LSD

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aprile 10, 2026

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aprile 10, 2026

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"Rationale for Treatment with LSD and UML Our interest in these drugs was due in part to their psychotomimetic effect, hoping thereby that the autistic defenses of schizophrenic children might be broken down. Of equal interest, on a theoretical basis, is the serotonin inhibiting effect and of greater interest is their effect on the autonomic and central nervous system. Brodie has described the effects of LSD and other hallucinogenic agents as "arousal and increased responsiveness to sensory stimuli, preponderance of sympathetic activity and increased skeletal muscle tone and activity." Of particular interest is their tonic effect on the vascular bed especially of the brain, as has been shown with UML in vascular headaches. The known effects of these drugs on perception further increases their interest in the treatment of schizophrenia. Such drugs were of interest to us for the treatment of childhood schizophrenia since our definition of this condition is a disorder in maturation characterized by an embryonic primitive plasticity in all areas of integrative brain functioning from which behavior subsequently arises. This includes all autonomic functions, perception, emotion, intelligence. It was hoped that 'these drugs might prove some-what specific in modifying the basic process as well as the secondary symptoms. Autism is seen as a withdrawal or denial defense against disturbing sensations arising from disturbed autonomic function and perceptual function and anxiety in the young child with lagging and atypical maturation. It was hoped that this autism might be disrupted and that more normal autonomic functions in the vascular bed, brain, intestines, skin and other organs as well as in perception would permit more normal development."

- LSD

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"LSD, lysergic acid diethylamid, or acid, was invented by accident in a Swiss laboratory in the 1930s by a doctor, Albert Hofmann, when a small amount of the compound on his fingertips resulted in "an altered state of awareness of the world." After the war, Hofmann's laboratory sold small amounts in the United States, where saxophonist John Coltrane, celebrated for his introspective brilliance, jazz trumpeter Dizzy Gilespie, and pianist Thelonious Monk experimented with the new drug, though not nearly as much as the CIA. The substance was hard to detect because it had neither odor, taste, nor color. An enemy surreptitiously exposed to LSD might reveal secrets or become confused and surrender. This was the origin of the idea of slipping acid into the water cooler. Plans under consideration included slipping acid to Egypt's Gamal Abdel Nasser and Cuba's Fidel Castro so that they would babble foolishly and lose their followings. But Castro's popularity among the young would probably have been enormously magnified once Allen Ginsberg and others learned that Fidel, too, was an acid head. Agents experimented on themselves, causing one to run outside to discover that cars were "bloodthirsty monsters." They also, in conjunction with the army, experimented on unknowing victims, including prisoners and prostitutes. The tests resulted in a number of suicides and psychotic patients and left the CIA convinced that it was almost impossible to usefully interrogate someone while under the influence of LSD. Acid experiments were encouraged by Richard Helms, who later, between 1967 and 1973, served as CIA director."

- LSD

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