"In my view the most fundamental statement of quantum mechanics is that the wavefunction, or more generally the density matrix, represents our knowledge of the system we are trying to describe. I shall return later to the question "whose knowledge?". It is well known that we have to use a wavefunction if we have a "pure state" i.e. if our knowledge of the system is complete, in the sense that any further knowledge is barred by the uncertainty principle. Failing such complete knowledge we must use a density matrix, which therefore contains both quantum and classical ignorance. The wavefunction is a special case of a density matrix, and I shall here talk about "density matrix" when I mean "wavefunction or density matrix"."
January 1, 1970
https://en.wikiquote.org/wiki/Quantum_information