"[Unsure whether or not he saw a healthy human woman or if it just his imagination] Is this how it starts? A trip to the laughing academy? No, you silly bastard, it starts with you asking yourself silly questions. Okay, let's get cleaned up."

"And Speedy Bob Neville- his great legs churning goes speeding across the finish line with a three minute and fifty second mile. Go ahead, let's see some son-of-a-bitch beat that."

"You know the old song? If you were the only girl in the world, and I was the only boy, well, okay, but until then, don't bother me? Well, I guess I'm the only boy...."

"[hearing the "Family" loudly holding a book-burning revel] At it again, I see? What will it be tonight? Museum of Science? Some library? Poor miserable bastards."

"[talking to his own image on a TV screen] Hi, Big Brother, how's your ass?"

"[Enters a car dealership in search of a new car, talks to a decomposed corpse of a car salesman] Cannot say I am too crazy about the paint job...Thanks a lot you cheating bastard."

"[first lines, as the last man on earth wrecks his car] There's never a cop around when you need one."

"[later, to the bust of Caesar] What day is it, anyway? Monday? Huh? The hell it is. It's Sunday. Sunday I always dress for dinner."

"[to the "Family"] SHUT UP! Why the hell can't you leave me alone?"

"Isn't he? Isn't he a sullen b- [stops when he hears the "Family" outside]"

"[makes drink] Join me? Hmm? Miserable schmuck! [to his own image on the video screen]"

"[To a bust of Julius Caesar set up near a chessboard] Your move, Imperator."

"Hi. Another day, another dollar."

"Giuseppe Mattei as the leader of the survivors. He was also uncredited."

"Carolyn De Fonseca dubbed for Ruth Collins' voice in the English release of the film. She was uncredited."

"Rolando De Rossi"

"Ettore Ribotta as the TV Reporter"

"Antonio Corevi as the Governor"

"Christi Courtland as Kathy Morgan"

"Umberto Raho as Dr. Mercer"

"Giacomo Rossi-Stuart as Ben Cortman"

"Emma Danieli as Virginia Morgan, the wife of Robert Morgan"

"Franca Bettoia as Ruth Collins, an infected individual"

"Vincent Price as Dr. Robert Morgan"

"Alive among the lifeless... alone among the crawling creatures of evil that make the night hideous with their inhuman craving!"

"Do you dare to imagine what it would be like to be... the last man on Earth... or the last woman?"

"Ben Cortman: Morgan! Do you hear, Morgan? Morgan, come out!"

"Kathy Morgan: Mommy, where are you? Mommy, I can't see."

"Freaks! All of you, freaks! Mutations! I'm a man! The last... man..."

"Your new society sounds charming."

"This is Robert Morgan. If somebody can hear me, answer me. For God's sake, answer me!"

"Another day... another day to start all over again."

"Better put that garlic back where it belongs. I can't live a heartbeat away from hell and forget it."

"[filling up a bag with stakes] How many more of these will I have to make before they're all destroyed? They want my blood. It's their lives or mine. I still get squeamish."

"I can't afford the luxury of anger. Anger can make me vulnerable. It can destroy my reason and reason's the only advantage I have over them."

"A dying world. An empty, dead, silent world."

"There was a time that eating was pleasurable. Now it bores me."

"December 1965. Is that all it has been since I inherited the world? Only three years. Seems like a hundred million."

"Another day to live through. Better get started."

"Virginia Morgan: [after becoming a vampire] Let... me... in."

"Mommy look, it's a butterfly!"

"Dr. Robert Neville, September 5th, 2012, GA series, serum 391. Animal trials. Streaming video. [goes over to a stack of glass cubicles containing KV infected rats] GA series results appear typical. Compounds 1, 3, 4, 6, 8, 9, 10, 11, 14, 16, 18 did not kill the virus. Compounds 2, 5, 7, 12, 13, 15, 17 all killed the host. [pause] Hold on a second. Compound 6 appears to be showing decreased aggression response. Partial pigmentation return. Slight pupil constriction. GA series, serum 391, Compound 6, next candidate for human trials. You hang in there, #6."

"My name is Robert Neville. I am a survivor living in New York City. I am broadcasting on all AM frequencies. I will be at the South Street Seaport everyday at mid-day, when the sun is highest in the sky. If you are out there... if anyone is out there... I can provide food, I can provide shelter, I can provide security. If there's anybody out there... anybody... please. You are not alone."

"It was such a wonderful exploration of myself. What happens is that you get in a situation where you don’t have people to create the stimulus for you to respond to. What happens is that you start creating the stimulus and the response. There is a connection with yourself, where your mind starts to drift so, in those types of situations, that you learn about yourself things you would never even imagination."

"We shut down six blocks of Fifth Avenue on a Monday morning. That was probably poor logistics, which was poor planning. You realize that you have never actually seen an empty shot of New York. When we were doing it, it’s chilling to walk down the middle of Fifth Avenue. There is never an opportunity to walk down the middle of Fifth Avenue. At 2 o’clock in the morning on Sunday you can’t walk down the middle of Fifth Avenue."

"Well, we actually, and this also is reflected in the casting of Emma Thompson in that cameo at the very beginning. Francis and Will, this would be chapter one on nerds on parade, spent an unbelievable amount of time at the CDC. I'm pretty sure [they] are probably infected right now with something, so you should all wear masks. But I think that [we] finally came to this idea that it's too easy to always assume that things will go wrong because someone was twirling their mustache. That, in fact, sometimes things go wrong out of people trying to do right. That was sort of trying to take a different turn on it. So that was where I think we came out. You really liked that. That was really you"

"[telling Anna about Bob Marley] He had this idea. It was kind of a virologist idea. He believed that you could cure racism and hate... literally cure it, by injecting music and love into people's lives. When he was scheduled to perform at a peace rally, a gunman came to his house and shot him down. Two days later he walked out on that stage and sang. When they asked him why — He said, "The people who are trying to make this world worse are not taking a day off. How can I? Light up the darkness.""