"We may be mistaken. No one has as yet seen or handled an individual molecule, and our molecular hypothesis may, in its turn, be supplanted by some new theory of the constitution of matter; but the idea of the existence of unnumbered individual things, all alike and all unchangeable, is one which cannot enter the human mind and remain without fruit. But what if these molecules, indestructible as they are, turn out to be not substances themselves, but mere affections of some other substance?"
January 1, 1970
https://en.wikiquote.org/wiki/The_Scientific_Papers_of_James_Clerk_Maxwell