"I ever accounted extraordinary madnesse that of those, who would make humane comprehension the measure of what nature hath a power or knowledge to effect; whereas on the contrary there is not any the least effect in Nature, which can be fully understood by the most speculative wits in the world. This their so vain presumption of knowing all, can take beginning from nothing, unlesse from their never having known anything; for if one hath but once onely experienced the perfect knowledg of one onely thing, and but truly tasted what it is to know, he shall perceive that of infinite other conclusions, he understands not so much as one."
January 1, 1970
https://en.wikiquote.org/wiki/The_Systeme_of_the_World%3A_in_Four_Dialogues