"One further speculation about the way that LSD acts in the brain can be offered. … It is proposed that LSD acts primarily on the pleasure or reward centers of the brain, producing a surge of nonspecific emotionality. If it registers as bliss or rapture, it dominates the sensory flow, the concept of self, the thinking process. This strong emotional discharge overwhelms all mental activity and produces a fusion or synesthesia of the neural pathways: perceptual beauty and glowing light, erasure of the self concept and elimination of rational thought. This is the transcendental state; its opposite, the psychotic state, occurs when the strong feeling discharge is apperceived as horrific and discordant."
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Sidney Cohen, The Beyond Within: The LSD Story (1967), p. xii
https://en.wikiquote.org/wiki/LSD
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LSD
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