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April 10, 2026
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"If there is any consistent enemy of science, it is not religion, but irrationalism."
"[A]lthough species may be discrete, they have no immutable essence. Variation is the raw material of evolutionary change. It represents the fundamental reality of nature, not an accident about a created norm. Variation is primary; essences are illusory. Species must be defined as ranges of irreducible variation."
"We often think, naĂŻvely, that missing data are the primary impediments to intellectual progressâjust find the right facts and all problems will dissipate. But barriers are often deeper and more abstract in thought. We must have access to the right metaphor, not only to the requisite information. Revolutionary thinkers are not, primarily, gatherers of facts, but weavers of new intellectual structures."
"The world, unfortunately, rarely matches our hopes and consistently refuses to behave in a reasonable manner."
"The progress of science requires more than new data; it needs novel frameworks and contexts. And where do these fundamentally new views of the world arise? They are not simply discovered by pure observation; they require new modes of thought. And where can we find them, if old modes do not even include the right metaphors? The nature of true genius must lie in the elusive capacity to construct these new modes from apparent darkness. The basic chanciness and unpredictability of science must also reside in the inherent difficulty of such a task."
"Siphonophores do not convey the messageâa favorite theme of unthinking romanticismâthat nature is but one gigantic whole, all its parts intimately connected and interacting in some higher, ineffable harmony. Nature revels in boundaries and distinctions; we inhabit a universe of structure. But since our universe of structure has evolved historically, it must present us with fuzzy boundaries, where one kind of thing grades into another."
"If genius has any common denominator, I would propose breadth of interest and the ability to construct fruitful analogies between fields."
"I want to argue that the âsuddenâ appearance of species in the fossil record and our failure to note subsequent evolutionary change within them is the proper prediction of evolutionary theory as we understand it. [âŚ] Evolutionary âsequencesâ are not rungs on a ladder, but our retrospective reconstruction of a circuitous path running like a labyrinth, branch to branch, from the base of the bush to a lineage now surviving at its top."
"We should therefore, with grace and optimism, embrace NOMA's tough-minded demand: Acknowledge the personal character of these human struggles about morals and meanings, and stop looking for definite answers in nature's construction. But many people cannot bear to surrender nature as a âtransitional objectââa baby's warm blanket for our adult comfort. But when we do (for we must), nature can finally emerge in her true form: not as a distorted mirror of our needs, but as our most fascinating companion. Only then can we unite the patches built by our separate magisteria into a beautiful and coherent quilt called wisdom."
"[H]istorical science is not worse, more restricted, or less capable of achieving firm conclusions because experiment, prediction, and subsumption under invariant laws of nature do not represent its usual working methods. The sciences of history use a different mode of explanation, rooted in the comparative and observational richness in our data. We cannot see a past event directly, but science is usually based on inference, not unvarnished observation (you don't see electrons, gravity, or black holes either)."
"The divine tape player holds a million scenarios, each perfectly sensible. Little quirks at the outset, occurring for no particular reason, unleash cascades of consequences that make a particular future seem inevitable in retrospect. But the slightest early nudge contacts a different groove, and history veers into another plausible channel, diverging continually from its original pathway. The end results are so different, the initial perturbation so apparently trivial."
"I am not insensible to natural beauty, but my emotional joys center on the improbable yet sometimes wondrous works of that tiny and accidental evolutionary twig called Homo sapiens. And I find, among these works, nothing more noble than the history of our struggle to understand natureâa majestic entity of such vast spatial and temporal scope that she cannot care much for a little mammalian afterthought with a curious evolutionary invention, even if that invention has, for the first time in some four billion years of life on earth, produced recursion as a creature reflects back upon its own production and evolution. Thus, I love nature primarily for the puzzles and intellectual delights that she offers to the first organ capable of such curious contemplation."
"The true beauty of nature is her amplitude; she exists neither for nor because of us, and possesses a staying power that all our nuclear arsenals cannot threaten (much as we can easily destroy our puny selves)."
"The silliest and most tendentious of baseball writing tries to wrest profundity from the spectacle of grown men hitting a ball with a stick by suggesting linkages between the sport and deep issues of morality, parenthood, history, lost innocence, gentleness, and so on, seemingly ad infinitum. (The effort reeks of silliness because baseball is profound all by itself and needs no excuses; people who don't know this are not fans and are therefore unreachable anyway.)"
"Biological evolution is a system of constant divergence without subsequent joining of branches. Lineages, once distinct, are separate forever. In human history, transmission across lineages is, perhaps, the major source of cultural change. Europeans learned about corn and potatoes from Native Americans and gave them smallpox in return."
"We live in a capitalist economy, and I have no particular objection to honorable self-interest. We cannot hope to make the needed, drastic improvement in primary and secondary education without a dramatic restructuring of salaries. In my opinion, you cannot pay a good teacher enough money to recompense the value of talent applied to the education of young children. I teach an hour or two a day to tolerably well-behaved near-adultsâand I come home exhausted. By what possible argument are my services worth more in salary than those of a secondary-school teacher with six classes a day, little prestige, less support, massive problems of discipline, and a fundamental role in shaping minds. (In comparison, I only tinker with intellects already largely formed.)"
"Memory is a fascinating trickster. Words and images have enormous power and can easily displace actual experience over the years."
"Included in this âalmost nothing,â as a kind of geological afterthought of the last few million years, is the first development of self-conscious intelligence on this planetâan odd and unpredictable invention of a little twig on the mammalian evolutionary bush. Any definition of this uniqueness, embedded as it is in our possession of language, must involve our ability to frame the world as stories and to transmit these tales to others. If our propensity to grasp nature as story has distorted our perceptions, I shall accept this limit of mentality upon knowledge, for we receive in trade both the joys of literature and the core of our being."
"Most impediments to scientific understanding are conceptual locks, not factual lacks. Most difficult to dislodge are those biases that escape our scrutiny because they seem so obviously, even ineluctably, just. We know ourselves best and tend to view other creatures as mirrors of our own constitution and social arrangements. (Aristotle, and nearly two millennia of successors, designated the large bee that leads the swarm as a king.)"
"The facts of nature are what they are, but we can only view them through the spectacles of our mind. Our mind works largely by metaphor and comparison, not always (or often) by relentless logic. When we are caught in conceptual traps, the best exit is often a change in metaphorânot because the new guideline will be truer to nature (for neither the old nor the new metaphor lies âout thereâ in the woods), but because we need a shift to more fruitful perspectives, and metaphor is often the best agent of conceptual transition."
"There are no shortcuts to moral insight. Nature is not intrinsically anything that can offer comfort or solace in human termsâif only because our species is such an insignificant latecomer in a world not constructed for us. So much the better. The answers to moral dilemmas are not lying out there, waiting to be discovered. They reside, like the kingdom of God, within usâthe most difficult and inaccessible spot for any discovery or consensus."
"The argument of the âlong viewâ may be correct in some meaninglessly abstract sense, but it represents a fundamental mistake in categories and time scales. Our only legitimate long view extends to our children and our children's children's childrenâhundreds or a few thousands of years down the road. If we let the slaughter continue, they will share a bleak world with rats, dogs, cockroaches, pigeons, and mosquitoes. A potential recovery millions of years later has no meaning at our appropriate scale."
"Lavoisier was right in the deepest, almost holy, way. His passion harnessed feeling to the service of reason; another kind of passion was the price. Reason cannot save us and can even persecute us in the wrong hands; but we have no hope of salvation without reason. The world is too complex, too intransigent; we cannot bend it to our simple will."
"Guessing right for the wrong reason does not merit scientific immortality."
"Science is a method for testing claims about the natural world, not an immutable compendium of absolute truths. The fundamentalists, by "knowing" the answers before they start, and then forcing nature into the straitjacket of their discredited preconceptions, lie outside the domain of scienceâor of any honest intellectual inquiry."
"When we seek a textbook case for the proper operation of science, the correction of certain error offers far more promise than the establishment of probable truth. Confirmed hunches, of course, are more upbeat than discredited hypotheses. Since the worst traditions of âpopularâ writing falsely equate instruction with sweetness and light, our promotional literature abounds with insipid tales in the heroic mode, although tough stories of disappointment and loss give deeper insight into a methodology that the celebrated philosopher Karl Popper once labeled as âconjecture and refutation.â"
"All interesting issues in natural history are questions of relative frequency, not single examples. Everything happens once amidst the richness of nature. But when an unanticipated phenomenon occurs again and againâfinally turning into an expectationâthen theories are overturned."
"We inhabit a complex world. Some boundaries are sharp and permit clean and definite distinctions. But nature also includes continua that cannot be neatly parceled into two piles of unambiguous yeses and noes. Biologists have rejected, as fatally flawed in principle, all attempts by anti-abortionists to define an unambiguous âbeginning of life,â because we know so well that the sequence from ovulation or spermatogenesis to birth is an unbreakable continuumâand surely no one will define masturbation as murder."
"The legends of fieldwork locate all important sites deep in inaccessible jungles inhabited by fierce beasts and restless natives, and surrounded by miasmas of putrefaction and swarms of tsetse flies. (Alternative models include the hundredth dune after the death of all camels, or the thousandth crevasse following the demise of all sled dogs.)"
"An old paleontological in joke proclaims that mammalian evolution is a tale told by teeth mating to produce slightly altered descendant teeth."
"Our world is not an optimal place, fine tuned by omnipotent forces of selection. It is a quirky mass of imperfections, working well enough (often admirably); a jury-rigged set of adaptations built of curious parts made available by past histories in different contexts. [âŚ] A world optimally adapted to current environments is a world without history, and a world without history might have been created as we find it. History matters; it confounds perfection and proves that current life transformed its own past."
"Hyper-selectionism has been with us for a long time in various guises; for it represents the late nineteenth century's scientific version of the myth of natural harmonyâall is for the best in the best of all possible worlds (all structures well designed for a definite purpose in this case). It is, indeed, the vision of foolish Dr. Pangloss, so vividly satirized by Voltaire in Candideâthe world is not necessarily good, but it is the best we could possibly have."
"The animals of the Burgess Shale are holy objectsâin the unconventional sense that this word conveys in some cultures. We do not place them on pedestals and worship from afar. We climb mountains and dynamite hillsides to find them. We quarry them, split them, carve them, draw them, and dissect them, struggling to wrest their secrets. We vilify and curse them for their damnable intransigence. They are grubby little creatures of a sea floor 530 million years old, but we greet them with awe because they are the Old Ones, and they are trying to tell us something."
"[C]ontingency is a thing unto itself, not the titration of determinism by randomness."
"It has become, in my view, a bit too trendy to regard the acceptance of death as something tantamount to intrinsic dignity. Of course I agree with the preacher of Ecclesiastes that there is a time to love and a time to die - and when my skein runs out I hope to face the end calmly and in my own way. For most situations, however, I prefer the more martial view that death is the ultimate enemy - and I find nothing reproachable in those who rage mightily against the dying of the light."
"I strongly reject any conceptual scheme that places our options on a line, and holds that the only alternative to a pair of extreme positions lies somewhere between them. More fruitful perspectives often require that we step off the line to a site outside the dichotomy."
"I believe [âŚ] that we can still have a genre of scientific books suitable for and accessible alike to professionals and interested laypeople. The concepts of science, in all their richness and ambiguity, can be presented without any compromise, without any simplification counting as distortion, in language accessible to all intelligent people. [âŚ] I hope that this book can be read with profit both in seminars for graduate students andâif the movie stinks and you forgot your sleeping pillsâon the businessman's special to Tokyo."
"But all evolutionary biologists know that variation itself is nature's only irreducible essence. Variation is the hard reality, not a set of imperfect measures for a central tendency. Means and medians are the abstractions."
"Wallace's error on human intellect arose from the inadequacy of his rigid selectionism, not from a failure to apply it. And his argument repays our study today, since its flaw persists as the weak link in many of the most âmodernâ evolutionary speculations of our current literature. For Wallace's rigid selectionism is much closer than Darwin's pluralism to the attitude embodied in our favored theory today, which, ironically in this context, goes by the name of âNeo-Darwinism.â"
"I am not unmindful of the journalist's quip that yesterday's paper wraps today's garbage. I am also not unmindful of the outrages visited upon our forests to publish redundant and incoherent collections of essays; for, like Dr. Seuss' Lorax, I like to think that I speak for the trees. Beyond vanity, my only excuses for a collection of these essays lie in the observation that many people like (and as many people despise) them, and that they seem to cohere about a common themeâDarwin's evolutionary perspective as an antidote to our cosmic arrogance."
"The beauty of nature lies in detail; the message, in generality."
"[A]s we discern a fine line between crank and genius, so also (and unfortunately) we must acknowledge an equally graded trajectory from crank to demagogue. When people learn no tools of judgment and merely follow their hopes, the seeds of political manipulation are sown."
"The problem may be briefly stated: What does "median mortality of eight months" signify in our vernacular? I suspect that most people, without training in statistics, would read such a statement as "I will probably be dead in eight months" - the very conclusion that must be avoided, since it isn't so, and since attitude matters so much."
"Yesterdayâs seer is todayâs bore."
"Few campaigns are more dangerous than emotional calls for proscription rather than thought."
"[T]rying to keep an intellectual away from literature works about as well as recommending chastity to Homo sapiens, the sexiest primate of all."
"Throughout his last half-dozen books, for example, Arthur Koestler has been conducting a campaign against his own misunderstanding of Darwinism. He hopes to find some ordering force, constraining evolution to certain directions and overriding the influence of natural selection. [âŚ] Darwinism is not the theory of capricious change that Koestler imagines. Random variation may be the raw material of change, but natural selection builds good design by rejecting most variants while accepting and accumulating the few that improve adaptation to local environments."
"I do not see why we should reject all genetic engineering because its technology might, one day, permit such a perversion of decency in the hands of some latter-day Hitlerâyou may as well outlaw printing because the same machine that composes Shakespeare can also set Mein Kampf. The domino theory does not apply to all human achievements. If we could, by transplanting a bacterial gene, confer disease or cold resistance upon an important crop plant, should we not do so in a world were people suffer so terribly from malnutrition? Must such a benefit imply that, tomorrow, corn and wheat, sea horses and orchids will be thrown into a gigantic vat, torn apart into genetic units, and reassembled into rows of identical human servants? Eternal vigilance, to recombine some phrases, is the price of technological achievement."
"Nature has no automatically transferable wisdom to serve as the basis of human morality. Passive observation and unquestioned reverence for nature are no substitute for ethical philosophy."
"This is a personal story of statistics, properly interpreted, as profoundly nurturant and life-giving."