Vaccination

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April 10, 2026

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April 10, 2026

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"Unlike bacteria, viruses do not replicate on their own. To make viral vaccines, large numbers of viruses must be grown in cell cultures specific to each virus. Some licensed viral vaccines (i.e., some formulations ofhepatitisA, poliovirus, rabies, rubella, and varicellazoster viruses or combination vaccines containing such component viruses) are produced by growing viruses that infect humans in WI-38 or MRC-5 cell cultures. WI-38 and MRC-5 represent two commonly used lineages of human diploid cell cultures, batches of immature cells with twice as many chromosomes as sperm or egg cells. Embryonic diploid cells are valuable in vaccine manufacture, because each aliquot ofthese cells can propagate several dozen times before senescence. Each of these cell lines started with cells harvested from a deliberately aborted fetus. The cell lines are used to grow the viruses, then discarded and not included in vaccine formulations. These cell lines cannot form a human being. TheWI-38 line was developed attheWistar Institute in Philadelphia in 1961, with lung cells from a female fetus of 3 months gestation aborted in Sweden, whose parents feltthey had too many children. Similarly, British scientists funded by the Medical Research Council developed the MRC-5 line in September 1966 with fetal lung fibroblasts “taken from a 14-weekold male fetus removed for psychiatric reasons from a 27-year-old woman. . .”. These cell lines, still in use today, gradually replaced primary cultures of monkey, duck, rabbit, chicken, dog, or mouse tissue, an approach vulnerable to contamination with viruses and bacteria."

- Use of fetal tissue in vaccine development

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"In the late 1990s—early 2000s, teams of ethicists at the National Catholic Bioethics Center and then at the Vatican’s Pontifical Academy for Life and elsewhere considered the virology, epidemiology, and theology of the matter in detail. Their considerations included both cooperation with evil and the principle of double effect. In this case, the cooperation related to those involved with the specific abortions in the 1960s. The principle of double effect applied insofar as using implicated vaccines today could appear to endorse or acquiesce to the acceptability of additional abortions in our current time. These teams concluded that the association between implicated vaccines and abortion was noncomplicit, and that using these vaccines is not contrary to a principled opposition to abortion. These centers reasoned that, because the abortions that enabled the production ofthese vaccines are in the past and (critically) the abortions were not undertaken with the intent of producing the cell lines, being immunized does not involve any sharing in immoral intention or action of others. In short, they are morally separate actions. In 2008, this position was elevated to the status of official Roman Catholic teaching. The bioethicist teams agreed that use of a vaccine in the present does not involve sharing in the action of those who carried out the abortion in the past. Further,they foundthatparents have a moral obligation to provide for the life and health of their children by means of immunization. The situation with vaccines differs morally from ongoing harvest of fetal tissue for pharmaceutical manufacturing or research, which could be used to justify future abortions. Still, these ethicists concluded that alternate vaccines should be used if available. They also recommended that parents and clinicians should speak out against abortion by asking governments and vaccine manufacturers to stop using cell lines that have links to aborted fetuses."

- Use of fetal tissue in vaccine development

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"In 1964, the Wistar Institute developed the RA 27/3 strain of rubella virus. The rubella virus isolate “was recovered from the explanted [kidney] tissue of a fetus obtained at therapeutic abortion from a mother who had been infected with rubella virus”. The scientific literature of that era indicates that the abortion was not conducted with the motive of isolating the virus, but rather because the mother was infected with rubella virus and risked major birth defects. After the RA 27/3 strain was isolated, it has been propagated serially in human diploid cells. The RA 27/3 strain produced superior antibody responses and was better tolerated, compared with other rubella vaccine strains available in the 1960s. No further abortions are necessary to sustain the manufacture of additional batches of rubella RA 27/3-strain vaccine. Use of the RA 27/3 rubella virus strain was also considered by the National Catholic Bioethics Center and the Pontifical Academy for Life. Using the same logic, they reasoned that because the one abortion that yielded the viral isolate was not undertaken with the intent to retrieve the virus and because no additional abortions are needed to obtain more virus, being immunized is morally acceptable and also associated with parental duty. The same provisions for preferring alternatives and petitioning governments and manufacturers also apply. Some find it meaningful that rubella vaccination prevents many cases of fetal death and congenital rubella syndrome that would otherwise occur if women were infected with rubella virus during pregnancy. Immunized women exposed to the virus during pregnancy are no longer confronted with the question (what some religions might consider temptation) of whether to terminate their pregnancies on that basis."

- Use of fetal tissue in vaccine development

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"It is important to note that the use of these vaccines, generated from fetal tissue of elective abortions, can only occur on a temporary basis, as it represents a “very remote mediate material cooperation” (Pontifical Academy for Life 2006, 547) with the original illicit act of abortion. The distinctions between the different forms of cooperation were established by St. Alphonsus Liguori and can be categorized by the proximity of actions to the original illicit act. An example using vaccines generated from fetal tissue of an elective abortion follows: Principal agent: The mother who elects to terminate her pregnancy. Formal cooperator: The abortionist who agrees with the actions of the principal agent and supports her by performing the abortion. Immediate material cooperator: A nurse who does not agree with the actions of the principal agent but supports the abortionist in performance of the abortion. Mediate material cooperators: The nurse who does not agree with the actions of the principal agent but prepares her for the abortion and monitors her recovery post-abortion. Remote mediate material cooperators: The technicians at the abortion clinic that process and package fetal tissue for future use in scientific research. The scientists who arrange to receive aborted fetal tissue from the clinic for their research. Very remote mediate material cooperators: Individuals utilizing a product, for example a vaccine that was generated utilizing aborted fetal tissue. Even the distant cooperation represented by these vaccines needs to be avoided as it is: moral coercion of the conscience of the parents, who are forced to choose to act against their conscience or otherwise, to put the health of their children and the population as a whole at risk. ...[Therefore,] doctors and fathers of families have a duty to take recourse to alternative vaccines (if they exist), putting pressure on the political authorities and health systems so that other vaccines without moral problems become available. (Pontifical Academy for Life 2006, 549, 547–8)"

- Use of fetal tissue in vaccine development

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"The human embryonic kidney (HEK) 293 cell line, derived from an elective abortion in the 1970s, is routinely used for production of proteins and cultivation of viruses due to the ease of transfection with gene constructs that are efficiently translated into appropriately folded proteins (Wong 2006). A PubMed search with the term “HEK,” lists more than thirty thousand citations, testifying to the extensive use of this cell line.1 The Catholic Church’s position on the use of HEK293 cells, or other cell lines generated from elective abortions, in medical research is that they should be avoided because other-wise this creates a “contradiction in the attitude of the [researcher] who says that he does not approve of the injustice perpetrated by others, but at the same time accepts for his own work the ‘biological material’ which the others have obtained by means of that injustice” (Congregation for the Doctrine of the Faith 2008, no. 35). Again, alternatives should be explored. Utilization of fetal tissue from spontaneous abortion (miscarriage) is licit. In addition, COS-1 cells that are not derived from elective abortions are effective for production of proteins that could be utilized in some studies (Smith 2009). Unfortunately, COS-1 cells are of monkey origin. Hence, xenogeneic differences between monkey and human proteins limit their use in the generation of vaccines."

- Use of fetal tissue in vaccine development

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"Recently, two articles were published in the New England Journal of Medicine that char acterized fetuses of elective abortions, one being thirty-two weeks old, from mothers who contracted Zika virus in the first trimester of pregnancy (Mlakar et al. 2016; Driggers et al. 2016). These studies identified Zika virus in the microcephalic brains of the fetuses indicating an association between in utero Zika virus infection and microcephaly. More research on human subjects with similar experimental designs has been proposed to better understand fetal infection (Check Hayden 2016). These studies would also involve pregnant women who have been exposed to Zika virus infection that are followed for microcephaly by ultrasound throughout pregnancy. They would be informed of ultrasound results and, if microcephaly was demonstrated, would receive counsel on the prognosis of their child and options available, including termination of the pregnancy. If the mother elects to abort her child and provides her consent, the aborted fetal tissue would then be utilized in research procedures. This experimental design denies the intrinsic right to life of unborn human beings as the success of the study is predicated on the decisions of mothers to abort their babies. The U.S. Department of Health and Human Services Code of Federal Regulations (CFR) Title 45 Part 46 Subpart B, “Additional Protections for Pregnant Women, Human Fetuses, and Neonates involved in Research,” indicates that: The risk to the fetus is caused solely by interventions or procedures that hold out the prospect of direct benefit for the woman or the fetus; or, if there is no such prospect of benefit, the risk to the fetus is not greater than minimal and the purpose of the research is the development of important biomedical knowledge which cannot be obtained by any other means. (U.S. Department of Health and Human Services 2009)."

- Use of fetal tissue in vaccine development

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"While the ultrasound procedure presents minimal risk to the fetus, diagnosis of microcephaly by ultrasound has the potential to place the fetus at greatest risk due to the mother’s decision to abort the fetus. To minimize the possibility that involvement in research will influence a mother’s decision to terminate a pregnancy, 45 CFR 46, Subpart B, indicates that, “no inducements, monetary or otherwise, will be offered to terminate a pregnancy” (U.S. Department of Health and Human Services 2009). In addition, it “excludes researchers from any decisions as to the timing, methods, or procedures used to terminate a pregnancy, or determinations on the viability of the fetus at the termination of the pregnancy” (U.S. Department of Health and Human Services 2009). Nevertheless, it is very challenging to design experimentation that identifies microcephaly in utero, which would not increase the number of elective abortions regardless of whether research scientists desiring aborted fetal tissue were excluded from involvement with patients’ decision making. Here, the Catholic Church’s perspective is invaluable: “sick and disabled people are not some separate category of humanity; in fact, sickness and disability are part of the human condition and affect every individual, even when there is no direct experience of it” (Congregation for the Doctrine of the Faith 2008, no. 22). Therefore, only an experimental design that recognized the dignity and legal status of both healthy and diseased fetuses would effectively discourage elective abortion in research studies. This design would not only protect the unborn but also limit scandal (Catechism of the Catholic Church, no. 2284), a behavior that leads another to do evil, from the actions of mothers and scientists. Development of a vaccine against Zika virus is a top priority; and as the virus infects fetal brain tissue, it is likely that cultivation of Zika virus for use in vaccines could occur in fetal tissue derived from elective abortions. However, alternative tissue that is not derived from elective abortions could be equally effective and should be investigated."

- Use of fetal tissue in vaccine development

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"Quite apart from the health benefits and risks associated with using or not using vaccines, some people oppose the use of certain common vaccines—such as Varivax (for chicken pox) and Meruvax II (for rubella)—because of the connection between the production of these vaccines and elective abortion. The production of these and some other vaccines involves a stage in which viruses are grown in human cell culture. Because viruses can reproduce only inside living cells, they are placed in the human cell culture and allowed to grow in large quantities. The viruses are removed from the cell culture, inactivated or modified, and then processed further in order to produce the vaccine. There are two human cell lines that provide the cell cultures needed for producing vaccines. One of these lines, called WI-38, was developed in 1961 in Philadelphia from the normal lung tissue of a three-month-old female fetus obtained by surgical abortion.19 The other line, called MRC-5, was developed from normal lung tissue of a fourteen-week-old male fetus, aborted “for psychiatric reasons.” The WI-38 human diploid cell line … has been shown to have one of the broadest human virus spectra of any cell population that has been tested and is especially useful for isolation of rhinoviruses. The cells are free of contaminating viruses, mycoplasmas or any other microorganism and do not form tumors when inoculated subcutaneously into terminal human cancer patients.21 MRC-5 cells replicate more rapidly and are less sensitive to adverse environmental factors than WI-38 cells. The MRC-5 cell line, like WI-38 (ATCC CCL-75), is susceptible to a wide range of human viruses, is suitable for the production of viral vaccines, and has been useful in senescence studies."

- Use of fetal tissue in vaccine development

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"These cell lines are maintained in such a way that they have an indefinite lifespan, providing all the cells needed for the production of vaccine and for some other uses. It is said to be unlikely that any additional human cell lines will be produced or needed for two reasons. First, for scientific purposes, it is desirable to make use of well-known cell lines that have proven over the years to be useful for these purposes and to be free of complicating or contaminating factors (as described in the preceding quotations). Second, any cell line such as these must be approved by the Food and Drug Administration, which means that it is probably financially prohibitive to try to gain the same approval for other lines when these have already proven effective. This situation generates a difficulty for people who both oppose abortion in principle and would like to have the benefits of these vaccines. Opposing abortion “in principle” here means moral condemnation of elective abortion itself without regard to circumstances, motives, or beneficial consequences. The various reasons, theological or philosophical, that people might bring forward to support this opposition are not immediately relevant; it is necessary only that the opposition be principled. This kind of attention to moral good, i.e., moral good understood as decisively superior to goods of health and life, opens the door to a different order of opposition to vaccination. For using the vaccines produced in the manner described above appears to involve profiting from abortion and it is a question whether someone can both use these vaccines and oppose abortion without moral incoherence. Is the moral integrity of a person opposed to abortion compromised by benefitting from the research following the abortion, which research has led to the development of several powerful vaccines? Is it immorally opportunistic, vulture-like, or hypocritical for someone to take advantage of something he or she condemns as evil? Or, on the other hand, since the abortions have already been accomplished, is not the best course of action to pursue whatever good can be derived from these abortions? To answer these questions, it is necessary to try to determine the moral relationship of the use of these vaccines to the two abortions25 that have already taken place and to try to determine whether the use of these vaccines either condones or promotes further abortions."

- Use of fetal tissue in vaccine development

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"When aborted fetal tissue is transplanted into others for experimental or therapeutic purposes, the very use of the tissue uses it up and additional uses require an additional supply of tissue, normally made available by further abortions. In vaccine production, the currently available cell lines provide all the fetal material that is needed now and, apparently, in the future. Indeed, the success of these particular cell lines makes it unlikely that any new lines will be developed (whether from induced or spontaneously aborted children). Hence, the production techniques themselves do not require further abortions. The moral difference between vaccine technology and tissue transplantation is not changed by the fact that the product labeling for Varivax, for example, states that each dose contains “residual components of MRC-5 cells including DNA and protein.” These trace particles do not function in any sense as active components in the effectiveness of the vaccine. Still, it remains necessary to inquire into the relationship between the production of the vaccines and the two abortions that yielded the tissue. According to all available reports, in both cases the decision to abort was independent of the desire to make use of fetal tissue. In other words, the abortions would have taken place whether or not the cell-line research would have followed. This means that the abortions were not undertaken in order to produce vaccines or to fulfill any other research purpose. Moreover, nothing indicates that the vaccine production requires cell lines from electively aborted fetuses; tissue that is sufficiently healthy to produce cell lines of the type requisite for vaccine production might have become available from a fetus that died from some other cause. Granted, healthy tissue is more commonly found in electively aborted fetuses, but nothing indicates that such tissue is necessarily unavailable from other sources. These points suggest that vaccine production and, hence, use is morally separable from abortion, even though current production in fact depends upon cell lines derived from aborted fetal tissue. Vaccine production and abortion are morally independent, which is to say that vaccine use and opposition to abortion are in principle morally coherent."

- Use of fetal tissue in vaccine development

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"One pertinent detail that I have not been able to discover is the exact manner in which the tissue was transferred from those who performed the abortions to those who initiated the research. Did the research teams make it known that they were seeking certain types of tissue in a certain condition and did this influence the time or manner of the relevant abortions? This is significant because it can determine the moral quality of the initial research work relative to the abortions. This can be seen clearly by considering the differences between ordinary abortions and abortions that might be performed with a view to using fetal tissue for therapeutic or research purposes. In some of these cases it could happen that the manner of the abortion would be dictated by the need for certain amounts of, say, neural tissue in a certain condition. And so it might become necessary for fetal tissue collection to take place while the fetus still lives, or, more accurately, it might be necessary that the manner of fetal tissue collection itself be the cause of fetal death. If some similar relationship obtained between the original abortionists and the researchers who developed the cell lines, these researchers would be morally implicated in the abortion. Nevertheless, judging those actions is not now the primary concern. Knowing the exact manner of the transfer of tissue would be significant for evaluating the moral character of the initial research uses of the fetal tissue, but it is not, I argue below, decisive for evaluating the use of the vaccines today."

- Use of fetal tissue in vaccine development

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"Now, in the present case, the only opportunity for cooperation in abortion occurs in connection with the initial transfer of tissue. Today, when a person receives a vaccine injection, there simply is no cooperative action with whoever performed the abortions. The vaccine user provides no material assistance in the abortion nor acts in such a way as to will that the abortions take place. It is true as a matter of fact that the cell lines used to produce vaccines come from abortions, but abortion is not essentially necessary as a means to this end. This does not mean that the use of the vaccine is totally unrelated to abortion, but only that the distinctions that help to assess cooperation in evil do not provide a coherent moral analysis. Considering the independence—not only in time and place, but also morally—of vaccination from abortion, one comes to see that one achieves a morally coherent understanding of vaccination without essential relation to one’s moral condemnation (or for that matter, approval) of abortion. The use of these cell lines for the production of vaccines is somewhat akin to the use of the organs of a murder victim for transplantation in order to benefit others. A murder victim’s organs are available because of a morally reprehensible deed, but their use to benefit someone else does not make the transplantation team or the recipient complicit in the murder. Once again, there simply is no cooperative action between the murderer and the organ recipient or even the transplantation team. Acknowledging that it is distasteful to draw personal benefit from another’s suffering, one must yet recognize that taking advantage of this situation in this manner is not, as such, morally evil or morally incoherent. Just as it would be preferable to receive organs without any murder having occurred, in the same way, it would be preferable if the vaccines had no connection with abortion. Nevertheless, the use of the vaccine is accidentally, not essentially related morally to those two abortions."

- Use of fetal tissue in vaccine development

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