geneticists

"Understanding these crosstalks will help design therapeutic approaches that promote healthy aging, reduce comorbidities and improve the quality of life for those affected”."

"We’re trying to understand the intersection between HIV, aging processes, and cognitive decline"

"The population of older adults with HIV is increasing globally, including in sub-Saharan Africa where 65% of the current 39 million people living with HIV reside.”"

"The goal is to understand how virus-triggered signals and cell interactions affect blood vessel health and contribute to diseases"

"Over half of people living with HIV in the USA are now over 50 years old and this proportion is expected to rise to 70% by 2030,”"

"Yes, the private sector is dependent on the public sector to produce the students. And they wait at the end of the pipeline and they suck them all up. So, yes, public-private partnerships early on are desirable, but I think there are challenges on all sides. I'm not so sure I'm not an economist, but I get a sense that, you know, having just been squeezed through the COVID pandemic, that there's challenges on all sides. So let's just hope that in years to come, there's better will, and that the private sector is more amenable to putting in more money into the system."

"I commit to maintain and exemplify the highest standards of scientific integrity and agree to follow the Academy’s Code of Conduct."

"I can't see that happening because the White Paper has been approved by Parliament, even the Decadal Plan, so the wheels are running. And at the end of the day, the politicians can't stall the momentum at which this is going. I mean, they may be able to chirp about certain things, but the doing is actually in the hands of the scientists. And therein lies, you know, some of the frustrations we feel are scientists. We come from a sporting nation. I mean, you know, we all know that the Springboks (national rugby team) are playing on Saturday. There'll be an overwhelming voice of support for that level of stuff. When it comes to politics, we are all very opinionated. You know we can, we can air our opinions, whether we have supported the evidence, etcetera. But at least with the science, even though we don't get the same recognition as scientists and what science can do, the value of science is that it is evidence based. There's a line of evidence, a chain of evidence in terms of support of what it is we are doing. But sadly, during the COVID era, the trust in science was kind of obliterated. And so we have a lot of work to do to rebuild the trust, the confidence and to allow people to see why science, whether it is the, you know, the physical sciences, the hard sciences or the social sciences, to just stand back a little and watch the way science rolls in motion."

"Is to succeed my master and founder of the Faculty of Medicine of Tunis, the late Professor Amor Chadli."

"It is an honour especially since in this category, I actually represent Africa. To this date, I remain the only member from the African continent to bear this title."

"I saw mothers that had two or three children with a serious and incurable genetic pathology. Such encounters made a strong impression on me and underscored the need for better care for genetic disorders."

"Type Sciences or ethics or disease or human in the Google search engine for example and you are sure to have a complete scientific file, well documented and even a discussion forum."

"To the entire Futura-Sciences team Futura-Sciences is a portal that I already knew well before it dedicated a section to me on the occasion of the UNESCO-L'OREAL prize."

"At a time when websites are flourishing so strongly, we need serious, effective portals to really be a scientific reference for young people and even professionals. Futura-Sciences is one in my opinion."

"I opted to specialize in medical genetics, a decision that caused much confusion within the medical fraternity."

"I then look into the technical problems of the diagnostic laboratory in consultation with my medical and technical biologist colleagues."

"In the afternoon, when I have a lesson to teach, I do it, otherwise I am in the research laboratory at the medical school, which is 300 meters from the hospital department. In this laboratory, I carry out most of my research activity and monitor the work of the students I supervise."

"I have other activities that I may be called upon to undertake, such as participation in the work of commissions or juries. And of course I regularly participate in scientific meetings both nationally and internationally."

"To many of them, the study of medical genetics sounded like a luxury, and the idea of a medical doctor conducting research was far too radical."

"I fulfilled a childhood dream of understanding how life started and how all human beings are eternal."

"“Indian and western Eurasian haplogroup U varieties differ profoundly; the split has occurred about as early as the split between the Indian and eastern Asian haplogroup M varieties. The data show that both M and U exhibited an expansion phase some 50,000 years ago, which should have happened after the corresponding splits.”... “We believe that there are now enough reasons not only to question a ‘recent Indo-Aryan invasion’ into India some 4000 BP, but alternatively to consider India as a part of the common gene pool ancestral to the diversity of human maternal lineages in Europe.”"

"Cavalli-Sforza and his team state that “Indian tribal and caste populations derive largely from the same genetic heritage of Pleistocene [=10000 to 3 mya] southern and western Asians and have received limited gene flow from external regions since the Holocene [=c 10000 to present]. The phylogeography [=neighbouring branches] of the primal mtDNA and Y-chromosome founders suggest that these southern Asian Pleistocene coastal settlers from Africa would have provided the inocula for the subsequent differentiation of the distinctive eastern and western Eurasian gene pools”"

"The noticeable genetic divergence of India from other regions is coupled with low levels of genetic divergence across the subgroups within India."

"In 2000 Kivisild and colleagues found that “even the high castes share more than 80 per cent of their maternal lineages with the lower castes and tribals.” Taking all aspects into consideration, the authors concluded that “there are now enough reasons not only to question a ‘recent Indo‐Aryan invasion’ into India some 4000 BP, but alternatively to consider India as a part of the common gene pool ancestral to the diversity of human maternal lineages in Europe” (Kivisild et al., 2000: 267–271)."

"This neatly fits the earlier findings of non-genetic (morphological) physical anthropology, viz. that the population type of northwestern India has remained the same for at least 8,000 years.... In deference to established Indological opinion, the biologists make a perfunctory nod toward the “supposed” Aryan invasion, only to state that they have found no evidence for this popular supposition: “Their low frequency [i.e. of the West-Asia-related genes] but still general spread all over India plus the estimated time scale does not support a recent massive Aryan invasion, at least as far as maternally inherited genetic lineages are concerned.”"

"In 2003 Kivisild and colleagues questioned the correlation between subsistence categories and genetic difference. Their conclusions highlighted India’s genetic complexity and antiquity, since “present‐day Indians [possess] at least 90 per cent of what we think of as autoch- thonous Upper Paleolithic maternal lineages.” Significantly, “the Indian mtDNA tree in general [is] not subdivided according to linguistic (Indo‐European, Dravidian) or caste affiliations, although there may occur (sometimes drastic) population‐wise differences in frequencies of particular sub‐clusters” (Kivisild et al., 2003a: 216–221). In other words, their results found broad agreement with archaeology and anthropology in con- cluding that language and ethnicity cannot be mapped in a one‐to‐one correspondence relationship. ... present-day Indians [possess] at least 90 per cent of what we think of as autochthonous Upper Palaeolithic maternal lineages.... “the Indian mtDNA tree in general [is] not subdivided according to linguistic (Indo-European, Dravidian) or caste affiliations,”... the straightforward suggestion would be that both Neolithic (agriculture) and Indo-European languages arose in India and from there, spread to Europe.”"

"We found an extensive deep late Pleistocene genetic link between contemporary Europeans and Indians, provided by the mtDNA haplogroup U, which encompasses roughly a fifth of mtDNA lineages of both populations. Our estimate for this split [between Europeans and Indians] is close to the suggested time for the peopling of Asia and the first expansion of anatomically modern humans in Eurasia and likely pre-dates their spread to Europe.” ...the genetic affinity between the Indian subcontinent and Europe “should not be interpreted in terms of a recent admixture of western Caucasoids10 with Indians caused by a putative Indo-Aryan invasion 3,000–4,000 years BP.”"

"Recent genome-sequencing efforts have confirmed that traditional "good-citizen" genes (those that encode functional RNA and protein molecules of obvious benefit to the organism) constitute only a small fraction of the genomic populace in humans and other multicellular creatures. The rest of the DNA sequence includes an astonishing collection of noncoding regions, regulatory modules, deadbeat pseudogenes, legions of repetitive elements, and hosts of oft-shifty, self-interested nomads, renegades, and immigrants. To help visualize functional operations in such intracellular genomic societies and to better encapsulate the evolutionary origins of complex genomes, new and evocative metaphors may be both entertaining and research-stimulating."

"An example of how this is the best of times for evolutionary biology is provided by the recent elucidation of a draft sequence of all 3-billion-plus nucleotide pairs in the human genome et al. 2001, et al. 2001). ... Some prognosticators believe that the application of recombinant DNA methods to gene therapy and gene replacement (the repair or replacement of defective genes in the body) soon may lead to a revolution in the history of medicine comparable to the introductions of sanitation, anesthesia, and antibiotics and vaccines. If the new recombinant gene technologies live up to their early billing, we or our children might see a day when gene therapy can alleviate sickle cell anemia, heart disease, cancer, or various other human genetic disorders. Just as we may marvel at our forebears' fortitude in the dark ages before the advent of our modern medicine, our grandchildren may look back with marvel at our fortitude in the era preceding the wide availability of gene therapies. Nonetheless, the technical hurdles remain daunting. … … Ecologists and natural historians are painfully aware that the subject matter of their devotion—biodiversity—is under assault worldwide as the continents fill with people. The collective weight of human activities is leading to the disappearance of wilderness. Atmosphere and oceans are being polluted, marine fisheries are collapsing worldwide, and wetlands and freshwater aquifers have shrunk dramatically. In short, Earth's renewable and nonrenewable resources are being tragically squandered. In the Amazon Basin, for example, which is famous for its rich biota, slash-and-burn fires are so numerous that their light is visible to astronauts in the space shuttle. Some of these astronauts have felt moved to speak in a deeply spiritual tenor about the beauty of the “blue planet” and to bemoan how we are despoiling this special, fragile place."

"Phylogeography is a field of study concerned with the principles and processes governing the geographic distribution of genealogical lineages, especially those within and among closely related species. As the word implies, phylogeography deals with historical, phylogenetic components of the spatial distributions of gene lineages. In other words, time and space are the jointly considered axes of phylogeography onto which (ideally) are mapped particular gene genealogies of interest ... The analysis and interpretation of lineage distributions usually require extensive input from molecular genetics, population genetics, ethology, demography, phylogenetic biology, paleontology, geology, and historical geography. Thus, phylogeography is an integrative endeavor that lies at an important crossroads of diverse microevolutionary and macroevolutionary disciplines ..."

"Scientists now routinely utilize the genetic information in biological macromolecules—proteins and DNA—to address numerous aspects of the behaviors, life histories, and evolutionary relationships of organisms. When used to best effect, molecular data are integrated with information from such fields as , , , , and paleontology. These time-honored biological disciplines remain highly active today, but each has been enriched if not rejuvenated by contact with the relatively young but burgeoning field of molecular evolution."

"When I was taught biology, we learned about the structure and code of DNA, and we learned about how proteins do all the heavy lifting in cells, and RNA was treated as this dull intermediary, sort of a middle manager ... I was quite surprised that there was this young genius, Jack Szostak, at Harvard who wanted to focus a hundred percent on RNA because he thought that it was the key to understanding the origin of life."

"I had this impression from the media that science was for old white guys, people who looked like Einstein, that it wasn’t for people like me ..."

"... CRISPR is, in fact, a bacterial immune system. It’s an ancient system that evolved in microbes to allow prevention of viral infection. Our interest in this started with that fundamental biology, asking, “How does this work?” We did a collaborative research project with Emmanuelle Charpentier, a medical microbiologist, and our work with her laboratory revealed that one of the components of this CRISPR immune system is, in fact, a protein that’s called , that can be programmed to find and cut virus DNA. We published this work back in the summer of 2012, and for me, life hasn't been the same since."

"... it's kind of a catchy acronym. It stands for Clusters of Regularly Interspaced Short Palindromic Repeats. Oh! Don't make me say that again. ... What it means — what it symbolizes — is an immune system in bacteria that uses sequences of DNA (that come originally from viruses) ... that are transcribed into molecules of RNA that can use a search-and-destroy mechanism in cells to find and cut up virus genetic material"

"... I just think you have to embrace your passions. You have to really go for it. People that have been less successful, in my opinion, are those that dabble in something, but then don’t really give it their all. They almost never give themselves a chance to succeed, as they back off too soon. I think for young people, I tell them go for it, find supportive mentors who will help you through the tough times, and then just keep going. Because if you have a good idea, it’s probably going to work out in some way. You may not be able to predict how, but you should just keep pursuing it."

"Two years ago, I was working on my laptop in an airport lounge in Newark, New Jersey, when I glanced up and saw a couple walking with their two boys. The younger boy slowly made his way on crutches, displaying the telltale signs of a hereditary disease called muscular dystrophy. Generally manifesting in childhood, the disease steadily robs those who have it of their ability to walk. Eventually, I knew, the crutches would no longer be enough. My heart skipped a beat. Most types of muscular dystrophy originate with genetic mutations that weaken key muscle proteins, and I had just come from a meeting where a cure appeared possible, using CRISPR technology to rewrite the DNA of kids just like him. Imagining how the technology I’d helped create could change this boy’s life, I was overwhelmed with emotion. Beyond hope and wonder, I was filled with a sense of fierce urgency to expand CRISPR’s impact to the people around the world who need it most."

"And my mother shrieked ... "You can't leave that child here alone!" And, you know, fair enough. And this unmistakable voice, above and behind me, said, "Emily and I will be fine." And I turned around and said, "Thank you." And my mother looked at me and said, "You can't leave Emily with a total stranger!" And I said, "Mom, if you can't trust Joe DiMaggio, who can you trust?""

"When those of us who are now middle-aged went to high school and to college, what we learned about cancer was completely descriptive. We learned how cancer cells look compared to the way normal cells look and it was beautiful, it was elegant. We learned how cancerous organs look compared to the way normal organs look. We learned about how patients decline with cancer. But it was very frustrating at least for me, because we didn’t have any understanding or sense of why these processes were occurring. Exactly what was happening, why it was it happening, when was it happening, how was it happening, all the questions you ask of mystery. We now don’t have them all answered — if it were an easy problem it would have long since been solved. But we do have a very good sense of the kinds of changes that a cell undergoes between the time it is a normal cell and the time that it is growing completely out of control, causes a tumor that can invade, metastasize and kill its host."

"When women our age started in the field, there were very few of us, and we were absolutely on the margins. People pretty much ignored us. I have come to realize that there was a great freedom in being ignored, that you could go after huge questions, because nobody noticed."

"While other countries are talking of electricity-powered vehicles, driverless trucks, and 200miles per hour trains, we are still battling with narrow gauge rail lines and Never Expect Power Always (NEPA), or Hold on your Power (Power Holding)."

"“With the funding from the Bill and Melinda Gates Foundation, we now have the white, black, brown, and the ash-line of the indigenous breed. There are also two mid-lines, which has 25 or 75 percent local blood. They are meat-lines; they are bigger with tougher meat than the imported stock. We can hardly meet the request of our customers here, and other Universities have been taking our stocks.""

"I am different from you because of my genetic makeup. You need to know your genotype yourself, to enable you to know the type of food you can eat and those you cannot eat or whether you are carrying genetic diseases"

"Nigeria spent 18 million dollars on chicken importation in 2009 alone. If the government spends half of that money on developing local breeds; imagine what that will translate to."

"Tissue Culture Laboratory alone could truly supply plants to millions of farmers, if we really invest into plant tissue culture and micro-propagation,”"

"FUNAAB’s Biotechnology Centre was fully equipped to provide an array of services that border on Animal Biotechnology, Plant Biotechnology, Protein Analysis, Bio-informatics, among others"

"Will 2022 be easier? I do not know the answer to this. But I know that together we will make it."

"It is not medicine we should fear, but the folly of mankind. Every day, the experience of our predecessors increases our ability to change nature by using its own laws. But using this power wisely is what each generation must learn in its turn. We are certainly more powerful today than ever before, but we are no wiser: Technology is cumulative, wisdom is not."

"The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution."

"Living cells respond to DNA damage by a variety of mechanisms, including a series of biochemical pathways called DNA repair. These include three discrete pathways for the excision of damaged bases, called base excision repair, mismatch repair and nucleotide excision repair (NER). NER in human cells is a complex biochemical process during which a large multiprotein complex is assembled at several types of base damage. This multiprotein complex (NER machine) catalyses the excision of damaged bases as oligonucleotide fragments."