"Why?! Why is this happening?! I just don't understand. It just doesn't make any sense. Was it loop over, loop under and pull, or loop under, loop over and pull?"

"You see, Papi, you may look at my life and think I've got nothing, but the truth is I've got everything."

"Step right up, ladies and gentlemen! It's finally arrived. The cure for everything that ails you. Yzma's Young and Beautiful!"

"[looking at the souvenir photo; disappointed] Rats, my eyes are closed."

"Dear Papi, remember how you never thought I'd amount to anything? Well, I got news for you. Good news. I finally got that big house on a hill you've always wanted me to have. It's really great. You're gonna love it. It's got all the amenities. Swimming pool, golf course… The windmill's a killer. And my favorite part of all. Pancake junction! I even built a cozy little guest wing just for you. Yep. Just a big, serious house for a big, serious guy. Like me. That's who I am."

"Doing good cost me my dream house. And then… (Mata: Don't tell me.) It cost me my girl. (Mata: I said, don't tell me.) These oven mitts were the last thing she touched, other than my fragile heart… Before she walked out of my life."

"I've finally done it, Kronk. I've created the elixir of life. The answer to everyone's prayers. Behold the fountain of youth in a bottle! [thunder crashes] Regular and diet."

"Welcome to my new secret lab!"

"Jake Goldsbie as Junior Littlegreen"

"Sunday Muse as Binky"

"Richard Binsley as Gene Littlegreen"

"Kristen Bone as Zowie"

"Joshua Tucci as Billy"

"Cole Caplan as Olie"

"Rob Smith as Spot and Spacedog (as Robert Smith)"

"Kyle Fairlie as Spaceboy and Young Dad"

"Catherine Disher as Mom and TV Journalist"

"Ellen-Ray Hennessy as Bonita"

"Rebecca Brenner as Pollie Pi"

"James Woods as Gloomius Maximus"

"Paul Haddad as Willy Jollie"

"Michael Cera as Young Gizmo"

"Philip Williams as Baxter"

"Al Mukadam as Wheelie (as Ali Mukaddam)"

"Noah Reid as Screwy"

"Len Carlson as Pappy"

"Adrian Truss as Dad and Uncle Gizmo"

"Juan Chioran as Wally Jollie"

"Neil Crone as Doctor Geary"

"as Sarah and Lee Kanker"

"as Nazz and May Kanker"

"Keenan Christenson as Jimmy"

"as Jonny / Captain Melonhead"

"as Edd / Double D"

"as Kevin and Marie Kanker"

"as Eddy's Brother"

"Mikey Kelley - Bill McLemore"

"Bob Bergen - Eric Staufer"

"Tom Kane - Professor Robert Kaufman"

"Grey DeLisle — Daphne, Cyber-Daphne"

"Gary Anthony Stugris - Phantom Virus"

"B.J. Ward — Velma, Cyber-Velma"

"w:Joe Alaskey - Officer Wembley"

"Frank Welker — Fred, Cyber-Fred, Gladiator Lion"

"Scott Innes — Scooby-Doo, Shaggy, Cyber-Scooby, Cyber-Shaggy"

"Willie Geist — Dim"

"Wayne Knight — Big Fun, Hom Lee"

"James Hong — Mr. Ping"