"Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors that regulate lipid and lipoprotein metabolism, glucose homeostasis and inflammation. The PPAR family consists of three proteins, Ī±, Ī²/Ī“ and Ī³. Recent data suggest that PPARĪ± and Ī³ activation decreases atherosclerosis progression not only by correcting metabolic disorders, but also through direct effects on the vascular wall. PPARs modulate the recruitment of leukocytes to endothelial cells, control the inflammatory response and lipid homeostasis of monocytes/macrophages and regulate inflammatory cytokine production by smooth muscle cells. Experiments using animal models of atherosclerosis and clinical studies in humans strongly support an anti-atherosclerotic role for PPARĪ± and Ī³ in vivo. Thus, PPARs remain attractive therapeutic targets for the development of drugs used in the treatment of chronic inflammatory diseases such as atherosclerosis. Future research will aim for the development of more potent drugs with co-agonist activity on PPARĪ±, PPARĪ²/Ī“ and/or PPARĪ³ as well as tissue and target gene-selective PPAR receptor modulators (SPPARMs)."
Quote Details
Added by wikiquote-import-bot
Unverified quote
0 likes
Original Language: English
Available Languages (1)
Sources
Caroline Duval, Giulia Chinetti, FranƧois Trottein, Jean-Charles Fruchart, and Bart Staels,
https://en.wikiquote.org/wiki/Atherosclerosis
Revision History
No revisions have been submitted for this quote.
Categories
Atherosclerosis
6 quotes on TrueQuotesView all quotes by Atherosclerosis ā
Related Quotes
"Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an ongoing inflammatory responsā¦"
"Experimental work has elucidated molecular and cellular pathways of inflammation that promote atherosclerosis. Unraveā¦"
"The clinical manifestations of atherosclerosis are nowadays the main cause of death in industrialized countries, but ā¦"
"Atherosclerosis, the principal cause of heart attack, stroke and gangrene of the extremities, is responsible for 50% ā¦"
"The lesions of atherosclerosis are responsible for changes in the heart that can lead to myocardial infarction, in thā¦"
"Carbuncle is a confluent folliculitis that is affecting multiple s leading to multiple sinuses discharging pus. Optimā¦"
"He continued at work until March, 1853, when he had an accidentāa fall while descending some steps. A few weeks laterā¦"
"When the cook came in he was in a bad mood. He had a developing carbuncle on the back of his neck and the skin from tā¦"
"The starting-point of this lecturing trip around the world was Paris, where we had been living for a year or two. We ā¦"
"A is a deep, necrotizing form of with involvement of the subcutaneous tissue. Several furuncles may coalesce to form ā¦"