"Extracellular matrix protein laminin binds specifically to yeast forms of Paracoccidioides brasiliensis and enhances adhesion of the fungus to the surface of epithelial Madin-Darby canine kidney cells in vitro. Immunoblotting of fungal extracts showed that the gp43 glycoprotein is responsible for adhesion. This was confirmed by binding assays using purified gp43, with a Kd of 3.7 nM. The coating of P. brasiliensis yeast forms with laminin before injection into hamster testicles enhanced the fungus virulence, resulting in a faster and more severe granulomatous disease. These results indicate that interaction of fungi with extracellular matrix elements may constitute a basis for the evolution of fungal infection toward regional spreading and dissemination."
Quote Details
Added by wikiquote-import-bot
Unverified quote
0 likes
Original Language: English
Available Languages (1)
Sources
Imported from EN Wikiquote
https://en.wikiquote.org/wiki/Laminin
Revision History
No revisions have been submitted for this quote.
Categories
Laminin
21 quotes on TrueQuotesView all quotes by Laminin →
Related Quotes
"The normal microbial colonization of sites in the body's tissues by certain bacteria requires that the bacteria first…"
"Anti-laminin antibodies were sought for in the serum of workers exposed to mercury vapour (Hg, n = 58), lead (Pb, n =…"
"The major glycoprotein component of animal cell basement membranes, laminin, is involved in a variety of cellular act…"
"Pseudomonas aeruginosa is a major human pathogen known to infect tissues that have been previously damaged in some wa…"
"Retinal explants from embryonic or adult mice were placed on laminin or merosin substrates and the outgrowth of optic…"
"Adhesion of Aspergillus fumigatus, the causative agent of human aspergillosis, to the extracellular matrix protein la…"
"Laminins, heterotrimers of α, β, and γ chains, are prominent constituents of basal laminae (BLs) throughout the body.…"
"We have previously demonstrated that Staphylococcus aureus, a highly invasive bacteria, presents a 52-kDa surface pro…"
"Mutations of LAMB2 typically cause autosomal recessive Pierson syndrome, a disorder characterized by congenital nephr…"
"Laminins are large molecular weight glycoproteins constituted by the assembly of three disulfide-linked polypeptides,…"