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April 10, 2026
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"the criteria, to meâthe way we judge whether someone is an addict is whether or not they have disruptions in their psychosocial functioning. Are they going to work? Are they handling their responsibilities? Or are they overindulging in the activity? And when we think about drugs like alcohol, wine every day, people can drink alcohol every day and still meet their responsibility. The same is true with crack cocaine. The same is true with powder cocaine. The same is true with marijuana. Think about it this way. The three most recent presidents all used illicit drugs, and they all have met their responsibilities. Theyâve reached the highest levels of power. And we would be proud if they were our children, if theyâdespite the fact that theyâve all used illegal drugs."
"We have automobiles. They are potentially dangerous, particularly if youâve been in New York City in these past couple of days, the icy roads and so forth. Now, in the 1950s, automobile accidents were relatively high. We instituted some measuresâseat belts, speed limits, all of those sorts of things. That rate, even though we have more cars on the road, has dramatically decreased. If people are really concerned about the dangers of marijuana, weâd be teaching people how to use marijuana and other drugs more safely, because theyâre not going anywhere."
"when people overindulge, like every day multiple times a day, itâs going to disrupt some of your psychosocial functioning. Now, that is a small number of people. Only a few people engage in behavior like that. And I assure you that if they engage in behavior like that, thatâs not their only problem. They have multiple other problems."
"when we think about alcohol, about 10 percent of the peopleâ10 to 15 percent of the people who use alcohol are addicted or meet criteria for alcoholism; for crack cocaine, about 15 to 20 percentâthe same sort of thing when we look at the numbers. And weâve known this in science for at least 40 years, weâve known this sort of thing, but we havenât told the public."
"if we continue the same sort of drug enforcement policies, one in three African-American males born today will spend some time in jail."
"Without welfare, I wouldnât be here."
"I marvel at what we are learning about how the brain works, in general. And so, we are not anywhere near being able to explain drug addiction with our brain science yet. But that doesnât mean that we shouldnât continue to try and figure out whatâs going on in the brain."
"while in England, I got quite an education about American racism. In England, they have programs on a regular basis like the U.S. PBS series Eyes on the Prize. And I learned a lot about the U.S. sort of civil rights movement and history while in England. And the British were not bashful in their criticism of American racism."
"the reefer-madness rhetoric of the past has not evaporated; it has evolved and reinvented itself...with each new generation, the myth of reefer madness is revamped and disguised as empirical evidence rather than as what it is: misinformed rhetoric."
"when we think about the numbers of African Americans who are in neuroscience and whyâtheyâre lowâand why the numbers are low, thatâs an issue that the society hasnât grappled with. And itâs related to some of this marijuana talk that weâre talking about. You played something about Kennedy earlier. Those kind of people, they sicken me, quite frankly, when we think about the role that racism has played in our drug enforcement, and those people donât knowledge that? Those kind ofâthose types of practices have played a role in why African Americans are not in many areas in the United States."
"People get addicted for a wide range of reasons. Some people have co-occurring or other psychiatric illnesses that contribute to their drug addiction. Other people get addicted because thatâs the best option available to them; other people because they had limited skills in terms of responsibility skills. People become addicted for a wide range of reasons. If we were really concerned about drug addiction, we would be trying to figure out precisely why each individual became addicted. But thatâs not what weâre really interested in. We are interested, in this society, of vilifying a drug. In that way, we donât have to deal with the complex issues for why people really become addicted."
"Itâs a proven fact that this mandatory minimums policy wasted billions of dollars, and, more importantly, many human lives were wasted in this action in the past."
"The real connection between drugs and violent crime lies in the profits to be made in the drug trade."
"When it comes to drugs, most people have beliefs that have no foundation in evidence."
"I grew up in the hood. And so, when we think about these communities that we care about, the communities that have been so-called devastated by drugs of abuse, I believed that narrative for a long time. In fact, Iâve been studying drugs for about 23 years; for about 20 of those years, I believed that drugs were the problems in the community. But when I started to look more carefully, started looking at the evidence more carefully, it became clear to me that drugs werenât the problem. The problem was poverty, drug policy, lack of jobsâa wide range of things. And drugs were just one sort of component that didnât contribute as much as we had said they have."
"Would we tolerate children being removed from their mother just because she drank a glass of wine?...Can you imagine being told that your child is better off without you merely because you smoked a joint?...The fact is that many parents who use drugs are good parents, and their children are clearly better off with them."
"one of the things that shocked me when I first started to understand what was going on, when I discovered that 80 to 90 percent of the people who actually use drugs like crack cocaine, heroin, methamphetamine, marijuanaâ80 to 90 percent of those people were not addicted. I thought, âWait a second. I thought that once you use these drugs, everyone becomes addicted, and thatâs why we had these problems.â That was one thing that I found out. Another thing that I found out is that if you provide alternatives to peopleâjobs, other sort of alternativesâthey donât overindulge in drugs like this. I discovered this in the human laboratory as well as the animal laboratory. The same thing plays out in the animal literature."
"If weâre really concerned, for example, like the opioids and heroin, we need to tell people how to stay safe, if weâre worried about overdose there. About 13,000 people die every year from heroin-related overdoses, whereas 35,000 people die from automobile accidents. We donât ban automobiles. Instead, we have regulations, and we try to make sure that people stay safe. We have speed limits. We have seat belts. We have all of these sorts of things. But with the opioids, weâre talking about arresting people. And by the way, for the opioids, at the federal level, 80 percent of the people who are arrested are Latino and black."
"Just like any other drug, most of the people who use these drugs do so without a problem."
"The main effects of smoking marijuana are contentment, relaxation, sedation, euphoria, and increased hunger, all peaking within five to fifteen minutes after smoking and lasting for about two hours...very high THC concentrations...can cause mild paranoia and visual and auditory distortions, but even these effects are rare and usually seen only in very inexperienced users."
"when we think about the deaths themselves, most of the people are dying in large part because they combine opioids with another sedative, like alcohol, like a benzodiazepine. A benzodiazepine is something like Xanax. They also combine opioids with older antihistamines. Those sorts of things, they increase the risk associated with opioids...Much of the heroin on the street today is now being tainted with this drug called fentanyl. Fentanyl is about 50 to a hundred times more potent than heroin, just simply means that less of the drug is needed to produce the required effect. But unsuspecting users may take the amount that they usually take with heroin, thinking that itâs heroin, when in fact itâs fentanyl."
"From my own experience-the combination of my scientific work and my personal drug use, I have learned that recreational drugs can be used safely to enhance many vital human activities."
"It's not like people are hiding data. It's just that the emphasis is on the negative aspects. I'm highlighting that something's wrong with that. Everybody knows it. But nobody's saying it."
"If the ideas expressed in this book are embraced, we can get on with the business of treating each other better and enjoying more meaningful and fulfilling lives. And isn't that what we all want?"
"the first priority of law enforcement should be to keep users safe, not to arrest them."
"What if I told you that the awfulness of drugs has been wildly exaggerated? The predominant effects of drugs are good. They have beneficial effects, but we get paid to study the negative effects of drugs."
"I'm now firm in my belief that marijuana is a key ingredient to happiness for a great number of people. What kind of person prevents another's responsible pursuit of happiness? Not a very humane one."
"my conscience will no longer allow me to remain silent about my drug use, nor can I remain silent about the absurdity of punishing people for what they put into their own bodies...The point is that whether I use a drug or not is my decision; it is not the government's decision."
"Contrary to popular media portrayals, most drug users are not addicts. They are responsible members of their communities. They pay their bills and taxes on time; they take care of their families; and they volunteer in their local and global communities. They are artists, engineers, firemen, homemakers, judges, lawyers, pastors, physicians, politicians, professors, schoolteachers, scientists, social workers, truck drivers, writers, and many other types of professionals."
"With every drug, whether it's cocaine, PCP, or marijuana, there's some historical report about the horrors of this drug producing superhuman strength. It provides a rationale to engage in police brutality. This is quintessential American racism."
"Our researchers are from a particular class and they are predominantly white. They don't even think of themselves as being a part of the political machinery, but they help to prop up our drug laws."
"If our current government-or any government-were genuinely concerned about the health and safety of drug users, it would ensure that free, anonymous drug-safety testing services were widely available. This practical approach informs users of the contents of their substances and decreases the likelihood of people ingesting fatal amounts of unknown substances."
"After reading this book, I hope you will be less likely to vilify individuals merely because they use drugs. That thinking has led to an incalculable number of deaths and an enormous amount of suffering. I hope you will come away with an appreciation for the prodigious potential good derived from drug use and a deeper understanding of why so many responsible grown-ups engage in this behavior. (Author's Note)"
"I wrote this book to present a more realistic image of the typical drug user: a responsible professional who happens to use drugs in his pursuit of happiness. Also, I wanted to remind the public that no benevolent government should forbid autonomous adults from altering their consciousness, as long as it does not infringe on the rights of others. (Author's Note)"
"all drugs can produce both negative and positive effects. So to act as if marijuana is intrinsically or morally superior to heroin-or any other drug, for that matter-highlights the ignorance of the holder of this belief. Such ignorance also decreases the odds of people honestly reporting the use of drugs other than marijuana because of the stigma attached to so-called harder drugs, such as heroin. (Chapter 2)"
"As with previous âdrug crises,â the opioid problem is not really about opioids. Itâs mainly about cultural, social, and environmental factors such as racism, draconian drug laws, and diverting attention away from the real causes of crime and suffering."
"the war on drugs is not a war on drugs; itâs a war on us."
"Heroin and other opioids, such as oxycodone and morphine, bring me pleasurable calmness, just as alcohol may function for the drinker subjected to uncomfortable social settings. Opioids are outstanding pleasure producers; I am now entering my fifth year as a regular heroin user. I do not have a drug-use problem. Never have. Each day, I meet my parental, personal, and professional responsibilities. I pay my taxes, serve as a volunteer in my community on a regular basis, and contribute to the global community as an informed and engaged citizen. I am better for my drug use."
"Each and every day, we all are faced with potential risks and must make risk-to-benefit calculations repeatedly. This is a basic fact of life. Our right to make decisions based on the outcome of these calculations is not outlawed by the government, except when it comes to certain recreational drugs. (Chapter 2)"
"Clearly, many people consume psychoactive substances âin the pursuit of happiness,â a right the government was established to secure, to protect. So why then is our current government arresting one million Americans each year for possessing drugs? Why are so many drug users hiding in the closet? This reality does not align with the spirit of the Declaration"
"Make sure we warn people not to combine opioids with another drug. Set up free drug purity testing sites. People who are addicted to opioids and who are having a problem, and they need treatment. We should look around the world, places like Switzerland."
"Attention-grabbing headlines claiming that opioids (or any other drug) are killing people are wrong. Ignorance and poverty are killing people, just as they have for centuries."
"people are focused on the money and not focused on being smart."
"Only about a quarter of the people who use something like heroin will become addicted. That means the vast majority are not addicted. But one way we can deal with the deaths, the major concernâanother way we can deal is just make naloxone, which is an opioid blocker, make it more available. One of the things that has happened in recent years is that pharmaceutical companies have jacked the price up of naloxone, an old drug thatâs been here since the 1960s. I mean, if Congress really wanted to do something, if the president really wanted to do something, he would hold those pharmaceutical companies accountable for increasing the price of naloxone, when the price of naloxone should be really cheap."
"we are all concerned about mass incarceration in the country today. If you want to know how we got there, right now what weâre doing, with people like Jeff Sessions and that guy in the White House, is how we got there. And theyâre trying to ensure that we go back there, in part because itâs going to affect primarily, negatively affect, black people and brown people in this country."
"The key is to keep the focus on people's actions, on their behaviors, rather than speculate about their motives. Trying to determine what's in a person's head or heart is a pointless distraction. It's impossible to know for certain the heart's inner secrets."
"I am an unapologetic drug user. I take drugs as part of my pursuit of happiness, and they work. I am a happier and better person because of them. I am also a scientist and a professor of psychology specializing in neuroscience at Columbia University, known for my work on drug abuse and addiction. It has taken me more than two decades to come out of the closet about my personal drug use. Simply put, I have been a coward."
"America's drug regime is a monstrous, incoherent mess."
"I wrote a piece in The New York Times in August where I pointed out that this isnât new. Even with crack, there were whiteâmore white users, and those white users got treatment, whereas the brothers and sisters, black brothers and sisters, went to jail. The same sort of thing is happening in this case. Eighty percent of the people who are being currently arrested for the opioids are black and Latino, even though they donât use those drugs at rates higher than their white brothers and sisters. And so, this is just the American pattern of dealing with drugs. Itâs not new. And we continue the same thing. So Iâm asking people: letâs not get crazy; letâs just focus on the real problems."
"I worry that people who need prescription opioids for their pain will not be able to get their prescription opioids, because we are getting crazy about opioids, in general. Opioids are excellent medications to treat pain. And we canât forget that. We also have seen, even before thisâwe know that, for example, black people are less likely to be prescribed opioids even when they need it, less likely than their white counterparts. And so, all of these sort of unintended consequences, they always happen when we get crazy about drugs. And we donât even save people."