"In the proline-based enamine catalysis, proline actually plays a dual role. The amino-group of proline acts as Lewis base, whereas the carboxylic group acts as a Brønsted acid … The potential of using relatively strong chiral organic Brønsted acids as catalysts (Specific Brønsted acid catalysis) has been essentially ignored over the last decades. Achiral acids such as p-TsOH have been used as catalysts for a variety of reactions since a long time, but applications in asymmetric catalysis havebeen extremely rare."
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S.C. Pan, B. List, "New Concepts for Organocatalysis" in Organocatalysis (2008) edited by M.T. Reetz, B. List, S. Jaroch, H. Weinmann.
https://en.wikiquote.org/wiki/Organocatalysis
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Organocatalysis
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