"Werner Heisenberg not only discovered but proved that in certain subatomic situations neither classical objectivity nor mechanical causality applied: that the act of the physicists observation (more exactly: his attempts at measurement) interfered either with the movement or with the situation of the object—which meant, among other things, a big crack in the fundament of Descartes's and Newton's objectivism and determinism. In other words: the study of the "reality" of matter was inseparable from the interference (and from the mind and purpose) of the scientist."
January 1, 1970
https://en.wikiquote.org/wiki/Uncertainty_principle