"There are at present fundamental problems in theoretical physics awaiting solution, e.g., the relativistic formulation of quantum mechanics and the nature of atomic nuclei (to be followed by more difficult ones such as the problem of life), the solution of which problems will presumably require a more drastic revision of our fundamental concepts than any that have gone before. Quite likely these changes will be so great that it will be beyond the power of human intelligence to get the necessary new ideas by direct attempts to formulate the experimental data in mathematical terms."
January 1, 1970
https://en.wikiquote.org/wiki/Mathematical_physics