"Can you keep a secret? In the next 72 hours, this desperate, unemployed actor will secretly audition for the lead of a soap opera. And become America's hottest new actress."

"What do you get when you cross a hopelessly straight starving actor with a dynamite red sequined dress? You get America's hottest new actress."

"He's Tootsie... She's Dustin Hoffman"

"Desperate, he took a female role and became a star. If only he could tell the woman he loves."

"This Is a Hell of a Way To Make a Living."

"Ron Carlisle: [after Dorothy reveals she is a man] I knew there was a reason she didn't like me!"

"John Van Horne: [after Dorothy reveals she is a man] Does Jeff know?"

"George Fields: [to Dorothy/Michael] I begged you to get therapy."

"Well, good night, Michael. It was a wonderful party. My date left with someone else. I had a lot of fun. Do you have any Seconol?"

"There is nothing you can do for me. I just have to feel like this until I don't feel like this anymore and you're gonna have to know that you're the one that made me feel this way."

"Mike, I really appreciate you're doing this, but... it is just for the money, isn't it? It's not just so you can wear these little outfits?"

"[to April, dressed only in bra and panties] What kind of mother would I be if I didn't give my girls tits... tips?"

"[in her audition] Oh I know what y'all really want is some gross caricature of a woman to prove some idiotic point that power makes a woman masculine, or masculine women are ugly. Well shame on you for letting a man do that, or any man that does that. That means you, dear. Miss Marshall. Shame on you, you macho shit head."

"You know, I could lay a big line on you and we could do a lot of role playing, but the simple truth is that I find you very interesting and I'd really like to make love to you."

"She Makes Dinner. She Does Windows. She Reads Bedtime Stories. She's a Blessing in Disguise."

"[reading a letter] "Dear Mrs. Doubtfire, two months ago, my mom and dad decided to separate. Now they live in different houses. My brother Andrew says that we aren't going to be a family anymore. Is this true? Did I lose my family? Is there anything I can do to get my parents back together? Sincerely, Katie McCormick." Oh, my dear Katie. You know, some parents, when they're angry, they get along much better when they don't live together. They don't fight all the time, and they can become better people, and much better mummies and daddies for you. And sometimes they get back together. And sometimes they don't, dear. And if they don't, don't blame yourself. Just because they don't love each other anymore, doesn't mean that they don't love you. There are all sorts of different families, Katie. Some families have one mommy, some families have one daddy, or two families. And some children live with their uncle or aunt. Some live with their grandparents, and some children live with foster parents. And some live in separate homes, in separate neighborhoods, in different areas of the country - and they may not see each other for days, or weeks, months... even years at a time. But if there's love, dear... those are the ties that bind, and you'll have a family in your heart, forever. All my love to you, poppet. You're going to be all right. Bye-bye."

"Dr. Toad — Todd the Bartender"

"Martin Mull — Justin Gregory"

"Anne Haney — Mrs. Sellner"

"Scott Capurro — Jack Hillard, Frank’s partner"

"Robert Prosky — Jonathan Lundy"

"Mara Wilson — Natalie Hillard, Daniel & Miranda’s daughter"

"Matthew Lawrence — Christopher Hillard, Daniel & Miranda’s son"

"Lisa Jakub — Lydia Hillard, Daniel & Miranda’s daughter"

"Polly Holliday — Gloria Chaney"

"Harvey Fierstein — Frank Hillard, Daniel’s brother"

"Pierce Brosnan — Stuart Dunmeyer, Miranda’s partner"

"Sally Field — Miranda Hillard, Daniel’s wife"

"Robin Williams — Daniel Hillard / Mrs. Euphegenia Doubtfire, Hillard’s housekeeper"

"She'll Rock Your World."

"Edward G. Robinson Jr. — Johnny Paradise"

"Beverly Wills — Dolores"

"Harry Wilson — Spats's henchman"

"Mike Mazurki — Spats's henchman"

"George E. Stone — "Toothpick" Charlie"

"Barbara Drew — Nellie Weinmeyer"

"Billy Gray — Sig Poliakoff"

"Dave Barry — Mister Beinstock"

"Joan Shawlee — Sweet Sue"

"Nehemiah Persoff — "Little Bonaparte""

"Joe E. Brown — Osgood Fielding III"