"Once we overcome our fear of being tiny, we find ourselves on the threshold of a vast and awesome Universe that utterly dwarfs — in time, in space, and in potential — the tidy anthropocentric proscenium of our ancestors. We gaze across billions of light-years of space to view the Universe shortly after the Big Bang, and plumb the fine structure of matter. We peer down into the core of our planet, and the blazing interior of our star. We read the genetic language in which is written the diverse skills and propensities of every being on Earth. We uncover hidden chapters in the record of our origins, and with some anguish better understand our nature and prospects. We invent and refine agriculture, without which almost all of us would starve to death. We create medicines and vaccines that save the lives of billions. We communicate at the speed of light, and whip around the Earth in an hour and a half. We have sent dozens of ships to more than seventy worlds, and four spacecraft to the stars. We are right to rejoice in our accomplishments, to be proud that our species has been able to see so far, and to judge our merit in part by the very science that has so deflated our pretensions."