows directly from the philosophy of dialectical materialism". It is interesting to note that the existence of the "world ether" was doubted long before Einstein by Engels, who in one of his letter to friend wrote "...the world ether, if it exists"."

"I once heard, and I think it is true, that only one man in the world—some Indian mathematician—understood the mathematics of string theory in eleven-dimensional space, and he dreamed it."

"Years from now, people will find our acceptance of the HIV theory of AIDS as silly as we find those who excommunicated Galileo."

"People keep asking me, "You mean you don’t believe that HIV causes AIDS?" And I say, "Whether I believe it or not is irrelevant! I have no scientific evidence for it." I might believe in God, and He could have told me in a dream that HIV causes AIDS. But I wouldn’t stand up in front of scientists and say, "I believe HIV causes AIDS because God told me." I’d say, "I have papers here in hand and experiments that have been done that can be demonstrated to others." It’s not what somebody believes, it’s experimental proof that counts. And those guys don’t have that."

"It’s not even probable, let alone scientifically proven, that HIV causes AIDS. If there is evidence that HIV causes AIDS, there should be scientific documents which either singly or collectively demonstrate that fact, at least with a high probability. There are no such documents."

"... Particularly important were the exact arguments needed to understand how Linus Pauling had discovered the . I soon was taught that Pauling's accomplishment was a product of common sense, not the result of complicated mathematical reasoning. Equations occasionally crept into his argument, but in most cases words would have sufficed. The key to Linus' success was his reliance on the simple laws of . The α-helix had not been found by only staring at X-ray pictures; the essential trick, instead, was to ask which atoms like to sit next to each other. In place of pencil and paper, the main working tools were a set of molecular models superficially resembling the toys of preschool children."

"I don't want to kill anybody. I am passionately opposed to killing, but I'm even more passionately fond of freedom. The freedom of Dr. Pauling and of myself expressing our opinions freely on any subject, however broad, however far removed of our proper competence, but particularly, to be able to express our opinions in the fields we really know; this would not be possible in Russia."

"An extraordinary person — a scientist, educator, humanist, and statesman with worldwide impact in each of these roles."

"In spite of our advances... there is no scientific evidence that can convince... more potently than a sincere and emotional testimonial. Such... does not always come from the regular guy... Linus Pauling... was said to believe in vitamin C's medicinal properties, himself ingesting massive doses. With his bully pulpit, he contributed to the common belief in vitamin C's curative properties. Many medical studies, unable to replicate Pauling's claims, fell on dear ears as it was difficult to undo the testimonial by a "Nobel Prize winner," even if he was not qualified to discuss matters related to medicine."

"The esteem with which he was regarded was vividly illustrated to me in 1951 when, as a postdoctoral fellow of Pauling's, I visited Albert Einstein in Princeton. Einstein's comment to me was "Ah, that man is a real genius!""