"Have you ever dreamt of a better version of yourself? Younger, more beautiful, more perfect. One single injection unlocks your DNA, starting a new cellular division, that will release another version of yourself. This is the Substance. You are the matrix. Everything comes from you. Everything is you. This is simply a better version of yourself. You just have to share. One week for one and one week for the other. A perfect balance of seven days each. The one and only thing not to forget: You. Are. One. You can't escape from yourself."

"[to the shareholders, about Sue] You will not be disappointed. She's my most beautiful creation. I have shaped her for success."

"Margaret Qualley - Sue"

"[watching Sue dismiss her career on a TV interview] Jurassic Fitness? I'll fucking show you. You wanna see some Jurassic Fitness? You want it? Come on, come get your fucking Jurassic Fitness!"

"Oscar Lesage - Troy"

"Fred: You haven't changed a bit! You're still the most beautiful girl in the whole wide world!"

"Hi everybody. I'm Sue. And it's time to Pump It Up!"

"I'm so happy to be with you tonight. I've missed you all so much..."

"If you follow the instructions, what could go wrong?"

"Demi Moore - Elisabeth Sparkle"

"Hugo Diego Garcia - Diego, boyfriend"

"What has been used on one side, is lost on the other side. There's no going back."

"Sue! These are the Shareholders, they are dying to meet you! Is everything okay? So SMILE! That's what we want tonight! Pretty girls should always SMILE!"

"Gore Abrams - Oliver"

"Tom Morton - doctor"

"Oliver: I am actually quite handy if you ever need me to be an aid. I have got a big hammer, you know what I mean!"

"[in a panic] I need a better version of myself. Please give me a better version of myself, please! Please! Come on!"

"[to Elisabeth] I won't be out late, so just wait for me. Don't eat too fast."

"[to Sue] Gorgeous. With a pure heart. People are gonna love that!"

"[on the phone in the bathroom] I don't care if I see every fucking young girl in this fucking town in the next few weeks. Look, I made it simple. We need her young. We need her hot. We need her now. How the old bitch has been able to stick around for this long, that's the fucking mystery to me. Oh, Oscar winner, my ass. When was that back in the 30s? What, for King Kong? [laughs] No, I don't give a fuck what we promised her. This is network TV, not a fucking charity. Find me someone new. NOW! Hey, did you know that a woman's fertility starts to decrease by the age of 25? How old is Jennifer? Ha ha. You better get busy. [laughs as he walks out]"

"Casting Director: Too bad her boobs aren't in the middle of her face instead of that nose!"

"Have you ever dreamt of a better version of yourself?"

"It'll change your life."

"You have to control yourself."

"Dennis Quaid - Harvey"

"Edward Hamilton Clark - Fred"

"Robin Greer - nurse"

"Christian Erickson - man at diner"

"[to lifeless Sue] You're the only part of me I don't hate."

"Dan Hedaya - Joe Maretto"

"Casey Affleck - Russel Hines"

"Maria Tucci - Angela Maretto"

"Joaquin Phoenix - Jimmy Emmett"

"Alison Folland - Lydia Mertz"

"Wayne Knight - Ed Grant"

"Nicole Kidman - Suzanne Stone"

"She will do anything to get what she wants...ANYTHING."

"Murder...scandal...fame...Who says you can't have it all?"

"She was prepared to go all the way...for what she wanted."

"But it's really something when you think that... I'm the one who's gonna be famous. Suzanne would die if she knew."

"[being interviewed about Suzanne] First impressions in one word? You really want to know? Four letters, begins with "C." [beat] Cold. C-O-L-D. Cold."

"She knew what it took to get to the top...a lot of heart and a little head."

"Matt Dillon - Larry Maretto"

"[to Lydia about Russell and Jimmy] It's their word against mine. Who are they? Bunch of 16-year-old losers who grew up in trailers whose parents sit around drinking and screwing their cousins! [laughs] I'm a professional person, for Christ's sake. I come from a good home. Who do you think a jury would believe?"

"I believe that in our fast-moving computer age it is the medium of television that joins together the global community, and it is the television journalist who serves as messenger bringing the world into our homes and our homes into the world. It has always been my dream to become such a messenger. I look to you, gentlemen, now to make that dream a reality."

"Any time it rains, or when there's thunder and lightning, or when it snows, I have to jack off."

"It's nice to live in a country where life, liberty...and all the rest of it still stand for something."

"The point is that, for instance, Connie Chung, who is married, I believe, to Maury Povich, the well-known interviewer, doesn't say: Hello, this is Connie Povich with the news. Now, does she? And I don't think she would be embarrassed by it because she's already pretty ethnic when you think about it. Or to take another example, someone who doesn't have an ethnic bone in her body. There's Jane Pauley, who I strongly relate to because, you know, we have similar physical traits. Although I don't have to struggle with the weight problem like she does. And she also, to the best of my knowledge, has never identified herself, audience-wise, as Jane Trudeau even though her husband, Mr. Trudeau, is a prominent cartoonist of some kind, and not, as so many people believe, the ex-president of Canada. So, what I'm saying is this: There are some people who never know who they are or who they wanna be until it's too late. And that is a real tragedy in my book, because I always knew who I was and who I wanted to be. Always."