"The premises of demonstrative knowledge must be true, primary, immediate, more knowable than and prior to the conclusion, which is further related to them as effect to cause... The premises must be the cause of the conclusion, more knowable than it, and prior to it; its causes, since we possess scientific knowledge of a thing only when we know its cause; prior, in order to be causes; antecedently known, this antecedent knowledge being not our mere understanding of the meaning, but knowledge of the fact as well. Now 'prior' and 'more knowable' are ambiguous terms, for there is a difference between what is prior and more knowable in the order of being and what is prior and knowable to man. I mean that objects nearer to sense are prior and more knowable to man; objects without qualification prior and more knowable are those further from sense. Now the most universal causes are furthest from sense and particular causes are nearest to sense, and they are thus exactly opposed to each other."