"The notion of a smooth spatial geometry, the central principle of general relativity, is destroyed by the violent fluctuations of the quantum world on short distance scales. ...The equations of general relativity cannot handle the rolling frenzy of the quantum foam. ...There are ...physicists ...who are deeply unsettled by the fact that the two foundational pillars of physics as we know it are at their core fundamentally incompatible, regardless of the ultramicroscopic distances that must be probed to expose the problem. This incompatibility, they argue, points to an essential flaw in our understanding of the physical universe. This opinion rests on an unprovable but profoundly felt view that the universe, if understood at its deepest and most elementary level, can be described by a logically sound theory whose parts are harmoniously united. Physicists have made numerous attempts at modifying either general relativity or quantum mechanics in some manner so as to avoid the conflict, but the attempts... have been met with failure after failure. That is, until the discovery of superstring theory."
January 1, 1970
https://en.wikiquote.org/wiki/Unification_in_science_and_mathematics