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April 10, 2026
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"1. Both positive and negative selection leave distinctive signatures at the molecular level that can be detected using statistical tests. 2. In population genetic data, selection may affect levels of variability, linkage disequilibrium, haplotype structure and allelic distribution in each nucleotide site (frequency spectrum). In comparative data, selection has a strong effect on the dN/dS ratio. 3. Statistical methods for detecting selection differ in the assumptions they make and how powerful they are. Most methods applicable to population genetic data rely on strong assumptions regarding the demography of the populations, while comparative methods are free of such assumptions. 4. An increasing amount of evidence suggests that positive selection is much more pervasive than previously thought. 5. Inferences regarding selection provide a powerful tool in functional studies, for example for the prediction of possible disease-related genomic regions."
Young though he was, his radiant energy produced such an impression of absolute reliability that Hedgewar made him the first sarkaryavah, or general secretary, of the RSS.
- Gopal Mukund Huddar
Largely because of the influence of communists in London, Huddar's conversion into an enthusiastic supporter of the fight against fascism was quick and smooth. The ease with which he crossed from one worldview to another betrays the fact that he had not properly understood the world he had grown in.
Huddar would have been 101 now had he been alive. But then centenaries are not celebrated only to register how old so and so would have been and when. They are usually celebrated to explore how much poorer our lives are without them. Maharashtrian public life is poorer without him. It is poorer for not having made the effort to recall an extraordinary life.
I regret I was not there to listen to Balaji Huddar's speech [...] No matter how many times you listen to him, his speeches are so delightful that you feel like listening to them again and again.
By the time he came out of Franco's prison, Huddar had relinquished many of his old ideas. He displayed a worldview completely different from that of the RSS, even though he continued to remain deferential to Hedgewar and maintained a personal relationship with him.