"Good evening, citizens of Frank. In the past few weeks of the campaign, my opponent has thrown around a lot of fancy words to try to confuse the issues. Words like "exercise," "low-fat," and "diet" - words designed to scare us into changing what has worked for so many years. Well, I say let's stay the course. Remember, a fat Frank is a happy Frank."

"It's just the way I like it: Extra disgusting."

"Janis Dardaris — Red Blood Cell Nurse"

"Antonio Fargas — Chill"

"Son, do me a favor and read what it says on your arm?"

"Thank you, Leah. Now get me the chief on the phone. There's a good girl."

"Exactly! Temporary. You're nothing but a wannabe, a placebo, a generic brand. Marked-down, over-the-counter, useless Tic-Tac! NOW, GET OUT OF MY BODY!"

"The bowels. Didn't always smell this way. No. There was a time when eating right and exercise kept this whole area a vital center of activity. But during Mayor Phlegmming's term, we've seen rot and stagnation paralyze this neighborhood as well as the colon and the sphincter. Well, I think it's time we get things moving again. I'm Tom Colonic. As Mayor, I would set long-term goals that include ordering salads and eating bran. Mayor Phlegmming may think that things are fine just the way they are. But I think that if we pull together and put in a little hard work, A new Frank could be right around the corner."

"JONES! IN MY OFFICE!"

"Get that thing to the hypothalamus now!"

"We have a situation in the throat, and I'm putting you on it."

"Can you believe those lies?"

"We're probably just drinking some hot coffee."

"Study? When you grow up on the wrong side of the digestive track, you ain't got no money for no fancy schools."

"See, I told you she'd be excited. Now, tidy up, will you? Here we go."

"I propose something that every organism in this city will enjoy. I give you a dream vacation to the annual chicken wing festival in Buffalo, New York! Final plans have been made and nothing is going to stand in our way!"

"Just as long as it doesn't hit 108 degrees, or Frank's daughter's an orphan."

"Michael Carven — Red Blood Cell"

"There will be plenty of new jobs for everyone on the back."

"You care more about your stupid re-election than you care about all our lives. Something's going on and I'm going to the hypothalamus to check it out."

"That's Chill. He's a flu shot."

"Come here, baby. I'm still Jonesin' for a little more Osmosis."

"Sir, he's got a point. When I came to work for you, you promised you would concentrate more on health issues."

"You want Osmosis? You got Osmosis!"

"Rodger Bumpass — Announcer of Nerve News Network and Joe Cramp"

"Paul Christie — Dan Matter and Germ"

"Eddie Frierson — Police Officer at Frank Police Department"

"Jones! Oh, thank Frank!"

"Okay, Frank. This is your, um, conscience speaking. Now listen carefully. This hiking trip means the world to her. Figure out a way to make it work. Use that charm."

"Well, you dealin' with a white blood cell here!"

"Careful. I'm contagious."

"What a zit. I mean, what is it? What is it? What do you want?"

"Ebola? Let me tell you something about Ebola, baby. Ebola is a case of DANDRUFF compared to me!"

"In the words of the immortal James Brown GET DOWN!"

"Eddie Barth — Conducter"

"[laughing] Oh, my God. Ha-ha! That was so funny! Oh, my God, I've got the giggles."

"[last words] SHANE!!"

"He's one cell of a guy."

"He's one cell of a guy and his partner's a real pill."

"Every body needs a hero."

"Chris Rock — Osmosis "Ozzy" Jones"

"Laurence Fishburne — Thrax"

"David Hyde Pierce — Drixenol "Drix" Koldreliff"

"Brandy Norwood — Leah Estrogen"

"William Shatner — Mayor Phlegmming"

"Ron Howard — Tom Colonic"

"Joel Silver — Chief (uncredited)"

"Kenny Olson"

"GET OUT! OUT! THE ANSWER IS NO! ABSOLUTELY NOT!"