"We now know that many compounds exist which are formed by the union of the same quantities by weight of the same elements, and, nevertheless, differ in properties; modern chemistry explains this fact by saying that the properties of a substance depend, not only on the kind of atoms which compose the minute particles of a compound, and the number of atoms of each kind, but also on the mode of arrangement of the atoms. The same doctrine was taught by Lucretius, two thousand years ago. " It often makes a great difference," he said, " with what things, and in what positions the same first beginnings are held in union, and what motions they mutually impart and receive.""
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History of chemistry
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