transhumanists

"In the long run, there is nothing to stop intelligent agents from identifying the molecular signature of experience below hedonic zero and eliminating it altogether — even in insects. Nociception is vital; pain is optional. I tentatively predict that the world's last unpleasant experience in our forward light-cone will be a precisely datable event — perhaps some micro-pain in an obscure marine invertebrate a few centuries hence."

"Suppose we encounter an advanced civilization that has engineered a happy biosphere. Population sizes are controlled by cross-species immunocontraception. Free-living herbivores lead idyllic lives in their wildlife parks. Should we urge the reintroduction of starvation, asphyxiation, disemboweling and being eaten alive by predators? Is their regime of compassionate stewardship of the biosphere best abandoned in favour of "re-wilding"? I suspect the advanced civilization would regard human pleas to restore the old Darwinian regime of "Nature, red in tooth and claw" as callous if not borderline sociopathic."

"[L]ike nonhuman animals in human factory farms, free-living nonhumans who are starving - or being disembowelled, asphyxiated or eaten alive - cannot console themselves by chanting the Four Noble Truths of Buddhism. The moral case for helping other sentient beings, regardless or race or species, does not rest on the distress their plight does (or doesn't) cause spectators."

"It's easy to support the status quo if one is not another of its victims."

"The reason for sketching what's technically feasible with the tools of synthetic biology is that only after human complicity in the persistence of suffering in the biosphere is acknowledged can we hope to have an informed socio-political debate on the morality of its perpetuation. No serious ethical discussion of free-living animal suffering can begin in the absence of recognition of human responsibility for nonhuman well-being."

"To be sure, risks abound; but no one is proposing compassionate stewardship of ecosystems by philosophers. Humans are capable of choosing our own future pain-sensitivity too; but any species-wide genomic shift in human pain tolerance will depend on the willingness of prospective parents to use preimplantation genetic screening."

"[H]uman nature as encoded in our DNA isn't immutable. Mankind's barbaric track-record to date is an unreliable guide to the future. If Homo sapiens' nastier alleles and their more sinister combinations can be silenced or edited out of the genome, and new improved code-sequences inserted instead, then the pessimists will be confounded. A major discontinuity in the development of life lies ahead. Providentially, we've learned that the DNA-driven world isn't written in God-given proprietary code it would be hubris to tamper with, but in bug-ridden open source amenable to improvement."

"... our descendants may recognize that we are the sociopathic emotional primitives in the grip of an affective psychosis. Jealousy, envy, resentment, ridicule, hate, anger, disgust, spite, contempt, schadenfreude and a whole gamut of nameless but mean-spirited states we undergo each day are a toxic legacy of our Darwinian past. More commonly, perhaps, our genetic make-up ensures we simply feel indifference to the plight of all but a handful of significant others in our lives. Right now, for instance, one knows dimly at some level that there is frightful and preventable suffering in the world. Yet most of us feel no overpowering moral urgency to do anything about it."

"[T]he existence of the mind-independent environment beyond one's world-simulation is a theoretical inference, not an empirical observation."

"Confusion of sapience with sentience can be ethically catastrophic."

"Why expect a false theory of the world, i.e. classical physics, to yield a true account of consciousness?"

"Genes and culture have co-evolved. But crudely, natural selection "designed" male human primates to hunt nonhumans and build coalitions of other male human primates in order to wage territorial wars of aggression. Nature didn't design us to become a scientific community and collaborate to overcome aging. It's difficult to imagine that any human enemy could inflict such gruesome damage on the victims as growing old. The ravages of aging strike down combatants and civilians alike. So the trillions of dollars that humans currently spend on ways to harm and kill each other ("defence") would be more fruitfully spent on defeating our common enemy. We should work together to build a "Triple S" civilisation of superlongevity, superhappiness and superintelligence."

"If we don't address the genetic causes of suffering (physical and mental) we will find ourselves in 500 years enjoying material abundance via nanotech, living in a perfect democracy, colonizing space, and still sitting around wondering "Why are we miserable so much of the time? Why can't we all just get along? Why are we not all happy?""

"Today, status quo bias runs deep. Conservation biology is an ideology masquerading as a science. Many researchers seek to extend the tenets of conservation biology to humans. By contrast, a benevolent superintelligence might view Darwinian life on Earth as an infestation of biological malware and act accordingly. The amount of suffering caused by Homo sapiens is hard to quantify. But the suffering is immense and growing daily with the spread of industrialised animal abuse."

"Humans are prone to status quo bias. So let's do a thought-experiment. Imagine we stumble across an advanced civilisation that has abolished predation, disease, famine, and all the horrors of primitive Darwinian life. The descendants of archaic lifeforms flourish unmolested in their wildlife parks – free living, but not "wild". Should we urge scrapping their regime of compassionate stewardship of the living world – and a return to asphyxiation, disembowelling and being eaten alive? Or is a happy biosphere best conserved intact?"

"I think there's an asymmetry. There's this fable of Ursula Le Guin, short story, Ones Who Walk Away From Omelas. We're invited to imagine this city of delights, vast city of incredible wonderful pleasures but the existence of Omelas, this city of delights depends on the torment and abuse of a single child. The question is would you walk away from Omelas and what does walking away from Omelas entail. Now, personally I am someone who would walk away from Omelas. The world does not have an off switch, an off button and I think if one is whether a Buddhist of a negative utilitarian, or someone who believes in suffering-focused ethics, rather than to consider these theoretical apocalyptic scenarios it is more fruitful to work with secular and religious life lovers to phase out the biology of suffering in favor of gradients of intelligent wellbeing because one of the advantages of hedonic recalibration, i.e. ratcheting up hedonic set points is that it doesn't ask people to give up their existing values and preferences with complications."

"All that matters is the pleasure-pain axis. Pain and pleasure disclose the world's inbuilt metric of (dis)value. Our overriding ethical obligation is to minimise suffering. After we have reprogrammed the biosphere to wipe out experience below "hedonic zero", we should build a "triple S" civilisation based on gradients of superhuman bliss. The nature of ultimate reality baffles me. But intelligent moral agents will need to understand the multiverse if we are to grasp the nature and scope of our wider cosmological responsibilities. My working assumption is non-materialist physicalism. Formally, the world is completely described by the equation(s) of physics, presumably a relativistic analogue of the universal Schrödinger equation. Tentatively, I'm a wavefunction monist who believes we are patterns of qualia in a high-dimensional complex Hilbert space. Experience discloses the intrinsic nature of the physical: the "fire" in the equations. The solutions to the equations of QFT or its generalisation yield the values of qualia. What makes biological minds distinctive, in my view, isn't subjective experience per se, but rather non-psychotic binding. Phenomenal binding is what consciousness is evolutionarily "for". Without the superposition principle of QM, our minds wouldn't be able to simulate fitness-relevant patterns in the local environment. When awake, we are quantum minds running subjectively classical world-simulations. I am an inferential realist about perception. Metaphysically, I explore a zero ontology [...] the total information content of reality must be zero on pain of a miraculous creation of information ex nihilo. Epistemologically, I incline to a radical scepticism that would be sterile to articulate. Alas, the history of philosophy twinned with the principle of mediocrity suggests I burble as much nonsense as everyone else."

"In future, nerve cell responsiveness to naturally occurring endogenous opioids can be increased via receptor enrichment in the brain too. In principle, we can modulate their lifelong "overexpression", intermittently heightened (or gently diminished) by whatever kinds of personal and environmental contingencies we judge fit. Both functionally and anatomically, our reward pathways can be made "bigger and better". But intelligent emotional self-mastery will involve re-engineering the mind-brain so we derive the most intense rewards from activities we deem most lastingly worthwhile: i.e. prioritising our higher-order desires over legacy first-order appetites. Natural selection has "encephalised" our emotions to benefit our genes. Rational agents can "re-encephalise" our emotions to benefit us."

"[T]rue hedonic engineering, as distinct from mindless hedonism or reckless personal experimentation, can be profoundly good for our character. Character-building technologies can benefit utilitarians and non-utilitarians alike. Potentially, we can use a convergence of biotech, nanorobotics and information technology to gain control over our emotions and become better (post-)human beings, to cultivate the virtues, strength of character, decency, to become kinder, friendlier, more compassionate: to become the type of (post)human beings that we might aspire to be, but aren't, and biologically couldn't be, with the neural machinery of unenriched minds. Given our Darwinian biology, too many forms of admirable behaviour simply aren't rewarding enough for us to practise them consistently: our second-order desires to live better lives as better people are often feeble echoes of our baser passions."

"[A]s well as seriously – indeed exhaustively – researching everything that could conceivably go wrong, I think we should also investigate what could go right. The world is racked by suffering. The hedonic treadmill might more aptly be called a dolorous treadmill. Hundreds of millions of people are currently depressed, pain-ridden or both. Hundreds of billions of non-human animals are suffering too. If we weren't so inured to a world of pain and misery, then the biosphere would be reckoned in the throes of a global medical emergency. Thanks to breakthroughs in biotechnology, pain-thresholds, default anxiety levels, hedonic range and hedonic set-points are all now adjustable parameters in human and non-human animals alike. We are living in the final century of life on Earth in which suffering is biologically inevitable. As a society, we need an ethical debate about how much pain and misery we want to preserve and create."

"All moral tradeoffs are messy. However, on some fairly modest ethical assumptions, when a severe and irreconcilable conflict of interests occurs, then the interests of the more sentient take precedence over the less sentient. This rule of thumb holds regardless of the age, race or species of the victim."

"...it won't just be the quality and quantity of consciousness in the world that will be transformed in the post-Darwinian Transition. As (post-)humanity emerges from the neurochemical Dark Ages, enriched dopaminergic function in particular may sharpen the sheer intensity and meaningfulness of every moment of conscious existence. For a generation whose lifetimes span both modes of awareness, it will be as if they had just woken up. They will feel they had hitherto been sleep-walking through life in a twilit stupor. Thereafter their former mundane and minimal existence may be recalled only as some kind of zombified trance-state whose nature they were physiologically incapable of recognising..."

"Much more seriously, in those traditional eco-systems that we chose to retain, millions of non-human animals will continue periodically to starve, die horribly of thirst and disease, or even get eaten alive. This is commonly viewed as "natural" and hence basically OK. It would indeed be comforting to think that in some sense this ongoing animal holocaust doesn't matter too much. We often find it convenient to act as though the capacity to suffer were somehow inseparably bound up with linguistic ability or ratiocinative prowess. Yet there is absolutely no evidence that this is the case, and a great deal that it isn't."

"The functional regions of the brain which subserve physical agony, the "pain centres", and the mainly limbic substrates of emotion, appear in phylogenetic terms to be remarkably constant in the vertebrate line. The neural pathways involving serotonin, the periaquaductal grey matter, bradykinin, dynorphin, ATP receptors, the major opioid families, substance P etc all existed long before hominids walked the earth. Not merely is the biochemistry of suffering disturbingly similar where not effectively type-identical across a wide spectrum of vertebrate (and even some invertebrate) species. It is at least possible that members of any species whose members have more pain cells exhibiting greater synaptic density than humans sometimes suffer more atrociously than we do, whatever their notional "intelligence"."

"No amount of happiness enjoyed by some organisms can notionally justify the indescribable horrors of Auschwitz. [...] Nor can the fun and games outweigh the sporadic frightfulness of pain and despair that occurs every second of every day. For there's nothing inherently wrong with non-sentience or [...] non-existence; whereas there is something frightfully and self-intimatingly wrong with suffering."

"Negative-utilitarianism is only one particular denomination of a broad church to which the reader may well in any case not subscribe. Fortunately, the program can be defended on grounds that utilitarians of all stripes can agree on. So a defence will be mounted against critics of the theory and application of a utilitarian ethic in general. For in practice the most potent and effective means of curing unpleasantness is to ensure that a defining aspect of future states of mind is their permeation with the molecular chemistry of ecstasy: both genetically precoded and pharmacologically fine-tuned. Orthodox utilitarians will doubtless find the cornucopian abundance of bliss this strategy delivers is itself an extra source of moral value. Future generations of native ecstatics are unlikely to disagree."

"It's easy to convince oneself that things can't really be that terrible, that the horror I allude to is being overblown, that what is going on elsewhere in space-time is somehow less real than the here-and-now, or that the good in the world somehow offsets the bad. Yet however vividly one thinks one can imagine what agony, torture or suicidal despair must be like, the reality is inconceivably worse. The force of "inconceivably" is itself largely inconceivable here. Blurry images of Orwell's "Room 101" can barely even hint at what I'm talking about. Even if one's ancestral namesakes [aka "younger self"] underwent great pain, then the state-dependence of memories means that much of pain's sheer dreadfulness is semantically, cognitively and emotionally inaccessible in the here-and-now. So this manifesto's rhapsodies on the incredible joys that do indeed lie ahead tend to belie its underlying seriousness of purpose. For the biological strategy is propounded here in deadly moral earnest."

"One should be wary of assuming that we're the folk who can properly look after ourselves, whereas our descendants, if they become genetically pre-programmed ecstatics, will get trapped in robot-serviced states of infantile dependence. For it shouldn't be forgotten that exuberantly happy people also have a fierce will to survive. They love life dearly. They take on daunting challenges against seemingly impossible odds. One of the hallmarks of many endogenous depressive states, on the other hand, is so-called behavioural despair. If one learns that apparently no amount of effort can rescue one from an aversive stimulus, then one tends to sink into a lethargic stupor. This syndrome of "learned helplessness" may persist even when the opportunity to escape from the nasty stimulus subsequently arises."

"Taking the abolitionist project to the rest of the galaxy and beyond sounds crazy today; but it's the application of technology to a very homely moral precept writ large, not the outgrowth of a revolutionary new ethical theory. So long as sentient beings suffer extraordinary unpleasantness - whether on Earth or perhaps elsewhere - there is a presumptive case to eradicate such suffering wherever it is found."

"Any plea ... for institutionalized risk-assessment, beefed-up bioethics panels, academic review bodies, worse-case scenario planning, more intensive computer simulations, systematic long-term planning and the institutionalized study of existential risks is admirable. But so is urgent action to combat the global pandemic of suffering. "The easiest pain to bear is someone else's"."

"Crocker stumbled across Wikipedia early on. There were gaping holes in the encyclopedia's content, so he pitched in. As a semiprofessional poker player, he wrote the site's original poker article. As a fan of the martini, he wrote about that topic. "In the early days, it was pretty easy to find topics that needed to be covered," Crocker said. "It's not that easy today. It's pretty complete." Crocker wrote entries about Ken Kesey, Walter Annenberg, the Sapir-Whorf Hypothesis and dozens of other topics. "Nowadays I'm not as active, but I still write," he said. "I spent a couple of hours on Wikipedia every day for a long time." In addition to writing articles, Crocker wrote new wiki software when the original program proved too slow to handle the site's growing popularity. Crocker embraced Wikipedia because he believes information should be free."

"Crocker's Rules didn't give you the right to say anything offensive, but other people could say potentially offensive things to you, and it was your responsibility not to be offended. This was surprisingly hard to explain to people; many people would read the careful explanation and hear, "Crocker's Rules mean you can say offensive things to other people.""

"If you declare Crocker's Rules, other people don't need to worry about being tactful to you. (You still need to worry about being tactful to them — Crocker's Rules only work one way.)"

"Declaring yourself to be operating by "Crocker's Rules" means that other people are allowed to optimize their messages for information, not for being nice to you. Crocker's Rules means that you have accepted full responsibility for the operation of your own mind — if you're offended, it's your fault. Anyone is allowed to call you a moron and claim to be doing you a favor. (Which, in point of fact, they would be. One of the big problems with this culture is that everyone's afraid to tell you you're wrong, or they think they have to dance around it.) Two people using Crocker's Rules should be able to communicate all relevant information in the minimum amount of time, without paraphrasing or social formatting. Obviously, don't declare yourself to be operating by Crocker's Rules unless you have that kind of mental discipline. Note that Crocker's Rules does not mean you can insult people; it means that other people don't have to worry about whether they are insulting you. Crocker's Rules are a discipline, not a privilege. Furthermore, taking advantage of Crocker's Rules does not imply reciprocity. How could it? Crocker's Rules are something you do for yourself, to maximize information received — not something you grit your teeth over and do as a favor."

"Rationality is the master lifehack which distinguishes which other lifehacks to use."

"There are no surprising facts, only models that are surprised by facts; and if a model is surprised by the facts, it is no credit to that model."

"The nature of "reality" is something about which I'm still confused, which leaves open the possibility that there isn't any such thing. But Egan's Law still applies: "It all adds up to normality." Apples didn't stop falling when Einstein disproved Newton's theory of gravity. Sure, when the dust settles, it could turn out that apples don't exist, Earth doesn't exist, reality doesn't exist. But the nonexistent apples will still fall toward the nonexistent ground at a meaningless rate of 9.8 m/s2."

"If you've been cryocrastinating, putting off signing up for cryonics "until later", don't think that you've "gotten away with it so far". Many worlds, remember? There are branched versions of you that are dying of cancer, and not signed up for cryonics, and it's too late for them to get life insurance."

"Physiologically adult humans are not meant to spend an additional 10 years in a school system; their brains map that onto "I have been assigned low tribal status". And so, of course, they plot rebellion—accuse the existing tribal overlords of corruption—plot perhaps to split off their own little tribe in the savanna, not realizing that this is impossible in the Modern World."

"Part of the rationalist ethos is binding yourself emotionally to an absolutely lawful reductionistic universe — a universe containing no ontologically basic mental things such as souls or magic — and pouring all your hope and all your care into that merely real universe and its possibilities, without disappointment."

"If cryonics were a scam it would have far better marketing and be far more popular."

"By and large, the answer to the question "How do large institutions survive?" is "They don't!" The vast majority of large modern-day institutions — some of them extremely vital to the functioning of our complex civilization — simply fail to exist in the first place."

"If I'm teaching deep things, then I view it as important to make people feel like they're learning deep things, because otherwise, they will still have a hole in their mind for "deep truths" that needs filling, and they will go off and fill their heads with complete nonsense that has been written in a more satisfying style."

"We underestimate the distance between ourselves and others. Not just inferential distance, but distances of temperament and ability, distances of situation and resource, distances of unspoken knowledge and unnoticed skills and luck, distances of interior landscape."

"The people I know who seem to make unusual efforts at rationality, are unusually honest, or, failing that, at least have unusually bad social skills."

"If dragons were common, and you could look at one in the zoo — but zebras were a rare legendary creature that had finally been decided to be mythical — then there's a certain sort of person who would ignore dragons, who would never bother to look at dragons, and chase after rumors of zebras. The grass is always greener on the other side of reality. Which is rather setting ourselves up for eternal disappointment, eh? If we cannot take joy in the merely real, our lives shall be empty indeed."

"This is crunch time for the whole human species, and not just for us but for the intergalactic civilization whose existence depends on us. This is the hour before the final exam and we're trying to get as much studying done as possible. It may be that you can't make yourself feel that for a decade or thirty years or however long this crunch time lasts, but the reality is one thing and the emotions are another... If you confront it full on, then you can't really justify trading off any part of intergalactic civilization for any intrinsic thing you could get nowadays, and at the same time, it's also true that there are very few people who can live like that (and I'm not one of them myself)."

"If you want to build a recursively self-improving AI, have it go through a billion sequential self-modifications, become vastly smarter than you, and not die, you've got to work to a pretty precise standard."

"Have I ever remarked on how completely ridiculous it is to ask high school students to decide what they want to do with the rest of their lives and give them nearly no support in doing so? Support like, say, spending a day apiece watching twenty different jobs and then another week at their top three choices, with salary charts and projections and probabilities of graduating that subject given their test scores? The more so considering this is a central allocation question for the entire economy?"

"Through rationality we shall become awesome, and invent and test systematic methods for making people awesome, and plot to optimize everything in sight, and the more fun we have the more people will want to join us."