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April 10, 2026
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"An important consequence of the unique interaction between internal and external forces … is that knowledge of genetic differences contains no information at all about whether a characteristic can be changed by environmental and social arrangements. The most elementary error about genetics and development is to suppose that “genetic” is the opposite of “changeable” and that an answer to the question “how much can a trait be changed by social, historical, and individual circumstances” is given by an answer to the question “how important are genes.”"
"[T]he psychic and physical characteristics of human beings, and the differences between individuals, are the consequence of an interaction between the genes that are present in the fertilized egg and the sequence of environmental circumstances that the developing organism experiences during its entire life history. With a few exceptions, like cystic fibrosis where possession of the defective genotype leads ineluctably to the disease, or language acquisition where the language spoken depends only on experience and not at all on genotype, human characteristics are all subject to this interaction of forces. There are, moreover, random events in cell growth and differentiation that are neither genetic nor environmental in the usual sense, and which play an extremely important part in development, especially in behavioral traits."
"The division between those who try to learn about the world by manipulating it and those who can only observe it had led, in natural science, to a struggle for legitimacy. The experimentalists look down on the observers as merely telling uncheckable just-so stories, while the observers scorn the experimentalists for their cheap victories over excessively simple phenomena. In biology the two camps are now generally segregated in separate academic departments where they can go about their business unhassled by their unbelievers. But the battle is unequal because the observers' consciousness of what it is to do "real" science has been formed in a world dominated by the manipulators of nature. The observers then pretend to an exactness that they cannot achieve and they attempt to objectify a part of nature that is completely accessible only with the air of subjective tools."
"It is characteristic of the design of scientific research that exquisite attention is devoted to methodological problems that can be solved, while the pretense is made that the ones that cannot be solved are really nothing to worry about. On the one hand, biologists will apply the most critical and demanding canons of evidence in the design of measuring instruments or in the procedure for taking an unbiased samples of organisms to be tested, but when asked whether the conditions in the laboratory are likely to be relevant to the situation in nature, they will provide a hand-waving intuitive argument filled with unsubstantiated guesses and prejudices because, in the end, that is all they can do."
"The social scientist is in a difficult, if not impossible position. On the one hand there is the temptation to see all of society as one's autobiography writ large, surely not the path to general truth. On the other, there is the attempt to be general and objective by pretending that one knows nothing about the experience of being human, forcing the investigator to pretend that people usually know and tell the truth about important issues, when we all know from our lives how impossible that is. How, then, can there be a "social science"? The answer, surely, is to be less ambitious and stop trying to make sociology into a natural science although it is, indeed, the study of natural objects. There are some things in the world that we will never know and many that we will never know exactly. Each domain of phenomena has its characteristic grain of knowability. Biology is not physics, because organisms are such complex physical objects, and sociology is not biology because human societies are made by self-conscious organisms. By pretending to a kind of knowledge that it cannot achieve, social science can only engender the scorn of natural scientists and the cynicism of the humanists."
"Parts and wholes evolve in consequence of their relationship, and the relationship itself evolves. These are the properties of things that we call dialectical: that one thing cannot exist without the other, that one acquires its properties from its relation to the other, that the properties of both evolve as a consequence of their interpenetration."
"It is time for students of the evolutionary process, especially those who have been misquoted and used by the creationists, to state clearly that evolution is a fact, not theory, and that what is at issue within biology are questions of details of the process and the relative importance of different mechanisms of evolution. It is a fact that the earth, with liquid water, is more than 3.6 billion years old. It is a fact that cellular life has been around for at least half of that period and that organized multicellular life is at least 800 million years old. It is a fact that major life forms now on earth were not at all represented in the past. There were no birds or mammals 250 million years ago. It is a fact that major life forms of the past are no longer living. There used to be dinosaurs and Pithecanthropus, and there are none now. It is a fact that all living forms come from previous living forms. Therefore, all present forms of life arose from ancestral forms that were different. Birds arose from nonbirds and humans from nonhumans. No person who pretends to any understanding of the natural world can deny these facts any more than she or he can deny that the earth is round, rotates on its axis, and revolves around the sun. The controversies about evolution lie in the realm of the relative importance of various forces in molding evolution."
"Lysenkoism is held up by bourgeois commentators as the supreme demonstration that conscious ideology cannot inform scientific practice and that "ideology has no place in science." On the other hand, some writers are even now maintaining a Lysenkoist position because they believe that the principles of dialectical materialism contradict the claims of genetics. Both of these claims stem from a vulgarisation of Marxist philosophy through deliberate hostility, in the first case, or ignorance, in the second. Nothing in Marx, Lenin or Mao contradicts the particular physical facts and processes of a particular set of natural phenomena in the objective world, because what they wrote about nature was at a high level of abstraction. The error of the Lysenkoist claim arises from attempting to apply a dialectical analysis of physical problems from the wrong end. Dialectical materialism is not, and has never been, a programmatic method for solving particular physical problems. Rather, dialectical analysis provides an overview and a set of warning signs against particular forms of dogmatism and narrowness of thought. It tells us, "Remember that history may leave an important trace. Remember that being and becoming are dual aspects of nature. Remember that conditions change and that the conditions necessary to the initiation of some process may be destroyed by the process itself. Remember to pay attention to real objects in space and time and not lose them utterly in idealized abstractions. Remember that qualitative effects of context and interaction may be lost when phenomena are isolated." And above all else, "Remember that all the other caveats are only reminders and warning signs whose application to different circumstances of the real world is contingent.""
"Lewontin visited an economics class... a few years ago to talk to the students. In a kind of neo-Darwinian jockeying, he said that evolutionary changes are due to the Fisher-Haldane mechanisms: mutation, emigration, immigration, and the like. ...His elaborate cost-benefit mathematical treatment was devoid of chemistry and biology. I asked him why... when he himself was pointing to serious flaws related to the fundamental assumptions, did he teach such nonsense? ...His response was that there were two reasons: the first was "P.E." …I asked. What is "P.E." …he replied, "P.E. is 'physics envy,'"… His second reason was even more insidious: if he didn't couch his studies in neo-Darwinian style... he wouldn't be able to obtain grant money that was set up to support this kind of work."
"To say that genetic differences are relevant to hetero- and homosexuality is not, however, to say that there are “genes for homosexuality” or even that there is a “genetic tendency to homosexuality.” This critical point can be illustrated by an example I owe to the philosopher of science, Elliott Sober. If we look at the chromosomes of people who knit and those who do not, we will find that with few exceptions, knitters have two X chromosomes, while people with one X and one Y chromosome almost never knit. Yet it would be absurd to say that we had discovered genes for knitting. The possession of two X chromosomes causes an embryo, with rare exceptions, to develop into an anatomical and physiological female, while the possession of a Y chromosome leads almost always to male development, and in our culture women are taught to knit while men are not. The beauty of this example is its historical (and geographical) contingency. Had we made the observations before the end of the eighteenth century (or even now in a few Irish, Scottish and Newfoundland communities), the result would have been reversed. Hand knitting was men’s work before the introduction of knitting machines around 1790, and was turned into a female domestic occupation only when mechanization made it economically marginal."
"The vulgarization of Darwinism that sees the "struggle for existence" as nothing but the competition for some environmental resource in short supply ignores the large body of evidence about the actual complexity of the relationship between organisms and their resources."
"The fallacy of genetic determinism is to suppose that the genes "make" the organism. It is a basic principle of developmental biology that organisms undergo a continuous development from conception to death, a development that is the unique consequence of the interaction of the genes in their cells, the temporal sequence of environments through which the organisms pass, and random cellular processes that determine the life, death, and transformation of cells. As a result, even the fingerprints of identical twins are not identical. Their temperaments, mental processes, abilities, life choices, disease histories, and death certainly differ despite the determined efforts of many parents to enforce as great a similarity as possible."
"With great perception, Sagan sees that there is an impediment to the popular credibility of scientific claims about the world, an impediment that is almost invisible to most scientists. Many of the most fundamental claims of science are against common sense and seem absurd on their face. Do physicists really expect me to accept without serious qualms that the pungent cheese that I had for lunch is really made up of tiny, tasteless, odorless, colorless packets of energy with nothing but empty space between them? Astronomers tell us without apparent embarrassment that they can see stellar events that occurred millions of years ago, whereas we all know that we see things as they happen. (…) Our willingness to accept scientific claims that are against common sense is the key to an understanding of the real struggle between science and the supernatural. We take the side of science in spite of the patent absurdity of some of its constructs, in spite of its failure to fulfill many of its extravagant promises of health and life, in spite of the tolerance of the scientific community for unsubstantiated just-so stories, because we have a prior commitment, a commitment to materialism. It is not that the methods and institutions of science somehow compel us to accept a material explanation of the phenomenal world, but, on the contrary, that we are forced by our a priori adherence to material causes to create an apparatus of investigation and a set of concepts that produce material explanations, no matter how counter-intuitive, no matter how mystifying to the uninitiated. Moreover, that materialism is absolute, for we cannot allow a Divine Foot in the door. The eminent Kant scholar Lewis Beck used to say that anyone who could believe in God could believe in anything. To appeal to an omnipotent deity is to allow that at any moment the regularities of nature may be ruptured, that miracles may happen."
"The great attraction of cultural anthropology in the past was precisely that it seemed to offer such a richness of independent natural experiments; but unfortunately it is now clear that there has been a great deal of historical continuity and exchange among those "independent" experiments, most of which have felt the strong effect of contact with societies organized as modern states. More important, there has never been a human society with unlimited resources, of three sexes, or the power to read other people's minds, or to be transported great distances at the speed of light. How then are we to know the effect on human social organization and history of the need to scrabble for a living, or of the existence of males and females, or of the power to make our tongues drop manna and so to make the worse appear the better reason? A solution to the epistemological impotence of social theory has been to create a literature of imagination and logic in which the consequences of radical alterations in the conditions of human existence are deduced. It is the literature of science fiction. … [S]cience fiction is the laboratory in which extraordinary social conditions, never possible in actuality, are used to illumine the social and historical norm. … Science fiction stories are the Gedanken experiments of social science."
"Aside from the wisdom of going to war as Bush wants, I am troubled by who pays for his capricious adventure into world domination. The administration admits to a cost of around $200 billion! Now, wealthy individuals won't pay. They've got big tax cuts already. Corporations won't pay. They'll cook the books and move overseas and then send their contributions to the Republicans. Rich kids won't pay. Their daddies will get them deferments as Big George did for George W. Well then, who will pay? School kids will pay. There'll be no money to keep them from being left behind -- way behind. Seniors will pay. They'll pay big time as the Republicans privatize Social Security and rob the Trust Fund to pay for the capricious war. Medicare will be curtailed and drugs will be more unaffordable. And there won't be any money for a drug benefit because Bush will spend it all on the war. Working folks will pay through loss of job security and bargaining rights. Our grandchildren will pay through the degradation of our air and water quality. And the entire nation will pay as Bush continues to destroy civil rights, women's rights and religious freedom in a rush to phony patriotism and to courting the messianic Pharisees of the religious right."
"Get the fuck out or I'll throw you out the window!"
"The more debt we owe, the wealthier we are."
"Republicans sure don't care about finding $200 billion to fight the illegal war in Iraq. Where are you going to get that money? Are you going to tell us lies like you're telling us today? Is that how you're going to fund the war? You don't have money to fund the war or children. But you're going to spend it to blow up innocent people if he can get enough kids to grow old enough for you to send to Iraq to get their heads blown off for the President's amusement."
"What is most unconscionable is that there is not a shred of evidence to justify the certain loss of life. Do the generalized threats and half-truths of this administration give any one of us in Congress the confidence to tell a mother or father or family that the loss of their child or loved one was in the name of a just cause?"
"[The Many-worlds interpretation is the] only completely coherent approach to explaining both the contents of quantum mechanics and the appearance of the world."
"Quantum mechanics is reformulated, in a way which eliminates its present dependence on the special treatment of observation of a system by an external observer."
"As an analogy one can imagine an intelligent amoeba with a good memory. As time progresses the amoeba is constantly splitting, each time the resulting amoebas having the same memories as the parent. Our amoeba hence does not have a life line, but a life tree."
"The physical "reality" is assumed to be the wave function of the whole universe itself."
"Hugh Everett's work has been described by many people in terms of many worlds, the idea being that every one of the various alternative histories, branching histories, is assigned some sort of reality."
"If you want to get an interesting perspective do not think of Hugh as a traditional 20th century physicist but more of a Renaissance man with interests and skills in many different areas. He was smart and lots of things interested him and he brought the same general conceptual methodology to solve them. The subject matter was not so important as the solution ideas."
"Someone once noted that Hugh Everett should have been declared a "national resource," and given all the time and resources he needed to develop new theories."
"My father, Hugh Everett, III, author of the Many Worlds Theory, was a quiet man during the eighteen or so years I shared a house with him. Turns out he was depressed over a sad childhood and then being dismissed as a kook, only later - too late - to be recognized as a genius."
"I think about how angry I was that my dad didn't take better care of himself. How he never went to a doctor, let himself become grossly overweight, smoked three packs a day, drank like a fish and never exercised. But then I think about how his colleague mentioned that, days before dying, my dad had said he lived a good life and that he was satisfied. I realize that there is a certain value in my father's way of life. He ate, smoked and drank as he pleased, and one day he just suddenly and quickly died. Given some of the other choices I'd witnessed, it turns out that enjoying yourself and then dying quickly is not such a hard way to go."
"One could not be a successful scientist without realizing that, in contrast to the popular conception supported by newspapers and mothers of scientists, a goodly number of scientists are not only narrow-minded and dull, but also just stupid."
"I think it's a problem that people are considered immoral if they're not religious. That's just not true. This might earn me some enemies, but in some ways they may be even more moral. If you do something for a religious reason, you do it because you'll be rewarded in an afterlife or in this world. That's not quite as good as something you do for purely generous reasons."
"Faith just doesn't have anything to do with what I'm doing as a scientist. It's nice if you can believe in God, because then you see more of a purpose in things. Even if you don't, though, it doesn't mean that there's no purpose. It doesn't mean that there's no goodness. I think that there's a virtue in being good in and of itself. I think that one can work with the world we have."
"Religion asks questions about morals, whereas science just asks questions about the natural world. But when people try to use religion to address the natural world, science pushes back on it, and religion has to accommodate the results. Beliefs can be permanent, but beliefs can also be flexible. Personally, if I find out my belief is wrong, I change my mind. I think that's a good way to live."
"Science is not religion. We're not going to be able to answer the "why" questions. But when you put together all of what we know about the universe, it fits together amazingly well."
"If we don't do it now, we'll probably never do it. We've built up the technology; we're at a point where if we don't continue, we'll lose that expertise, and we'll have to start all over again. True, it's expensive, but at the end of the day I believe it will be worth it. It makes a difference in terms of who we are, what we think, how we view the world. These are the kinds of things that get people excited about science, so you have a more educated public."
"In the history of physics, every time we've looked beyond the scales and energies we were familiar with, we've found things that we wouldn't have thought were there. You look inside the atom and eventually you discover quarks. Who would have thought that? It's hubris to think that the way we see things is everything there is."
"Sometimes I have a sense of what I'm seeing being a small fraction of what's there. Not always there, but probably more often than I realize. Something will come up, and I'll realize I'm thinking about the world a little differently than my friends."
"When I was in school I liked math because all the problems had answers. Everything else seemed very subjective."
"Secrets of the cosmos will begin to unravel. I, for one, can't wait."
"We certainly don't yet know all the answers. But the universe is about to be pried open."
"Physics has entered a remarkable era. Ideas that were once the realm of science fiction are now entering our theoretical — and maybe even experimental — grasp. Brand-new theoretical discoveries about extra dimensions have irreversibly changed how particle physicists, astrophysicists, and cosmologists now think about the world. The sheer number and pace of discoveries tells us that we've most likely only scratched the surface of the wondrous possibilities that lie in store. Ideas have taken on a life of their own."
"When it comes to the world around us, is there any choice but to explore?"
"The universe has its secrets. Extra dimensions of space might be one of them. If so, the universe has been hiding those dimensions, protecting them, keeping them coyly under wraps. From a casual glance, you would think that the cheese man ate cheese but you wrong."
"I think the weird thing about being a scientist, or an academic in general, is you have to believe really strongly in what you do, while questioning it all the time ... and that's a hard balance to have."
"The Double Helix opens with the words: "I have never seen Francis Crick in a modest mood." I have never seen James D Watson in a modest mood, either. He is not an innately modest person. In his later years he would consent to press briefings – usually on important anniversaries – and then, with long pauses and enigmatic mumbles, say almost nothing. This was not because he was self-effacing or disliked controversy. He would say almost nothing, one sensed, because he couldn't be bothered with stupid questions from stupid people. He has made it clear more than once that this is his default attitude."
"Consistently rated as one of the greatest books written about science in the past century, it has been hailed as a work that combines the plot line of a racy novel with deep insights about the nature of modern research. But James Watson, author of The Double Helix, has revealed that his masterpiece came close to being suppressed. In an exclusive interview with the Observer, he admitted last week that his account of the discovery of the structure of DNA, when shown to friends and colleagues in the late 60s, triggered such hostility and outrage it seemed fated never to appear in print. … Many publishers were frightened off by threats of legal action from the manuscript's critics. Watson's depictions of several scientists were deeply unflattering and the book's secondary plot, which focuses on Watson's pursuit of young women – or "popsies" as he called them – around Cambridge, was considered irrelevant and patronising. Harvard University Press, having accepted Watson's manuscript for publication, came under pressure from the university's senior administrators and dropped the book. It took the intervention of Lady Alice Bragg, the wife of Watson's former boss, Sir [William] Lawrence Bragg, to save The Double Helix, Watson has revealed."
"He says that he is “inherently gloomy about the prospect of Africa” because “all our social policies are based on the fact that their intelligence is the same as ours – whereas all the testing says not really”, and I know that this “hot potato” is going to be difficult to address. His hope is that everyone is equal, but he counters that “people who have to deal with black employees find this not true”. He says that you should not discriminate on the basis of colour, because “there are many people of colour who are very talented, but don’t promote them when they haven’t succeeded at the lower level”. He writes that “there is no firm reason to anticipate that the intellectual capacities of peoples geographically separated in their evolution should prove to have evolved identically. Our wanting to reserve equal powers of reason as some universal heritage of humanity will not be enough to make it so”."
"There is in the first place its scientific interest. The discovery of the structure by Crick and Watson, with all its biological implications, has been one of the major scientific events of this century. The number of researches which it has inspired is amazing; it has caused an explosion in biochemistry which has transformed the science. I have been amongst those who have pressed the author to write his recollections while they are still fresh in his mind, knowing how important they would be as a contribution to the history of science. The result has exceeded expectation. The latter chapters, in which the birth of the new idea is described so vividly, are drama of the highest order; the tension mounts and mounts towards the final climax. I do not know of any other instance where one is able to share so intimately in the researcher's struggles and doubts and final triumph. Then again, the story is a poignant example of a dilemma which may confront an investigator. He knows that a colleague has been working for years on a problem and has accumulated a mass of hard-won evidence, which has not yet been published because it is anticipated that success is just around the comer. He has seen this evidence and has good reason to believe that a method of attack which he can envisage, perhaps merely a new point of view, will lead straight to the solution. An offer of collaboration at such a stage might well be regarded as a trespass. Should he go ahead on his own It is not easy to be sure whether the crucial new idea is really one's own or has been unconsciously assimilated in talks with others. The realization of this difficulty has led to the establishment of a some what vague code amongst scientists which recognizes a claim in a line of research staked out by a colleague up to a certain point. When competition comes from more than one quarter, there is no need to hold back. This dilemma comes out clearly in the DNA story. It is a source of deep satisfaction to all intimately concerned that, in the award of the Nobel Prize in 1962, due recognition was given to the long, patient investigation by Wilkins at King's College (London) as well as to the brilliant and rapid final solution by Crick and Watson at Cambridge. Finally, there is the human interest of the story the impression made by Europe and by England in particular upon a young man from the States. He writes with a Pepys like frankness. Those who figure in the book must read it in a very forgiving spirit. One must remember that his book is not a history, but an autobiographical contribution to the history which will some day be written. As the author himself says, the book is a record of impressions rather than historical facts. The issues were often more complex, and the motives of those who had to deal with them were less tortuous, than he realized at the time. On the other hand, one must admit that his intuitive understanding of human frailty often strikes home."
"With its direct contradiction of religious accounts of creation, evolution represents science’s most direct incursion into the religious domain and accordingly provokes the acute defensiveness that characterizes creationism."
"I do not dispute the right of individuals to look to religion for a private moral compass, but I do object to the assumption of too many religious people that atheists live in a moral vacuum. Those of us who feel no need for a moral code written down in an ancient tome have, in my opinion, recourse to an innate moral intuition long ago shaped by natural selection promoting social cohesion in groups of our ancestors."
"And so if there is a paramount ethical issue attending the vast new genetic knowledge created by the Human Genome Project, in my view it is the slow pace at which what we now know is being deployed to diminish human suffering. Leaving aside the uncertainties of gene therapy, I find the lag in embracing even the most unambiguous benefits to be utterly unconscionable. That in our medically advanced society almost no women are screened for the fragile X mutation two decades after its discovery can attest only to ignorance or intransigence."