Academics From Austria

"Like other modern artists faced with the advent of the photography, Klimt sought newer truths that could not be captured by the camera. He... turned the artists view inward—away from the three-dimensional outside world and toward the multidimensional inner self and the unconscious mind."

"I was very much influenced by the psychology of Freud and by early workers in the field of learning and memory—James, Thorndike, Pavlov, Skinner, and Ulric Neisser. Their thinking, and even their errors, provided a wonderfully rich cultural background for my later work."

"The remarkable insight that characterized Klimt's later work was contemporaneous with Freud's psychological studies and presaged the inward turn that would pervade all fields of inquiry in Vienna in 1900. This period... was characterized by the attempt to make a sharp break with the past and to explore new forms of expression in art, architecture, psychology, literature, and music. It spawned an ongoing pursuit to link these disciplines."

"Modernism began in the mid-nineteenth century as a response not only to the restrictions and hypocrisies of everyday life, but also as a reaction to the Enlightenment's emphasis on the rationality of human behavior. ...The founders of the Royal Society thought of God as a mathematician who had designed the universe according to logical and mathematical principles. The role of the scientist—the natural philosopher was to... decipher the codebook that God had used in creating the cosmos."

"As astronomy and physics inspired the Enlightenment, so biology inspired Modernism. ...This new view led to a reexamination in art of the biological nature of human existence, as evident in Édouard Manet's Déjeuner sur l’Herbe... Manet's painting... reveals a theme... the complex relationship between the sexes and between fantasy and reality. ...also startlingly modern because of its style. Several decades before Cézanne began to collapse three dimension into two, Manet here had already flattened the viewer's sense of perspective..."

"In Vienna, Modernism had three main characteristics. The first was the new view of the human mind as being largely irrational by nature. ...they questioned what constitutes reality, what lies below the surface appearances of people, objects, and events. ...They discovered that ...people harbor not only unconscious erotic feelings, but also unconscious aggressive impulses that are directed against themselves as well as against others. Freud later called these dark impulses the death instinct."

"The Age of Insight is a product of my subsequent fascination with the intellectual history of Vienna from 1890 to 1918, as well as my interest in Austrian modernist art, psychoanalysis, art history, and the brain science that is my life's work. In this book I examine the ongoing dialogue between art and science that had its origins in fin-de-siècle Vienna..."

"In the early 1960s, Kandel made the bold decision to conduct research on an unlikely animal, the large sea snail Aplysia californica. Kandel found this invertebrate attractive for neuroscience research because it has fewer and larger neurons than more traditional laboratory animals. This simple neural system would subsequently serve as an invaluable model for understanding the cellular basis of learning."

"Giacomo Rizzolatti... calls these "mirror neurons" and suggests that they provide the first insight into imitation, identification, empathy, and possibly the ability to mime vocalization—the mental processes intrinsic to human interaction. Vilayanur Ramachandran has found evidence of comparable neurons in the premotor cortex of people. ...one can see a whole new area of biology opening up... that can give us a sense of what makes us social, communicating beings. An ambitious undertaking of this sort might... teach us something about the factors that give rise to tribalism, which is so often associated with fear, hatred, and intolerance of outsiders."

"I would like to develop a reductionist approach to the problem of attention by focusing on how place cells... create an enduring spatial map only when an organism is paying attention to its surroundings."

"...in various types of organisms, from snails to flies to mice to people. ...learning and memory, as well as synaptic and neuronal plasticity, represent a family of processes that share a common logic and some key components but vary in the details of their molecular mechanisms."

"The Vienna School of Art History, influenced in part by Sigmund Freud's psychological work, began to develop a science-based psychology of art that was initially focused on the beholder. Today, the new science of mind has... again focused on the beholder."

"I outline in simple terms... our current understanding of the cognitive psychological and neurobiological basis of perception, memory, emotion, empathy, and creativity. ...the principles of the viewer's response to art are applicable to all periods of painting."

"The function of the modern artist was not to convey beauty, but to convey new truths."

"Much as Leonardo da Vinci and other Renaissance artists used the revelations of human anatomy to help them depict the body more accurately and compellingly, so, too, many contemporary artists may create new forms of representation in response to revelations about how the brain works."

"The portraits of the Viennese modernists, with their conscious and dramatic attempts to depict their subject's inner feelings, represent an ideal example of how psychological and biological insights can enrich our relationship with art."

"Reductionism can expand our vision and give us new insights into the nature and creation of art."

"A brain scan may reveal the neural signs of depression, but a Beethoven symphony reveals what that depression feels like. Both perspectives are necessary if we are to fully grasp the nature of mind, yet they are rarely brought together."

"Science may explain aspects of art but it will not replace the inspiration that art evokes..."

"Nothing is more stimulating for self-education than working in a new area."

"It is much more meaningful and enjoyable to read the scientific literature about experiments you are involved in yourself than to read about science in the abstract."

"Having been trained in history and the humanities, where one learns early on how depressing life can be, I am delighted to have ultimately switched to biology, where a delusional optimism still abounds."

"The idea that we are unaware of much of out mental life, first developed by Hermann Helmholtz, is central to psychoanalysis. Freud has added the interesting idea that although we are not aware of most instances of mental processing, we can gain conscious access... by paying attention."

"We now understand that every mental state and every mental disorder is a disorder of brain function. Treatments work by altering the structure and function of the brain."

"Cori Bargmann... has studied two variants of C. elegans... The only difference between the two is one amino acid in an otherwise shared receptor protein. Transferring the receptor from a social worm to a solitary worm makes the solitary worm social."

"I entered Harvard to become a historian and left to become a psychoanalyst, only to abandon both... to follow my intuition that the road to a real understanding of mind must pass through the cellular pathways of the brain."

"My hope is that the difference in the three generations' attitudes may signal a lessening of anti-Semitism in Austria."

"I continue to explore the science in which I work almost like a child, with naïve joy, curiosity, and amazement."

"Pernkopf was only one of many Austrians who were "rehabilitated" in the postwar period. Their rehabilitation underscores the tendency of Austria to forget, suppress, and deny the events of the Nazi period. ...Anton Pelinka ...has called this phenomenon the "great Austrian taboo." It is precisely this moral vacuum that induced Simon Wiesenthal to establish his documentation center for Nazi war crimes in Austria, not Germany."

"The intellectual life of turn-of-the-century Vienna is in my blood: my heart beats in three-quarter time."

"I was astonished to discover that working in the laboratory—doing science in collaboration with interesting and creative people—is dramatically different from taking courses and reading about science."

"One of the characteristic features of Viennese life at this time was the continual, easy interaction of artists, writers, and thinkers with scientists."

"The history of Austrian culture and scholarship in the modern era largely paralleled the history of Austrian Jewry."

"The Viennese Kultusgemeinde... was going bankrupt... European governments typically compensate Jewish agencies... but the Austrian government's compensation was not adequate. ...I owe my existence in the United States to the generosity of the Viennese Kultusgemeinde."

"The life of a biological scientist in the United States is a life of discussion and debate—it is the Talmudic tradition writ large. ...The egalitarian structure of American science encourages this camaraderie. ...this would not—could not—have taken place in the Austria, the Germany, the France, or perhaps even the England of 1955."

"I have at times felt alone, uncertain, without a well-trodden path to follow. Every time I embarked on a new course, there were well-meaning people... who advised against it. I had to learn early on to be comfortable with insecurity and to trust my own judgement on key issues."

"The idea that different aspects of visual perception might be handled in separate areas of the brain was predicted by Freud at the end of the nineteenth century. ...a cortical defect that affected [the] ability to combine aspects of vision into a meaningful pattern. ...defects, which Freud called agnosias (loss of knowledge)..."

"Segregation occurs in the primary visual area of the cortex, which gives rise to two parallel pathways. ...the "what" pathway, carries information about the form of an object... the "where" pathway, carries information about the movement of the object in space: where the object is located."

"What strategy does the brain use to read itself out? That question, which is central to the unitary nature of conscious experience, remains one of the many unresolved mysteries of the new science of mind."

"Each sensory system first analyzes and deconstructs, then restructures the raw, incoming information to its own built-in connections and rules—shades of Immanuel Kant."

"Aspects of visual perception—motion, depth, form, and color—are segregated from one another and conveyed in separate pathways in the brain, where they are brought together and coordinated into a unified perception."

"The firing of individual nerve cells involved in perceptual and motor processing is modified by attention and decision making."

"O'Keefe... argued that many forms of explicit memory (for example, memory for people and objects) use spatial coordinates... we typically remember people and events in a spatial context."

"Mountcastle discovered that tactile sensation is made up of several distinct modalities; for example, touch includes... hard pressure on the skin as well as a light brush... He found that each distinct submodality has its own private pathway within the brain and that this segregation is maintained at each relay..."

"Birds in which spatial memory is particularly important—those that store food at a large number of sites, for example—have larger hippocampuses than other birds. ...London taxi drivers have a larger hippocampus than others the same age. ...the size of their hippocampus continues to increase with time on the job."

"Cajal revealed the precision of the interconnections between populations of individual nerve cells. Mountcastle, Hubel, and Wiesel revealed the functional significance of those patterns of interconnections. They showed that the connections filter and transform sensory information on the way to and within the cortex, and that the cortex is organized into functional compartments, or modules."

"Long-term potentiation helps stabalize the internal representation of space, and... attention, a defining feature of explicit memory storage, modulates the representation of space."

"The fact that a gene must be switched on to form a long-term memory shows clearly that genes are not simply determinants of behavior but are also responsive to environmental stimulation, such as learning."

"CPEB is the first self-propogating form of a prion known to serve a physiological function... perpetuation of synaptic facilitation and memory storage."

"The growth and maintenance of new synaptic terminals makes memory persist. ...The ability to grow new synaptic connections as a result of experience appears to have been conserved throughout evolution. As an example... the cortical maps of the body surface are subject to constant modification in response to changing input from sensory pathways."