Neuroscientists

"Panˈdemik/: pan means "all"; demic (or demographic) means "people." It is well-named, because pandemic flu spreads easily throughout the world. Unlike seasonal flu, pandemics occur when a completely new or emerges. This sort of virus can emerge directly from animal reservoirs or be the result of a dramatic series of mutations -- so-called events -- in previously circulating viruses. In either case, the result is something mankind has never seen before: a that can spread easily from person to defenseless person, our immune systems never primed to launch any sort of defense."

"When most people hear "flu," they typically think of . No doubt, seasonal flu can be deadly, especially for the very young and old, as well as those with compromised immune systems. For most people, however, the seasonal flu virus, which mutates just a little bit every year, is not particularly severe because our immune systems have already probably seen a similar flu virus and thus know how to fight it. It's called native immunity or protection, and almost all of us have some degree of it. Babies are more vulnerable because they haven't been exposed to the seasonal flu and older people because their immune systems may not be functioning as well. Pandemic flu is a different animal, and you should understand the difference."

"flu is apolitical and does not discriminate between rich and poor. Geographical boundaries are meaningless, and it can circle the globe within hours. In terms of potential impact on mankind, the only thing that comes close is climate change. And, like climate change, pandemic flu is so vast, it can be challenging to wrap your head around it."

"Experts say we are "due" for one. When it happens, they tell us, it will probably have a greater impact on humanity than anything else currently happening in the world. And yet, like with most people, it is probably something you haven't spent much time thinking about. After all, it is human nature to avoid being consumed by hypotheticals until they are staring us squarely in the face. Such is the case with a highly lethal flu pandemic. And when it comes, it will affect every human alive today."

"It was the neurosurgeons who fascinated me. When they explained what they could do surgically to help, I thought, I want to be like them. I want to know what they know and have the ability to heal like they do. Eventually my grandfather got better, and my path in life was started."

"I was in my teens when our family faced a medical crisis. My grandfather, with whom I was very close, had a stroke and landed in the hospital. Sitting anxiously at his bedside, I watched nurses come and go, checking his vitals and looking at the monitors attached to his body. I remember sitting there wondering what could I do to make him feel better—to bring back the warm, thoughtful man I knew."

"A psychological consequence of this is the following: when we analyze a mechanism we tend to over estimate its complexity."

"It is actually impossible in theory to determine exactly what the hidden mechanism is without opening the box, since there are always many different mechanisms with identical behavior. Quite apart from this, analysis is more difficult than invention in the sense in which, generally, induction takes more time to perform than deduction: in induction one has to search for the way, whereas in deduction one follows a straightforward path."

"We will talk only about machines with very simple internal structures, too simple in fact to be interesting from the point of view of mechanical or electrical engineering. Interest arises, rather, when we look at these machines or vehicles as if they were animals, in a natural environment. We will be tempted, then, to use psychological language in describing their behavior. And yet we know very well that there is nothing in these vehicles that we have not put there ourselves."

"This is an exercise in fictional science, or science fiction, if you like that better. Not for amusement: science fiction in the service of science. Or just science, if you agree that fiction is a part of it, always was, and always will be as long as our brains are only miniscule fragments of the universe, much too small to hold all the facts of the world but not too idle to speculate about them."

"Imagine the inside of St. Peter’s in Rome filled with a huge quantity of fibers around a millimeter in diameter that crisscross the building in every direction creating a firm mat – then you have an idea of what the brain looks like when magnified a thousand times."

"Ad Aertsen succeeds in allowing his sense of humour to shine through the deep seriousness of his scientific ethos. He also has a very balanced attitude to the question of "theory or experiment"."

"A structure made up of fine threads, so many and so fine that even the strongest magnification of the microscope was hardly sufficient to allow all of them to be seen clearly. Some of the threads ran together in bundles and in layers in specific directions; others lay seemingly randomly distributed every which way through the tissue. Embedded in this felted mass of fibers, it was possible to discern spherical structures, the nuclei of the nerve cells..."

"The brain is encased in the head, the part of the body which in most walking, flying or swimming animals is the leading end of the moving body (with few exceptions: starfish, cuttlefish, humans, penguins when they are not swimming). The obvious risks which this localization entails are apparently compensated by the advantage of direct short connections with the sense organs localized in or on top of the head (olfaction, taste, vision, audition, vestibular sense), which together with the brain could be seen as something like the cockpit of the animal, or the pilot if one prefers."

"His life’s work and his extraordinary personality were inextricably interwoven... The focus of his research was the functional interpretation of brain structures. When electronic computers emerged in the 1950s, it was clear to Braitenberg that they presented conceptual models for brain function. Thus, his neuroanatomical studies aimed at identifying the typical network structure of individual brain areas."

"In Vehicles, Valentino Braitenberg (1984) proposed a series of 14 different thought experiments. Each of these experiments involved conceptualizing a fairly simple machine, and considering how that machine might behave in different environments. Some of these machines are reminiscent of Elmer and Elsie. As Braitenberg's book progresses, the hypothetical machines become more sophisticated, as does their consequent behavior."

"Not it is different with type 14 vehicles. They move through their world with consistent determination, always clearly after something that very often we cannot guess at the outset - something that may not even be there when the vehicle reaches the place it wants to get to. But it seems to be a good strategy, this running after a dream. Most of the time the chain of optimistic predicitions that seems to guide the vehicles's behaviour proves to be correct, and Vehicle 14 achieves goals that Vehicle 13 and its predecessors "couldn't not even dream of." The point is that while the vehicle goes through its optimistic predicitions, the succession of internal states implies movements and actions of the vehicle itself. While dreaming and sleepwalking, the vehicle transforms the world (and its own position in the world) in such a way that ultimately the state of the world is a more favorable one."

"[The final chapter of the book] sketch a few facts about animal brains that have inspired some of the properties of our vehicles, and their behavior will then seem less gratuitous than it may have seemed up to this poin.t"

"We must be careful, however, not to let the process of acquiring new ideas interfere with the detailed knowledge that our vehicle has assiduously collected and carefully stored in many associative connections during its lifetime. We know that this may happen in humans who are overly dedicated to the development of ideas. They tend to connect many individual cases into general categories ad then use the categories as if they were things, losing the potential for categorizing in other ways by remembering each instance."

"You may regret this, but you will soon notice that is a good idea to give chance a chance in the further creation of new brands of vehicles. This will make available a source of intelligence that is much more powerful than any engineering mind."

"The mechanism of learning is of course one of the most enthralling and baffling mysteries in the field of biology."

"[A] famous photograph... showing McCulloch (1898–1969) and Norbert Wiener (1894–1964) with British Cyberneticians Ross Ashby (1903–1972) and Grey Walter (1910–1977), first appeared in de Latil (1953) with the caption "The four pioneers of Cybernetics get together in Paris", and encapsulates a view of the development of cybernetics that has slowly become more accepted: that there were important British contributions from the outset."

"His popular and academic reputation encompassed a heterogeneous series of roles ranging from robotics pioneer, home guard explosive experts, wife swapper, t.v.-pundit, experimental drugs user, and skindiver to anarcho-syndicalist champion of leucotomy and electro-convulsive therapy."

"In a modest villa on the outskirts of Bristol lives Dr Grey Walter, a neurologist, who makes robots as a hobby. They are small, and he doesn’t dress them up to look like men – he calls them tortoises. And so cunningly have their insides been designed that they respond to the stimuli of light and touch in a completely life-like manner. This model is named Elsie, and she sees out of a photo-electric cell which rotates about her body. When light strikes the cell, driving and steering mechanisms send her hurrying towards it. If she brushes against any objects in her path, contacts are operated which turn the steering away, and so automatically she takes avoiding action. Mrs Walter’s pet is Elmer, Elsie’s brother, in the darker vest. He works in exactly the same way. Dr Walter says that his electronic toys work exactly as though they have a simple two-cell nervous system, and that, with more cells, they would be able to do many more tricks. Already Elsie has one up on Elmer: when her batteries begin to fail, she automatically runs home to her kennel for charging up, and in consequence can lead a much gayer life."

"Rapidly going over what I could recall of Jim Bursley's information about pathological curves confirmed the conjecture. The snowball curve, derived from an equilateral triangle, is a perimeter of infinite length enclosing a finite area. The angles or points of the perimeter are uncountable. An equilateral triangle projected integrally in the third dimension is a triangular pyramid of equal surfaces. The three-dimensional snowflake derived from this pyramid--hence its diamantine appearance--is a finite volume enclosed in a surface of infinite area. The convolutions of such a surface, to be gathered around its defined content extrude a number of discrete angles or points beyond all possibility of computation. The pressure on each point is infinitesimal, unmeasurably small; the total external pressure exerted on any part of the surface is an aggregate of infinitesimal values, itself infinitesimal."

"Simon, always a fool for simplicity, accepted. Punch took an envelope out of his pocket and scribbled on the back of it. He said, 'This has a simple arithmetical proof but no rational explanation of the paradox.' He gave it to Simon. Simon read it, looked at Punch with raised eyebrows, hunched his shoulders, shook his head sadly, and got up and left the room without a word."

"Some of these patterns of performance were calculable, though only as types of behaviour, in advance; some were quite unforeseen."

"Not in looks, but in action, the model must resemble an animal. Therefore it must have these or some measure of these attributes: exploration, curiosity, free-will in the sense of unpredictability, goalseeking, self-regulation, avoidance of dilemmas, foresight, memory, learning, forgetting, association of ideas, form recognition, and the elements of social accommodation. Such is life."

"The first notion of constructing a free goal-seeking mechanism goes back a wartime talk with the psychologist, , whose untimely death was one of the greatest losses Cambridge has suffered in years. When he was engaged on a warjob for the Government, he came to get the help of an automatic analyzer with some very complicated curves he had obtained, curves relating to the aiming errors of air gunners. Goal-seeking missiles were literally much in the air in those days; so, in our minds, were scanning mechanisms. Long before the home study was turned into a workshop, the two ideas, goal-seeking and scanning, had combined as the essential mechanical conception of a working model that would behave like a very simple animal."

"[A]n electro-mechanical creature which behaves so much like an animal that it has been known to drive a not usually timid lady upstairs to lock herself in her bedroom, an interesting blend of magic and science."

"These models are of course so simple that any more detailed comparison between them and living creatures would be purely conjectural."

"[E]xperiments with a simple little machine, designed to mimic certain elementary features of animal behavior... Consisting only of two vacuum tubes, two motors, a photoelectric cell and a touch contact, all enclosed in a tortoise-shaped 'shell, the model was a species of artificial creature which could explore its surroundings and seek out favorable conditions. It was named Machine speculatrix."

"[Walter even gave the tortoises a mock-biological name, Machina speculatrix] because they illustrate particularly the exploratory, speculative behaviour that is so characteristic of most animals."

"In any case there is an intense modern interest in machines that imitate life. The great difference between magic and the scientific imitation of life is that where the former is content to copy external appearance, the latter is concerned more with performance and behavior."

"In the dark ages before the invention of the electronic vacuum tube there were many legends of living statues and magic pictures. One of the commonest devices of sorcerers and witches was the model of an enemy which somehow embodied his soul, so that injury to the model would be reflected by suffering or death of the original... Idolatry, witchcraft and other superstitions are so deeply rooted and widespread that it is possible that even the most detached scientific activity may be psychologically equivalent to them; such activity may help to satisfy the desire for power, to assuage the fear of the unknown or to compensate for the flatness of everyday existence."

"Man is ruined by servility, conformism, obsequiousness, rather than aggressiveness, which is much more common in the environment than within ourselves."

"She seemed able to face with equal equanimity the rigours of fascist cruelty and suppression that she was dealt as a Jew; the problems of practising underground medicine in wartime; the difficulties posed by prejudice and discrimination against women; and the near isolation and challenges of those working at the cutting edge of science."

"She had this feeling for what was happening biologically. She was an intuitive observer, and she saw that something was making these nerve connections grow and was determined to find out what it was."

"The allegations against Fidia cannot be true. The process for awarding Nobel prizes is so complex that it cannot be corrupted."

"After centuries of dormancy, young women can now look toward a future moulded by their own hands."

"It is imperfection — not perfection — that is the end result of the program written into that formidably complex engine that is the human brain, and of the influences exerted upon us by the environment and whoever takes care of us during the long years of our physical, psychological and intellectual development."

"The young need to know how lucky they are to have been born in this splendid country, Italy."

"I consider imperfection a Darwinian spring of natural selection. For example, present day insects are identical to those of six million years ago: they were already perfect, and there was no reason for them to change. Man was instead imperfect, and this was the proxy for his own development and evolution."

"Better to add life to your days than days to your life."

"Those who are lucky enough to have faith are granted with a great support in all stages of life. If instead of an anthropomorphous God, who rewards the good, one replaces the imperative chiselled in our genetic program that good deeds have a price in themselves, and that evil has its own punishment, both the non-believer and the believer will find the same answer."

"I'm an atheist: I don't know what it means to believe in God."

"Everything came easy to me in life. I could always shake off difficulties, like water on a duck's wings."

"Rare are those people who use the mind, few use the heart and really unique are those who use both."

"I have lost a bit of my sight, much of my hearing. At conferences, I can't see the presentations and can't hear well. But I think more now than when I when I was twenty. The body can do whatever it likes. I am not the body: I am the mind."

"I never had any hesitation or regrets in this sense. My life has been enriched by excellent human relations, work and interests. I have never felt lonely."